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Self-Tuning Control for Ratational Speed of Slider-Crank Mechanism
Hitoshi SAITO,Jun ISHIKAWA,Tetsuo SHIOTSUKI,Katsuhisa FURUTA 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
This paper proposes a self_tuning control method based on generalized minimum variance control for rotational speed control of a slider_crank mechanism. Dynamic characteristics of the slider_crank mechanism significantly changes depending on the wheel rotational angle. Thus, to achieve a good control performance, it is necessary for the plant parameters to be identified at the each section divided into six by the wheel angle. This kind of control based on the local modeling is useful not only for such a slikder_crank mechanism but also for highly_accurate positioning control systems with significant nonlinearity. The validity of the proposed method is verified through simulations and experiments.
( Teruaki Saito ),( Genki Sakuta ),( Hitoshi Kobayashi ),( Kenji Ouchi ),( Satoshi Inatomi ) 한국균학회 2019 Mycobiology Vol.47 No.4
For the purpose of protecting the rights of Lentinula edodes breeders, we developed a new simple sequence repeat (SSR) marker set consisting only of genetically independent tetranucleotide or longer core motifs. Using available genome sequences for five L. edodes strains, we designed primers for 13 SSR markers that amplified polymorphic sequences in 20 L. edodes cultivars. We evaluated the independence of every possible marker pair based on genotype data. Consequently, eight genetically independent markers were selected. The polymorphic information content values of the markers ranged from 0.269 to 0.764, with an average of 0.409. The markers could distinguish among 20 L. edodes cultivars and produced highly repeatable and reproducible results. The markers developed in this study will enable the precise identification of L. edodes cultivars, and may be useful for protecting breeders’ rights.
Classication of fNIRS Data Using an Articial Neural Network for Image Sequence Recognition
Sei Takahashi,Nagako Saito,Hideo Nakamura,Hitoshi Tsunashima 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
We describe classication of functional near-infrared spectroscopy (fNIRS) data acquired during finger tapping and motor imagery tasks performed by a human subject, using an articial neural network for image sequence recognition. Our goal is to develop a brain-computer interface. We used an fNIRS system to collect neural information from brain activity. For discrimination of fNIRS data, we used our previously proposed neural network model called the Neocognitron-type Image Sequence Recognition Model (Neo-ISRM), which is suitable for multichannel temporal patterns. Finger tapping and its motor imagery were used as the motion and mental tasks to be discriminated using Neo-ISRM. The model gave good discrimination results for each category of tasks.
Haruhisa Kato,Makiko Naito,Tomoko Saito,Takuto Hideyama,Yasuhiro Suzuki,Takashi Kimura,Shin Kwak,Hitoshi Aizawa 대한신경과학회 2022 Journal of Clinical Neurology Vol.18 No.4
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease. Selective deficiency of edited adenosine deaminase acting on RNA 2 (ADAR2), a key molecule in the acquisition of Ca2+ resistance in motor neurons, has been reported in sporadic ALS (sALS) spinal motor neurons. Since ADAR2 activity is positively regulated by prolyl isomerase Protein never in mitosis gene A interacting-1 (Pin1), a known phosphorylation-dependent peptidyl-prolyl cis/trans isomerase, we investigated Pin1 expression in spinal motor neurons in sALS. Methods Specimens of the spinal cord were obtained from the lumbar region in eight sALS patients and age-matched five controls after postmortem examinations. The specimens were double stained with anti-Pin1 and anti-TAR DNA-binding protein of 43 kDa (TDP-43) antibodies, and examined under a fluorescence microscope. Results This study analyzed 254 and 422 spinal motor neurons from 8 sALS patients and 5 control subjects, respectively. The frequency of motor neurons with high cytoplasmic Pin1 expression from the spinal cord did not differ significantly between sALS specimens without cytoplasmic TDP-43 inclusions and control specimens. However, in sALS specimens, neurons for which the Pin1 immunoluminescence intensity in the cytoplasm was at least twice that in the background were more common in specimens with cytoplasmic TDP-43 inclusions (p<0.05 in χ2 test). Conclusions In sALS, neurons with higher expression levels of Pin1 levels had more TDP-43 inclusions. Despite the feedback mechanism between Pin1 and ADAR2 being unclear, since Pin1 positively regulates ADAR2, our results suggest that higher Pin1 expression levels in motor neurons with TDP-43 pathology from sALS patients represent a compensatory mechanism
