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Obesity induced by high fat diet in Rhomboid family member 2 (Rhbdf2) KO mice
Sung-Jun Kim(Sung-Jun Kim),Seul Gi Park(Seul Gi Park),Young-Sub Byun(Young-Sub Byun),Eun-Kyoung Kim(Eun-Kyoung Kim),Sang-Mi Cho(Sang-Mi Cho),Harim Kim(Harim Kim),Young-Suk Won(Young-Suk Won),Hyoung-Ch 한국예방수의학회 2017 한국예방수의학회 학술대회자료집 Vol.2017 No.-
Inhibition of cytochrome P450 2B6 by Astragalus extract mixture HT042
Kim Harim,Lee Yejin,Kim Vitchan,Lee Rowoon,Bae Soo Kyung,Kwak Mi-Kyoung,Lee Sung Hoon,Kim Donghak 한국독성학회 2020 Toxicological Research Vol.36 No.3
Astragalus extract mixture (AEM) HT042 is a functional food approved by the MFDS (Korean FDA) for increasing height. It comprises a mixture of three standardized extracts from Astragalus membranaceus root, Eleutherococcus senticosus stem, and Phlomis umbrosa root. In this study, drug–functional food interaction was analyzed using six major human cytochrome P450 enzymes. The inhibitory effect of AEM HT042 on P450 activities was studied using a P450–NADPH P450 reductase reconstitution system. Among the six P450 enzymes (1A2, 2A6, 2B6, 2D6, 2C9, and 3A4), only P450 2B6 activity was markedly decreased by AEM HT042 addition. The bupropion hydroxylation activity of P450 2B6 was analyzed using ultraperformance liquid chromatography-tandem mass spectrometry (UPLC–MS/MS). A calculated IC50 value of 10.62 μg/ml was obtained. To identify the inhibitory compounds in the mixture, four active compounds in AEM HT042 were analyzed. Shanzhiside methylester exhibited inhibitory effects on P450 2B6, whereas formononetin, eleutheroside E, and sesamoside did not affect P450 2B6 activity at all. Our results suggest that shanzhiside methylester in AEM HT042 is responsible for the inhibitory effect on P450 2B6 metabolism. Characterization of the inhibitory effect on P450 can help determine the safe administration of functional foods along with many clinical drugs that are metabolized by P450.
소나무, 벚나무, 느티나무 단근 후 연고 처리에 따른 발근 비교
박준형,김지연,권시균,김해랑,권준형,이하림,김다원,마지원,김판기,고상현,김기우,Park, Junhyung,Kim, Jiyeon,Kweon, Si-Gyun,Kim, Haerang,Kwon, Junhyung,Lee, Harim,Kim, Dawon,Ma, Jiwon,Kim, Pan-Gi,Koh, Sang-Hyun,Kim, Ki Woo 한국산림과학회 2019 한국산림과학회지 Vol.108 No.2
본 연구에서는 뿌리 수술과 수목 이식 현장에서 단근 부위에 처리하는 뿌리연고에 대한 상처 반응 및 세근 발달을 3종의 수종에서 비교하였다. 2014년 5월부터 2016년 11월까지 경상북도 상주시에 식재된 소나무, 벚나무, 느티나무 성목에서 직경 2~4 cm에 해당하는 뿌리를 절단하고 상처 부위를 바셀린과 유기질 비료로 연고 처리하여 6개월이 경과한 후, 시료를 채취하여 세근 생장량을 조사하였다. 단근 후 세근 발달은 전반적으로 느티나무와 벚나무에서 우수하였지만 소나무에서는 저조하였다. 세근 생장량은 느티나무에서 단근과 유기질 비료 처리구에서 높게 나타났다. 벚나무에서는 처리별로 뚜렷한 효과가 없었다. 이상의 결과는 단근과 상처 처리에 대한 세근 발달이 수종별로 상이하므로 단근 후 수종별로 처리방법의 세분화가 필요함을 시사한다. The aim of our study was to compare the wound responses and fine root development after root cutting and wound dressing among different tree species. The roots (2~4 cm in diameter) of mature Pinus densiflora, Prunus serrulata var. spontanea, and Zelkova serrata grown in Sangju, South Korea, were cut every 6 months from May 2014 to November 2016. The cut roots were subjected to pastes of vaseline and organic fertilizer. Six months after cutting, fine root development in the cut roots was examined. There was a significant increase in the fine root development in P. serrulata and Z. serrata; however, the development was rarely observed in P. densiflora. Zelkova serrata showed the highest fine root development among the three species in both the control and organic paste treatment groups. No significant differences in fine root development were observed in P. serrulata among the treatments. These results indicate that different tree species exhibit different responses to wound dressing after root cutting, which suggests that specific treatments must be applied to specific tree species.
