Pseudo-Gitelman씨 증후군 1예

김성렬,조영일,이해운,이정연,안해련,송종오,명승운 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

Gitelman's syndrome is a rare disorder with a characteristic set of metabolic abnormalities. These include hypokalemia, metabolic alkalosis, hypocalciuria and hypomagnesemia. The clinical manifestations of Gitelman's syndrome are very similar with those of Bartter's syndrome and diuretic abuse. Gitelman' syndrome and Bartter's syndrome can be distinguished by renal clearance study after administration of furosemide and thiazide, since the primary defect in each of these disorders is an impairment in sodium reabsorption in the distal tubule and loop of Henle, respectively. Pseudo-Bartter's syndrome due to diuretic abuse can be distinguished by history of diuretic use and a positive urine assay for diuretics. We have experienced a case of pseudo-Gitelman's syndrome in 56-year old woman with unexplained hypokalemic metabolic alkalosis, hypocalciuria, and hypomagnesemia. The patient denied ingestion of diuretic medication. The results of renal clearance study using furosemide and thiazide in this case suggested the presence of the primary defect of sodium reabsorption in the distal tubule rather than in the loop of Henle. These clinical and laboratory findings were consistent with those of Gitelman's syndrome. But, this case was confirmed as pseudo-Gitelman's syndrome since diuretics were detected by a urine assay for diuretics. Furosemide and hydrochlorothiazide were contained in the pill that she had been taking due to constipation. Herein, we report the case of pseudo-Gitelman's syndrome by abuse of cathartics containig diuretics presented as Gitelman's syndrome in renal clearance study.

방향전환성 두위안진을 유발한 선천성 내이기형

정운교,김문석,양해동,이주환 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.1

게놈 유형이 다른 무릇(Scilla scilloides comlpex)에서 FISH를 이용한 인 우성 다양성 분석

이상은,최혜운,방재욱 충남대학교 생물공학연구소 2004 생물공학연구지 Vol.10 No.2

Nucleolar dominance, an epigenetic phenomenon in which one parental set of ribosomal RNA gene is silenced in an interspecific hybrid, was investigated in different cytotype plants of Scilla scilloides complex; AA, BB, AABB, ABBB, BBBB and AABBB. To determine the loci of the nucleolar organizer regions (NORs) in metaphase chromosomes, physical mapping of 45S rRNA gene (3.8 Kb) using FISH method was applied. Two signals of the 45S rRNA gene loci were observed in both the cytotypes of AA (2n=16) and BB (2n=18). Four signals were found in tetraploid BBBB, while two and three signals were found in cytotypes of AABB and ABBB, respectively. However, AABB plants in the population of Daegukhul-do Island had four NORs in both the A and B genome. Four signals were found in pentaploid AABBB plants. The different numbers of 45S rRNA gene signals suggested the phenomenon of nucleolar dominance or amphiplasty among different cytotype plants of S. scilloides. It is speculated that inactivation of NORs on a2 chromosome in the cytotype AABB plants is the result of the amphiplastic suppression between A and B genomes.

마산연안지역의 국지풍 순환 및 대기오염물질 확산에 관한 연구

김유근,이화운,문윤섭,김해동,원경미,정우식,오인보 부산대학교 환경문제연구소 1997 環境硏究報 Vol.15 No.1

To investigate a horizontal windrose and the mixing height in Masan coastal area, a local atmospheric flow and the concentration of air pollutants were analyzed by abserved data from AWS, airsonde and air sampler. The land-sea breeze model and the ISCST2 model of U. S. EPA(Environmental Protection Agency) were used to predict the concentration of air pollutants such as SO2 and TSP. As a result, during spring the principal wind direction in the Masan region is mainly represented by windrose of the WNW and NW, which can be induced by land breeze and the SE and SSW of sea breeze even if weak wind speed. The mixing height during the measurement was marked with the range from 400 m(0900 LST) to 1450 m(1500 LST), and the height of an inverse layer was presented as the range from 30 m(2100 LST) to 150 m(0300 LST). It is very important to cosider the local wind field for the accurate diffusion and movement of air pollutants in coastal urban area. The atmospheric flow was simulated by the two-dimensional local wind model upon considering the orographic characteristics such as land-sea contrast, mountain valley and urban building. The result of air quality simulated by ISCST2 support that the dispersion pattern of the pollutants in that area was followed as local circulation system in coastal urban area.

