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Hao Tang,Nian-Guang Li,Zhi-Hao Shi,Yu-Ping Tang,Qian-Ping Shi,Ze-Xi Dong,Peng-Xuan Zhang,Jin-ao Duan 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10
The binding abilities of scutellarin (Scu) andscutellarein (Scue) with bovine serum albumin (BSA) wereinvestigated using equilibrium dialysis, high performanceliquid chromatography, fluorescence spectroscopy, competitivesite marker and molecular docking. The resultsshowed that the average protein binding ratios of Scu andScue with BSA were (79.85 ± 1.83) and (85.49 ± 1.21) %respectively. Under simulated physiological conditions, thefluorescence data indicated that Scu and Scue bound withBSA through a static mechanism. The thermodynamicparameters indicated that the interactions of Scu-BSA andScue-BSA mainly occurred by van der Waals forces andhydrogen bonds and it was easier for Scue to bind withBSA than Scu, indicating that the glucuronic acid moleculein Scu decreased the binding affinity. Site competitivemarker experiments showed that the binding sites of Scuand Scue mainly located within the sub-domain IIA ofBSA. Furthermore, molecular docking studies indicatedthat one BSA could bind three Scue, while one BSA couldcarry only two Scu. All these results clearly indicated theinteractions of Scu and Scue with BSA, which will lay thefoundation for further research to determine the pharmacologyand pharmacodynamics of Scu and Scue for treatingischemic cerebrovascular disease.
A higher-order beam model for the snap-buckling analysis of FG pipes conveying fluid
Hao-Xuan Ding,Gui-Lin She 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.80 No.1
The snap buckling of the FG curved pipes conveying fluid has not been reported due to the existing research on the snap-buckling problem. Therefore, the purpose of this paper is to explore this issue. First, we adopt a new high-order shear theory model and consider the thermal and geometric nonlinearity effects, and assume that the density and modulus of elasticity of the liquid are independent of temperature. Based on the generalized variational principle, the governing equation of the FG curved pipes conveying fluid is derived. Then, we assume that the FG curved pipes conveying fluid has simply supported boundary or fixed supported boundary conditions, and use the two step perturbation method to obtain the expression of the relationship between load and deflection. Then, we investigate the influence of boundary conditions, shear deformation, temperature variation, functional gradient index parameters, liquid flow velocity and geometry size on the snap buckling problems of the FG curved pipes conveying fluid. The results show that these factors have significant influence on the fluidstructure interaction problems.
Ma, Hao Xuan,Kim, Chang Woo,Kim, Dong Soo,Jeong, Ji Hun,Kim, In Ho,Kang, Young Soo The Royal Society of Chemistry 2015 Nanoscale Vol.7 No.17
<P>The Nd2Fe14B alloy has been successfully synthesized by nitrate-citrate auto-combustion followed by the reduction and diffusion process with low energy consumption. H3BO3, Fe(NO3)3·9H2O, and Nd(NO3)3·6H2O were used as precursors and citric acid was used as the chelating ligand of metal ions. Ammonia water was used to adjust pH to 7. CaH2 was used as a reducing agent for the reduction and diffusion process. NdFeO3 and Fe2O3 were produced during auto-combustion of gel. The combustion process of the gel was investigated by TGA/DTA curve measurements. The phase compositions were studied by XRD measurements. The differences of the overall morphology and magnetic properties were measured by SEM, TEM and vibrating sample magnetometry (VSM) at 300 K. The comparison of the magnetic properties of the reduced samples between the pellet type and the random powder type was done with VSM and it showed better magnetic properties of the pellet type Nd2Fe14B. Making a compact pellet type sample for reduction is more efficient for solid reduction and phase transition for higher coercivity.</P>
( Xuan Ma ),( Yang Liu ),( Hao Tian ),( Bo Zhang ),( Meiling Wang ),( Xia Gao ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.7
LINC01272 is a long non-coding RNA (lncRNA) that has been considered as a biomarker for many diseases including lung squamous cell carcinoma. Here, we investigated the function and mechanism of LINC01272 on lung cancer (LC). The differential expression of LINC01272 in LC and normal samples was analyzed by GEPIA based on the data from TCGA-LUAD database, as survival prognosis was analyzed through Kaplan-Meier Plotter. LINC01272 overexpression plasmid and miR-7-5p mimic were transfected into A549 and PC-9 cells. LINC01272, miR-7-5p and cardiolipin synthase 1 (CRLS1) mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction. Cell viability was detected through MTT assay. Cell multiplication was evaluated by cell formation assay. Cell apoptosis was assessed through flow cytometry assay. Through bioinformatics, the target miRNA of LINC01272 and downstream genes of miR-7-5p were predicted. The targeting relationship was tested by dual luciferase reporter analysis. CRLS1, B-cell lymphoma-2 (Bcl-2), BCL2-associated X (Bax) and cleaved caspase-3 protein levels were detected through western blot. LINC01272 was downregulated in LC and low LINC01272 expression had poor prognosis. In A549 and PC-9 cells, LINC01272 inhibited cell viability and multiplication and induced apoptosis. LINC01272 negatively regulated miR-7-5p and CRLS1 was a target of miR-7-5p. MiR-7-5p reversed the effect of LINC01272 on viability, multiplication, apoptosis and expression of miR-7-5p and CRLS1 as well as apoptosis-related factors (Bcl-2, Bax and cleaved caspase-3). LINC01272 suppressed cell multiplication and induced apoptosis via regulating the miR-7-5p/CRLS1 axis in LC.
Xuan Zhang,Hao Guo,Xinhong Jia,Qinghua Liao 한국광학회 2018 Current Optics and Photonics Vol.2 No.5
An optimal matching approach is proposed to maximally ensure the output power uniformity of the cascaded encoder in the passive optical network (PON) monitoring system based on a remote coding scheme. The calculation results show that the optimum arrangement can effectively reduce the difference of the total insertion loss in comparison to the random arrangement (i.e., 0.07 dB vs 2.67 dB in the cascaded encoder with 16 output ports). The proposed approach realizes the optimum configuration for the 1 × 2 optical splitters used without adding any extra components. The test results of the fabricated cascaded encoder with 32 output ports prove the feasibility of the proposed approach.