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Copper complexes of the non-innocent β-diketiminate ligand containing phenol groups
Takaichi, June,Ohkubo, Kei,Sugimoto, Hideki,Nakano, Motohiro,Usa, Daisuke,Maekawa, Hiroaki,Fujieda, Nobutaka,Nishiwaki, Nagatoshi,Seki, Shu,Fukuzumi, Shunichi,Itoh, Shinobu The Royal Society of Chemistry 2013 Dalton Transactions Vol.42 No.7
<P>A new type of non-innocent β-diketiminate ligand having redox active phenol groups (<B>LH<SUB>3</SUB></B>, fully protonated form) has been developed, and the structure, physical properties and reactivity of the supported copper(<SMALL>II</SMALL>) complex [Cu<SUP>II</SUP>(<B>L<SUP>3−</SUP></B>)]<SUP>−</SUP> (<B>L<SUP>3−</SUP></B>, fully deprotonated tri-anionic form) as well as the one-electron and two-electron oxidised complexes, [Cu<SUP>II</SUP>(<B>L&z.rad;<SUP>2−</SUP></B>)] and [Cu<SUP>II</SUP>(<B>L<SUP>−</SUP></B>)]<SUP>+</SUP>, have been examined in detail. The two-electron oxidised form [Cu<SUP>II</SUP>(<B>L<SUP>−</SUP></B>)]<SUP>+</SUP> exhibited hydrogen atom abstraction ability from 1,4-cyclohexadiene (CHD), whereas the one-electron oxidised form [Cu<SUP>II</SUP>(<B>L&z.rad;<SUP>2−</SUP></B>)] was found to disproportionate into [Cu<SUP>II</SUP>(<B>L<SUP>3−</SUP></B>)]<SUP>−</SUP> and [Cu<SUP>II</SUP>(<B>L<SUP>−</SUP></B>)]<SUP>+</SUP> during the course of the reaction with CHD.</P> <P>Graphic Abstract</P><P>Structure, physicochemical properties, and reactivity of the copper(<SMALL>II</SMALL>)-phenoxyl radical complexes of the non-innocent β-diketiminate ligand containing phenol groups are reported. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2dt32413j'> </P>
Koh Kitagawa,Akira Mitoro,Takahiro Ozutsumi,Masanori Furukawa,Yukihisa Fujinaga,Kenichiro Seki,Norihisa Nishimura,Yasuhiko Sawada,Kosuke Kaji,Hideto Kawaratani,Hiroaki Takaya,Kei Moriya,Tadashi Namisa 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.3
Background/Aims: Covered self-expandable metallic stents (CMSs) are widely used for malignant distal biliary obstructions (MDBOs)caused by pancreatic carcinoma. This study compared the efficacy and safety of the laser-cut-type and braided-type CMSs. Methods: To palliate MDBOs caused by pancreatic carcinoma, the laser-cut-type CMSs was used from April 2014 to March 2017, andthe braided-type CMSs was used from April 2017 to March 2019. The tested self-expandable metallic stents were equipped with differentanti-migration systems. Results: In total, 47 patients received CMSs for MDBOs (24 laser-cut type, 23 braided-type). The time to recurrent biliary obstruction(TRBO) was significantly longer in the braided-type CMSs (p=0.0008), and the median time to stent dysfunction or patient death was141 and 265 days in the laser-cut-type CMSs and braided-type CMSs, respectively (p=0.0023). Stent migration was the major cause ofstent dysfunction in both groups, which occurred in 37.5% of the laser-cut-type CMSs and 13.0% of the braided-type CMSs. Therewere no differences in the survival duration between the groups. Conclusions: The TRBO was significantly longer for the braided-type CMSs with an anti-migration system than for the laser-cut-type. Stent migration tended to be less frequent with the braided-type CMSs than with the laser-cut-type CMSs.
Shinya Sato,Kei Moriya,Masanori Furukawa,Soichiro Saikawa,Tadashi Namisaki,Mitsuteru Kitade,Hideto Kawaratani,Kosuke Kaji,Hiroaki Takaya,Naotaka Shimozato,Yasuhiko Sawada,Kenichiro Seki,Koh Kitagawa,T 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.1
Background/Aims: L-carnitine not only alleviates hyperammonemia and reduces muscle cramps in patients with liver cirrhosis, but also improves anemia in patients with chronic hepatitis and renal dysfunction. This study prospectively evaluated the preventative efficacy of L-carnitine supplementation against hemolytic anemia during antiviral treatment using ribavirin in patients with hepatitis C virus (HCV)-related chronic liver disease. Methods: A total of 41 patients with chronic hepatitis were consecutively enrolled in this study. Group A (n=22) received sofosbuvir plus ribavirin for 3 months, whereas group B (n=19) was treated with sofosbuvir, ribavirin, and L-carnitine. Hemoglobin concentration changes, the effects of antiviral treatment, and the health status of patients were analyzed using short form-8 questionnaires. Results: A significantly smaller decrease in hemoglobin concentration was observed in group B compared to group A at every time point. Moreover, the prescribed dose intensity of ribavirin in group B was higher than that of group A, resulting in a higher ratio of sustained virological response (SVR) 24 in group B compared with group A. The physical function of patients in group B was also significantly improved compared to group A at the end of antiviral treatment. Conclusions: L-carnitine supplementation alleviates ribavirin-induced hemolytic anemia in patients with HCV and helps relieve the physical burden of treatment with ribavirin-containing regimens. These advantages significantly increase the likelihood of achieving SVR.