http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Alzheimer's Disease Diagnosis Using Misfolding Proteins in Blood
HeeYang Lee,Daniella Ugay,Seungpyo Hong,김영수 대한치매학회 2020 Dementia and Neurocognitive Disorders Vol.19 No.1
Alzheimer's disease (AD) is pathologically characterized by a long progressive phase of neuronal changes, including accumulation of extracellular amyloid-β (Aβ) and intracellular neurofibrillary tangles, before the onset of observable symptoms. Many efforts have been made to develop a blood-based diagnostic method for AD by incorporating Aβ and tau as plasma biomarkers. As blood tests have the advantages of being highly accessible and low cost, clinical implementation of AD blood tests would provide preventative screening to presymptomatic individuals, facilitating early identification of AD patients and, thus, treatment development in clinical research. However, the low concentration of AD biomarkers in the plasma has posed difficulties for accurate detection, hindering the development of a reliable blood test. In this review, we introduce three AD blood test technologies emerging in South Korea, which have distinctive methods of heightening detection sensitivity of specific plasma biomarkers. We discuss in detail the multimer detection system, the self-standard analysis of Aβ biomarkers quantified by interdigitated microelectrodes, and a biomarker ratio analysis comprising Aβ and tau.
Preventive approach for overcoming dementia
HeeYang Lee,DaWon Kim,Woogyeong Lee,Hye Yun Kim,YoungSoo Kim 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.8
Dementia is used as a general term to describechronic disorders of mental processes caused by the deteriorationof cognitive functions to the extent that one’sability to perform daily activities is impaired. Currently,age is known to be the main risk factor for dementia,suggesting that the risk of being diagnosed with dementiasignificantly increases later in one’s life. Therefore, thereare two approaches one can take when confrontingdementia: to cure it when it occurs in late adulthood or toprevent the onset of symptoms beforehand. Recently, thelatter strategy of delaying and preventing Alzheimer’sdisease, the most prevalent form and most studied type ofdementia, through both pharmaceutical and nonpharmaceuticalinterventions is becoming increasingly recognized. In this review, we discuss studies conducted in variousfields that addresses nonpharmaceutical lifestyle interventions,including diet, physical activity, cognitive stimulation,and social engagement, and their effects in preventingand inhibiting dementia.