표식한 HEMA 유사체를 이용한 상아질 부착계면의 STEM/EDS 분석

에?, 제이 디,한호진,김철위 서울대학교 치과대학 치과생체재료학교실 1997 치과생체재료학 논문집 Vol.5 No.1

상아질 부착제 계면의 모습과 상아질 표면과 관계하여 부착제의 습윤과 침투정도를 비교하기 위해 STEM과 EDS로 4종의 상아질 부착체계를 연구하였다. 많은 상아질 부착제 체계에 상용하는 단량체인 HEMA를 황화물 유사체인 HETMA로 변형하였다. HEMA 분자의 골격에서 산소원자를 EDS와 STEM으로 추적할 수 있는 황으로 대체하였다. 이 유사체는 용해도와 습윤성 및 기타 물성이 HEMA와 유사하며 각각 다른 프라이머나 식각제로 전처리한 4 세트의 치아표본에 이유사체를 적용하였다. 3종의 전처리제 (질산, 말레이산 및 구연산)로 상아질 표면에 약 1~3㎛의 탈회부위를 형성하였다. 셋중 뒤의 2종의 전처리제를 사용하였을 때 HET-MA는 이 부위로 자유로이 침투하였으나 질산으로 탈회한 상아질 층은 HETMA에 불투과성 이었다. 4째 전처리제로 인산에스터인 PENTA와 HEMA를 포함하는 알콜성 용액으로 도말층을 약간 변형하였으며 상아질을 탈회하지 않았다. PENTA와 HEMA로 전처리한 표본에 HETMA를 적용하였을 때 상아질과 긴밀한 접촉을 하여 도말층을 변형하였으나 이 부위로 침투하거나 확산하지 못하였다. 각각 다른 체계에서 명확히 일어나듯 상아세관으로 흘러들어갔다. 결론으로 산으로 상아질을 전처리하여 상아질 결합제의 습윤성에 큰 영향을 주었으며 상아질 결합체계의 결합강도에 영향을 주었다.

한국의 싸리나무(Lespedeza sp.)에서 분리한 근류균의 식물생장촉진특성과 근류형성 측정

SaP.팔라니아판 ( P. Palaniappan ),임우종 ( Woo Jong Kim ),M.마두하이안 ( M. Madhaiyan ),HP데카보루아 ( H. P. Boruah ),라쉐드 ( M. R. Islam ),사동민 ( Tong Min Sa ) 한국토양비료학회 2009 한국토양비료학회 학술발표회 Vol.2009 No.-

제3회 HP 인디고 디지털라벨 및 포장 어워드

HP, HP (사)한국포장협회 2009 包裝界 Vol.199 No.-

한국인의 Friedman Curve와 Buscopan Compositum이 이에 미치는 영향

이효표(HP Lee),라건영(KY Rha) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.2

For many years the traditional method of characterizing labor has been made by recording the length of the first, second and third stage. In 1954, Friedman developed a method which was more suitable for the statistical evaluation of the curve of labor. The Friedman curve was obtained by carefully recording the degree of dilation of the cervix in the coures of time. In this paper primigravidae and multigravidae were selected from the department of obstetrics and gynaecology, Seoul National University Hospital and the labor curves were recorded for each patient. In order to evaluate the normal labor curve in Korean women, 54 normal primigravidae and 51 multigravidae were selected out. Besides, 39 primigravidae and 34 multigravidae were selected in order to assess the effect of Buscopan Comp. This drug was administered in the frist stage of labour when the cervix was dilated to 2-4 cm, and regular and moderately strong contractions were present. The result of this study is that the labor curve in Korean women is very similar to the Friedman curve, and that Buscopan Comp. has the property shortening remarkably the first stage of labor. Consequently the over all duration of labor in the Buscopan Comp. group was much shorter than that in the control group.

