경상북도 후포와 강원도 장호에서 정치망으로 채집된 어류 종조성 비교

강정하 ( Jung Ha Kang ),김이경 ( Yi Gyeong Kim ),박중연 ( Jung Youn Park ),김진구 ( Jin Koo Kim ),유정화 ( Jung Hwa Ryu ),강충배 ( Chung Bae Kang ),박정호 ( Jeong Ho Park ) 한국수산과학회 2014 한국수산과학회지 Vol.47 No.4

Two major temperature fronts, the Subpolar (Gosung, Gang-won-do; 38°-41° N) and Thermal (Jukbyun, Gyeong-sang-buk-do; 36°-37° N) fronts, are found in the East Sea along the east coast of Korea. These are located roughly where the Tsushima Warm Current and North Korea Cold Current intersect. To clarify the effect of the Thermal Front, we investigated seasonal variation in fish species composition using set nets in two areas located north (Jangho, Gang-won-do) and south (Hupo, Gyeong-sang-buk-do) of Jukbyun, Gyeong-sang-buk-do, and compared the sea water temperature and salinity. We collected a total of 38 fish species in Hupo and 25 in Jangho. Trachurus japonicus was the most common species at both sites, but the subdominant species differed. At Hupo, the subdominant species were Konosirus punctatus and Diodon holocanthus, whereas Clupea pallasii and Scomber japonicus were subdominant at Jangho. Based on Froese and Pauly (2014), subtropical fishes accounted for 55% of fish in Hupo but only for 33% in Jangho. The difference in fish species composition was most obvious in May and August. According to the Korea Hydrographic and Oceanographic Administration, sea surface temperature and salinity were slightly higher at Hupo than at Jangho. Our findings suggest that the oceanographic boundary resulting from the Thermal Front near Jukbyun, Gyeong-sang-buk- do may have a major effect on the distribution of migratory fish species.

65세 이상 외래 방문환자를 대상으로 한 심전도 소견

하원철,성낙일,김강,이경미,박준형,배준호,나득영 동국대학교 의학연구소 2008 東國醫學 Vol.15 No.1

The electrocardiogram is one of the most widely used diagnostic tools. Especially it is useful to the patients who have cardiovascular disease. Because elderly population are the fastest growing component of national population, I analyzed the frequencies of specific electrocardiogram findings in patients aged 65 years and older living in Gyeong-ju to collecting ECG data. Sinus bradycardia (17.0%) and Left ventricular hypertrophy (25.2%), QT prolongation (30.9%) were the most common abnormalities found in the population as a whole. Left-axis deviation (11.6% vs. 3.1%, p = 0.001) and right bundle branch block (11.9% vs. 4.1%, p= 0.001) were more common in men than women. First-atrioventricular block (2.2% vs. 5.5%, p = 0.025) and T wave abnormalities (4.1% vs. 13.2%, p = 0.001), left ventricular hypertrophy (21.6% vs. 28.0%, p = 0.049) were more common in women. QT prolongation were more common in 75 years and older (26.7% vs. 38.1%, p = 0.001). Left-axis deviation (9.4% vs. 3.9%, p = 0.024) and Right bundle branch blocks (9.8% vs. 3.0%, p = 0.003) were more common in men aged 65~74 years. Left ventricular hypertrophy (20.9% vs. 30.0%, p = 0.025) and T wave abnormalities (4.3% vs. 12.2%, p = 0.002) were more common in women aged 65~74 years. Atrial fibrillation (7.1% vs. 1.1%, p = 0.013) and left-axis deviation 17.6% vs. 2.1%, p = 0.001), Right bundle branch block (17.6% vs. 5.3%, p = 0.001) were more common in men aged 75 years and older. First-atrioventricular block (0% vs. 5.9%, p = 0.020) and T wave abnormalities (3.5% vs. 14.4%, p = 0.008) were more common in women aged 75 years and older. In conclusion, Left ventricular hypertrophy and sinus bradycardia, QT prolongation were most common electrocardiographic findings in as a whole. Left-axis deviation and right bundle branch block, fist-atrioventricular block, T wave abnormalities, QT prolongation were significantly different in age and gender. 심전도는 전 세계적으로 가장 널리 사용되는 진단적 도구로서, 특히 심혈관계 질환이 있는 환자에게 그 유용성이 크다. 현대 사회는 고령화 사회로 노인 인구에 대한 사회적, 의학적 관심이 높다. 이에 본 연구자는 노인 인구에 대한 심전도 자료를 수집하기 위해 동국대 경주 병원 외래 진료실을 방문한 65세 이상 노인 환자 737명을 대상으로 심전도 검사를 시행하였다. 좌심실 비대(25.2%), QT 간격 연장(30.9%)과 동성 서맥(17.0%)을 보인 경우가 가장 많았고, 좌축 편위 (11.6% vs. 3.1%, p = 0.001), 우각 차단(11.9% vs. 4.1%, p = 0.001)의 경우 여자 환자보다 남자 환자에서 빈도가 높았고, 1도 방실 차단(2.2% vs. 5.5%, p = 0.025)과 비정상적인 T파 양상(4.1% vs. 13.2%, p = 0.001), 좌심실 비대(21.6% vs. 28.0%, p = 0.049)의 경우 남자 환자보다 여자 환자에서 빈도가 높았다. 75세 이상 환자 군에서 QT 간격 연장(26.7% vs. 38.1%, p = 0.001)이 65세에서 74세 사이 환자 군에 비해 빈도가 높은 것 외에 유의한 차이는 없었다. 결론적으로 고령 환자에서 비정상적인 심전도 소견으로 좌심실 비대와 QT 간격 연장, 동성 서맥의 빈도가 높았으며 좌축 편위, 우각 차단, 1도 방실 차단 등은 성별, 연령대별로 유의한 차이가 있었다.

