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Chen Huadong,Zhou Luyao,Liao Bing,Cao Qinghua,Jiang Hong,Zhou Wenying,Wang Guotao,Xie Xiaoyan 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.6
Objective: This study aimed to evaluate the role of preoperative two-dimensional (2D) shear wave elastography (SWE) in assessing the stages of liver fibrosis in patients with suspected biliary atresia (BA) and compared its diagnostic performance with those of serum fibrosis biomarkers. Materials and Methods: This study was approved by the ethical committee, and written informed parental consent was obtained. Two hundred and sixteen patients were prospectively enrolled between January 2012 and October 2018. The 2D SWE measurements of 69 patients have been previously reported. 2D SWE measurements, serum fibrosis biomarkers, including fibrotic markers and biochemical test results, and liver histology parameters were obtained. 2D SWE values, serum biomarkers including, aspartate aminotransferase to platelet ratio index (APRi), and other serum fibrotic markers were correlated with the stages of liver fibrosis by METAVIR. Receiver operating characteristic (ROC) curves and area under the ROC (AUROC) curve analyses were used. Results: The correlation coefficient of 2D SWE value in correlation with the stages of liver fibrosis was 0.789 (p < 0.001). The cut-off values of 2D SWE were calculated as 9.1 kPa for F1, 11.6 kPa for F2, 13.0 kPa for F3, and 15.7 kPa for F4. The AUROCs of 2D SWE in the determination of the stages of liver fibrosis ranged from 0.869 to 0.941. The sensitivity and negative predictive value of 2D SWE in the diagnosis of ≥ F3 was 93.4% and 96.0%, respectively. The diagnostic performance of 2D SWE was superior to that of APRi and other serum fibrotic markers in predicting severe fibrosis and cirrhosis (all p < 0.005) and other serum biomarkers. Multivariate analysis showed that the 2D SWE value was the only statistically significant parameter for predicting liver fibrosis. Conclusion: 2D SWE is a more effective non-invasive tool for predicting the stage of liver fibrosis in patients with suspected BA, compared with serum fibrosis biomarkers.
Xuan Zhang,Hao Guo,Xinhong Jia,Qinghua Liao 한국광학회 2018 Current Optics and Photonics Vol.2 No.5
An optimal matching approach is proposed to maximally ensure the output power uniformity of the cascaded encoder in the passive optical network (PON) monitoring system based on a remote coding scheme. The calculation results show that the optimum arrangement can effectively reduce the difference of the total insertion loss in comparison to the random arrangement (i.e., 0.07 dB vs 2.67 dB in the cascaded encoder with 16 output ports). The proposed approach realizes the optimum configuration for the 1 × 2 optical splitters used without adding any extra components. The test results of the fabricated cascaded encoder with 32 output ports prove the feasibility of the proposed approach.