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Haneul Kim,Heeyoung Kang,Wonyong Kim,김명겸,Jung-Hoon Yoon,Seung Bum Kim,Taegun Seo,전체옥,임완택,조기성 국립생물자원관 2023 Journal of species research Vol.12 No.-
In 2021, a total of 27 bacterial strains were isolated from soil, tree bark, moss, wetland, sea sediment, tidal flat, seawater and seaweed within Republic of Korea. Based on the analysis of 16S rRNA gene sequence (>98.7% sequence similarity), these isolates were assigned to the class Alphaproteobacteria as unrecorded species in Korea. The 27 strains were classified into the 10 families: Maricaulaceae of the order Caulobacterales; Brucellaceae, Methylobacteriaceae, Nitrobacteraceae and Rhizobiaceae of the order Hyphomicrobiales; Micropepsaceae of the order Micropepsales; Rhodobacteraceae of the order Rhodobacterales; Azospirillaceae of the order Rhodospirillales; and Erythrobacteraceae and Sphingomonadales of the order Sphingomonadaceae. There is no official report of these 27 species in Korea. Therefore, we report 27 isolates as unrecorded species, and described isolation sources, Gram-stain reactions, physiological and biochemical properties and morphologies of these strains.
국내 양식 무지개송어(Oncorhynchus mykiss)에서 분리된 Photobacterium sp. YW2207의 특성
김현우 ( Hyunwoo Kim ),이은섭 ( Eunsup Lee ),이승준 ( Sung Jun Lee ),김한을 ( Haneul Kim ),한소라 ( So-ra Han ),오태진 ( Tae-jin Oh ),김명석 ( Myoung Sug Kim ),김수진 ( Soo-jin Kim ),권세련 ( Se Ryun Kwon ) 한국어병학회 2023 한국어병학회지 Vol.36 No.2
Photobacterium sp. YW2207 was isolated from rainbow trout raised in a fish farm located in Yeongwol-gun, Gangwon Province, South Korea. Based on 16S rRNA sequence analysis and phylogenetic analysis, it was confirmed that Photobacterium sp. YW2207 showed 100% similarity with Photobacterium piscicola and Photobacterium phosphoreum, and 94.6% similarity with P. damselae subsp. damselae. Biochemical analysis revealed that Photobacterium sp. YW2207 is a Gram-negative, motile bacterium with a cell size of 1.5~3×3~5 μm. The bacteria were cultured on nutrient agar, brain heart infusion agar, Muller-Hinton agar, tryptic soy agar, and thiosulfate citrate bile sucrose agar with NaCl concentrations ranging from 0 to 2.5%. The API50CHE and API20E tests indicated lower utilization capabilities compared to the P. damselae strains provided in the API database. Furthermore, unlike most Photobacterium species, Photobacterium sp. YW2207 presented negative for catalase test. Results from the flow cytometric measurement indicated that Photobacterium sp. YW2207 exhibited a more diverse distribution of cell sizes and had larger cell sizes compared with P. damselae subsp. damselae. Minimum inhibitory concentration tests showed that Photobacterium sp. YW2207 had low susceptibility to β-Lactam and aminoglycoside antibiotics, while having high susceptibility to tetracycline, doxycycline, and quinolone antibiotics. Pathogenicity on rainbow trout revealed that an immersion of 1×10<sup>5</sup> CFU/ml did not cause mortality or clinical symptoms.
선박용 3 차원 서라운드뷰 학습모델을 위한 사용자평가 기반의 학습 데이터 합성
김동욱(Dongwook Kim),김종훈(Jonghun Kim),정태민(Taemin Jeong),김하늘(Haneul Kim),김동준(Dongjoon Kim) 한국HCI학회 2023 한국HCI학회 학술대회 Vol.2023 No.2
Surround View Monitor (SVM) 시스템은 차량에 장착된 카메라 영상으로 차량 주변 영상을 재구성하는 시스템이다. SVM 은 차량 주차 시 필요한 영상 정보를 하나의 뷰로 제공하며, 이는 선박의 정박에도 유용하게 사용된다. 그러나, 기존 SVM 시스템은 고정된 수평면을 가정한 호모그래피에 기반하므로 지형 정보가 왜곡된 주변영상을 제공하는 한계가 있다. 본 연구는 선박의 정박상황에 특화된 SVM 을 목표로 하며, 기존 SVM 시스템의 한계를 극복하기 위해 장면재구성 (scene reconstruction) 및 영상완성 (image completion) 학습모델을 블록빌딩으로 하는 프레임워크를 제안한다. 제안 프레임워크를 구성하는 학습모델을 위한 효과적인 학습데이터 획득 및 학습모델 설계를 위해 정박 상황의 시뮬레이션 영상을 활용한다. 또한, 선박 정박 상황을 몰입형 가상현실로 구현하여 선박운항 전문가가 고난도 정박 상황을 경험하게 하고 제안한 시스템에서 생성한 SVM 을 경험하게 한다. 최종적으로 이를 통해 획득한 사용자 평가데이터를 제안한 SVM 시스템의 학습데이터 생성 및 학습모델 설계에 활용한다.
