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- 저자 : ( Nana Nomimura ) (검색결과 1 건)
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( Yukie Kidani ),( Yasuo Miki ),( Nana Nomimura ),( Shiori Minakawa ),( Norifumi Tanaka ),( Hiroshi Miyoshi ),( Koichi Wakabayashi ),( Yoshiki Kudo ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
Objectives: Hypoxic-ischemic encephalopathy (HIE) is a major cause of cerebral palsy in full-term infants. HIE occurs at a rate of about three per thousand live-born infants, even in developed countries. In recent years stem cell therapies have been applied in several fields of medicine. Endothelial progenitor cells (EPCs) are one of the major stem/progenitor cell subsets with the potential for repairing vascular injury. Therefore, we have speculated that the transplantation of CD133<sup>+</sup> cells, as a EPCs containing fraction, from umbilical cord blood could also be an useful therapy in perinatal hypoxia-induced brain injury. We established the ex vitro hypoxic-ischemic encephalopathy model to assess the effects of CD133<sup>+</sup> cells (endothelial progenitor cells) derived from human umbilical cord blood on nerve extension. In this study, we have investigated the therapeutic effects of CD133<sup>+</sup> cells for the treatment of neonatal HIE on an animal model. Methods: Hypoxic-ischemic brain lesions were induced in neonatal severe combined immunodeficiency mice using the Rice-Vanucci method. CD133<sup>+</sup> cells were administered by intraperitoneal injection 24 h after injury. Macroscopic assessment, growth evaluation and immunohistochemical analysis were performed. To evaluate motor function, rotarod test was performed every 7days between day 28 and day 56 of postnatal. Results: Immunohistochemical analysis revealed that intraperitoneally transplanted CD133<sup>+</sup> cells migrate towards the brain 48 h after injection. The ratio of lesioned to non-lesioned hemisphere area in the CD133<sup>+</sup> group was significantly higher than in the HI group. Moreover, in CD133<sup>+</sup> cell-treated animals, motor function improved and the brain was protected from the hypoxic-ischemic insult compared with untreated animals. Conclusion: Our results suggest that CD133<sup>+</sup> cells derived from human umbilical cord blood have therapeutic po-tential in neonatal hypoxic-ischemic encephalopathy.
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