유산균(L.lactis CBT-8)및 발효 추출물의 Helicobacter pylori 억제 능력

진춘조,박형석,이혜운,김성렬,강동구,이준상,이재동,왕준호 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

Helicobacter pylori infection was the cause of chronic gastritis, duodenal ulcer and gastric MALT lymphoma. The eradication rates of H. pylori using antibiotics are around 80%. Lactobacilli have been demonstrated to have in vivo and in vitro inhibitory effects on H. pylori infection. We aimed to evaluate the inhibitory effect of L. lactis CBT-8 and its extract on H. pylori in human stomach. Thirty-five H. pylori-infected volunteers(30-49 yr)were randomized into two groups which were treated with L. lactis CBT-8 and its extract(Group A n=17) or milk containing L. lactis CBT-8(Group B, n=18). They underwent 13C-urea breath tests before and after treatment. The DOB30 of group A(n=14) was decreased 41.0% after treatment(26.0±4.9 before, 15.3±2.1 after treatment)(p<0.05). the DOB30 of group B(n=13) was decreased 22.3% after treatment(22.0±2.2 before, 17.1±1.7 after treatment)(p<0.05). In conclusion, L. lactis CBT-8 was effective in suppressing H. pylori infection in human stomach.

모형실험에 의한 사질토 자반에서의 군말뚝 거동에 관한 연구

유남재,김영길,이명욱,정해운 江原大學校 産業技術硏究所 1995 産業技術硏究 Vol.15 No.-

The purpose of this paper is to analyze the bearing capacity, settlement and pile action of pile groups in cohesionless soil, based on a wide range of model test in laboratory. Model test were conducted with changing the variables affecting the behavior of group pile; Number of pile, Diameters, Spacings between piles and Arrangement of piles. Effects of these variables on group efficiency were investigated by analyzing test results. Test results were also compared with the existing analytical method and data obtained in-situ tests.

Co(Ⅱ)와 Methylthmol blue사이의 착물형성에 있어 평형상수에 미치는 압력과 온도의 영향

오대섭,최술한,이해운 慶北大學校 物理化學硏究所 1982 硏究論文集 Vol.3 No.-

Co(Ⅱ)와 Methylthymol blue(MTB) 사이의 착물 형성에 있어서 안정도에 미치는 압력과 온도의 영향을 자외선 분광광도법으로 연구 하였다. 사용된 압력은 1 bar에서 1200 bar이며 온도는 20, 30, 40℃ 사이에서 측정하였다. 이때 착물의 평형상수는 압력 및 온도의 증가에 따라 증가함을 알 수 있었으며 흡광계수도 또한 증가함을 알 수 있었다. 이들 각 평형상수로부터 착물 형성에 따른 부피, 엔탈피, 자유에너지 및 엔트로피의 변화량을 구함으로서 이 착물은 흡열반응이며 압력과 온도의 증가에 따라 반응이 더욱 잘 일어남을 알 수 있었다. 그리고 압력의 증가에 따른 흡수 maximum의 red shift 현상 및 압력 변화에 따른 진동자 세기와의 관계를 열역학적 함수와 관계를 지워 설명하였다. The effect of pressures and temperatures on the stabilities of the Co(Ⅱ)-Methylthymol blue complex have been investigated through ultraviolet spectrophotometric measurement. The stabilities of complexes were measured at 20 30 and 40℃ under 1300 600 900 and 1200 bars. The equilibrium constant of the complex was increased with pressure and temperature raising. The absorption coefficient was increased with both pressure and temperature. Change of volume, free energe, entropy and enthalpy for the formation of complexes were obtained from the equilibrium constants. The red shift observed a higher pressure and the relation between pressure and oscillator strength were discussed by means of thermodynamic function.

