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김용배,장원기,황보영,김화성,안규동,이병국,이용진,이종은,이준숙,이찬구,이한정,이성수 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1
Objective : Serum uric acid has now been identified as a marker for a number of metabolic and hemodynamic abnormalities. The aim of this study is to evaluate risk factors which influence hyperuricemia in the citizens of Asan. Method : The study design was cross-sectional and research subjects were 1086 citizens of Asan. General characteristics, cigarette smoking, alcohol consumption, and past history were obtained by interview using a structural questionnaire. Also, we measured height, weight and blood pressure, and serum uric acid of the subjects. Results : The mean serum uric acid level was 5.27 ㎎/㎗ in men and 4.01 ㎎/㎗, in women, In the multiple logistic regression analysis, statically significant risk factors of hyperuhcemia were gender, body mass index, blood lead concentration, and serum creatinine. Conclusion : Our results suggest that gender, body mass index, blood lead concentration, and serum creatinine might be the most important risk factors of hyperurcemia. Education program as well as routine check-up for serum uric acid was highly recommended for the effective prevention of hyperuricemia.
류공식,최상구,이화우 群山大學校基礎科學硏究所 1993 基礎科學硏究 Vol.8 No.-
에폭시 수지의 경화제와 경화조건을 변화시켜가며 유리섬유/에폭시 적층판의 충격특성을 연구하였다. 상온경화에서는 분자사슬이 긴 폴리아미드(G-1034)를 경화제로 사용했을 때 가장 큰 충격강도를 나타내었다. 가열경화에서는 파괴개시에너지가 상온경화에 비하여 높게 나타났으며, 후경화에서는 파괴 전파에너지가 높게 나타났다. 저온시험에서는 모재로부터 섬유의 이탈이 많이 일어난 것이 높은 충격 강도를 나타내었다. The influence of hardener and curing condition were studied on the impact properties of epoxy resin laminated with glass- fiber experimentally. Generally, the initiation energy of the epoxy composites was increased with heat - cure, and the propagation energy was also increased with post-cure. The total impact strength of composites cured with hardener of polyamide type was than that of aliphatic or aromatic amine type. The impact strength was increased with enhancement of propagation energy when it was tested at low temperature.
Safety of Laparoscopic Radical Gastrectomy in Gastric Cancer Patients with End-Stage Renal Disease
Lee, Hayemin,Park, Cho Hyun,Park, Seung Man,Kim, Wook,Chin, Hyung Min,Kim, Jin Jo,Song, Kyo Young,Kim, Sung Geun,Jun, Kyong Hwa,Kim, Jeong Goo,Lee, Han Hong,Lee, Junhyun,Kim, Dong Jin The Korean Gastric Cancer Association 2018 Journal of gastric cancer Vol.18 No.3
Purpose: The surgical outcomes of end-stage renal disease (ESRD) patients undergoing radical gastrectomy for gastric cancer were inferior compared with those of non-ESRD patients. This study aimed to evaluate the short- and long-term surgical outcomes of ESRD patients undergoing laparoscopic gastrectomy (LG) and open gastrectomy (OG) for gastric cancer. Materials and Methods: Between 2004 and 2014, 38 patients (OG: 21 patients, LG: 17 patients) with ESRD underwent gastrectomy for gastric cancer. Comparisons were made based on the clinicopathological characteristics, surgical outcomes, and long-term survival rates. Results: No significant differences were noted in the clinicopathological characteristics of either group. LG patients had lower estimated blood loss volumes than OG patients (LG vs. OG: 94 vs. 275 mL, P=0.005). The operation time and postoperative hospital stay were similar in both the groups. The postoperative morbidity for LG and OG patients was 41.1% and 33.3%, respectively (P=0.873). No significant difference was observed in the long-term overall survival rates between the 2 groups (5-year overall survival, LG vs. OG: 82.4% vs. 64.7%, P=0.947). Conclusions: In ESRD patients, LG yielded non-inferior short- and long-term surgical outcomes compared to OG. Laparoscopic procedures might be safely adopted for ESRD patients who can benefit from the advantages of minimally invasive surgery.
Lee, Hwa Shim,Lee, Jong Man,Park, Sang Ryoul,Lee, Je Hoon,Kim, Yong Goo Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.6
Glucose is a common medical analyte measuring in human serum or blood samples. The development of a primary method is necessary for the establishment of traceability in measurements. We have developed an isotope dilution liquid chromatography tandem mass spectrometry as a primary method for the measurement of glucose in human serum. Glucose and glucose-$^{13}C_6$ in sample were ionized in ESI negative mode and monitored at mass transfers of m/z 179/89 and 185/92 in MRM, respectively. Glucose was separated on $NH_2P$-50 2D column, and the mobile phase was 20 mM $NH_4OAc$ in 30% acetonitrile/70% water. Verification of this method was performed by the comparison with NIST SRMs. Our results agreed well with the SRM values. We have developed two levels of glucose serum certified reference material using this method and distributed them to the clinical laboratories in Korea as samples for proficiency testings. The expended uncertainty was about 1.2% on 95% confidence level. In proficiency testings, the results obtained from the clinical laboratories showed about 3.6% and 3.9% RSD to the certified values. Primary method can provide the traceability to the field laboratories through proficiency testings or certified reference materials.
Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.
