On the Locating of transmission Zero`s in the ARMA Modeling

Haiyang Gao,Tosiro Koga 대한전자공학회 1990 JTC-CSCC : Joint Technical Conference on Circuits Vol.- No.-

Experimental Study on Pull-Out Behavior of Wedge-Grouted Rockbolt in Wind Turbine Tower Foundation

Haiyang Gao,Lianguang Wang,Xue Li,Yaosheng Zhang 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.6

To investigate the the pull-out behaviors of wedge-grouted rockbolts and grouted rockbolts in strongly weathered and moderately weathered rocks, the rockbolts with lengths of 8.0 m, 10.5 m and 13.0 m were tested under freeze–thaw cycle and cyclic load. The test result shows that the minimum anchoring length of wedge-grouted rockbolt is less than 3.0 m and of grouted rockbolt is less than 4.0 m in the strongly weathered or moderately weathered rock. The effect of the wedge head on restricting the deformation of the rockbolt is not obvious when the anchoring length is less than 6.0 m. Freeze–thaw cycle had little effect on the stiffness and deformation of the two kinds of rockbolts. The wedge-grouted rockbolts have better deformation performance than the grouted rockbolts. The bonding force between the rockbolt and the grout or the grout and the surrounding rock is greater than the tensile strength of the rockbolt. Furthermore, the calculation models of shear stress and axial strain can provide reasonable predictions for two kinds of rockbolts, and the development trends of strain and shear stress under different pullout loads were calculated.

Growth Inhibitory and Pro-Apoptotic Effects of Hirsuteine in Chronic Myeloid Leukemia Cells through Targeting Sphingosine Kinase 1

Gao Shan,Guo Tingting,Luo Shuyu,Zhang Yan,Ren Zehao,Lang Xiaona,Hu Gaoyong,Zuo Duo,Jia Wenqing,Kong Dexin,Yu Haiyang,Qiu Yuling 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.6

Chronic myeloid leukemia (CML) is a slowly progressing hematopoietic cell disorder. Sphingosine kinase 1 (SPHK1) plays established roles in tumor initiation, progression, and chemotherapy resistance in a wide range of cancers, including leukemia. However, small-molecule inhibitors targeting SPHK1 in CML still need to be developed. This study revealed the role of SPHK1 in CML and investigated the potential anti-leukemic activity of hirsuteine (HST), an indole alkaloid obtained from the oriental plant Uncaria rhynchophylla, in CML cells. These results suggest that SPHK1 is highly expressed in CML cells and that overexpression of SPHK1 represents poor clinical outcomes in CML patients. HST exposure led to G2/M phase arrest, cellular apoptosis, and downregulation of Cyclin B1 and CDC2 and cleavage of Caspase 3 and PARP in CML cells. HST shifted sphingolipid rheostat from sphingosine 1-phosphate (S1P) towards the ceramide coupled with a marked inhibition of SPHK1. Mechanistically, HST significantly blocked SPHK1/S1P/S1PR1 and BCR-ABL/PI3K/Akt pathways. In addition, HST can be docked with residues of SPHK1 and shifts the SPHK1 melting curve, indicating the potential protein-ligand interactions between SPHK1 and HST in both CML cells. SPHK1 overexpression impaired apoptosis and proliferation of CML cells induced by HST alone. These results suggest that HST, which may serve as a novel and specific SPHK1 inhibitor, exerts anti-leukemic activity by inhibiting the SPHK1/S1P/ S1PR1 and BCR-ABL/PI3K/Akt pathways in CML cells, thus conferring HST as a promising anti-leukemic drug for CML therapy in the future.

Complexity Comparison for Drinkers' and Normal People's EEG Using Wavelet Entropy

Jiufu Liu,Lei Gao,Zaihong Zhou,Haiyang Liu,Zhengqian Wang,Wenyuan Liu,Jianyong Zhou 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.8

This paper investigates the influence of alcohol on brain complexity. Considering electro-encephalogram (EEG) has the nonlinear dynamics characteristic of time-varying and non-stationary, we introduce the wavelet entropy (WE) analysis. We denoise EEG signal by using wavelet decomposition, then calculate the wavelet entropy of the denoised signal and analyze the nonlinear complexity. In 64 conductive poles experiments and in different stimulus experiments for FP2 electrode's EEG, the drinkers' EEG wavelet entropy is greater than normal people's. The wavelet entropy of every conductive pole of drinkers’ or normal persons’ is inconformity.

