Patients with Terminal Cancer in Japan and Their Experiences

Kimiyo Shimoai,Hidetoshi Furukawa,Kyohei Yamaguchi,Yuko Nakamura,Hiromi Inoko,Sachiko Fukuda,Takiko Kita,Kazuo Kato 한국간호과학회 2015 한국간호과학회 학술대회 Vol.2015 No.10

Relation between N–H complexes and electrical properties of GaAsN determined by H implantation

Jong-Han Lee,Hidetoshi Suzuki,Xiuxun Han,Katahiko Honda,Tomohiro Tanaka,Jong-Ha Hwang,Boussairi Bouzazi,Makoto Inagaki,Nobuaki Kojima,Yoshio Ohshita,Masafumi Yamaguchi 한국물리학회 2010 Current Applied Physics Vol.10 No.3

We investigated the relation between N–H complexes and the electrical properties of GaAsN, which is a potential material for fabricating super-high-efficiency multi-junction tandem solar cells. In order to separate the effect of other residual carrier such as carbon in a GaAsN film on the electrical properties, hydrogen (H) ions were implanted into GaAsN grown by chemical beam epitaxy (CBE) and then rapid thermal annealing from 250 to 650 ℃ was carried out. Two N–H complexes related to local vibrational modes (LVMs) in GaAsN were observed at 3098 and 3125 cm-1. With an increasing annealing temperature,the integrated peak intensity of the 3098 cm-1 peak (I3098) decreased, while that of the 3125 cm-1 peak (I3125) increased. This indicates that N–H complexes related to the 3125 cm-1 peak are thermally more stable than those related to the other peak. The hole concentrations and mobilities exhibited an increasing trend until an annealing temperature of 550 ℃ was reached. Their increases are attributed to the removal of donor-type defects. It is suggested that the N–H complexes related to the 3098 cm-1 peak are electrically active, while those giving the 3125 cm-1 peak are inactive.

Properties of Chemical Beam Epitaxy grown GaAs0.995N0.005 homo-junction solar cell

Boussairi Bouzazi,Kenichi Nishimura,Hidetoshi Suzuki,Nobuaki Kojima,Yoshio Ohshita,Masafumi Yamaguchi 한국물리학회 2010 Current Applied Physics Vol.10 No.2

The minority carrier diffusion length in Chemical Beam Epitaxy (CBE) grown GaAs0.995N0.005 based homojunction solar cell was estimated and found to be L = 0.08 lm. In addition, the majority carrier traps in Nvarying unintentionally doped p-type GaAsN samples grown by CBE were investigated using Deep Level Transient Spectroscopy (DLTS) technique. Five hole traps, HC1–HC5, were detected, where HC2 and HC5coexist in all samples. These two hole traps were suggested to be a N-related defect and the double donor state of EL2, respectively.

Predisposing Factors for Intraoperative Endplate Injury of Extreme Lateral Interbody Fusion

Kotaro Satake,Tokumi Kanemura,Hidetoshi Yamaguchi,Naoki Segi,Jun Ouchida 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.5

Study Design: Retrospective study. Purpose: To compare intraoperative endplate injury cases and no injury cases in consecutive series and to identify predisposing factors for intraoperative endplate injury. Overview of Literature: Unintended endplate violation and subsequent cage subsidence is an intraoperative complication of extreme lateral interbody fusion (XLIF). It is still unknown whether it is derived from inexperienced surgical technique or patients’ inherent problems. Methods: Consecutive patients (n=102; mean age, 69.0±0.8 years) underwent XLIF at 201 levels at a single institute. Preoperative and immediately postoperative radiographs were compared and cases with intraoperative endplate injury were identified. Various parameters were reviewed in each patient and compared between the injury and no injury groups. Results: Twenty one levels (10.4%) had signs of intraoperative endplate injury. The injury group had a significantly higher rate of females (p =0.002), lower bone mineral density (BMD) (p =0.02), higher rate of polyetheretherketone as cage material (p =0.04), and taller cage height (p =0.03) compared with the no injury group. Multivariate analysis indicated that a T-score of BMD as a negative (odds ratio, 0.52; 95% confidence interval, 0.27–0.93; p =0.03) and cage height as a positive (odds ratio, 1.84; 95% confidence interval, 1.01–3.17; p =0.03) were predisposing factors for intraoperative endplate injury. Conclusions: Intraoperative endplate injury is correlated significantly with reduced BMD and taller cage height. Precise evaluation of bone quality and treatment for osteoporosis might be important and care should be taken not to choose excessively taller cage.

Development and Performance Test of the Analysis Software for the CRIB Active Target

이필수,이춘식,문준영,채경육,차수미,Hidetoshi Yamaguchi,Taro Nakao,David M. Kahl,Shigeru Kubono,Silvio Cherubini,Seiya Hayakawa,Cosimo Signorini 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.3

Software for genuinely event-by-event analysis and event reconstruction of data obtained by usingan active target has been developed in the graphical user interface under the CERN ROOT framework. The primary motivation for developing the software was to provide physicists who performexperiments using an active target a more user-friendly environment for the purpose of investigatingthe performance of detection systems and obtaining ideas about physics from a large amount ofexperimental data. To test the performance of the software, we analyzed experimental data froma 16N radioactive ion beam experiment for α-decay measurements. As a result of the analysis, weobserved the Bragg curve and measured the range of the 16N RI beam in the detector. Data werecalibrated against the calculation after comparing the Bragg curve to the one obtained from anenergy loss calculation in P-10 gas. We present a detailed description of the analysis software andits test results.

