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Guillermo Portillo Perez,Agneev Mukherjee,Marie-Josée Dumont 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.70 No.-
In recent decades, the concept of biorefinery has gained considerable momentum as a promisingapproach to obtain energy commodity chemicals. 5-hydroxymethylfurfural (HMF) is one of the mostpromising building blocks for biobased chemicals and a strong candidate for large scale production. However, one of the main factors holding its transition is the need for green, sustainable, andfinanciallyfeasible processes. This review provides a critical assessment of the progresses made towards catalyticand autocatalytic systems used for HMF production, as well as advancements in catalyst research, theirmechanisms analyses, efficiency and sustainability. It also provides key information which can facilitatethe selection and development of catalysts for HMF production.
Anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human uterus
Munoz-Perez, Victor Manuel,Ortiz, Mario I.,Ponce-Monter, Hector A.,Monter-Perez, Vicente,Barragan-Ramirez, Guillermo The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.4
The aim of this study was to evaluate the in vitro anti-inflammatory and utero-relaxant effect of ${\alpha}$-bisabolol on the pregnant human myometrium. Samples from the pregnant human myometrium were used in functional tests to evaluate the inhibitory effect of ${\alpha}$-bisabolol (560, 860, 1,200 and $1,860{\mu}M$) on spontaneous myometrial contractions. The intracellular cyclic adenosine monophosphate (cAMP) levels generated in response to ${\alpha}$-bisabolol in human myometrial homogenates were measured by ELISA. The anti-inflammatory effect of ${\alpha}$-bisabolol was determined through the measurement of two pro-inflammatory cytokines, tumor necrosis factor-${\alpha}$ ($TNF{\alpha}$) and interleukin $(IL)-1{\beta}$, and the anti-inflammatory cytokine IL-10, in pregnant human myometrial explants stimulated with lipopolysaccharide (LPS). Forskolin was used as a positive control to evaluate the cAMP and cytokine levels. ${\alpha}$-Bisabolol was found to induce a significant inhibition of spontaneous myometrial contractions at the highest concentration level (p<0.05). ${\alpha}$-Bisabolol caused a concentration-dependent decrease in myometrial cAMP levels (p<0.05) and a concentration-dependent decrease in LPS-induced $TNF{\alpha}$ and $IL-1{\beta}$ production, while IL-10 production did not increase significantly (p>0.05). The anti-inflammatory and utero-relaxant effects induced by ${\alpha}$-bisabolol were not associated with an increase in cAMP levels in pregnant human myometrial samples. These properties place ${\alpha}$-bisabolol as a potentially safe and effective adjuvant agent in cases of preterm birth, an area of pharmacological treatment that requires urgent improvement.
Current Sharing Control Strategy for IGBTs Connected in Parallel
Perez-Delgado, Raul,Velasco-Quesada, Guillermo,Roman-Lumbreras, Manuel The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.2
This work focuses on current sharing between punch-through insulated gate bipolar transistors (IGBTs) connected in parallel and evaluates the mechanisms that allow overall current balancing. Two different control strategies are presented. These strategies are based on the modification of transistor gate-emitter control voltage V<sub>GE</sub> by using an active gate driver circuit. The first strategy relies on the calculation of the average value of the current flowing through all parallel-connected IGBTs. The second strategy is proposed by the authors on the basis of a current cross reference control scheme. Finally, the simulation and experimental results of the application of the two current sharing control algorithms are presented.
Current Sharing Control Strategy for IGBTs Connected in Parallel
Raul Perez-Delgado,Guillermo Velasco-Quesada,Manuel Roman-Lumbreras 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.2
This work focuses on current sharing between punch-through insulated gate bipolar transistors (IGBTs) connected in parallel and evaluates the mechanisms that allow overall current balancing. Two different control strategies are presented. These strategies are based on the modification of transistor gate-emitter control voltage VGE by using an active gate driver circuit. The first strategy relies on the calculation of the average value of the current flowing through all parallel-connected IGBTs. The second strategy is proposed by the authors on the basis of a current cross reference control scheme. Finally, the simulation and experimental results of the application of the two current sharing control algorithms are presented.