Kim, Se Hyun,Jang, Mi,Kim, Jiye,Choi, Harim,Baek, Kyung-Youl,Park, Chan Eon,Yang, Hoichang The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.37
<P>Photo and temperature cured polymer dielectrics could be fabricated on a gate-patterned glass, with two immiscible polymer precursors, divinyltetramethyldisiloxane-bis(benzocyclobutene) (BCB precursor) and poly(melamine-<I>co</I>-formaldehyde)acrylate (PMFA), which have excellent insulating properties, but show discernible dielectric constants and polarities. On hydrophobic BCB-assisted PMFA blend dielectrics (approximately 400 nm thick), organic field-effect transistors (OFET) and complementary inverters were demonstrated using pentacene and <I>N</I>,<I>N</I>′-ditridecylperylene-3,4,9,10-tetracarboxylic diimide (PTCDI-C13) as semiconducting channels. The values of field-effect mobilities showed up to 0.33 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP> (for pentacene) and 0.85 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP> (for PTCDI-C13), respectively. In addition, these based complementary inverter was successfully demonstrated with a high voltage gain of <I>ca.</I> 41, specifically, onto the 10 wt% BCB-assisted PMFA dielectric optimized to achieve a hydrophobic and smooth surface by vertically phase-separating the immiscible polymers.</P> <P>Graphic Abstract</P><P>Photo and temperature cured polymer dielectrics could be fabricated on a gate-patterned glass, with two immiscible polymer precursors, BCB and PMFA, which have excellent insulating properties, but show discernible dielectric constants and polarities. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm33203e'> </P>
Digital Infrared Thermal Imaging of Crape Myrtle Leaves Infested with Sooty Mold
Kim, Jiyeon,Kweon, Si-Gyun,Park, Junhyung,Lee, Harim,Kim, Ki Woo The Korean Society of Plant Pathology 2016 Plant Pathology Journal Vol.32 No.6
The spatial patterns for temperature distribution on crape myrtle leaves infested with sooty mold were investigated using a digital infrared thermal imaging camera. The mean temperatures of the control and sooty regions were $26.98^{\circ}C$ and $28.44^{\circ}C$, respectively. In the thermal images, the sooty regions appeared as distinct spots, indicating that the temperatures in these areas were higher than those in the control regions on the same leaves. This suggests that the sooty regions became warmer than their control regions on the adaxial leaf surface. Neither epidermal penetration nor cell wall dissolution by the fungus was observed on the adaxial leaf surface. It is likely that the high temperature of black leaves have an increased cooling load. To our knowledge, this is the first report on elevated temperatures in sooty regions, and the results show spatial heterogeneity in temperature distribution across the leaf surface.
Harim Choe,Hoyong Sung,Geon Hui Kim,On Lee,Hyo Youl Moon,Yeon Soo Kim 한국역학회 2021 Epidemiology and Health Vol.43 No.-
OBJECTIVES: Glycemic control is essential for preventing severe complications in patients with diabetes mellitus. This study investigated the association between grip strength and glycemic control in Korean adults with type 2 diabetes mellitus. METHODS: From the Korea National Health and Nutrition Examination Survey, 2,498 participants aged over 19 years that patients with diabetes mellitus who did not have a history of cardiovascular disease or cancer were selected for analysis. Grip strength was assessed using a handheld dynamometer and was represented as age-specific and sex-specific tertiles. Multivariable logistic regression was performed to calculate the odds ratio (OR) and 95% confidence interval (CI) of glycemic control according to the grip strength tertiles. RESULTS: A significantly lower probability (OR, 0.67; 95% CI, 0.47 to 0.97) for glycemic control was found in the lowest tertile of grip strength compared to the highest tertile. Furthermore, a subgroup analysis by sex only found significant associations between grip strength and glycemic control in males. CONCLUSIONS: Lower grip strength was associated with poor glycemic control in patients with diabetes mellitus, especially in males. However, further studies are needed to confirm the causal relationship between grip strength and glycemic control.