Lee, Seunghee,Kim, Dae-Hwan,Goo, Young Hwa,Lee, Young Chul,Lee, Soo-Kyung,Lee, Jae W Endocrine Society 2009 Molecular endocrinology Vol.23 No.5
<P>Nuclear receptor (NR) transactivation involves multiple coactivators, and the molecular basis for how these are functionally integrated needs to be determined to fully understand the NR action. Activating signal cointegrator-2 (ASC-2), a transcriptional coactivator of many NRs and transcription factors, forms a steady-state complex, ASCOM (for ASC-2 complex), which contains histone H3-lysine-4 (H3K4) methyltransferase MLL3 or its paralog MLL4. Here, we show that ASCOM requires a functional cross talk with the ATPase-dependent chromatin remodeling complex Swi/Snf for efficient NR transactivation. Our results reveal that ASCOM and Swi/Snf are tightly colocalized in the nucleus and that ASCOM and Swi/Snf promote each other's binding to NR target genes. We further show that the C-terminal SET domain of MLL3 and MLL4 directly interacts with INI1, an integral subunit of Swi/Snf. Our mutational analysis demonstrates that this interaction underlies the mutual facilitation of ASCOM and Swi/Snf recruitment to NR target genes. Importantly, this study uncovers a specific protein-protein interaction as a novel venue to couple two distinct enzymatic coactivator complexes during NR transactivation.</P>
Performance Improvement of Wireless Uplink Channels Using Packet Diversity
Lee, Goo-Yeon,Kim, Hwa-Jong,Jeong, Choong-Kyo,Lee, Yong 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.B
In this paper, we introduce a packet diversity scheme to increase uplink channel utilization in a wireless network where forward error correction is used. The packet diversity allows neighbor base stations to receive uplink packets from a mobile terminal in order to increase the utilization of the uplink channel. By allowing multiple base stations to receive the same packets, we can improve the error correction capability in an uplink channel. By incorporating the packet diversity we can reduce the parity overhead of each packet for a given tolerable loss probability, which improves the link efficiency.
( Hwa Youn Lee ),( Hyoung Goo Park ),( Young Ran Lim ),( Im Soon Lee ),( Beom Joon Kim ),( Cheul Hun Seong ),( Young Jin Chun ),( Dong Hak Kim ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.1
Malassezia globosa is a common pathogenic fungus that causes skin diseases including dandruff and seborrheic dermatitis in humans. Analysis of its genome identified a gene (MGL_1677) coding for a putative NADPH-P450 reductase (NPR) to support the fungal cytochrome P450 enzymes. The heterologously expressed recombinant M. globosa NPR protein was purified, and its functional features were characterized. The purified protein generated a single band on SDS-PAGE at 80.74 kDa and had an absorption maximum at 452 nm, indicating its possible function as an oxidized flavin cofactor. It evidenced NADPH-dependent reducing activity for cytochrome c or nitroblue tetrazolium. Human P450 1A2 and 2A6 were able to successfully catalyze the O-deethylation of 7- ethoxyresorufin and the 7-hydroxylation of coumarin, respectively, with the support of the purified NPR. These results demonstrate that purified NPR is an orthologous reductase protein that supports cytochrome P450 enzymes in M. globosa.
Goo, Young-Hwa,Lee, Soo-kyung,Na, Soon-Young,Lee, Jae Woon 이화여자대학교 세포신호전달연구센터 2001 고사리 세포신호전달 심포지움 Vol. No.3
ASC-2 is a recently isolated transcriptional co integrator molecule, which is amplified in human cancers and stimulates transactivation by nuclear receptors, AP-1, NFĸB, SRF, and numerous other transcription factors. ASC-2 contained two nuclear receptor-interaction domains; i.e., the C-terminal LXXLL motif specifically interacting with oxysterol receptors and the N-terminal motif binding a broad range of nuclear receptors. Interestingly, ASC-2 contained a distinct, indirect androgen receptor-interacting domain that involves Rb/Swi/Snf complexes. In addition, we found that the previously defined autonomous transactivation function of ASC-2 also requires Rb/Swi/Snf. Surprisingly, Rb/Swi/Snf was required for ASC-2 to mediate transactivation by androgen and glucocorticoid receptors but not retinoid and thyroid hormone receptors. These results strongly suggest that distinct, ASC-2-containing coactivator complexes are actively assembled in a target factor-specific manner in vivo.
Fusion protein of retinol-binding protein and albumin domain III reduces liver fibrosis
Lee, Hongsik,Jeong, Hyeyeun,Park, Sangeun,Yoo, Wonbaek,Choi, Soyoung,Choi, Kyungmin,Lee, Min-Goo,Lee, Mihwa,Cha, DaeRyong,Kim, Young-Sik,Han, Jeeyoung,Kim, Wonkon,Park, Sun-Hwa,Oh, Junseo BlackWell Publishing Ltd 2015 EMBO molecular medicine Vol.7 No.6
<P>Activated hepatic stellate cells (HSCs) play a key role in liver fibrosis, and inactivating HSCs has been considered a promising therapeutic approach. We previously showed that albumin and its derivative designed for stellate cell-targeting, retinol-binding protein–albumin domain III fusion protein (referred to as R-III), inactivate cultured HSCs. Here, we investigated the mechanism of action of albumin/R-III in HSCs and examined the anti-fibrotic potential of R-III <I>in vivo</I>. R-III treatment and albumin expression downregulated retinoic acid (RA) signaling which was involved in HSC activation. RA receptor agonist and retinaldehyde dehydrogenase overexpression abolished the anti-fibrotic effect of R-III and albumin, respectively. R-III uptake into cultured HSCs was significantly decreased by siRNA-STRA6, and injected R-III was localized predominantly in HSCs in liver. Importantly, R-III administration reduced CCl<SUB>4</SUB>- and bile duct ligation-induced liver fibrosis. R-III also exhibited a preventive effect against CCl<SUB>4</SUB>-inducd liver fibrosis. These findings suggest that the anti-fibrotic effect of albumin/R-III is, at least in part, mediated by downregulation of RA signaling and that R-III is a good candidate as a novel anti-fibrotic drug.</P>