Correlations of Four Genetic Single Nucleotide Polymorphisms in Brain-Derived Neurotrophic Factor with Posttraumatic Stress Disorder

JunCheng Guo,YiJun Yang,Min Guo,XiaoDan Wang,Yang Juan,YunSuo Gao,LinQiu Fu,XiangLing Jiang,LinMei Fu,Tao Huang 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.4

Objective-To investigate the correlations of four genetic single nucleotide polymorphisms (SNPs) of brain-derived neurotrophic factor (BDNF) with posttraumatic stress disorder (PTSD). Methods-A total of 300 patients with sporadic PTSD and 150 healthy subjects (the control group) were selected according to the diagnostic criteria of PTSD (DSM-IV), and the genotypes of the BDNF SNPs G-712A, C270T, rs6265, and rs7103411 were detected by polymerase chain reaction and direct DNA sequencing to determine intergroup differences in the genotypes and allele frequencies; the pvalues were corrected with the permutation test. Results-The genotypes and allele frequencies of the SNPs G-712A, rs6265, and rs7103411 of BDNF showed no significant intergroup differences (p>0.05). However, the genotype and allele frequencies of C270T showed significant differences between the PTSD group and the control group (p<0.05). Conclusion-The SNP C270T of BDNF may be associated with PTSD. Individuals carrying the polymorphic T allele of C270T may be more likely to suffer from PTSD.

Selective Removal of Al(III) from Rare Earth Solutions Using Peas-based Activated Carbon

Fu-Qiang An,Rui-Yan Wu,Zhi-Guo Yuan,Tuo-Ping Hu,Jian-Feng Gao 대한화학회 2017 대한화학회지 Vol.61 No.5

Efficiently removing Al(III) from rare earth is very significant because even trace amount of Al(III) can cause serious harm to the rare earth materials. In this paper, a nitrogen-containing activated carbon, AC-P700, was synthesized using peas as raw materials. The AC-P700 was characterized by surface area analyzer, FT-IR, and XPS methods. The adsorption and recognition properties of AC-P700 towards Al(III) were investigated, and the recognition mechanism was also analyzed. The BET special surface area of AC-P700 was 1277.1 m2·g−1, and the average pore diameter was 1.90 nm. The AC-P700 possesses strong adsorption affinity and excellent recognition selectivity towards Al(III). The adsorption capacity for Al(III) could reach to 0.53 mmol·g−1, and relative selectivity coefficients relative to La(III) and Ce(III) is 9.6 and 8.7, respectively. Besides, ACP700 possesses better regeneration ability and reusability.

Effective removal of anilines using porous activated carbon based on ureaformaldehyde resin

Fu-Qiang An,Dong Zhang,Xiao-Xia Yue,Guo-Li Ou,Jian-Feng Gao,Tuo-Ping Hu 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.2

The effective removal of aniline and its derivatives from wastewater is very important due to the high toxicity. Adsorption with a high-performance adsorbent is an efficient pathway. A novel activated carbon, ACUF-700, was synthesized using homemade ureaformaldehyde resin as the major carbon source carbonized at 700 oC. ACUF-700 is characterized by surface area analyzer, FTIR, elemental analyzer, and SEM. The adsorption properties of ACUF-700 towards anilines are also investigated by using batch methods. The test results showed that the ACUF-700 possesses higher specific surface area and narrower pore size distribution. In virtue of its developed pore structure and nitrogencontaining chemical groups, the adsorption capacities towards aniline, p-toluidine and p-chloroaniline could reach 95.6, 108.1 and 128.9mg/g, respectively. The adsorption process could be well described by the intra-particle mass transfer diffusion model and Sips model. Besides, ACUF700 was regenerated easily using diluted hydrochloric acid solution as eluent and ACUF700 possesses better reusability.