생물리학적 감시를 이용한 산전 태아상태의 평가

이효표(HP Lee),신면우(MW Shin) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.10

Five fetal biophysical variables, fetal breathing movements, fetal movements, fetal tone, qualitative amniotic fluid volume, and the nonstress test were measured in the same observation period in 61 high risk and 30 normal patients hospitalized at S.N.U.H. All delivered within one week of the last observation. The relationship between individual biophysical variables and combinations of variables to the outcome of pregnancy as judged by five-minute Apgar Score, fetal distress in labor, and perinatal mortality rate was determined. For single test, the false negative rate was significantly low except qualitative amniotic fluid volume and was similar volume. Combining tests resulted in a significant change in both the false negative and false positive rates as compared to any single test. The most accurate differentiation of the normal from the compromised fetus was obtained when all five variables were studied. The perinatal mortality ranged from 0 when all variables were normal to 500 per 1,000 when 3 variables were abnormal. These data suggest that combined fetal biophysical testing is a more accurate method of antepartum fetal evaluation than any single method relatively.

포상기태 후 혈청내 b-hCG치 회귀의 예후적 특성에 관한 연구

이효표(HP Lee),김규현(KH Kim) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.10

The importance of human chorionic gonadotropin(hCG) determinations folowing evacuations of a hydatidiform mole to detect trophoblastic disease has been universally recognized. However, indications for diagnosis and treatment of post-molar trophoblastic disease based on serial hCG measurements are frequently too general to resolve the individual chlinical problems. The postevacuation serum human chorionic gonadotropin regression curves of 29 cases with hydatidiform mole admitted at Seoul National University Hospital was analyzed to fefine the criteria for diagnosis and treatment of post-molar trophoblastic disease. The results were as follows: 1. Eighteen cases (62%) demonstrated a progressive fall in serum Beta-hCG titers to levels undetectable by radioimmunoassay within 14 weeks. 2. In remaining 11 cases (38%), the regression curve exhibited a plateau or rise in titer, during the first 6 weeks after evacuation. The significance of these curves was discussed with a brief review of literature.

복강경의 진단적 이용에 관한 임상적 연구

이효표(HP Lee) 대한산부인과학회 1978 Obstetrics & Gynecology Science Vol.21 No.12

One hundred seventy-three diagnostic laparoscopies have been performed to assess the clinical impression from April, 1975 to November, 1978 in Seoul National University Hospital. Infertility, possible ectopic pregnancy and obsure pelvic mass are the leading indications for laparoscopy. The results obtained are summerized as follows: 1. The accuracy of the clinical diagnosis confirmed by laparoscopy was 60.0%. 2. The accuracy of the laparoscopic diagnosis confirmed by laparotomy was 97.0%. 3. Laparoscopy revealed 5 cases(55.6%) of associated pelvic pathology in 9 cases of unexplained infertility. 4. The correlation of laparoscopic findings in 63 patients with abnormal hysterosalpingograpy was investgated. In only 36 cases(57.1%) there was complete agreement between hysterosalpingography and laparoscopy. 5. In the 38 cases with possible ectopic pregnancy, only 14 cases(36.8%) have been proved to be ectopic pregnancy. 6. In the 22 patients with suspicious ovarian cyst, 17(77.3%) were found to have ovarian cyst, and 5 were interpreted as not ovarian cyst. 7. In the 24 primary amenorrhea patients many useful findings for treatment have been found by laparoscopy. 8. Varying degree of therapeutic procedures were performed in 9 of the total 173 cases.

