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Effect of Nozzle Geometry on the Near Field Structure of Under Expanded, Dual, Coaxial Jet
Lee Kwon-Hee(이권희),Setoguchi Toshiake(세토구치 토시아키),Kim Heuy-Dong(김희동) 대한기계학회 2004 대한기계학회 춘추학술대회 Vol.2004 No.4
The near field structures of an under-expanded, dual, coaxial, jets issuing from the coaxial nozzles with four different geometries are visualized by using a shadowgraph optical method. Experiments are conducted to investigate the effects of the nozzle-lip thickness, secondary stream thickness, the nozzle pressure ratio and the secondary swirl stream on the characteristics of under-expanded jets. The results show that the presence of secondary annular swirling stream causes the Mach disk to move further downstream and increases its diameter, which decreases with a decrease in the nozzle-lip thickness. The secondary stream thickness has an influence on the location of an annular shock wave.
Factors Associated with Doses of Mood Stabilizers in Real-world Outpatients with Bipolar Disorder
Norio Yasui-Furukori,Naoto Adachi,Yukihisa Kubota,Takaharu Azekawa,Eiichiro Goto,Koji Edagawa,Eiichi Katsumoto,Seiji Hongo,Hitoshi Ueda,Kazuhira Miki,Masaki Kato,Reiji Yoshimura,Atsuo Nakagawa,Toshiak 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.4
Objective: Several evidence-based practice guidelines have been developed to better treat bipolar disorder. However, the articles cited in these guidelines were based on clinical or basic studies with specific conditional settings and were not sufficiently based on real-world clinical practice. In particular, there was little information on the doses of mood stabilizers. Methods: The MUlticenter treatment SUrvey on BIpolar disorder in Japanese psychiatric clinics (MUSUBI) is a study conducted to accumulate evidence on the real-world practical treatment of bipolar disorder. The questionnaire included patient characteristics such as comorbidities, mental status, treatment period, Global Assessment of Functioning (GAF) score, and details of pharmacological treatment. Results: Most patients received mood stabilizers such as lithium (n = 1,317), valproic acid (n = 808), carbamazepine (n = 136), and lamotrigine (n = 665). The dose of lithium was correlated with age, body weight, number of episodes, depression and GAF. The dose of valproic acid was correlated with body weight, number of episodes, presence of a rapid cycle and GAF. The dose of carbamazepine was correlated with age, mania, and the presence of a rapid cycle. The dose of lamotrigine was correlated with the number of episodes, depression, mania, psychotic features, and the presence of a rapid cycle. Doses of coadministered mood stabilizers were significantly correlated, except for the combination of valproic acid and lamotrigine. Conclusion: The dose of mood stabilizers was selectively administered based on several factors, such as age, body composition, current mood status and functioning. Further prospective studies are required to confirm these findings.