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Effects of daily quercetin-rich supplementation on cardiometabolic risks in male smokers
Lee, Kyung-Hea,Park, Eun-Ju,Lee, Hye-Jin,Kim, Myeong-Ok,Cha, Yong-Jun,Kim, Jung-Mi,Lee, Hye-Ran,Shin, Min-Jeong The Korean Nutrition Society 2011 Nutrition Research and Practice Vol. No.
Limited information from human studies indicates that dietary quercetin supplementation influences blood lipid profiles, glycemic response, and inflammatory status, collectively termed cardiometabolic risks. We tested the hypothesis that quercetin-rich supplementation, derived from onion peel extract, improves cardiometabolic risk components in healthy male smokers in a randomized, double blinded, placebo-controlled parallel design. Randomly assigned subjects were instructed to take either the placebo (n=43) or 100 mg quercetin capsules each day (n=49) for 10 weeks. Anthropometric parameters and blood pressure were measured, and blood lipids, glucose, interleukin-6, and soluble vascular cell adhesion molecule-1 (sVCAM-1) were determined at baseline and after 10 weeks of quercetin supplementation. Quercetin-rich supplementation significantly reduced serum concentrations of total cholesterol (P<0.05) and LDL-cholesterol (P<0.01), whereas these effects were not shown in the placebo group. Furthermore, significant increases were observed in serum concentrations of HDL-cholesterol both in the placebo (P<0.005) and quercetin-rich supplementation group (P<0.001); however, changes in HDL-cholesterol were significantly greater in subjects receiving quercetin-rich supplementation than the placebo. Both systolic (P<0.05) and diastolic blood pressure (P<0.01) decreased significantly in the quercetin-rich supplementation group. Glucose concentrations decreased significantly after 10 weeks of quercetin-rich supplementation (P<0.05). In contrast, no effects of quercetin-rich supplementation were observed for the inflammatory markers-IL-6 and sVCAM-1. Daily quercetin-rich supplementation from onion peel extract improved blood lipid profiles, glucose, and blood pressure, suggesting a beneficial role for quercetin as a preventive measure against cardiovascular risk.
Stereoselective Synthesis of MLN4924, an Inhibitor of NEDD8-Activating Enzyme
Lee, Hyuk Woo,Nam, Soo Kyung,Choi, Won Jun,Kim, Hea Ok,Jeong, Lak Shin American Chemical Society 2011 Journal of organic chemistry Vol.76 No.9
<P>MLN4924 (<B>1</B>), which is in clinical trials as an anticancer agent, was stereoselectively synthesized from <SMALL>d</SMALL>-ribose via a route involving stereoselective reduction, regioselective cleavage of an isopropylidene moiety, and selective displacement of a cyclic sulfate moiety as key steps.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/joceah/2011/joceah.2011.76.issue-9/jo2001897/production/images/medium/jo-2011-001897_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jo2001897'>ACS Electronic Supporting Info</A></P>
Hea-Seon Ha,Jung-Ja Hong,In Ok Kim, M.Sc.,Sae-Rom Lee,Ah-Young Lee,Tae-Yong Ha,Gi Won Song,Dong-Hwan Jung,Gil-Chun Park,Chul-Soo Ahn,Deok-Bog Moon,Ki Hun Kim,Sung Gyu Lee,Shin Hwang 대한이식학회 2019 Korean Journal of Transplantation Vol.33 No.4
Background: The Korean model for end-stage liver disease (MELD) score-based liver allocation system was started in June 2016 in Korea. Methods: This study analyzed the detailed allocation results of deceased donor liver transplantation (DDLT) during the first 2 years after the MELD score-based liver allocation system implementation at a high-volume liver transplantation (LT) center in Korea. Results: This study included 174 patients with age above 12 years. The patient ABO blood groups were A (n=65, 37.4%), B (n=51, 29.3%), O (n=28, 16.1%), and AB (n=30, 17.2%). The LT types were primary LT in 141 patients (81.0%) and retransplantation in 33 (19.0%). The Korean Network for Organ Sharing status categories at LT were as follows: status 1 (n=11, 6.3%), status 2 (n=82, 47.1%), status 3 (n=63, 36.2%), and status 4 (n=18, 10.3%). The mean MELD score at LT and waiting period were 36.6±4.6 and 62.1±98.2 days in blood group A; 37.6±3.6 and 25.7±38.1 days in blood group B; 38.8±2.7 and 26.0±30.5 days in blood group O; and 34.8±5.5 and 68.4±110.5 days in blood group AB (P<0.001 and P=0.012), respectively. Patients with blood group O and AB had the highest and lowest mean MELD scores at LT allocation, respectively. Conclusions: Serious deceased organ donor shortage resulted in very high MELD score cutoffs for DDLT allocation. Additionally, a significant inequality was observed in the possibility for DDLT according to blood group compatibility. Nationwide follow-up studies are necessary to precisely determine the allocation status of DDLT.