Red Ginseng Ameliorates Place Learning Deficits in Aged Rats and in Young Rats with Selective Hippocampel Lesions

Young Mei Zhong,Hisao Nishiko,Teruko Uwano,Hidetoshi Yamaguchi,Taketoshi Ono 고려인삼학회 1998 International Symposium on Ginseng Vol.- No.-

Comparative Radiographic Outcomes of Lateral and Posterior Lumbar Interbody Fusion in the Treatment of Degenerative Lumbar Kyphosis

Hiroaki Nakashima,Tokumi Kanemura,Kotaro Satake,Yoshimoto Ishikawa,Jun Ouchida,Naoki Segi,Hidetoshi Yamaguchi,Shiro Imagama 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.3

Study Design: Retrospective case–control study. Purpose: To compare surgical invasiveness and radiological outcomes between posterior lumbar interbody fusion (PLIF) and lateral lumbar interbody fusion (LLIF) for degenerative lumbar kyphosis. Overview of Literature: LLIF is a minimally invasive interbody fusion technique; however, few reports compared the clinical outcomes of conventional PLIF and LLIF for degenerative lumbar kyphosis. Methods: Radiographic data for patients who have undergone lumbar interbody fusion (≥3 levels) using PLIF or LLIF for degenerative lumbar kyphosis (lumbar lordosis [LL] <20°) were retrospectively examined. The following radiographic parameters were retrospectively evaluated preoperatively and 2 years postoperatively: segmental lordotic angle, LL, pelvic tilt (PT), pelvic incidence (PI), C7 sagittal vertical axis, and T1 pelvic angle. Results: Nineteen consecutive cases with PLIF and 27 cases with LLIF were included. There were no significant differences in patients’ backgrounds or preoperative radiographic parameters between the PLIF and the LLIF groups. The mean fusion level was 5.5±2.5 levels and 5.8±2.5 levels in the PLIF and LLIF groups, respectively (p=0.69). Although there was no significant difference in surgical times (p=0.58), the estimated blood loss was significantly greater in the PLIF group (p<0.001). Two years postoperatively, comparing the PLIF and LLIF groups, the segmental lordotic angle achieved (7.4°±7.6° and 10.6°±9.4°, respectively; p=0.03), LL (27.8°±13.9° and 39.2°±12.7°, respectively; p=0.006), PI–LL (19.8°±14.8° and 3.1°±17.5°, respectively; p=0.002), and PT (22.6°±7.1° and 14.2°±13.9°, respectively; p=0.02) were significantly better in the LLIF group. Conclusions: LLIF provided significantly better sagittal alignment restoration in the context of degenerative lumbar kyphosis, with less blood loss.

Unplanned Second-Stage Decompression for Neurological Deterioration Caused by Central Canal Stenosis after Indirect Lumbar Decompression Surgery

Hiroaki Nakashima,Tokumi Kanemura,Kotaro Satake,Yoshimoto Ishikawa,Jun Ouchida,Naoki Segi,Hidetoshi Yamaguchi,Shiro Imagama 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.4

Study Design: Prospective cohort study. Purpose: This study aimed to identify risk factors for unplanned second-stage decompression for postoperative neurological deficit after indirect decompression using lateral lumbar interbody fusion (LLIF) with posterior fixation. Overview of Literature: Indirect lumbar decompression with LLIF has been used as a minimally invasive alternative to direct decompression to treat degenerative lumbar diseases requiring neural decompression. However, evidence on the prevalence of neurological deficits caused by spinal canal stenosis after indirect decompression is limited. Methods: This study included 158 patients (mean age, 71.13±7.98 years; male/female ratio, 67/91) who underwent indirect decompression with LLIF and posterior fixation. Indirect decompression was performed at 271 levels (mean level, 1.71±0.97). Logistic regression analysis was used to identify the risk factors for postoperative neurological deficits. The variables included were age, sex, body mass index, presence of primary diseases, diabetes mellitus, preoperative motor deficit, levels operated on, preoperative severity of lumbar stenosis, and preoperative Japanese Orthopedic Association (JOA) score. Results: Postoperative neurological deficit due to spinal canal stenosis occurred in three patients (1.9%). Spinal stenosis due to hemodialysis (p<0.001), ligament ossification (p<0.001), presence of preoperative motor paralysis (p<0.001), low JOA score (p=0.004), and severe canal stenosis (p=0.02) were significantly more frequent in the paralysis group. Conclusions: Severe preoperative canal stenosis and neurological deficit were identified as risk factors for postoperative neurological deterioration caused by spinal canal stenosis. Additionally, uncommon diseases, such as spinal stenosis due to hemodialysis and ligament ossification, increased the risk of postoperative neurological deficit; therefore, in such cases, indirect decompression is contraindicated.

