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Hong, Seungpyo,Kim, Dongsup Oxford University Press 2016 Bioinformatics Vol.32 No.11
<P>Motivation: Developments in biotechnology have enabled the in vitro evolution of binding proteins. The emerging limitations of antibodies in binding protein engineering have led to suggestions for other proteins as alternative binding protein scaffolds. Most of these proteins were selected based on human intuition rather than systematic analysis of the available data. To improve this strategy, we developed a computational framework for finding desirable binding protein scaffolds by utilizing protein structure and sequence information. Results: For each protein, its structure and the sequences of evolutionarily-related proteins were analyzed, and spatially contiguous regions composed of highly variable residues were identified. A large number of proteins have these regions, but leucine rich repeats (LRRs), histidine kinase domains and immunoglobulin domains are predominant among them. The candidates suggested as new binding protein scaffolds include histidine kinase, LRR, titin and pentapeptide repeat protein.</P>
Seungpyo Hong(홍승표),Sejin Kim(김세진),Donghyun You(유동현) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.4
A control policy of a fly-scale flyer’s kinematics for stable flight toward a destination in various flow fields is obtained through an integrated framework of computational fluid dynamics (CFD) and deep reinforcement learning (deep-RL). As the flyer gets smaller, high-fidelity CFD is required as substitute for modeling aerodynamics around a flapping wing because of its unsteadiness and nonlinearity. While coupling with deep-RL to gain a control policy, the main challenge of adopting CFD is to obtain sufficient amount of data required for deep-RL due to high computational cost. In order to overcome data deficiency, a novel data reproduction method is devised. The focal point of the method is to reproduce diversified and huge amount of data from original one in terms of learning while maintaining the system dynamics unchanged. To get a control policy that works in various flow fields, multiple flyers are released in the environments with different flow speeds and share their experience with a deep-RL network. The learned network is able to make a decision on the flyer’s kinematics in temporally and spatially varying flows. The superior performance of the control policy is demonstrated through performing aerobatics in the complex flow field with abrupt disturbances.
A Study on the Influence Factors of Suicide TERRORISM
Seungpyo Hong J-INSTITUTE 2021 International Journal of Terrorism & National Secu Vol.6 No.2
Purpose: The purpose of this study is to identify the factors influencing the occurrence of suicide terrorism. Specifically, the nationality of the suicide terrorist and the country belonging to the group that committed suicide terrorism were checked, and the factors that influence the occurrence of suicide terrorism were identified after comparing the social indicators of the outbreak country and the non-occurrence country. In addition, the purpose of this study is to prepare measures to prevent the occurrence of suicide terrorism based on this. Method: After confirming the suicide terrorism incident that occurred in 2014, the factors influencing the occurrence of suicide terrorism were identified from a macroscopic point of view, and the world peace index was used for this. A Poisson regression analysis was performed to confirm the influence on the occurrence of suicide terrorism by setting the variables corresponding to the general strain factor and the relative deprivation factor of the Global Peace Index(GPI) as independent variables. Results: As a result of the analysis, macroscopic factors influencing the occurrence of suicide terrorism could be identified. Factors influencing the occurrence of suicide terrorism include the country s crime perception level, murder rate, possibility of violent demonstrations, violent crime level, fatality index from domestic and foreign disputes, military expenditure, ratio of migrants to population, domestic and foreign It was confirmed that the factors of conflict affect the occurrence of suicide terrorism. Conclusion: Based on such research results, policy suggestions to prevent the occurrence of suicide terrorism were suggested. First of all, in relation to political terrorism, it can be said that there is a need for an institutional plan to prohibit political terrorism such as torture for reasons of ideology, religion, race, and ethnicity. In addition, it can be said that there is a need for an institutional plan that can resolve domestic disputes in a peaceful way rather than in a violent way, and efforts to create a safe environment by trying to reduce military expenditures are needed.