Lee, Kang Man,Choi, Won Jun,Lee, Yoon Ji,Lee, Hyun Joo,Zhao, Long Xuan,Lee, Hyuk Woo,Park, Jae Gyu,Kim, Hea Ok,Hwang, Kwang Yeon,Heo, Yong Seok,Choi, Sun,Jeong, Lak Shin 梨花女子大學校 藥學硏究所 2011 藥學硏究論文集 Vol.- No.21
The X-ray crystal structure of human S-adenosylhomocysteine (AdoHcy) hydrolase was first determined as a tetrameric form bound with the novel mechanism-based inhibitor fluoroneplanocin A (4b). The crystallized enzyme complex showed the closed conformation and turned out to be the intermediate of mechanism-based inhibition. It confirmed that the cofactor depletion by 3'-oxidation of fluoroneplanocin A contributes to the enzyme inhibition along with the irreversible covalent modification of AdoHcy hydrolase. In addition, a series of haloneplanocin A analogues (4b-e and 5b-e) were designed and synthesized to characterize the binding role and reactivity of the halogen substituents and the 4'-CH(2)OH group. The biological evaluation and molecular modeling studies identified the key pharmacophores and structural requirements for the inhibitor binding of AdoHcy hydrolase. The inhibitory activity was decreased as the size of the halogen atom increased and/or if the 4'-CH(2)OH group was absent. These results could be utilized to design new therapeutic agents operating via AdoHcy hydrolase inhibition.
Lee, Jeong A,Kim, Hea Ok,Tosh, Dilip K.,Moon, Hyung Ryong,Kim, Sanghee,Jeong, Lak Shin 이화여자대학교 약학연구소 2008 藥學硏究論文集 Vol.- No.17
◁화학식 삽입▷ (원문을 참조하세요) Stereoselective synthesis of 2´-C-methyl-cycloprophy-fused carbanucleosides was accomplished via stereoselective cyclopropanation, regioselective cleavage of the isopropylidene group, stereoselective Grignard reaction, and cyclic sulfate chemistry."
( Hea Sung Ok ),( Hyoun Soo Lee ),( Man Je Park ),( Ki Hoon Kim ),( Byeong Ki Kim ),( Yu Mi Wi ),( June Myung Kim ) 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.6
Background/Aims: The high mortality attributable to persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in spite of glycopeptide treatment has heightened the need for early detection and intervention with alternative agents. The purpose of this study was to determine the clinical characteristics of and risk factors for persistent MRSA bacteremia. Methods: All first episodes of significant MRSA bacteremia at a 710-bed academic medical center from November 2009 through August 2010 were recorded. Blood cultures were conducted at 3 days and every 2 to 3 days thereafter until clearance. Clinical characteristics and outcomes were compared between persistent MRSA bacteremia (≥ 7 days) and nonpersistent MRSA bacteremia (≤ 3 days). Results: Of 79 patients with MRSA bacteremia during the study period, 31 (39.2%) had persistent MRSA bacteremia. The persistent MRSA bacteremia group had significantly higher 30-day mortality than the nonpersistent MRSA bacteremia group (58.1% vs. 16.7%, p < 0.001). Multivariate analysis indicated that metastatic infection at presentation (odds ratio [OR], 14.57; 95% confidence interval [CI], 3.52 to 60.34; p < 0.001) and delayed catheter removal in catheter-related infection (OR, 3.80; 95% CI, 1.04 to 13.88; p = 0.004) were independent predictors of persistent MRSA bacteremia. Patients with a time to blood culture positivity (TTP) of < 11.8 hours were at increased risk of persistent MRSA bacteremia (29.0% vs. 8.3%, p = 0.029). Conclusions: High mortality in patients with persistent MRSA bacteremia was noted. Early detection of metastatic infection and early removal of infected intravascular catheters should be considered to reduce the risk of persistent MRSA bacteremia. Further studies are needed to evaluate the role of TTP for predicting persistent MRSA bacteremia.
Kim, Hea Ok,Jeong, Lak Shin,Lee, Sun Nan,Yoo, Soo Jeong,Moon, Hyung Ryong,Kim, Kil Soo,Chun, Moon Woo 梨花女子大學校 藥學硏究所 2000 藥學硏究論文集 Vol.- No.9
L-β-2'-Deoxy-4'-thio-1'-purine nucleosides were synthesized efficiently utilizing the neighboring group effect of the 2-benzoy-4-thiosugar acetate.
3,4-디히드로-3-옥소-2H-1,2,4-벤조치아디아진-1,1-디옥사이드 유도체의 합성 및 세포 독성
박혜영(Hea Young Park),한윤정(Yun Jong Han),이정옥(Jeong Ok Lee) 대한약학회 1995 약학회지 Vol.39 No.6
A series of 3,4-dihydro-3-oxo-2H-1,2,4-benzothiadiazine-l,l,dioxides with cytotoxic activity against human solid tumors is described. Synthesized compounds showed mild but broad spectrum cytotoxicity in vitro. The lipophilic substituents like alkyl, alkoxy and chloro on benzene ring increased the activity. Also hydrophobic group on 3 or 4 position of benzothiadiazine was important for the activity