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800㎿급 발전소 복수기의 최적 운전점 및 운전방법에 대한 연구
장철호(Cheol-Ho Jang),홍은기(Eun-Kee Hong),황광원(Kwang-Won Hwang),윤린(Rin Yun) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.5
Along with the recent construction of a 800㎿ thermal power plant it is necessary to check the soundness of the current operation of the condenser, and to investigate the effects of vacuum level of it on the turbine efficiency for the power plant. In this study, the performances of the condenser and the turbine for the 800㎿ thermal power plant were tested based on the ASME PTC 6 and ASME PTC 12.2 with the variation of the vacuum level. When the condenser vacuum levels were 719.91 ㎜Hg, 724.5 ㎜Hg, and 729.6 ㎜Hg, the turbine efficiencies were 47.36%, 47.47%, and 47.55%, respectively. From the regression analysis of the present data, it was estimated that the optimal vacuum point is between 729 ㎜Hg and 731 ㎜Hg. When this optimal point is to be applied to the condenser, the profit of 5.5 billion won/year is expected based on the '09 caloric cost.
Efficacy and safety of topical application of epidermal growth factor (EGF) for Korean acne patient
( Won Jong Oh ),( Eun Jung Ko ),( Sun Young Choi ),( Kwang Ho Yoo ),( Beom Joon Kim ),( Chang Kwun Hong ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Commonly prescribed medications for acne vulgaris are oral antibiotics and retinoids. However, those have clinical limitation due to its resistance and teratogenicity, respectively. In that EGF helps reducing sebum secretion and enhances skin moisturizing, topicalapplication of EGF is implied as a new treatment modality for acne vulgaris. Objectives: We aim to evaluate the clinical efficacy and safety of topical recombinant human (rh) EGF in treating facial acne vulgaris. Methods: Twenty three Korean with mild acne vulgaris has applied topical rhEGF cream (Trouble control EGF) on the face twice daily for four weeks. Acne lesion counts were scored by investigator’s global assessment, while efficacy and satisfaction were evaluated by subjects. Skin sebum output, hydration and redness level were also measured at each visit. Results: Skin sebum level, transepidermal water loss, skin redness statistically decreased and acne lesions were significantly reduced. No severe side effects were observed during the study. Conclusion: Topical rhEGF seems to be an effective and safe adjuvant treatment option for mild acne vulgaris.
Kwang-Soo Cho,Young-Ho Yoon,Su-Young Hong,Bong-Kyoung Yun,Hong-sik Won,Jeong-Ki Jeon 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
Bitter buckwheat, also called tartari buckwheat (F. tartaricum), contains large amount of rutin and it has antioxidant activity compared to common buckwheat. But after harvesting and processing, the discrimination of two species through visual inspection was almost impossible. Therefore we developed InDel markers to identify common and tartari buckwheat content based on the chloroplast genome sequence. We conducted complete full chloroplast genome sequence of tartari buckwheat and compared with common buckwheat chloroplast genome sequence (NC010776). Based on the mVISTA alignment, we found eight big InDel (above 50bp) regions. Among the InDel, 6 regions are intergenic region and two are genic region in ycf1. We designed InDel specific primers and applied to PCR with buckwheat genomic DNA to check the discrimination of two species. These InDel specific primers also applied to buckwheat germplasm, 75 tartari and 21 common buckwheat. Among the primers, 5 markers could be successfully amplified in all germplasm species specific amplicon. And we can detect 10pg/ul of DNA and processed food such as tea and noodle. These results could improve the QC (Quality control) of tartari buckwheat food
Kwang-Soo Cho,Ji-Hong Cho,Bong-Kyoung Yun,Hong-sik Won,Jeong-Ki Jeon,Hwang-Bae Sohn 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
