Structure properties and electrical mechanisms of Si(001)/SiO2 interface with varying Si layer thickness in nano-scale transistor

Haixia Li,Aiming Ji,Canyan Zhu,Ling-Feng Mao 한국물리학회 2018 Current Applied Physics Vol.18 No.9

To illustrate the impacts of stress/strain effect on nano-scale transistor, a theoretical investigation of stress/strain and transition region of interface are presented in this paper. It is found that the residual stress changes from −1.8098 to 0.3159 GPa with Si layer thickness increasing. At the same time, SiSi average bond length reduces from 2.397Å to 2.355 Å and finally approaches to 2.352 Å (the bond length of ideal silicon crystal). The further calculations demonstrate that the above mentioned changes also decrease surface potential. And the relative decrease in the surface potential becomes larger with the applied gate voltage decreasing especially when it is less than 1.5 V. Moreover, when the doping concentration is 1 × 1019cm−3, the threshold voltage and subthreshold swing (SS) reduce from 2.9 V to 2 V and 551mV/dec to 198mV/dec respectively. It implies that we can get a better device performance by growing appropriate thickness of silicon.

Rheinic acid ameliorates radiation‑induced acute enteritis in rats through PPAR‑γ/NF‑κB

Haixia Sha,Yu Gu,Weixing Shen,Li Zhang,Fei Qian,Yudong Zhao,Haixiao Li,Ting Zhang,Weimin Lu 한국유전학회 2019 Genes & Genomics Vol.41 No.8

Background Acute radiation enteritis (ARE), a common complication of intestinal caused by abdominal and pelvic radiation therapy. Rheinic acid is a major active ingredient derived from Rhubarb. Rhubarb could suppress inflammation, tumor, fibrosis oxidative damage. However, RA as the main active component and extract monomer of Rhubarb, the pharmacological activity and the underlying molecular mechanism on various diseases has not yet been revealed. Objective To determine the potential role of rheinic acid (RA) in ameliorating inflammation of rats with acute radiation enteritis (ARE), and explore the underlying mechanism. Methods ARE rat model was established by irradiated with single-dose 10 Gy X-rays at a rate of 0.62 Gy/min to the abdomen. The rats were executed after orally administered with Rheinic acid 7 days and used in the subsequent experiments. Body weight, fecal characteristics and bloody of rats were used to assess the disease activity index. Histological analysis of the jejunum and colon were evaluated using H&E staining. The pro-inflammatory cytokines levels were measured by immunohistochemistry and ELISA. The levels of nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) were also determined. The mRNA and protein expression were examined by real-time polymerase chain reaction (qRT-PCR) and western blot, respectively. Results Rheinic acid promoted intestinal functional recovery, and ameliorated intestinal damage and bloody stool in ARE rats. Rheinic acid strongly decreased the levels of tumor necrosis factor-α, interleukin-1, interleukin-6, NO, and MDA, whereas increased levels of anti-oxidants, SOD and GSH. Moreover, the expression of apoptosis-related proteins, cleaved caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP), were decreased with RA treatment. Further study indicated that PPAR-γ was activated and thereby NF-κB and p38 MAPK signaling pathway were suppressed after rheinic acid treatment. Conclusion Rheinic acid could ameliorate acute radiation enteritis and the underlying molecular mechanism is, at least partially, through PPAR-γ/NF-κB and p38 MAPK/JNK pathways.

Effects of Naoxintong-containing serum on NO and CGRP in rat cerebral microvascular endothelial cells

Lanfang, Li,Canghai, Li,Haixia, Dang,Nan, Jiang,Jianyou, Guo,Shuying, Guo,Hairu, Huo,Tingliang, Jiang Kyung Hee Oriental Medicine Research Center 2005 Oriental pharmacy and experimental medicine Vol.5 No.3

Effects of Naoxintong (NXT, a formula of Chinese Materia Medica)-containing serum on Nitrogen monoxide (NO) and calcitonin gene related peptide (CGRP) in rat cerebral microvascular endothelial cells (rCMEC) was investigated, rCMEC was injured in vitro by incubating for 4 hours at 100% NO in a hypoxia chamber. The results indicated that NXT could antagonize the reduction of NO and CGRP secreted by rCMEC during hypoxia, the effect of which was dose-dependent. After treated with NXT-containing serum at dosage of 5.0 - 30 and 50 -1.1 g/kg/U respectively, the amount of NO and CGRP secreted by rCMEC were remarkably increased during hypoxia in vitro.