Literature Review on Recent Magnetocardiography and Impedance-MagnetocardiographyTechnologies
Y. Seki,A. Tsukamoto,K. Tsukada,Hitoshi Horigome,Miki Yokokawa,Yoshihide Chiba,Kimio Tanaka,A. Kandori,T. Miyashita,K. Ogata,D. Suzuki,K. Saito,K. Yokosawa,Satsuki Yamada,Shigeyuki Watanabe,Iwao Yamag 한국초전도학회 2006 Progress in superconductivity Vol.8 No.1
Toshio Suzuki,Ryota Akagi,Fumio Nanba,Shizuka Saito,Toshinari Maruo,Toshiya Toda,Yoko Yamashita,Hitoshi Ashida 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.2
Black soybean seed coat extract (BE) contains multiple bioactive polyphenols, including flavan-3-ols andanthocyanins. BE improves endothelial function; however, it is unclear whether BE protects endothelial cells from senescence. In this study, we examined the effects of BE on endothelial cell senescence and vascular function in healthy individuals. High concentrations of glucose were used to induce senescence in bovine aortic endothelial cells incubated with BE. Senescence, vascular function, and oxidative stress markers were measured. Incubation with BE remarkably inhibitedsenescence-associated b-galactosidase and lactate dehydrogenase activities and dose dependently reduced intracellular reactiveoxygen species levels in bovine aortic endothelial cells. BE treatment increased the levels of endothelial nitric oxidesynthase (eNOS) mRNA and endothelial nitric oxide (NO) metabolites and increased the mRNA expression of klotho, a geneassociated with an antiaging phenotype. To examine the effects of BE in humans, we conducted a clinical study using the secondderivative of the fingertip photoplethysmogram to investigate vascular function and aging in 24 healthy volunteers. The participantsconsumed BE supplements (100mg/day) or a placebo for 2 weeks. When compared with the placebo group, the BE groupshowed considerably improved vascular function, NO metabolite levels, and oxidative stress. These results suggest that BEsupplementation improves endothelial function, possibly through antioxidant activity and NO production, and may consequentlyreduce the cardiovascular risk associated with aging. BE supplementation may be an effective and safe approach to reduce the riskof atherosclerosis and cardiovascular disease; however, additional studies investigating chronic vascular inflammation are needed.
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer
Sakamoto, Hiromi,Yoshimura, Kimio,Saeki, Norihisa,Katai, Hitoshi,Shimoda, Tadakazu,Matsuno, Yoshihiro,Saito, Daizo,Sugimura, Haruhiko,Tanioka, Fumihiko,Kato, Shunji,Matsukura, Norio,Matsuda, Noriko,Na Nature Pub. Co 2008 Nature genetics Vol.40 No.6
Gastric cancer is classified into intestinal and diffuse types, the latter including a highly malignant form, linitis plastica. A two-stage genome-wide association study (stage 1: 85,576 SNPs on 188 cases and 752 references; stage 2: 2,753 SNPs on 749 cases and 750 controls) in Japan identified a significant association between an intronic SNP (rs2976392) in PSCA (prostate stem cell antigen) and diffuse-type gastric cancer (allele-specific odds ratio (OR) = 1.62, 95% CI = 1.38–1.89, P = 1.11 × 10<SUP>−9</SUP>). The association was far less significant in intestinal-type gastric cancer. We found that PSCA is expressed in differentiating gastric epithelial cells, has a cell-proliferation inhibition activity in vitro and is frequently silenced in gastric cancer. Substitution of the C allele with the risk allele T at a SNP in the first exon (rs2294008, which has r<SUP>2</SUP> = 0.995, D′ = 0.999 with rs2976392) reduces transcriptional activity of an upstream fragment of the gene. The same risk allele was also significantly associated with diffuse-type gastric cancer in 457 cases and 390 controls in Korea (allele-specific OR = 1.90, 95% CI = 1.56–2.33, P = 8.01 × 10<SUP>−11</SUP>). The polymorphism of the PSCA gene, which is possibly involved in regulating gastric epithelial-cell proliferation, influences susceptibility to diffuse-type gastric cancer.