임신 및 산욕시 혈청 Amylase 활성도에 관한 연구

이효표(HP Lee) 대한산부인과학회 1977 Obstetrics & Gynecology Science Vol.20 No.12

1977년 7월1일부터 10월 31일까지 서울대학교 의과대학 부속병원 산부인과에 내원한 임신 6주부터 40주까지의 정상임신 135예와 입원한 정상만삭임신 및 합병증없이 정상만삭 질식분만한 후 제4일까지의 산모 98예를 대상으로 주정맥혈액을 채혈하여 SmithRoe변법을 사용하여 혈청 amylase치를 측정하였다. 그리고 대조군으로서는 질환이 없고 임신중이 아닌 부인 25예를 대상으로 하였다. 한편 21예에서 질식분만시 모체혈액과 제대혈액을 함께 채취하여 혈청 amylase치를 측정하였다. 이상의 성적을 분석검토하여 다음과 같은 결과를 얻었다. 1. 비임신 대조군의 평균 혈청amylase치는 108.0±23.5U.이었다. 2. 임신중의 혈청 amylase치를 살펴보면 임신 6∼10주군에는 107.1±25.4U이었으나 차 츰 상승하여 임신 21∼25주군에는 175.9±44.8U.로서 최고로 높았으며 그 후 차츰 저하 되어 임신 36∼40주군에는 127.0±38.9U.로 저하되었으나 비임신 대조군에 비하여 아직 도 유의하게 높았다. 3. 임신중에는 임부의 혈청amylase치가 25주까지는 계속 상승하였고 그 후에는 임신종 말까지 점차적으로 그러나 현저하지는 않게 저하하였다. 4. 제2 및 제3 trimester의 정상임부의 상당수에서 혈청 amylase치는 비임신 대조군의 정상상한치(평균치+2표준편차) 155.0U.를 훨씬 초과 하였다. 5. 산후 1∼4일의 산모 혈청 amylase치는 대체로 정상만삭임부에 비하여 아직 높기는 하나 통계적 유의성은 없었다. 6. 제대혈액의 혈청 amylase치는 모체혈액에서 보다 훨씬 낮았으며 이 효소의 모체/태 아의 비는 3.14:1이었다. Total serum amylase activity was measured by means of Smith-Roe`s modified method in the randomly selected 135 normal pregnant women between 6 to 40 weeks and 98 normal term graved and normal postpartum subjects through the fourth day afeter vaginal delivery at the Department of Obstetrics and Gynecology, seoul National University Hospital during the period from July 1 to October 31, 1977. In addition, 25 normal nonpregnant women without systemic disease were strdied. From 21 patients paired maternal venous and cord blood samples were obtained at vaginal delivery and carried through the same analytical procedure, and the maternal/fetal ratio of enzyme levels clculated. The results are as follows; 1) the mean serum amylase value recorded in our nonpregnant control subjects was 108.0±23.5 unit. 2) By contrast with this value, the mean serum amylase value, computed for each of the 5 week periods between weeks 6 to 40 of pregnancy, rose from107.1 ±25.4 unit in the 6 to 10 week to 175.9±44.8 unit in the 21 to 25 week, and then diminished to 127.0±38.9 unit in the 36 to 40 week. 3) there was a progressive rise in serum amylase from weeks 6 to 25 during pregnancy, followed by a gradual but less pronounced fall to the end of pregnancy. 4) In a considerable number of these normal pregnant women in the second and the presumptive upper limit of normal(mean+2S.D.) in this study. 5) the level of serum amylase activity in the early puerperal women was slightly, but insignificantly increased as compared with normal nonpregnant women. 6) Serum amylase activity was consistently demonstrated in cord serum although it was much lower than in maternal blood. The mean ratio of maternal to fetal enzyme levels was 3.14:1.

부인과 악성종양의 화학요법 감수성검사를 위한 in Vitro Clonlgenic Assay

이효표(HP Lee),차상헌(SH Cha),주권량(KR Joo),강순범(SB Kang),장윤석(YS Chang),김노경(NK Kim) 대한산부인과학회 1987 Obstetrics & Gynecology Science Vol.30 No.5