The newly developed varieties, Jayoung (violet flesh color) and Hongyoung (red flesh color) that harboring various anthocyanins and flavonoids in flesh colored potato are highly increase their interesting not only for food but also functional characteristics such as anti-inflammatory effects. Up to date, most of the molecular markers developed in potato are linked to disease resistance including late blight and PVY, nematode. A few markers linked to economically important functional materials such as anthocyanin biosynthesis are published. With the low cost and high throughput of NGS (Next Generation Sequencing) technology, numerous molecular markers are highly increased in may crops. Among the molecular markers, SNPs (Single nucleotide Polymorphisms) are most useful markers owing to their large numbers in inter and intra varieties in potato. Here we reported SNPs discovery from transcriptome sequencing data acquired from colored flesh potato cultivars, Jayoung and Hongyoung with white flesh color Atlantic. Total RNA was isolated from shoot in tuber after breaking dormancy about 2cm length. Short read sequence data were obtained form Illumina Hiseq2000 and the raw dat set were trimmed with Q socore over 20. Sequencing data were align to reference genome (Solanum tuberosum v4.03, http://potatogeomics.plantbiolgy.msu.edu). About 70% of sequence read were mapped int to reference genome. 139,050, 140,976 and 146,429 total SNPs were discovered in Hongyoung, Jayoung and Atlantic, respectively. All SNPs are mapped into the psedomolecules in reference genome by chromosome. SNPs are also analyzed with homozygous and heterozygous SNPs and genic and intergenic region. SNPs are compared with Potato Infinium 8K Chip data. SNPs found in candidate genes of anthocyanin biosynthesis were discovered. These SNPs information of flesh colored potato will be further analyzed for the allele mining for anthocyanin syhthesis and control region
Hong, Chung-Oui,Lee, Hyun Ah,Rhee, Chae Hong,Choung, Se-Young,Lee, Kwang-Won Japan Society for Bioscience, Biotechnology, and A 2013 Bioscience, biotechnology, and biochemistry Vol.77 No.1
<P>Considering the growing evidence of the presence of antioxidant compounds in plant extracts, the objectives of this study were to identify antioxidant compounds in Lindera obtusiloba Blume (Lauraceae) and to evaluate their antimelanogenic activities on B16F10 melanoma cells. Organic solvent fractions were separated from L. obtusiloba extracts (LOE). The ethyl acetate fraction (LOE-E) was significantly active against oxidative damage induced by tert-butyl hydroperoxide in primary rat hepatocytes. Two single purified compounds, quercitrin (quercetin-3-O-α-L-rhamnopyranoside) and afzelin (kaempferol-3-O-α-L-rhamnoside), were identified by HPLC and NMR. These compounds were evaluated for antioxidant activities by 1,1-diphenyl 2-picrylhydrazyl (DPPH) radical scavenging assay and ferric reducing antioxidant power (FRAP) assay, and for their antimelanogenic activities by tyrosinase inhibitory assay melanin formation inhibition assay and Western bolt analysis for the signaling pathway. The significant effects of quercitrin on antioxidant and antimelanogenic activities, and signal modulation of ERK and MITF in B16F10 melanoma cells were observed. This is the first report to identify quercitrin in L. obtusiloba and its whitening effect.</P>
Kwang Man Park,Hong Jae Lee,구기태,Heithem Ben Amara,Richard Leesungbok,Kwantae Noh,Sang Cheon Lee,Suk-Won Lee 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.1
BACKGROUND: The effect of nano controlled sequential release of trichloroacetic acid (TCA) and epidermal growth factor (EGF) on the oral soft tissue regeneration was determined. METHODS: Hydrophobically modified glycol chitosan (HGC) nano controlled system was developed for the sequential release of TCA and EGF, and the release pattern was identified. The HGC-based nano controlled release system was injected into the critical-sized defects created in beagles’ palatal soft tissues. The palatal impression and its scanned body was obtained on various time points post-injection, and the volumetric amount of soft tissue regeneration was compared among the three groups: CON (natural regeneration control group), EXP1 (TCA-loaded nano controlled release system group), EXP2 (TCA and EGF individually loaded nano controlled release system). DNA microarray analysis was performed and various soft tissue regeneration parameters in histopathological specimens were measured. RESULTS: TCA release was highest at Day 1 whereas EGF release was highest at Day 2 and remained high until Day 3. In the volumetric measurements of impression body scans, no significant difference in soft tissue regeneration between the three groups was shown in two-way ANOVA. However, in the one-way ANOVA at Day 14, EXP2 showed a significant increase in soft tissue regeneration compared to CON. High correlation was determined between the histopathological results of each group. DNA microarray showed up-regulation of various genes and related cell signaling pathways in EXP2 compared to CON. CONCLUSION: HGC-based nano controlled release system for sequential release of TCA and EGF can promote regeneration of oral soft tissue defects.