The Anti-compaction Behavior of Aramid Fiber Based Polyvinylidene Fluoride Composite Separation Membranes

Hongbin Li,Wenying Shi,Shuo Mei,Jinchao Li,Qiyun Du,Longwei Qin,Haixia Zhang 한국섬유공학회 2019 Fibers and polymers Vol.20 No.2

Poly(p-phenylene terephthalamide) (PPTA), as the raw polymer material of Aramid fiber-1414, has high modulus and high strength which is commonly used in the reinforced composites. However, the general blending often accompany the microphase incompatibility in polymer matrix. In this study, PPTA molecules were incorporated into poly(vinylidene fluoride) (PVDF) membrane matrix through in situ polycondensation of p-phenylene diamine (PPD) and terephthaloyl chloride (TPC) in PVDF solution and PPTA/PVDF molecular composite membranes were prepared via the subsequent nonsolvent induced phase separation (NIPS) process. The anti-compaction properties of resulted PPTA/PVDF molecular composite membranes were systematically investigated including the variations of bursting pressure and membrane thickness, porosity, pure water flux under different pressures. The results suggested that membrane comprehensive anticompaction properties were improved with the increasing of PPTA content in PVDF membrane matrix. Combining the variation trends of membrane anti-compaction properties with morphologies, the compaction-deformation evolution processes of two membrane pore types (sponge-like and finger-like pores) were proposed at the end.

De novo assembly and microsatellite marker development of the transcriptome of the endangered Brachymystax lenok tsinlingensis

Sien Wen,Ping Li,Feng Wang,Jiale Li,Haixia Liu,Ning Li 한국유전학회 2020 Genes & Genomics Vol.42 No.7

Background Brachymystax lenok tsinlingensis is an endemic freshwater fish in Northeast Asia, but experienced a dramatic population decline due to over-exploitation, deteriorated habitats and global climate change. It has been listed as a threatened or endangered species in South Korea and China, respectively. However, the conservation and restoration work in wild B. lenok tsinlingensis populations require large amount of genetic and molecular data to support effective management of genetic resources, while the corresponding information is very limited. Objective This study was conducted to generate transcriptome assembly and annotation, as well as to develop novel microsatellite markers for B. lenok tsinlingensis. Methods We collected gill and liver tissues and performed transcriptome sequencing. Then the first transcriptome for B. lenok tsinlingensis was de novo assembled and annotated. Microsatellite markers were searched in the assembled transcripts and characterized within ninety individuals collected from three natural sites. Results A total of 110,712 protein-coding transcripts were assembled, of which 82,861 transcripts were successfully annotated. This assembly displayed a high level of completeness with retrieving 94% of the single-copy orthologs conserved across vertebrate species. Furthermore, 75,891 microsatellite loci were identified from this transcriptome assembly and 20 polymorphic markers were randomly selected for characterization. Conclusions The microsatellite markers and the first transcriptome assembly would provide valuable resources for investigating genetic diversity and phylogeographic structure of wild populations and molecular mechanisms responding to stressful environments (e.g. increased water temperature) to guide future conservation studies and breeding programs.

Seismic Performance of Encased Steel Plate-Reinforced Gangue Concrete Composite Shear Walls

Haixia Zhang,He Liu,Guochang Li,Xin Ning 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.7

In this paper, a new type of shear wall, referred to as encased steel plate-reinforced gangue concrete composite shear wall, is proposed. To investigate the seismic performance of the shear wall, one of the specimens was subjected to monotonic loading, and the remaining 5 specimens were tested under reversed cyclic loading. The failure mode, hysteretic and skeleton curve, strength degeneration, stiffness degeneration, ductility and energy dissipation capacity of these specimens were compared and analyzed. In addition, finite element models were also established and verified using the test results. Furthermore, the effects of the height-towidth ratio and the axial compression ratio on the seismic behavior of the composite wall were explored. The experimental and numerical results indicate that the specimen has a large load-carrying capacity, excellent ductility and energy dissipation capacity, little strength degradation and minimal stiffness degradation. Moreover, the results also show that the method of welded stiffened short reinforcement on the surface of the steel plate can significantly improve the bond interaction between the steel plate and gangue concrete to maintain the overall work performance of gangue concrete and steel as well as the load bearing capacity of the specimen.