원가기획의 도입이 경영성과에 미치는 영향

김순기,정순여,하경종 서강대학교 경영학연구원 2003 서강경영논총 Vol.14 No.1

Catechins activate muscle stem cells by Myf5 induction and stimulate muscle regeneration

Kim, A Rum,Kim, Kyung Min,Byun, Mi Ran,Hwang, Jun-Ha,Park, Jung Il,Oh, Ho Taek,Kim, Hyo Kyeong,Jeong, Mi Gyeong,Hwang, Eun Sook,Hong, Jeong-Ho Elsevier 2017 Biochemical and biophysical research communication Vol. No.

<P><B>Abstract</B></P> <P>Muscle weakness is one of the most common symptoms in aged individuals and increases risk of mortality. Thus, maintenance of muscle mass is important for inhibiting aging. In this study, we investigated the effect of catechins, polyphenol compounds in green tea, on muscle regeneration. We found that (−)-epicatechin gallate <B>(</B>ECG) and (−)-epigallocatechin-3-gallate (EGCG) activate satellite cells by induction of Myf5 transcription factors. For satellite cell activation, Akt kinase was significantly induced after ECG treatment and ECG-induced satellite cell activation was blocked in the presence of Akt inhibitor. ECG also promotes myogenic differentiation through the induction of myogenic markers, including Myogenin and Muscle creatine kinase (MCK), in satellite and C2C12 myoblast cells. Finally, EGCG administration to mice significantly increased muscle fiber size for regeneration. Taken together, the results suggest that catechins stimulate muscle stem cell activation and differentiation for muscle regeneration.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Catechins stimulate muscle regeneration after muscle damage. </LI> <LI> Catechins activate muscle satellite cells through Akt activation and Myf5 induction. </LI> <LI> Catechins stimulate myogenesis through the induction of Myogenin and MCK. </LI> </UL> </P>

MR Mismatch Profiles in Patients with Intracranial Atherosclerotic Stroke: A Comprehensive approach Comparing Stroke Subtypes

Kim, Suk Jae,Seok, Jin Myoung,Bang, Oh Young,Kim, Gyeong-Moon,Kim, Keon Ha,Jeon, Pyoung,Chung, Chin-Sang,Lee, Kwang Ho,Alger, Jeffry R,Liebeskind, David S SAGE Publications 2009 Journal of cerebral blood flow and metabolism Vol.29 No.6