Effects of Sn and Mn Addition on the Microstructure and Mechanical Properties of As-Extruded Mg–2Al–1Zn Alloys

Fu‑Hao Gao,Bin‑Jiang Lv,Tie‑Wei Xu,Ning Cui,Feng Guo 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.11

The effects of low Sn (1.0 wt%) and Mn (0.5 wt%) content on the microstructures and mechanical properties of as-extrudedMg–2Al–1Zn (AZ21) alloys were systematically investigated. The combined addition of Sn and Mn significantly refinedthe grains of the AZ21 alloy, reducing the average grain size from 25.77 to 2.17 μm. The volume fraction of the dynamicallyrecrystallized (DRXed) grains decreased from 78.49 to 43.81% with Sn (1.0 wt%) and Mn (0.5 wt%) addition. The Al8Mn5,Al11Mn4,and Al9Mn4phases were formed in Mg–2Al–1Zn–1Sn–0.5Mn (AZTM2110) alloy, and the Mg17Al12phase disappeared. The orientation relationship between Al9Mn4and Al11Mn4was (002)Al11Mn4//(̄ 302)Al9Mn4, [ ̄ 100]Al11Mn4//[223]Al9Mn4,and the orientation relationship between Al8Mn5and α-Mg was ( ̄ 252)Al8Mn5//(̄ 12̄ 13)α−Mg. The Al9Mn4and Al11Mn4phasesgrew in the same direction. The intensity of basal fiber texture of AZTM2110 alloy decreased by 21.7%. The ultimatetensile strength, yield strength, and elongation of the AZ21 alloy increased by 29.03%, 65.05%, and 61.02%, respectively. Grain-refinement strengthening was the main mechanism underlying the improvement in AZTM2110 alloy strength. Grainrefinement and the weakened basal fiber texture improved the plasticity of the AZTM2110 alloy.

Analysis of Isolated Attosecond Pulse Generation from a Multi-cycle Two-color Pulse

Gao Chen,Feng-Dong Zhang,Yu-Jun Yang,Fu-Ming Guo 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.1

We theoretically investigate the high-order harmonic and attosecond pulse generation by numerically solving the one-dimensional time-dependent Schr¨odinger equation for a hydrogen atom in a two-color laser field that is synthesized by adding a suitable multi-cycle infrared pulse to a multicycle 800-nm fundamental pulse. Our result clearly shows that with the addition of a suitable second optical field, the electric field profile of the synthesized pulse presents multi-segments and that in the first and the last segments, the amplitudes of the electric field are dramatically suppressed. If this synthesized pulse is adopted as an incident driving pulse, only the amplitude of the electric field in the middle segment makes a major contribution to the plateau and to the cutoff region of the harmonic spectrum. This will cause a wide quasicontinuous spectrum around the cutoff position. Thus, an isolated attosecond pulse can be obtained even if we adopt the synthesized pulse with a multi-cycle pulse duration.

Biotransformation, a Promising Technology for Anti-cancer Drug Development

Gao, Fei,Zhang, Jin-Ming,Wang, Zhan-Guo,Peng, Wei,Hu, Hui-Ling,Fu, Chao-Mei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

With the high morbidity and mortality caused by cancer, finding new and more effective anti-cancer drugs is very urgent. In current research, biotransformation plays a vital role in the research and development of cancer drugs and has obtained some achievements. In this review, we have summarized four applications as follows: to exploit novel anti-cancer drugs, to improve existing anti-cancer drugs, to broaden limited anti-cancer drug resources and to investigate correlative mechanisms. Three different groups of important anti-cancer compounds were assessed to clarify the current practical applications of biotransformation in the development of anti-cancer drugs.

Studies on CFST column to steel beam joints using endplates and long bolts under central column removal

Shan Gao,Bo Yang,Lanhui Guo,Man Xu,Feng Fu 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.42 No.2

In this paper, four specimens of CFST column joints with endplates and long bolts are tested in the scenario of progressive collapse. Flush endplate and extended endplate are both adopted in this study. The experimental results show that increasing the thickness of the endplate could improve the behavior of the joint, but delay the mobilization of catenary action. The thickness of the endplate should not be relatively thick in comparison to the diameter of the bolts, otherwise catenary action would not be mobilized or work effectively. Effective bending deformation of the endplate could help the formation and development of catenary action in the joints. The performance of flexural action in the joint would affect the formation of catenary action in the joint. Extra middle-row bolts set at the endplates and structural components set below the bottom beam flange should be used to enhance the robustness of joints. A special weld access hole between beam and endplate should be adopted to mitigate the chain damage potential of welds. It is suggested that the structural components of joints should be independent of each other to enhance the robustness of joints. Based on the component method, a formula calculating the stiffness coefficient of preloaded long bolts was proposed whose results matched well with the experimental results.