저자들은 1985년 3월부터 1985년 8월까지 서울대학병원 산부인과에 입원한 부인과 악성종양환자 19명을 대상으로 in vitro clonogenic assay 즉 HTSCA를 시행하여 다음과 같은 결과를 얻었다 1 자궁경암은 11례중 3예에서 성장을 보여 27 3%, 난소암은 4례중 3례에서 성장을 보여 75%, 자궁내막암은 3례중 2례에서 성장을 보여 66 7%의 성적을 보였고 원발소 불명의 선암은 1례중 1례에서 성장을 보였다 즉 전체 부인과악성종양 19례중 9례에서 성증을 보여 47 4%의 성적을 나타내었다 2 암세포집낙형성율은 자궁경암은 0 005∼0 01%, 난소암은 0 008∼1 2%, 자궁내막암은 0 008∼0 1%였고 원발소불명암은 0 005∼0 5%였다 3 자궁경암에서의 최대혈장농도의 1/10에서의 집낙생존수의 약제관련도는 vincristine 32%, cis-platinum 40%, vinblastine 42%, bleomycin 45%, mitomycin-C 45%, methotraxate 55%, cyclophosphamide 64%, 5-fluorouracil 76%, actinomycin-D 78%순이었다 4 난소암에서의 cis-platinum의 최대 혈장농도와 최대혈장농도의 1/10에서의 집낙생존수의 약제관련도는 44%와 56%로서 중등도의 감수성을 보였다 5 자궁내막암에서의 최대혈장농도의 1/10에서 집낙생존수의 약제관련도는 cis-platinum 34%, cyclophosphamide 38%, 5-fluorouracil 42%, mitomycin-C 44%, actinomycin-D 48%, vincristine 48%, vinblastine 52%, methotraxate 60%, bleomycin 64%순이었다 In vitro clonogenic assay provides a way of testing the effectiveness of chemotherapeutic agents in treatment of cancer as well as a study of tumor biologh Tumor specimens from 19 patients having cervical, ovarian, or endometrial carcinomas were studied with the in vitro clonogenic assay, 9 of which grew in vitro since May, 1985 Various chemotherapeutic agents by the culture surface drug application technique were tested against these tumors on soft agarose The results were as follows: 1 The percentage of tumor specimen which grew in the soft agarose plate was 47 4% Of the 11 cervical cancer studied, 3 grew(27 3% growth rate) Of the 4 ovarian tumors tested in the labortory, 3 grew(75%), 2 of 3 endometrial cancers grew(66 7%) and 1 of 1 adenocarcinoma of unknown primary site grew(100%) 2 Plating efficiencies of cervical cancer were 0 005-0 01%, that of ovarian cancer were 0 008-1 2%, that of endometrial cancer were 0 008-0 1% and that of adenocarcinoma of unknown origin was 0 005-0 05% 3 Of the 3 patients whose cervical cancer specimens grew in culture, the dose-related degree of colony survival at 1/10 peak plasma level was demonstrated in the order of the following: vincristine 32%, cis-platinum 40%, vinblastine 42%, bleomycin 45%, mitomycin-C 50%, methotraxate 55%, cyclophosphamide 64%, 5-fluorouracil 76% and actinomycin-D 78% 4 Of the 3 patients whose ovarian cancer specimens grew in the laboratory, the dose-related degree of colony survival of cis-platinum at peak plasma concentration was 44% 5 Of the 2 patients whose endometrial carcinoma specimens grew in the plate, the dose-related degree of colony survival at 1/10 peak plasma level was as follows: cis-platinum 34%, cyclophosphamide 38%, 5-fluorouracil 42%, mitomycin-C 44%, actinomycin-D 48%, vincristine 48%, methotraxate 60% and bleomycin 64%

임신중 고혈압성질환의 모성사망에 관하여

이효표(HP Lee) 대한산부인과학회 1979 Obstetrics & Gynecology Science Vol.22 No.8

우리나라의 모성사망율의 삼대원인 중 아직까지도 높은 모성사망률을 보이고 있는 임신중 고혈압성질환은 그동안 여러 환자에 의해 임상적인 자료를 보급 분석하여 역학적인 고찰을 함으로서 예방과 치료의 지침을 세움과 동시에 모성사망률을 감소시키기 위해 노력해왓으며 선진국에서는 일찌기 여러가지 노력의 결과로 모성사망률을 급격히 감소시킬 수 있었으나 우리나라는 아직도 높은 사망률을 보이고 있는 실정이다. 지금까지의 본 저서의 통계적인 고찰과 여러 학자의 역학적인 연구결과를 토대로 할 때 우리나라의 모성사망률을 감소시키기 위해서는 첫째로 철저한 산전관리와 이로 인한 병원분만수의 증가와 모자보건의 향상이 무엇보다도 중요하다고 하겠고, 둘째로 병원측의 부적절한 처치를 개선하기 위한 일반의와 간호원등 보ㅗ건요원에 대한 재교육이며, 세째로 고위험률 임신연령군에 대한 조사와 치료강화고, 네째로는 정확한 사인을 규명하기 위해 부검의 권장이며, 다섯째로 병원분만의 증가를 위한 제도적 뒷받침과 병원시설의 확충 및 전문의의 자문활동의 증가이며, 끝으로 미국과 같이 임산부 사망위원회 설치등을 들 수 있겠다.