Factors Affecting Postoperative Sagittal Alignment after Lateral Lumbar Interbody Fusion in Adult Spinal Deformity: Posterior Osteotomy, Anterior Longitudinal Ligament Rupture, and Endplate Injury

Hiroaki Nakashima,Tokumi Kanemura,Kotaro Satake,Yoshimoto Ishikawa,Jun Ouchida,Naoki Segi,Hidetoshi Yamaguchi,Shiro Imagama 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.5

Study Design: Prospective cohort study. Purpose: To identify factors that affect sagittal alignment correction in lateral lumbar interbody fusion (LIF) surgery for adult spinal deformity (ASD) and to investigate the degree of correction in each condition. Overview of Literature: LIF is a useful procedure for ASD, but the degree of correction can be affected by posterior osteotomy, intraoperative endplate injury, or anterior longitudinal ligament (ALL) rupture. Methods: Radiographical data for 30 patients who underwent LIF for ASD were examined prospectively. All underwent two-stage surgery (LIF followed by posterior fixation). Radiographical parameters were measured preoperatively, after LIF, and after posterior fixation; these included the segmental lordotic angle, lumbar lordosis (LL), and other sagittal alignment factors. Results: LL was corrected from 16.5°±16.7° preoperatively to 33.4°±13.8° after LIF (p<0.001) and then to 52.1°±7.9° following posterior fixation (p<0.001). At levels where Schwab grade 2 osteotomy was performed, the acquired segmental lordotic angles from the preoperative value to after posterior fixation and from after LIF to after posterior fixation were 19.5°±9.2° and 9.9°±3.9°, respectively. On average, 12.4° more was added than in cases without osteotomy. Endplate injury was identified at 21 levels (19.4%) after LIF, with a mean loss of 3.4° in the acquired segmental lordotic angle (5.3°±8.4° and 1.9°±5.9° without and with endplate injury, respectively). ALL rupture was identified at seven levels (6.5%), and on average 19.3° more was added in these cases between the preoperative and postoperative values than in cases without ALL rupture. Conclusions: LIF provides adequate sagittal alignment restoration for ASD, but the degree of correction is affected by grade 2 osteotomy, intraoperative endplate injury, and ALL rupture.

Changes in Sagittal Alignment Following Short-Level Lumbar Interbody Fusion: Comparison between Posterior and Lateral Lumbar Interbody Fusions

Hiroaki Nakashima,Tokumi Kanemura,Kotaro Satake,Yoshimoto Ishikawa,Jun Ouchida,Naoki Segi,Hidetoshi Yamaguchi,Shiro Imagama 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.6

Study Design: Retrospective case-control study. Purpose: We aimed to compare radiologic outcomes between posterior (PLIF) and lateral lumbar interbody fusion (LLIF) in short-level spinal fusion surgeries. Overview of Literature: Although LLIF enables surgeons to insert large lordotic cages, it is unknown whether LLIF more effectively corrects local and global sagittal alignments compared with PLIF in short-level spinal fusion surgeries. Methods: Radiographic data acquired from patients with lumbar interbody fusion (≤3 levels) using PLIF or LLIF for degenerative lumbar diseases were analyzed. The following radiographic parameters were evaluated preoperatively and at 2 years postoperatively: segmental lordotic angle, disk height, lumbar lordosis (LL), pelvic tilt (PT), C7 sagittal vertical axis, and thoracic kyphosis (TK). Results: In total, 144 patients with PLIF (193 fused levels) and 101 with LLIF (159 fused levels) were included. Patients’ backgrounds and preoperative radiographic parameters for any level of fusion did not differ significantly between PLIF and LLIF procedures. The LLIF group exhibited significantly greater changes at 1-level fusion compared to the PLIF group in the parameters of segmental lordotic angle (5.1°±5.8° vs. 2.1°±5.0°, p<0.001), disk height (4.2±2.3 mm vs. 2.2±2.0 mm, p<0.001), LL (7.8°±7.6° vs. 3.9°±8.6°, p=0.004), and PI–LL (−6.9°±6.8° vs. −3.6°±10.1°, p=0.03). While, a similar trend was observed regarding 2-level fusion, significantly greater changes were only observed in LL (12.1°±11.1° vs. 4.2°±9.1°, p=0.047) and PI–LL (−11.2°±11.3° vs. −3.0°±9.3°, p=0.043), PT (−6.4°±4.9° vs. −2.5°±5.3°, p=0.049) and TK (7.8°±11.8° vs. −0.3°±9.7°, p=0.047) in the LLIF group at 3-level fusion. Conclusions: LLIF provides significantly better local sagittal alignment than PLIF in 1- or 2-level fusion cases and improves spinopelvic alignment and local alignment for 3-level fusion cases. Thus, LLIF was demonstrated to be a useful lumbar interbody fusion technique, constituting a powerful tool for achieving sagittal realignment with minimal surgical invasiveness.