Selective Removal of Al(III) from Rare Earth Solutions Using Peas-based Activated Carbon

An, Fu-Qiang,Wu, Rui-Yan,Li, Min,Yuan, Zhi-Guo,Hu, Tuo-Ping,Gao, Jian-Feng Korean Chemical Society 2017 대한화학회지 Vol.61 No.5

Efficiently removing Al(III) from rare earth is very significant because even trace amount of Al(III) can cause serious harm to the rare earth materials. In this paper, a nitrogen-containing activated carbon, AC-P700, was synthesized using peas as raw materials. The AC-P700 was characterized by surface area analyzer, FT-IR, and XPS methods. The adsorption and recognition properties of AC-P700 towards Al(III) were investigated, and the recognition mechanism was also analyzed. The BET special surface area of AC-P700 was $1277.1m^2{\cdot}g^{-1}$, and the average pore diameter was 1.90 nm. The AC-P700 possesses strong adsorption affinity and excellent recognition selectivity towards Al(III). The adsorption capacity for Al(III) could reach to $0.53mmol{\cdot}g^{-1}$, and relative selectivity coefficients relative to La(III) and Ce(III) is 9.6 and 8.7, respectively. Besides, AC-P700 possesses better regeneration ability and reusability.

Immune and Anti-oxidant Functions of Ethanol Extracts of Scutellaria baicalensis Georgi in Mice Bearing U14 Cervical Cancers

Peng, Yong,Guo, Cong-Shan,Li, Pan-Xia,Fu, Zhan-Zhao,Gao, Li-Ming,Di, Ya,Ju, Ya-Kun,Tian, Ru,Xue, Jia-Jia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10

Background: The objective was to study the effect of Scutellaria baicalensis Georgi ethanol extracts (SBGE) on immune and anti-oxidant function in U14 tumor-bearing mice. Materials and Methods: U14 tumor-bearing mice were randomly divided into eight groups: a control group, a cyclophosphamide (CTX) group, three dose groups of SBGEI (high, medium, low), and three dose groups of SBGEII (high, medium, low). After two weeks, the thymus and spleen weight indices of mice bearing U14 cervical cancer were calculated. Enzyme linked immunosorbent assays (ELISA) was used to determine the levels of serum IL-2, TNF-${\alpha}$, IL-8, and PCNA. MDA activity and SOD activity in plasma were measured with detection kits. Results: In the SBGE groups, thymus weight and spleen weight indices of U14 tumor-bearing mice were significantly higher than in the control group or CTX group (p<0.05). Compared to control group, the levels of serum IL-2 and TNF-${\alpha}$ in U14 tumor-bearing mice increased significantly, whereas the contents of serum IL-8 and PCNA decreased (p<0.05). The activity of SOD increased with the growing dose of SBGE, while the activity of MDA decreased significantly in the highe-rdose groups of SBGE. Conclusions: These findings suggested that SBGE, especially at high dose, 1000 mg/kg, showed significant immune and anti-oxidant effects infU14 tumor-bearing mice, which might be the mechanisms of SBGE inhibition of tumor growth.

Rediscovering Impacts of Collaboration through Workflow Analysis to Value Service Development

Chengxiang Ren,Yucong Duan,Zhangbing Zhou,Guohua Fu,Zhen Guo,Honghao Gao 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.11

Information and service economies are developing rapidly in recent years with the development of information technology and new applications. Software and service development are becoming more and more complex relating to different participants, organizations and alliances. This phenomenon has caused urgent requirements on economic and technical fusion through coordination and collaboration among stakeholders. This paper addresses the gap between business layer and technical development in roles and activities. We then propose a combination of economic value and profits and technical service development processes. We also consider value exchange under profit sharing contracts in participants' workflows. A simulation and an experiment are performed to show related impacts.