<P> Most clinical trials have focused on the presence of perfusion- and diffusion-weighted imaging (PWI-DWI) mismatch by more than 20%, and different stroke subtypes were lumped together. We hypothesized that intracranial large artery atherosclerotic stroke (IC-LAA) would show different PWI-DWI and magnetic resonance angiography (MRA)-DWI mismatch profiles, compared with other stroke subtypes. Consecutive patients underwent pretreatment multiparametric magnetic resonance imaging for the acute middle cerebral artery infarcts within 6 h of symptom onset. We assessed the difference in the DWI-PWI mismatch ratio, severity of hypoperfusion, and MRA-DWI mismatch among the stroke subtypes. Of 86 patients, 19 (22.1%) had IC-LAA; 42 (48.8%) cardioembolic stroke, 15 (17.4%) extracranial-LAA, and 10 (11.6%) had cryptogenic embolic stroke. Although the volume of the penumbra was not different among the groups, the mismatch ratio was higher (P=0.003) and the severity of hypoperfusion was lower in the IC-LAA group (P=0.001). The MRA-DWI mismatch was more prevalent in the IC-LAA group than in other groups ( P < 0.001). Collateral grading, assessed in 41 patients, was more likely to be intermediate/excellent in the IC-LAA group ( P < 0.001). Multivariate testing revealed that a larger mismatch ratio and less severe hypoperfusion, and MRA-DWI mismatch were independently associated with IC-LAA. Our data show that patients with IC-LAA had different mismatch profiles, which were related to better collaterals, compared with other subtypes. </P>

Identification of relationship between pork colour and physicochemical traits in American Berkshire by canonical correlation analyses

Kim, Tae Wan,Kim, Il-Suk,Kwon, Seul Gi,Hwang, Jung Hye,Park, Da Hye,Kang, Deok Gyeong,Ha, Jeongim,Kim, Sam Woong,Kim, Chul Wook CSIRO PUBLISHING 2017 Animal Production Science Vol.57 No.6

HNRNPA1, a Splicing Regulator, Is an Effective Target Protein for Cervical Cancer Detection: Comparison With Conventional Tumor Markers

Kim, Young-Jon,Kim, Byoung-Ryun,Ryu, Jae-Suk,Lee, Gyeong-Ok,Kim, Hak-Ryul,Choi, Keum-Ha,Ryu, Jae-Won,Na, Kyoung-Suk,Park, Min-Cheol,So, Hong-Seob,Cho, Ji-Hyun,Park, Do-Sim Blackwell Scientific Publications 2017 International journal of gynecological cancer Vol.27 No.2

<B>Objective</B><P>Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), serine/arginine-rich splicing factor 1 (SRSF1), and SRSF3 are splicing regulators associated with oncogenesis. However, the alterations of SF proteins and their diagnostic values in cervical cancer are unclear. To apply SFs clinically, effective marker selection and characterization of the target organ properties are essential.</P><B>Materials and Methods</B><P>We concurrently analyzed HNRNPA1, SRSF1, SRSF3, and the conventional tumor markers squamous cell carcinoma antigen (SCCA) and carcinoembryonic antigen (CEA) in cervical tissue samples (n = 127) using semiquantitative immunoblotting. In addition, we compared them with p16 (cyclin-dependent kinase inhibitor 2A [CDKN2A]), which has shown high diagnostic efficacy in immunohistochemical staining studies and has been proposed as a candidate protein for point-of-care screening biochemical tests of cervical neoplasia.</P><B>Results</B><P>HNRNPA1, higher molecular weight forms of SRSF1 (SRSF1-HMws), SRSF3, CEA, and p16 levels were higher (<I>P</I> < 0.05) in cervical carcinoma tissue samples than in nontumoral cervical tissue samples. However, the levels of SRSF1-Total (sum of SRSF1-HMws and a lower molecular weight form of SRSF1) and SCCA, a commonly used cervical tumor marker, were not different between carcinoma and nontumoral tissue samples. In paired sample comparisons, HNRNPA1 (94%) showed the highest incidence of up-regulation (carcinoma/nontumor, >1.5) in cervical carcinoma, followed by p16 (84%), SRSF1-HMws (69%), SRSF3 (66%), CEA (66 %), SCCA (32%), and SRSF1-Total (31%). HNRNPA1 (92%) and p16 (91%) presented the two highest diagnostic accuracies for cervical carcinoma, which were superior to those of SRSF3 (75%), SRSF1-HMws (72%), CEA (72%), SCCA (59%), and SRSF1-Total (55%).</P><B>Conclusions</B><P>Our results identified that HNRNPA1 is the best diagnostic marker among the SFs and conventional markers given its excellent diagnostic efficacy for cervical carcinoma, and it has a p16-comparable diagnostic value. We suggest that HNRNPA1 is an additional effective target protein for developing cervical cancer detection tools.</P>

Determination of Fluazinam Residues in Agricultural Commodities Using GC-ECD/MS

Gyeong-Ha Kim,Kyung-Geun Ahn,Gi-Ppeum Kim,Hong-Heon Rhee,Ryeon-Woong Kang,Myunghyun Kim,Heeju Kwon,Young-Sun Hwang,Young Deuk Lee,Myoung-Gun Choung 한국농약과학회 2015 한국농약과학회 학술발표대회 논문집 Vol.2015 No.10