Computational characterization of chromatin domain boundary-associated genomic elements
Hong, Seungpyo,Kim, Dongsup Oxford University Press 2017 Nucleic acids research Vol.45 No.18
<P><B>Abstract</B></P><P>Topologically associated domains (TADs) are 3D genomic structures with high internal interactions that play important roles in genome compaction and gene regulation. Their genomic locations and their association with CCCTC-binding factor (CTCF)-binding sites and transcription start sites (TSSs) were recently reported. However, the relationship between TADs and other genomic elements has not been systematically evaluated. This was addressed in the present study, with a focus on the enrichment of these genomic elements and their ability to predict the TAD boundary region. We found that consensus CTCF-binding sites were strongly associated with TAD boundaries as well as with the transcription factors (TFs) Zinc finger protein (ZNF)143 and Yin Yang (YY)1. TAD boundary-associated genomic elements include DNase I-hypersensitive sites, H3K36 trimethylation, TSSs, RNA polymerase II, and TFs such as Specificity protein 1, ZNF274 and SIX homeobox 5. Computational modeling with these genomic elements suggests that they have distinct roles in TAD boundary formation. We propose a structural model of TAD boundaries based on these findings that provides a basis for studying the mechanism of chromatin structure formation and gene regulation.</P>
윈도우즈 운영체제 기반의 3D 가상 데스크톱 시스템 설계 및 구현
홍승표(Seungpyo Hong),오명진(Myeongjin Oh),신정훈(Junghoon Shin),이상준(Sangjun Lee) 한국정보과학회 2010 정보과학회 컴퓨팅의 실제 논문지 Vol.16 No.12
개인용 컴퓨터의 성능이 향상되면서 대부분의 컴퓨터 사용자에게 여러 개의 애플리케이션을 구동시키는 다중작업은 일반화되었다. 윈도우즈 운영체제는 다중작업중인 여러 애플리케이션을 구동할 작업공간을 오직 하나만 제공하고 있기 때문에 많은 사용자들이 불편함을 느끼고 있다. 본 논문에서는 이러한 윈도우즈 운영체제의 단점을 보완하여 윈도우즈 운영체제 환경에서 사용자에게 여러 작업공간을 제공하며, 리눅스 Compiz와 같이 사용자에게 화려하고 직관적인 UI(User Interface)를 제공하기 위해 DirectX를 이용하여 작업공간의 전환 과정을 3D 모션으로 보여줄 수 있는 3D 가상 데스크톱을 제안한다. As personal computers have been recently improved in performance, the multi tasking of running several applications at the same time has been generalized. Since only one task space is provided for performing such tasks on Windows operating system, a number of computer users feel inconvenient. In this paper, we propose a 3D Virtual Desktop System which can show a process of switching task spaces in 3D motion using DirectX. The proposed system can provide a computer user with more task spaces and the intuitive UI(User Interface) such as Compiz of Linux.
VOCs 방출챔버를 이용한 자동차 내장재의 휘발성유기화합물 방출특성에 관한 연구
홍승표(Seungpyo Hong),이준규(Jungyu Lee),김상철(Sangcheol Kim),정수경(Sookyung Jung) 한국실내환경학회 2011 한국실내환경학회지 Vol.8 No.4
There has been a growing concern about the emissions of formaldehyde and VOCs from automotive interior materials which could have an important impact on the in-vehicle air quality(IVAQ) of automotive vehicles. Many leading automobile manufacturers have now introduced their own specification standards for testing and limiting emissions from products produced by their suppliers. In addition, ISO (International Standard Organization) has been established ISO 12219-1, 2, 3, 4, 5 to determine the emissions of volatile organic compounds from automotive vehicle. The objective of this paper is to compare the area specific emission rates determined from surface emissions testing using the microchamber(MC) in comparison with a 1 ㎥ emission test chamber(ETC) operated in accordance with ISO 12219-3, ISO 12219-4. Measured emission concentrations in absolute terms were different between Microchamber and 1 ㎥ chamber. However, qualitative comparison of the chromatograms shows that the Microchamber is able to perform a screening test.