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MEMS for Heterogeneous Integration of Devices and Functionality
Hiroyuki Fujita 대한전자공학회 2007 Journal of semiconductor technology and science Vol.7 No.3
Future MEMS systems will be composed of larger varieties of devices with very different functionality such as electronics, mechanics, optics and bio-chemstry. Integration technology of heterogeneous devices must be developed. This article first deals with the current development trend of new fabrication technologies; those include self-assembling of parts over a large area, wafer-scale encapsulation by wafer-bonding, nano imprinting, and roll-to-roll printing. In the latter half of the article, the concept towards the heterogeneous integration of devices and functionality into micro/nano systems is described. The key idea is to combine the conventional top-down technologies and the novel bottom-up technologies for building nano systems. A simple example is the carbon nano tube interconnection that is grown in the via-hole of a VLSI chip. In the laboratory level, the position-specific self-assembly of nano parts on a DNA template was demonstrated through hybridization of probe DNA segments attached to the parts. Also, bio molecular motors were incorporated in a micro fluidic system and utilized as a nano actuator for transporting objects in the channel.
MEMS for Heterogeneous Integration of Devices and Functionality
Fujita, Hiroyuki The Institute of Electronics and Information Engin 2007 Journal of semiconductor technology and science Vol.7 No.3
Future MEMS systems will be composed of larger varieties of devices with very different functionality such as electronics, mechanics, optics and bio-chemistry. Integration technology of heterogeneous devices must be developed. This article first deals with the current development trend of new fabrication technologies; those include self-assembling of parts over a large area, wafer-scale encapsulation by wafer-bonding, nano imprinting, and roll-to-roll printing. In the latter half of the article, the concept towards the heterogeneous integration of devices and functionality into micro/nano systems is described. The key idea is to combine the conventional top-down technologies and the novel bottom-up technologies for building nano systems. A simple example is the carbon nano tube interconnection that is grown in the via-hole of a VLSI chip. In the laboratory level, the position-specific self-assembly of nano parts on a DNA template was demonstrated through hybridization of probe DNA segments attached to the parts. Also, bio molecular motors were incorporated in a micro fluidic system and utilized as a nano actuator for transporting objects in the channel.
Growth of ZnO Nanostructures by Using Ultrasonic Spray Chemical Vapor Deposition with a Au Catalyst
Hiroyuki Nishinaka,Toshiyuki Kawaharamura,Shizuo Fujita 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.5
ZnO nanorods were grown by using an ultrasonic spray chemical vapor deposition method with a Au catalyst. The growth was performed in the vapor-liquid-solid growth mode. The lowmagnification and the high-resolution transmission electron microscopy (TEM) observation revealed that the ZnO nanorods had no stacking faults and were single crystals. The high-esolution TEM showed that the lattice length of the ZnO nanorods grown at 900 ℃ was 0.16 nm and that the growth direction was [11¯20]. The diameters of the ZnO nanorods almost depended on those of the Au particles that aggregated from a Au thin film. The diameters of the ZnO nanorods were slightly bigger than those of the Au particles because the ZnO nanorods grew not only in the direction along the nanorods but also in the direction of the diameter. The room-temperature photoluminescence emission of the ZnO nanorods was dominated by a near band-edge luminescence with weak deep-level emissions.
Overview of JCGGDB including New Released GlycoProtDB
Toshihide Shikanai,Hiroyuki Kaji,Yoshinori Suzuki,Noriaki Fujita,Masako Maeda,HonglingWen,Madoka Ishizaki,Hiromichi Sawaki,Hisashi Narimatsu. 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
The JST/NBDC integrated database project has kicked off last year. JCGGDB was selected as a promotion program of DB integration, aiming to integrate all the glycan-related databases in Japan and build user- friendly search systems. As part of the project, the construction of ACGG-DB (an integrated database for the ACGG: Asian Communications for Glycobiology and Glycotechnology) is also planned in cooperation with Asian countries. As of now we have consolidated data from various Japanese institutes into JCGGDB and developed a cross-search function by keyword entry and integrated search functions by glycan stcurctures. These functions enabled users to easily access various glycan-related databases with a single search. Cheminformatics technologies using chemical structural formula for glycan has been also adopted to provide a search for glycan structures, glycan synthetic products by organic chemistry and recombinant enzymes, glycogene inhibitors, glycosides, and commercial glycans. This Summer, we have released AIST GlycoProtDB, which stores the data of experimentally-proven glycosylation sites on each mouse tissue. We are continuously accumulating experimental results of glycosylation sites, while collecting more information from scientific journals, toward the release of ACGG Glycoprotein Database in autumn. For the future, we will keep developing base technologies for DB integration and linking with databases related to glycoscience as well as other study areas. Some more bioinformatics tools are also being developed to support experimental study. Our aim is to create contents which could be easily and intuitively understood by every user.
Ohashi Takashi,Fujita Yukiyoshi,Irisawa Hiroyuki,Nakaminami Hidemasa,Arai Takahiro,Takahashi Masumi,Momiyama Emi,Murata Naoya,Murayama Kayoko,Saito Taeko 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.1
Background Arbekacin (ABK) is an aminoglycoside that exhibits anti-methicillin-resistant Staphylococcus aureus (MRSA) and anti-Pseudomonas aeruginosa activities. Therefore, for patients with febrile neutropenia (FN) and concurrent pneumonia suspected to be caused by MRSA, ABK may be sufficiently effective even as a single agent. Materials and Methods Patients with hematologic malignancies treated with ABK who met the following criteria were included: 1) fever during neutropenia or functional neutropenia, 2) FN complicated by pneumonia, and 3) possible infection by antimicrobial-resistant Gram-positive cocci. Results This study encompassed 22 episodes involving 19 patients, of which, 15 (68.2%) were successfully treated with ABK. Of the nine episodes showing inadequate response to other anti-MRSA drugs, eight were successfully treated with ABK. Grade 2 or worse adverse events included acute kidney injury (13.6%) and increased transaminase levels (9.1%). Conclusion The present study demonstrated that ABK is effective and safe in patients with FN and concurrent pneumonia caused by antimicrobial-resistant Gram-positive cocci. ABK may also be effective in patients who are unresponsive to other anti-MRSA drugs. Therefore, ABK may be beneficial in the treatment of pneumonia caused by antimicrobial-resistant Gram-positive cocci in patients with FN. Background Arbekacin (ABK) is an aminoglycoside that exhibits anti-methicillin-resistant Staphylococcus aureus (MRSA) and anti-Pseudomonas aeruginosa activities. Therefore, for patients with febrile neutropenia (FN) and concurrent pneumonia suspected to be caused by MRSA, ABK may be sufficiently effective even as a single agent. Materials and Methods Patients with hematologic malignancies treated with ABK who met the following criteria were included: 1) fever during neutropenia or functional neutropenia, 2) FN complicated by pneumonia, and 3) possible infection by antimicrobial-resistant Gram-positive cocci. Results This study encompassed 22 episodes involving 19 patients, of which, 15 (68.2%) were successfully treated with ABK. Of the nine episodes showing inadequate response to other anti-MRSA drugs, eight were successfully treated with ABK. Grade 2 or worse adverse events included acute kidney injury (13.6%) and increased transaminase levels (9.1%). Conclusion The present study demonstrated that ABK is effective and safe in patients with FN and concurrent pneumonia caused by antimicrobial-resistant Gram-positive cocci. ABK may also be effective in patients who are unresponsive to other anti-MRSA drugs. Therefore, ABK may be beneficial in the treatment of pneumonia caused by antimicrobial-resistant Gram-positive cocci in patients with FN.