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부인과 악성종양의 화학요법 감수성검사를 위한 in Vitro Clonlgenic Assay
이효표(HP Lee),차상헌(SH Cha),주권량(KR Joo),강순범(SB Kang),장윤석(YS Chang),김노경(NK Kim) 대한산부인과학회 1987 Obstetrics & Gynecology Science Vol.30 No.5
저자들은 1985년 3월부터 1985년 8월까지 서울대학병원 산부인과에 입원한 부인과 악성종양환자 19명을 대상으로 in vitro clonogenic assay 즉 HTSCA를 시행하여 다음과 같은 결과를 얻었다 1 자궁경암은 11례중 3예에서 성장을 보여 27 3%, 난소암은 4례중 3례에서 성장을 보여 75%, 자궁내막암은 3례중 2례에서 성장을 보여 66 7%의 성적을 보였고 원발소 불명의 선암은 1례중 1례에서 성장을 보였다 즉 전체 부인과악성종양 19례중 9례에서 성증을 보여 47 4%의 성적을 나타내었다 2 암세포집낙형성율은 자궁경암은 0 005∼0 01%, 난소암은 0 008∼1 2%, 자궁내막암은 0 008∼0 1%였고 원발소불명암은 0 005∼0 5%였다 3 자궁경암에서의 최대혈장농도의 1/10에서의 집낙생존수의 약제관련도는 vincristine 32%, cis-platinum 40%, vinblastine 42%, bleomycin 45%, mitomycin-C 45%, methotraxate 55%, cyclophosphamide 64%, 5-fluorouracil 76%, actinomycin-D 78%순이었다 4 난소암에서의 cis-platinum의 최대 혈장농도와 최대혈장농도의 1/10에서의 집낙생존수의 약제관련도는 44%와 56%로서 중등도의 감수성을 보였다 5 자궁내막암에서의 최대혈장농도의 1/10에서 집낙생존수의 약제관련도는 cis-platinum 34%, cyclophosphamide 38%, 5-fluorouracil 42%, mitomycin-C 44%, actinomycin-D 48%, vincristine 48%, vinblastine 52%, methotraxate 60%, bleomycin 64%순이었다 In vitro clonogenic assay provides a way of testing the effectiveness of chemotherapeutic agents in treatment of cancer as well as a study of tumor biologh Tumor specimens from 19 patients having cervical, ovarian, or endometrial carcinomas were studied with the in vitro clonogenic assay, 9 of which grew in vitro since May, 1985 Various chemotherapeutic agents by the culture surface drug application technique were tested against these tumors on soft agarose The results were as follows: 1 The percentage of tumor specimen which grew in the soft agarose plate was 47 4% Of the 11 cervical cancer studied, 3 grew(27 3% growth rate) Of the 4 ovarian tumors tested in the labortory, 3 grew(75%), 2 of 3 endometrial cancers grew(66 7%) and 1 of 1 adenocarcinoma of unknown primary site grew(100%) 2 Plating efficiencies of cervical cancer were 0 005-0 01%, that of ovarian cancer were 0 008-1 2%, that of endometrial cancer were 0 008-0 1% and that of adenocarcinoma of unknown origin was 0 005-0 05% 3 Of the 3 patients whose cervical cancer specimens grew in culture, the dose-related degree of colony survival at 1/10 peak plasma level was demonstrated in the order of the following: vincristine 32%, cis-platinum 40%, vinblastine 42%, bleomycin 45%, mitomycin-C 50%, methotraxate 55%, cyclophosphamide 64%, 5-fluorouracil 76% and actinomycin-D 78% 4 Of the 3 patients whose ovarian cancer specimens grew in the laboratory, the dose-related degree of colony survival of cis-platinum at peak plasma concentration was 44% 5 Of the 2 patients whose endometrial carcinoma specimens grew in the plate, the dose-related degree of colony survival at 1/10 peak plasma level was as follows: cis-platinum 34%, cyclophosphamide 38%, 5-fluorouracil 42%, mitomycin-C 44%, actinomycin-D 48%, vincristine 48%, methotraxate 60% and bleomycin 64%
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