Critical seismic incidence angle of transmission tower based on shaking table tests

Li Tian,Xu Dong,Haiyang Pan,Guodong Gao,Aiqiang Xin 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.76 No.2

Transmission tower-line systems have come to represent one of the most important infrastructures in today’s society. Recent strong earthquakes revealed that transmission tower-line systems are vulnerable to earthquake excitations, and that ground motions may arrive at such structures from any direction during an earthquake event. Considering these premises, this paper presents experimental and numerical studies on the dynamic responses of a 1000 kV ultrahigh-voltage (UHV) transmission tower-line system under different seismic incidence angles. Specifically, a 1:25 reduced-scale experimental prototype model is designed and manufactured, and a series of shaking table tests are carried out. The influence of the seismic incidence angle on the dynamic structural response is discussed based on the experimental data. Additionally, the incidence angles corresponding to the maximum peak displacement of the top of the tower relative to the ground (referred to herein as the critical seismic incidence angles) are summarized. The experimental results demonstrate that seismic incidence angle has a significant influence on the dynamic responses of transmission tower-line systems. Subsequently, an approximation method is employed to orient the critical seismic incidence angle, and a corresponding finite element (FE) analysis is carried out. The angles obtained from the approximation method are compared with those acquired from the numerical simulation and shaking table tests, and good agreement is observed. The results demonstrate that the approximation method can properly predict the critical seismic incidence angles of transmission tower-line systems. This research enriches the available experimental data and provides a simple and convenient method to assess the seismic performance of UHV transmission systems.

Expression profile and estrogenic regulation of Amh during gonadal sex differentiation in northern snakehead (Channa argus)

Qing Luo,Mi Ou,Jian Zhao,Haiyang Liu,Dandan Gao,Yanduo Wu,Lanlan Zhang,Kunci Chen 한국유전학회 2020 Genes & Genomics Vol.42 No.7

Background Anti-Müllerian hormone (Amh) plays a critical role in both early sex determination and later gonad development in vertebrate species. However, it remains unknown in northern snakehead (Channa argus), which is economically important freshwater fish with sexual dimorphism. Objective This study aimed to identify the expression profiles and estrogenic regulation of CaAmh during gonadal sex differentiation in C. argus. Methods The cDNA and genomic DNA sequences of CaAmh were identified by PCR and RACE techniques. The expression patterns of CaAmh were detected by qRT-PCR during the gonadal sex differentiation and after 17α-ethinyloestradiol (EE2) treatments. Results CaAmh is composed of seven exons and six introns, and its full-length cDNA is 2413 bp in length, with 1635 bp open reading frame (ORF) that encodes a 544 amino acid protein. Tissues expression patterns revealed that CaAmh display the highest expression in testis of XY males (40.36 folds, p < 0.01). The spatio-temporal expression patterns during gonadal sex differentiation indicated that CaAmh expression differed between XX females and XY males at 30 day after hatching (dah), and reached to the peak (36.03 folds, p < 0.01) at 90 dah in XY gonads. However, CaAmh expression in XX gonads remained low throughout the sampling period. Furthermore, CaAmh expression in the gonads (ovaries) of the sex-reversed XY fish (XY-F) by the administration of estrogen EE2 was downregulated to low level, similar to that in ovaries of normal XX females (XX-F). Conclusions These results show that Amh plays a critical role in testicular differentiation of C. argus and it is apparently modulated by estrogens in this species.

High Temperature Oxidation Resistance of NiCoCrAl High Entropy Alloy Coating on the TiAl Alloy

Yuanyuan Sun,Qiang Miao,Wenping Liang,Kai Zang,Yuting Wu,Haiyang Yu,Mengjuan Yin,Xiguang Gao,Yindong Song 대한금속·재료학회 2024 METALS AND MATERIALS International Vol.30 No.1

The high entropy alloy coating is considered as one of the most promising methods to improve the high-temperature oxidationresistance of titanium aluminum alloys due to its fine mechanical property and thermal stability. However, the high entropyalloy coating prepared so far has poor coating quality, and low coating forming efficiency and there are certain requirementsfor the substrate alloys. To this end, a NiCoCrAl high entropy alloy coating was developed using the double glow plasmaalloying technique on the TiAl alloy. The morphology, phase structure, and high temperature oxidation resistance of thecoating were comprehensively studied. The results indicate that a uniform and dense coating with a single solid solution offace-centered cube phase formed on the alloy surface. Furthermore, isothermal oxidation test was performed, and the oxidationfailure process of the TiAl substrate and the NiCoCrAl-coated sample with different oxidation times was analyzed. It isfound that the coating efficiently prevented the TiAl alloy from degeneration for up to 100 h at 900 °C.