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( Hiroshi Yamawaki ),( Seiji Futagami ),( Mayumi Shimpuku ),( Hitomi Sato ),( Taiga Wakabayashi ),( Yuuta Maruki ),( Yasuhiro Kodaka ),( Hiroyuki Nagoya ),( Tomotaka Shindo ),( Tetsuro Kawagoe ),( Cho 대한소화기기능성질환·운동학회 2014 Journal of Neurogastroenterology and Motility (JNM Vol.20 No.1
Background/Aims The association between clinical symptoms, gastric emptying, quality of life and sleep disorders in distinct functional dyspepsia (FD) patients has not been studied yet in detail. Methods We enrolled 79 FD patients (postprandial distress syndrome [PDS], n = 65; epigastric pain syndrome [EPS], n = 47; EPS-PDS overlap, n = 33) and 44 healthy volunteers. Gastric motility was evaluated. We used Rome III criteria to evaluate clinical symptoms and State-Trait Anxiety Inventory (STAI) scores to determine anxiety status. Sleep disorder was evaluated using the Pittsburgh Sleep Quality Index scores. Results There were no significant differences in age, sex and Helicobacter pylori positivity between FD subtypes and healthy volunteers. The scores of Glasgow dyspepsia severity scores (GDSS), SF-8 and Pittsburgh Sleep Quality Index (PSQI) in distinct subtypes of FD patients were significantly different from those in healthy volunteers. However, there were not significant differences in these scores, Tmax and T1/2 among 3 subtypes of FD patients. PSQI score was significantly (P = 0.027, P = 0.002 and P = 0.039, respectively) associated with GDSS among EPS, PDS and EPS-PDS overlap patients. In addition, 8-item short form health survey (SF-8; Physical Component Score and Mental Component Score) was significantly associated with global PSQI score in PDS and EPS-PDS overlap patients. In contrast, SF-8 (Mental Component Score) only was significantly linked to global PSQI score in EPS patients. Conclusions Prevalences for sleep disorders, gastric motility and quality of life in 3 subtypes of FD patients were similar levels. In PDS and EPS-PDS overlap patients, SF-8 was significantly associated with global PSQI score. (J Neurogastroenterol Motil 2014;20:104-112)
Internal Bias Field in Glycine Phosphite Crystal
Jannatul Nayeem,Toshio Kikuta,Hiroshi Wakabayashi,Noriyuki Nakatani,Toshinari Yamazaki 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.42 No.IV
The distributions of internal bias eld Eb have been investigated under the carbon-powder pattern and mercury electrode techniques in GPI ferroelectric crystals. Polarity and intensity of Eb are distributed depending on crystal growth sectors. Crystal symmetry 2/m is observed obviously in the distribution of Eb. The polarities of Eb are head-to-head manner in those growth sectors where a surface is growing parallel to the crystallographic a-axis and tail-to-tail manner in the other growth sectors in the crystal. The maximum intensity of Eb is found in the sectors f010g where the growing surfaces are perpendicular to the ferroelectric b-axis.
( Yukie Kidani ),( Yasuo Miki ),( Nana Nomimura ),( Shiori Minakawa ),( Norifumi Tanaka ),( Hiroshi Miyoshi ),( Koichi Wakabayashi ),( Yoshiki Kudo ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
Objectives: Hypoxic-ischemic encephalopathy (HIE) is a major cause of cerebral palsy in full-term infants. HIE occurs at a rate of about three per thousand live-born infants, even in developed countries. In recent years stem cell therapies have been applied in several fields of medicine. Endothelial progenitor cells (EPCs) are one of the major stem/progenitor cell subsets with the potential for repairing vascular injury. Therefore, we have speculated that the transplantation of CD133<sup>+</sup> cells, as a EPCs containing fraction, from umbilical cord blood could also be an useful therapy in perinatal hypoxia-induced brain injury. We established the ex vitro hypoxic-ischemic encephalopathy model to assess the effects of CD133<sup>+</sup> cells (endothelial progenitor cells) derived from human umbilical cord blood on nerve extension. In this study, we have investigated the therapeutic effects of CD133<sup>+</sup> cells for the treatment of neonatal HIE on an animal model. Methods: Hypoxic-ischemic brain lesions were induced in neonatal severe combined immunodeficiency mice using the Rice-Vanucci method. CD133<sup>+</sup> cells were administered by intraperitoneal injection 24 h after injury. Macroscopic assessment, growth evaluation and immunohistochemical analysis were performed. To evaluate motor function, rotarod test was performed every 7days between day 28 and day 56 of postnatal. Results: Immunohistochemical analysis revealed that intraperitoneally transplanted CD133<sup>+</sup> cells migrate towards the brain 48 h after injection. The ratio of lesioned to non-lesioned hemisphere area in the CD133<sup>+</sup> group was significantly higher than in the HI group. Moreover, in CD133<sup>+</sup> cell-treated animals, motor function improved and the brain was protected from the hypoxic-ischemic insult compared with untreated animals. Conclusion: Our results suggest that CD133<sup>+</sup> cells derived from human umbilical cord blood have therapeutic po-tential in neonatal hypoxic-ischemic encephalopathy.