Hierarchically three-dimensional (3D) nanotubular sea urchin-shaped iron oxide and its application in heavy metal removal and solar-induced photocatalytic degradation

Lee, Soon Chang,Jeong, Yesul,Kim, Youn Jung,Kim, Hyeran,Lee, Hyun Uk,Lee, Young-Chul,Lee, Sang Moon,Kim, Hae Jin,An, Ha-Rim,Ha, Myoung Gyu,Lee, Go-Woon,Lee, Young-Seak,Lee, Gaehang Elsevier 2018 Journal of hazardous materials Vol.354 No.-

<P><B>Abstract</B></P> <P>In this study, hierarchically three-dimensional (3D) nanotubular sea urchin-shaped iron oxide nanostructures (3D-Fe<SUB>2</SUB>O<SUB>3</SUB>) were synthesized by a facile and rapid ultrasound irradiation method. Additives, templates, inert gas atmosphere, pH regulation, and other complicated procedures were not required. Dense 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> with a relatively large Brunauer–Emmett–Teller (BET) surface area of 129.4 m<SUP>2</SUP>/g was synthesized within 23 min, and the BET surface area was further improved to 282.7 m<SUP>2</SUP>/g by a post heat-treatment process. In addition, this post processing led to phase changes from maghemite (γ phase) to hematite (α phase) Fe<SUB>2</SUB>O<SUB>3</SUB>. Subsequent characterization suggested that the growth mechanism of the 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> follows self-assembly and oriented attachment. The prepared 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> was applied to wastewater purification. Ultrasound-irradiated 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> can eliminate a As(V) and Cr(VI) from water with 25 times faster removal rate by using a one third smaller amount than commercial α-Fe<SUB>2</SUB>O<SUB>3</SUB>. This was attributed to the inter-particle pores and relatively positively charged surface of the nanostructure. In addition, post heat treatment on ultrasound-irradiated 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> significantly influenced the photocatalytic degradation of methylene blue and phenol, with a 25 times higher removal efficiency than that of commercial α-Fe<SUB>2</SUB>O<SUB>3</SUB>, because of both high BET surface area and good crystallization of the prepared samples.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The 3D- Fe<SUB>2</SUB>O<SUB>3</SUB> can be mass-produced by ultrasound irradiation method. </LI> <LI> The 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> possesses high BET surface area and interconvertible phase. </LI> <LI> The 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> exhibits rapid adsorption rates for heavy metals. </LI> <LI> The 3D-Fe<SUB>2</SUB>O<SUB>3</SUB> exhibits excellent photocatalytic activities toward the dyes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Micro-cavity design of bottom-emitting AMOLED with white OLED and RGBW color filters for 100% color gamut

Lee, Baek-woon,Ju, Young-gu,Hwang, Young In,Lee, Hae-yeon,Kim, Chi Woo,Lee, Jin Seok,Souk, Jun Hyung Wiley (John WileySons) 2009 Journal of the Society for Information Display Vol.17 No.2

Fgfbp1 Is Essential for the Cellular Survival during Zebrafish Embryogenesis

Lee, Hae-Ock,Choe, Hye-Rim,Seo, Kyung-Woon,Lee, Hyun-Sook,Lee, Jin-Seon,Kim, Jhin-Gook Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.5

Fibroblast growth factor binding protein 1 (FGFBP1) is expressed in various tumors and may serve as a diagnostic marker and/or a therapeutic target. Previous studies suggested FGFBP1 functions as an angiogenic switch molecule by regulating the activity of FGF2, and it was later found to associate with a broad spectrum of FGFs. To study FGFBP1, we used zebrafish, in which the function of extracellular matrix protein can be easily studied in intact tissues or organisms. When Fgfbp1 expression was knocked down, morphants manifested massive cell death and structural abnormalities. Cell death was most prominent in the brain and the neural tube, but not limited to those regions. These findings suggest that the primary function of Fgfbp1 may be to sustain cellular survival throughout embryogenesis. For comparison, the expression of fgf2 was limited to the early stage of embryogenesis and fgf2 morphants showed more severe phenotype, with high morbidity before reaching 14-somites. Taken together, our work reveals the physiologic function of Fgfbp1, and that its function could be exerted in a Fgf2-independent manner.