Murray, Nigel P,Albarran, Vidal,Perez, Guillermo,Villalon, Ricardo,Ruiz, Amparo Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11
Background: The aim of this study was to assess detection of circulating tumor cells (CTC) using anti-CEA pre and post surgery in Chilean patients with colo-rectal cancer. Materials and Methods: The presence of CTCs was evaluated in 80 colorectal cancer patients pre and post surgery using standard immunocytochemistry and the results were compared with findings for standard clinico-pathological parameters. Results: In patients presurgery CEA (+) CTCs were frequently found, with no relation to tumor size or nodal status. After surgery, the presence of CTCs was associated with such clinico-pathological parameters. The frequency of CTC detection in node positive patients did not change after surgery. In patients with metastasis there was also no change in the frequency of CTC detection, and clusters of 3 or more CTCs were evident. Conclusions: Secondary CTCs are associated with clinico-pathological parameters only after surgical removal of the primary tumor, and might be important in identifying patients at high risk of relapse. Primary CTCs detected before surgical removal are frequently found, are not associated with the clinico-pathological parameters and might have a role in cancer screening. These findings suggest the need for studies with a larger population of patients.
Perla Leon-Flores,Nayelli Najera,Elizabeth Perez,Blanca Pardo,Fiacro Jimenez,Dylan Diaz-Chiguer,Francisco Villarreal,Isabel Hidalgo,Guillermo Ceballos,Eduardo Meaney 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.7
Therapeutic approaches to decrease serum triglyceride (TG) concentrations are not successful mainly due to poor adherence or adverse effects of therapies. In consequence, the search for new low-cost and safer therapeutic alternatives is mandatory. Dark chocolate and cacao have shown promising results improving lipid profiles. Recently, using cacao by-products to reduce elevated cardiometabolic risk markers in an animal model of obesity induced by a high-fat diet and fructose, we showed that TGs, low-density lipoprotein cholesterol, and the TG/high-density lipoprotein (HDL) ratio decreased, suggesting that cacao by-products improved the metabolic function of obese animals. Based on these results, as a proof of concept, a blinded placebo-controlled study was implemented to explore the effects of cacao by-products on anthropometric and biochemical variables in a group of overweight subjects participating in a program composed of reduced-calorie-diet counseling plus a simple aerobic exercise plan. The results showed that counseling induced weight and abdominal circumference reductions in both groups. TGs did not change in the control group; however, TG decreased significantly by 54.9 mg/dL (27.9%) in the experimental group. The TG/HDL cholesterol ratio changed markedly (1.5) in the experimental group. The results reported suggest the use of cacao by-products as an alternative for the treatment of hypertriglyceridemia.
Ricardo Beltran,Nicolas Velazquez,Alma Cota Espericueta,Daniel Sauceda,Guillermo Perez 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.10
This paper presents a mathematical model that allows representing the optical behavior of a solar parabolic dish concentrator and the thermal performance of a cavity receiver. A procedure and a graphical method for the design of dish/cavity systems are proposed. A parametric study of the main geometric variables is performed and the influence of climate variables on the thermal behavior of the system coupled to a Stirling engine is analyzed. The model considers errors of solar collector, intercept factor, reflected and emitted radiation,conduction, and convection heat losses. For the validation of the model, the results obtained were compared with theoretical and experimental results reported in the literature. The calculation of the radiation losses, emitted and reflected from the receiver presented errors of up to 14%, and the average error for the rest of the thermal losses, interception factor and the absorber’s temperature, was less than 3%. These results show that the proposed model can be used with sufficient certainty to design and optimize solar dish collectors with cavity receivers.
Angel T. Pineiro-Vazquez,Jorge R. Canul-Solis,Guillermo O. Jimenez-Ferrer,Jose A. Alayon-Gamboa,Alfonso J. Chay-Canul,Armin J. Ayala-Burgos,Carlos F. Aguilar-Perez,Juan C. Ku-Vera 아세아·태평양축산학회 2018 Animal Bioscience Vol.31 No.11
Objective: The aim of the experiment was to assess the effect of increasing amounts of Leucaena leucocephala forage on dry matter intake (DMI), organic matter intake (OMI), enteric methane production, rumen fermentation pattern and protozoa population in cattle fed Pennisetum purpureum and housed in respiration chambers. Methods: Five crossbred heifers (Bos taurus×Bos indicus) (BW: 295±6 kg) were fed chopped P. purpureum grass and increasing levels of L. leucocephala (0%, 20%, 40%, 60%, and 80% of dry matter [DM]) in a 5×5 Latin square design. Results: The voluntary intake and methane production were measured for 23 h per day in respiration chambers; molar proportions of volatile fatty acids (VFAs) were determined at 6 h postprandial period. Molar concentration of VFAs in rumen liquor were similar (p>0.05) between treatments. However, methane production decreased linearly (p<0.005), recording a maximum reduction of up to ~61% with 80% of DM incorporation of L. leucocephala in the ration and no changes (p>0.05) in rumen protozoa population were found. Conclusion: Inclusion of 80% of L. leucocephala in the diet of heifers fed low-quality tropical forages has the capacity to reduce up to 61.3% enteric methane emission without affecting DMI, OMI, and protozoa population in rumen liquor.