Occurrence and characterization of oseltamivir-resistant influenza virus in children between 2007-2008 and 2008-2009 seasons

Kim, Seoung Geun,Hwang, Yoon Ha,Shin, Yung Hae,Kim, Sung Won,Jung, Woo Sik,Kim, Sung Mi,Oh, Jae Min,Lee, Na Young,Kim, Mun Ju,Cho, Kyung Soon,Park, Yeon Gyeong,Min, Sang Kee,Lee, Chang Kyu,Kim, Jun Su The Korean Pediatric Society 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.4

Purpose: There was a global increase in the prevalence of oseltamivir-resistant influenza viruses during the 2007-2008 influenza season. This study was conducted to investigate the occurrence and characteristics of oseltamivir-resistant influenza viruses during the 2007-2008 and 2008-2009 influenza seasons among patients who were treated with oseltamivir (group A) and those that did not receive oseltamivir (group B). Methods: A prospective study was conducted on 321 pediatric patients who were hospitalized because of influenza during the 2007-2008 and 2008-2009 influenza seasons. Drug resistance tests were conducted on influenza viruses isolated from 91 patients. Results: There was no significant difference between the clinical characteristics of groups A and B during both seasons. Influenza A/H1N1, isolated from both groups A and B during the 2007-2008 and 2008-2009 periods, was not resistant to zanamivir. However, phenotypic analysis of the virus revealed a high oseltamivir $IC_{50}$ range and that H275Y substitution of the neuraminidase (NA) gene and partial variation of the hemagglutinin (HA) gene did not affect its antigenicity to the HA vaccine even though group A had a shorter hospitalization duration and fewer lower respiratory tract complications than group B. In addition, there was no significant difference in the clinical manifestations between oseltamivir-susceptible and oseltamivir-resistant strains of influenza A/H1N1. Conclusion: Establishment of guidelines to efficiently treat influenza with oseltamivir, a commonly used drug for treating influenza in Korean pediatric patients, and a treatment strategy with a new therapeutic agent is required.

Cerebral Ischemia Detected with Diffusion-Weighted MR Imaging after Protected Carotid Artery Stenting: Comparison of Distal Balloon and Filter Device

Kim, Suk Jung,Roh, Hong Gee,Jeon, Pyoung,Kim, Keon Ha,Lee, Kwang Ho,Byun, Hong Sik,Moon, Won-Jin,Kim, Gyeong-Moon,Kim, Young-Wook,Kim, Dong Ik The Korean Radiological Society 2007 KOREAN JOURNAL OF RADIOLOGY Vol.8 No.4

<P><B>Objective</B></P><P>The aim of this study was to examine the incidence of ischemia during protected carotid artery stenting (CAS) as well as to compare the protective efficacy of the balloon and filter devices on diffusion-weighted MR imaging (DWI).</P><P><B>Materials and Methods</B></P><P>Seventy-one consecutive protected CAS procedures in 70 patients with a severe (> 70%) or symptomatic moderate (> 50%) carotid artery stenosis were examined. A balloon device (PercuSurge GuardWire) and a filter device (FilterWire EX/EZ, Emboshield) was used in 33 cases (CAS-B group) and 38 cases (CAS-F group) to prevent distal embolization, respectively. All the patients underwent DWI within seven days before and after the procedures. The number of new cerebral ischemic lesions on the post-procedural DWI were counted and divided into ipsilateral and contralateral lesions according to the relationship with the stenting side.</P><P><B>Results</B></P><P>New cerebral ischemic lesions were detected in 13 (39.4%) out of the 33 CAS-Bs and in 15 (39.5%) out of the 38 CAS-Fs. The mean number of total, ipsilateral and contralateral new cerebral ischemic lesion was 2.39, 1.67 and 0.73 in the CAS-B group and 2.11, 1.32 and 0.79 in the CAS-F group, respectively. No statistical differences were found between the two groups (<I>p</I> = 0.96, 0.74 and 0.65, respectively). The embolic complications encountered included two retinal infarctions and one hemiparesis in the CAS-B group (9.09%), and one retinal infarction, one hemiparesis and one ataxia in the CAS-F group (7.89%). There was a similar incidence of embolic complications in the two groups (<I>p</I> = 1.00).</P><P><B>Conclusion</B></P><P>The type of distal protection device used such as a balloon and filter does not affect the incidence of cerebral embolization after protected CAS.</P>