http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : He Zhilong (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Nonlinear dynamic analysis of cutting head-rotor-bearing system of the roadheader
Zhilong Huang,Zhongchao Zhang,Yiming Li,Guiqiu Song,Yang He 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.3
In order to study the dynamic characteristics of cutting head and cantilever system, a nonlinear dynamic model with a 13 degrees of freedom (13-DOF) lateral torsional coupled cutting head-rotor-bearing system (CHRBS) is established. The nonlinear coupled factors of spline clearance and bearing contact force are mainly considered, the dynamic analysis of CHRBS under time-varying load is carried out. The results show that there is no positive correlation between the cutting rock thickness and the states of chaotic motion and quasiperiodic motion. The system is in the two states mentioned above when in low speed region. With the increase of rotational speed, the chaotic motion becomes periodic motion. When the hardness of rock is lower, increasing rotational speed can reduce the vibration of the system, and the cutting thickness can be increased to improve the productivity and lump rock rate. As the hardness of rocks increases, the coupled system shows complex dynamic characteristics when the rotational speed changes from low to high, and the vibration increased. When cutting hard rock, the cutting speed should be increased. However, when the speed is too high, the cutting torque of system becomes smaller. In the case of cutting hard rock, reasonable rotational speed should be chosen between improving stability and increasing cutting force. The dynamic analysis results provide strong support for the vibration reduction and dynamic design of roadheader.
-
The Existence and Stability Analysis of Periodic Solution of Izhikevich Model
Yi Li,Chuandong Li,Zhilong He,Zixiang Shen 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.5
In this paper, based on the Izhikevich model, a more realistic hybrid impulsive neuron model combining model with state-dependent impulsive effects is proposed. By means of the theory of impulsive semidynamic system, the Poincaré section and the ordinary differential equation geometry theory, the properties of the equilibrium points and the sufficient conditions for the existence and stability of different order-1 or order-2 periodic solutions of the system are derived near the equilibrium point or limit cycle. In addition, subthreshold bifurcation behavior which are saddle-node bifurcation, Andronov-Hopf bifurcation, Bogdano-Takens bifurcation and bifurcation behavior of the model with state-dependent impulsive effects are also studied. Final, the main results are illustrated by numerical simulations, and the bifurcation diagram shows that the system becomes more complicated due to the existence of impulses, and there exist bifurcations and chaos phenomena, indicating that the system has rich dynamic behavior.
-
RhoGDI2 induced malignant phenotypes of pancreatic cancer cells via regulating Snail expression
Yi Bin,Hu You,Zhu Dongming,Yao Jun,Zhou Jian,Zhang Yi,He Zhilong,Zhang Lifeng,Zhang Zixiang,Yang Jian,Tang Yuchen,Huang Yujie,Li Dechun,Liu Qiuhua 한국유전학회 2022 Genes & Genomics Vol.44 No.5
Background: Rho GDP dissociation inhibitor 2 (RhoGDI2) has been shown to contribute to the aggressive phenotypes of human cancers, such as tumor metastasis and chemoresistance. Objective: This study aimed to assess the effects of RhoGDI2 on tumor progression and chemoresistance in pancreatic cancer cells. Methods: The expression of RhoGDI2 in pancreatic cancer cells was detected by Western blot analysis. Gain-of-function and loss-of-function approaches were done to examine the malignant phenotypes of the RhoGDI2-expressing or RhoGDI2-depleting cells. The correlation between RhoGDI2 and Snail was also analyzed. Results: Differential expression of RhoGDI2 protein in pancreatic cancer cell lines was identified. Gain-of-function and loss-of-function experiments showed that RhoGDI2 induced the malignant phenotypes of pancreatic cancer cells, including proliferation, migration, invasion, and gemcitabine (GEM) chemoresistance. The upregulation of RhoGDI2 stimulated the expression of Snail, resulting in the altered expression of epithelial marker E-cadherin and mesenchymal marker Vimentin, which were characteristics of the tumorigenic activity of epithelial-mesenchymal transition. The expression of RhoGDI2 and Snail was upregulated in clinical tumor samples, and higher expression of RhoGDI2 or Snail was significantly associated with poor patient survival in pancreatic ductal adenocarcinoma (PDAC). Conclusion: The findings indicated that RhoGDI2 promoted GEM resistance and tumor progression in pancreatic cancer and that RhoGDI2 might be a potential therapeutic target in patients with PDAC.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