Kim, Byeong-Gon,Lee, Pureun-Haneul,Lee, Sun-Hye,Baek, Ae-Rin,Park, Jong-Sook,Lee, Junehyuk,Park, Sung-Woo,Kim, Do-Jin,Park, Choon-Sik,Jang, An-Soo The Korean Academy of Asthma, Allergy and Clinical 2018 Allergy, Asthma & Immunology Research Vol.10 No.5
<P><B>Purpose</B></P><P>The tight junction protein claudin-5 (CLDN5) is critical to the control of endothelial cellular polarity and pericellular permeability. The role of CLDN5 in chronic obstructive pulmonary disease (COPD) remains unclear. The aim of this study was to investigate the association between CLDN5 levels and clinical variables in patients with COPD.</P><P><B>Methods</B></P><P>In total, 30 patients with COPD and 30 healthy controls were enrolled in the study. The plasma CLDN5 level was checked in patients with stable or exacerbated COPD and in healthy controls.</P><P><B>Results</B></P><P>The mean plasma CLDN5 level of patients with COPD was 0.63 ± 0.05 ng/mL and that of healthy controls was 6.9 ± 0.78 ng/mL (<I>P</I> = 0.001). The mean plasma CLDN5 level was 0.71 ± 0.05 ng/mL in exacerbated COPD patients and 0.63 ± 0.04 ng/mL in patients with stable COPD (<I>P</I> < 0.05). The plasma CLDN5 level among COPD subjects was correlated with the smoking amount (<I>r</I> = −0.530, <I>P</I> = 0.001). The plasma CLDN5 level in stable COPD patients was correlated with forced expiratory volume in one second (FEV1, %pred.) (<I>r</I> = −0.481, <I>P</I> = 0.037).</P><P><B>Conclusions</B></P><P>The plasma CLDN5 level was not correlated with age. CLDN5 may be involved in the pathogenesis of COPD. Further studies having a larger sample size will be needed to clarify CLDN5 in COPD.</P>
Clinicodermoscopic features of atypical dermatofibroma compared with typical type
( Haneul Oh ),( Tae Jun Park ),( Bo Young Kim ),( Chang Min Kim ),( Hwa Jung Ryu ),( Hye Rim Moon ),( Il-hwan Kim ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Dermatofibroma is a common benign skin neoplasm that is usually easy to recognize, but in some cases its differentiation from atypical dermatofibroma may be difficult. Objectives: To describe the clinical and dermoscopic features of atypical dermatofibromas and to differentiate from typical type according to the above features. Methods: We retrospectively searched the database of patients from Korea University Ansan Hospital from January 2010 to July 2018, who had skin biopsy or excision operation with the resulting pathology report of typical and atypical dermatofibroma. Analysis of the clinical demographics (age, gender, anatomical site etc.) and dermoscopic features was done. Results: Of the 240 patients diagnosed with dermatofibroma, 19 (7.9%) were identified as atypical deramtofibroma. In comparison of clinical features, the atypical type was not significantly different from the typical type. However, dermoscopy findings of four patients with atypical dermatofibroma were analyzed, and These dermoscopic findings are patterns that appear below 6% in typical types. Conclusion: Atypical dermatofibroma is clinically difficult to distinguish from the typical counterpart and biopsy is essential for diagnosis. If dermatofibroma is suspected and exhibits rare dermoscopy findings, it may be an atypical type and should be treated with caution when treating because of the tendency to recur and metastasis.
Kim, Haneul,Lee, Hyung Eun,Jung, In Ho,Jeon, Se Jin,Zhang, Jiabao,Kwon, Yubeen,Jang, Dae Sik,Ryu, Jong Hoon Elsevier 2018 Journal of Ethnopharmacology Vol.211 No.-
<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P>The seeds of <I>Ziziphus jujuba</I> var. <I>spinosa</I> (Bunge) Hu ex H.F Chow (Rhamnaceae) and the roots of <I>Codonopsis lanceolata</I> (Siedbold & Zucc.) Benth. & Hook. f ex Trautv. (Campanulaceae), contained in the DHP1402, have long been used for treating dementia or hypomnesia as folk medicine.</P> <P><B>Aim of the study</B></P> <P>It has been reported that <I>Z. jujuba</I> var. <I>spinosa</I> and <I>C. lanceolata</I> are effective in improving cognitive function, but via different mechanisms. Therefore, in the present study, we evaluated the synergistic effects of <I>Z. jujuba</I> var. <I>spinosa</I> and <I>C. lanceolata</I> on scopolamine-induced memory impairment.</P> <P><B>Materials and methods</B></P> <P>Scopolamine, a cholinergic muscarinic receptor antagonist, was used to induce cognitive dysfunction. We employed several behavioral tasks to estimate the synergistic effect of the seeds of <I>Z. jujuba</I> var. <I>spinosa</I> and the roots of <I>C. lanceolata</I>. In addition, we introduced the Western blotting, the antagonism passive avoidance task to investigate a synergistic effect of an herbal formulation.</P> <P><B>Results</B></P> <P>Synergistic effects of a combination of <I>Z. jujuba</I> var. <I>spinosa</I> and <I>C. lanceolata</I> at a 5:1 ratio [(w/w), DHP1402] were observed against cognitive dysfunction in the passive avoidance and Y-maze tasks. DHP1402 also ameliorated memory deficits in a dose-dependent manner in these behavioral tasks, as well as in the Morris water maze task. According to the Western blot results, the phosphorylation levels of protein kinase A (PKA), extracellular signal-regulated kinase (ERK) and cAMP response element-binding protein (CREB) in the hippocampus were also increased in a synergistic manner after the administration of DHP1402. In addition, we found that the effects of DHP1402 on cognitive function were mediated by <I>N</I>-methyl-<I>D</I>-aspartate (NMDA) receptor signalling, based on the antagonism studies. Furthermore, we found that DHP1402 has inhibitory activity against acetylcholinesterase (AChE).</P> <P><B>Conclusion</B></P> <P>DHP1402 attenuates cholinergic blockade-induced cognitive dysfunction through NMDA receptor modulation, PKA-ERK-CREB pathway activation, and AChE inhibition. Therefore, DHP1402 could be a candidate for alleviating cognitive dysfunction.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>