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      • KCI등재

        Prediction of ultimate moment anchorage capacity of concrete filled steel box footing

        Muhammad Aun Bashir,Hitoshi Furuuchi,Tamon Ueda,M. Nauman Bashir 국제구조공학회 2013 Steel and Composite Structures, An International J Vol.15 No.6

        The objective of the study is to predict the moment anchorage capacity of the concrete filled steel box (CFSB) as footing by using the 3D finite element program CAMUI developed by authors' laboratory. The steel box is filled with concrete and concrete filled steel tube (CFT) column is inserted in the box. Numerical simulation of the experimental specimens was carried out after introducing the new constitutive model for post peak behavior of concrete in compression under confinement. The experimental program was conducted to verify the reliability of the simulation results by the FE program. The simulated peak loads agree reasonably with the experimental ones and was controlled by concrete crushing near the column. After confirming the reliability of the FEM simulation, effects of different parameters on the moment anchorage capacity of concrete filled steel box footing were clarified by conducting numerically parametric study.

      • Slide Session : OS-END-02 ; Diabetes : The Incidence of Diabetic Foot Ulcer on Lower Extrem-ity Amputation and All- Cause Mortality in Patients with Type 1 and 2 Diabetes in Miyoshi, Hiroshima

        ( Shinsuke Mikami ),( Takafumi Sugihiro ),( Satoshi Mouri ),( Yusuke Ueda ),( Hitoshi Susawa ),( Kengo Kobayashi ),( Haruki Tanaka ),( Kouichi Tanaka ),( Yukihito Higashi ),( Yasuki Kihara ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: Foot ulcers are costly complication among diabetes patients. These patients have an increased risk of amputation and increased mortality rate. Early recognition of the high-risk foot and sufficient care will save legs and improve patients` quality of life. Figures of incidence of foot ulcers varies and there are only limited information in relation the change of incidence over time. The aim of this study was to estimate 5-year risk for diabetic foot ulcer (DFU), lower extremity amputation (LEA) and all cause of death. Methods: Retrospective cohort study including all subjects with diabetes enrolled in our diabetic outpatient clinic from beginning 2008 until middle 2014. Data were collected from clinical records. Results: 528 subjects with mean age of 61.3 (±13.8), 57.4% were male. The mean of HbA1c in diabetic patients at baseline were 8.1% +/- 1.9%. Cumulative incidence was 1.3% for DFU, 0.18% for LEA and 4.7% for all-cause of death. The prevalence of cardiovascular and cerebrovascular conditions, pneumonia were 2.3%, 1.9%, 2.3%, respectively. Cause of deaths was cancer (64%), pneumonia (20%), cardiovascular death (4%). Conclusions: Several factors may explain the incidence in diabetes-related LEAs. Diabetes prevention strategies and controlling risk factors are important in people with type 1 and 2 diabetes.

      • Study of Trehalase during Autolysis of the Fruit-body in Pleurotus sp.

        Alireza Arastoo,Masami Nakazawa,Tatsuji Sakamoto,Mizuho Kusuda,Hitoshi Kobayashi,Kenji Ouchi,Satoshi Inatomi,Mitsuhiro Ueda 한국버섯학회 2017 버섯 Vol.21 No.2

        Fruiting bodies were degraded themselves by the several glycoside hydrolases after spore releasing from mature fruiting bodies or harvesting. The enzymes involved in autolysis such as glucanase and chitinase have been studied. However, there are almost no information about the relationship between several glycoside hydrolases and autolysis. In this study, we studied to obtain the enzymatic properties of trehalase, and also to get the new information on the relationship between trehalase and autolysis. Crude enzymes were prepared from each fruiting body of Pleurotus sp. (from the immature stage to the autolysis stage) and the trehalase activities were measured at each growth stage. Trehalase activities sharply increased in autolysis stage. Trehalase was partially purified from fruiting bodies of the autolysis stage using various column chromatography and its properties were examined. The optimum temperature was 50 °C and the optimum pH was 4.5. In order to elucidate the localization of trehalase, fruit bodies of the autolysis stage were divided into the stipes and the pileuses, and the each trehalase activity was measured. High trehalase activities were found in the pileuses. Furthermore, in order to elucidate trehalase activities in autolysis more detail, the each fruiting body of autolysis progressing stages was finely divided into the stipes and the pileuses, and their activities were measured. The activities in the outer part of the pileuses were highest at the initial stage of autolysis and the activities shifted from the outer side to the inner side of the pileuses according to the progress of autolysis.

      • KCI등재

        Factors Associated with Doses of Mood Stabilizers in Real-world Outpatients with Bipolar Disorder

        Norio Yasui-Furukori,Naoto Adachi,Yukihisa Kubota,Takaharu Azekawa,Eiichiro Goto,Koji Edagawa,Eiichi Katsumoto,Seiji Hongo,Hitoshi Ueda,Kazuhira Miki,Masaki Kato,Reiji Yoshimura,Atsuo Nakagawa,Toshiak 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.4

        Objective: Several evidence-based practice guidelines have been developed to better treat bipolar disorder. However, the articles cited in these guidelines were based on clinical or basic studies with specific conditional settings and were not sufficiently based on real-world clinical practice. In particular, there was little information on the doses of mood stabilizers. Methods: The MUlticenter treatment SUrvey on BIpolar disorder in Japanese psychiatric clinics (MUSUBI) is a study conducted to accumulate evidence on the real-world practical treatment of bipolar disorder. The questionnaire included patient characteristics such as comorbidities, mental status, treatment period, Global Assessment of Functioning (GAF) score, and details of pharmacological treatment. Results: Most patients received mood stabilizers such as lithium (n = 1,317), valproic acid (n = 808), carbamazepine (n = 136), and lamotrigine (n = 665). The dose of lithium was correlated with age, body weight, number of episodes, depression and GAF. The dose of valproic acid was correlated with body weight, number of episodes, presence of a rapid cycle and GAF. The dose of carbamazepine was correlated with age, mania, and the presence of a rapid cycle. The dose of lamotrigine was correlated with the number of episodes, depression, mania, psychotic features, and the presence of a rapid cycle. Doses of coadministered mood stabilizers were significantly correlated, except for the combination of valproic acid and lamotrigine. Conclusion: The dose of mood stabilizers was selectively administered based on several factors, such as age, body composition, current mood status and functioning. Further prospective studies are required to confirm these findings.

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