The influence of high-temperature nitridation process on the crystalline quality of semipolar (1122) GaN epitaxial films

Li Wenlong,Wang Lianshan,Chai Ruohao,Wen Ling,Lu Haixia,Wang Huanhua,Yang Shaoyan,Sun Wenhong 한국물리학회 2022 Current Applied Physics Vol.39 No.-

Semipolar (1122) GaN epitaxial films were grown on m-plane sapphire substrates by metal-organic chemical vapor deposition and additional high-temperature nitridation was introduced during the growth. The growth mechanism, surface microtopography, and the full width at half maximum (FWHM) of X-ray rocking curves (XRCs) of on-axis and off-axis (1122) GaN planes were investigated. The results demonstrate that additional high-temperature nitridation process could reduce surface roughness and anisotropy, and suppress the other orientations, and partially improve the crystalline quality of (1122) GaN epitaxial films. The XRCs FWHM of the off-axis (1122) GaN planes decrease and show a different varying tendency after additional high-temperature nitridation process associated with the partial dislocations and basal plane stacking faults (BSFs). The results of the modified Williamson-Hall (W–H) analysis and photoluminescence spectrum show the BSFs increased while the partial dislocations decreased after an additional high-temperature nitridation process. The improvement of crystalline quality was mainly correlated to the reduction of partial dislocations.

Grading Plant Available Non-Exchangeable Potassium According to its Release Rate Levels Using Sodium Tetraphenylboron

Ting Li,Huoyan Wang,Haixia Sun,Jianmin Zhou 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Fast Single-Phase All Digital Phase-Locked Loop for Grid Synchronization under Distorted Grid Conditions

Peiyong Zhang,Haixia Fang,Yike Li,Chenhui Feng 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.5

High-performance Phase-Locked Loops (PLLs) are critical for grid synchronization in grid-tied power electronic applications. In this paper, a new single-phase All Digital Phase-Locked Loop (ADPLL) is proposed. It features fast transient response and good robustness under distorted grid conditions. It is designed for Field Programmable Gate Array (FPGA) implementation. As a result, a high sampling frequency of 1MHz can be obtained. In addition, a new OSG is adopted to track the power frequency, improve the harmonic rejection and remove the dc offset. Unlike previous methods, it avoids extra feedback loop, which results in an enlarged system bandwidth, enhanced stability and improved dynamic performance. In this case, a new parameter optimization method with consideration of loop delay is employed to achieve a fast dynamic response and guarantee accuracy. The Phase Detector (PD) and Voltage Controlled Oscillator (VCO) are realized by a Coordinate Rotation Digital Computer (CORDIC) algorithm and a Direct Digital Synthesis (DDS) block, respectively. The whole PLL system is finally produced on a FPGA. A theoretical analysis and experiments under various distorted grid conditions, including voltage sag, phase jump, frequency step, harmonics distortion, dc offset and combined disturbances, are also presented to verify the fast dynamic response and good robustness of the ADPLL.

EGR1 promotes stemness and predicts a poor outcome of uterine cervical cancer by inducing SOX9 expression

Juanhong Zhao,Haixia Li,Miao Yuan 한국유전학회 2021 Genes & Genomics Vol.43 No.5

Background Early growth response-1 (EGR1) is a transcription factor involved in the progression of several cancer types. However, the expression and clinical signifcance of EGR1 in uterine cervical cancer (CC) have not been elucidated. Objective To investigate the expression, clinical signifcance and prognostic value of EGR1 in CC. Methods The expression of EGR1 was detected in 13 CCs and paired adjacent tissues with qRT-PCR and in 144 CC tissues with immunohistochemistry (IHC). The IHC scores were used to divide the patients into subsets with low and high EGR1 expression. The correlations between the EGR1 expression and clinicopathological factors were analyzed with the chi-square test, and the prognostic signifcance of EGR1 expression was evaluated with univariate and multivariate analyses. The functions of EGR1 in the proliferation, invasion and stemness of CC cells were investigated, and the molecular mechanism was assessed by in vitro experiments. Results High expression of EGR1 was signifcantly associated with low survival rates of CC. EGR1 is an independent prognostic biomarker of CC, and its high expression predicted a poor outcome. EGR1 facilitated stemness and thus promoted proliferation and invasion of CC cells. SOX9 played an essential role in the EGR1-induced progression of CC cells. Conclusions EGR1 is an independent prognostic biomarker of CC. High EGR1 expression promoted proliferation, invasion and stemness by increasing SOX9 expression in CC cells. Our results suggested that the EGR1-SOX9 axis may be a potential drug target and that blocking the EGR1-SOX9 axis may be a possible approach to treating CC.