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Giwon Kim,Yeon Sil Kim,Eun Ji Han,Ie Ryung Yoo,Jin-Ho Song,Sang-Nam Lee,Jong Hoon Lee,Byung-Oak Choi,Hong-Seok Jang,Sei-Chul Yoon 대한방사선종양학회 2011 Radiation Oncology Journal Vol.29 No.4
Purpose: To evaluate the prognostic value of metabolic tumor volume (MTV) and maximum standardized uptake value (SUVmax) on initial positron emission tomography-computed tomography (PET-CT) and investigate the clinical value of SUVmax for early detection of locoregional recurrent disease after postoperative radiotherapy in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Materials and Methods: A total of 100 patients with locally advanced HNSCC received primary tumor excision and neck dissection followed by adjuvant radiotherapy with or without chemotherapy. The MTV and SUVmax were measured from primary sites and neck nodes. The prognostic value of MTV and SUVmax were assessed using initial staging PET/CT (study A). Follow-up PET/CT scan available after postoperative concurrent chemoradiotherapy or radiotherapy were evaluated for the SUVmax value and correlated with locoregional recurrence (study B). A receiver operating characteristic (ROC) curve analysis was used to define a threshold value of SUVmax with the highest accuracy for recurrent disease assessment. Results: High MTV (>41 mL) is negative prognostic factor for disease free survival (p = 0.041). Postradiation SUVmax was significantly correlated with locoregional recurrence (hazard ratio 1.812; 95% confidence interval 1.361 to 2.413; p < 0.001). A cut-off value of 5.38 from follow-up PET/CT was identified as having maximal accuracy for detecting locoregional recurrence by ROC analysis. Conclusion: MTV at staging work-up was significantly associated with disease free survival. The SUVmax value from follow-up PET/CT showed high diagnostic accuracy for the detection of locoregional recurrence in postoperatively irradiated HNSCC.
최강원 ( Kang-won Choi ),김관호 ( Kwan-ho Kim ),남기원 ( Giwon Nam ) 한국농공학회 2014 한국농공학회 학술대회초록집 Vol.2014 No.-
북한의 곡물재배면적 중 약 45 %가 벼농사를 하는데 단위 면적당 생산성이 남한에 비해 현저하게 낮게 나타나는 것으로 보고되고 있다. 본고에서는 북한 논의 생산성을 남한과 비교하고 북한의 지역 및 연도별 생산성을 비교·분석하였다. 1. 서론 북한 농업에 대한 자료는 매우 제한적이지만, FAO/WFP는 현지조사를 바탕으로 주요 식량작물의 작황을 보고하고 있으며, 특히 2002년 이후에는 지역(도)별로 주요곡물의 재배면적, 생산량 및 생산성 등의 통계적 자료를 제시하고 있다. 본고에서는 FAO/WFP의 특별보고서(2002년∼2013년)에 보고된 자료 중 단위면적당 생산량(톤/ha)을 중심으로 지역 및 연도별 생산성 차이를 분석하였다. 남한 벼농사의 생산성은 통계청 국가통계포털의 농작물생산조사 결과를 이용하였다. 2. 북한 벼농사의 생산성 차이 2.1 일반적 비교 농업는 북한 GDP에서 큰 비중을 차지하고 있어 북한경제의 기본이라고 할 수 있다. 그러나 북한벼농사의 평균 생산성은 조곡기준으로 4.2 톤/ha이고 남한 6.6 톤/ha의 63 % 수준이다. 이는 기후, 지형 및 토양, 영농기술, 영농자재, 농업기반시설 등이 취약하기 때문이라고 판단된다. 2.2 지역별 차이 북한은 지형조건과 토지자원 등을 고려하여 농업지역을 설정하였는데, 서해안 벌방지대는 벼재배면적의 약 13 %가 집중되어 있다. 북한의 서해안 벌방지대를 제외한 지역은 경사지가 대부분이고 토심은 얕고 비옥도가 낮아 평균 생산성이 약 3.3∼4.9 톤/ha로 지역별 차이가 크다. 2.2 연도별 변화 북한의 연도별 생산성의 표준편차는 약 17 %로서 남한의 4 %보다 크게 분석되었다. 특히, 가뭄, 홍수 등 자연재해와 재배기간의 월평균기온이 낮은 연도는 평년에 비해 생산성이 크게 낮은 것으로 나타났다. 3. 고찰 북한 벼농사의 생산성은 남한에 비해 낮으며 지역별, 연도별 차이가 크다. 생산성의 제약요인은 영농자재(종자 및 농업용 비닐, 비료 등), 농업기술, 자연재해에 취약한 농업생산기반 시설 및 농업관리방식(협동농장 등)이다. 특히, 통일에 대비하고 농업생산기반시설은 많은 예산과 장기간이 소요됨을 감안한다면, 남·북한의 쌀 수급과 생산성을 고려하여 전략적으로 농업생산기반시설을 구축할 수 있는 중장기 계획이 필요하다.
Yang Chulseung,Ku Giwon,Jung Jiseong,Choi Junhyuk,Kim Kyungho 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.5
Because drowsy driving increases the incidence of traffic accidents and leads to fatal accidents, a lot of social attention is needed. The number of accidents by drowsy drivers increases every year. So various studies have been performed to solve the issue all over the world. Among others, we focus on the non-contact method. Various vibration signals such as engine, tire, and body vibration are generated in a driving or stationary car. The existing static system is used to measure microscopic vibrations generated from the drivers breathing and heartbeat. It is necessary to design a structure that can cushion vehicle vibration through an advanced signal processing program. In this study, actual vehicles test was conducted to analyze the transmission characteristics of fine vibration through the change of plate structure under sensors. The plate structure is a urethane structure plate that can cushion vehicle vibration while driving. Furthermore, we developed an AI algorithm that classifies whether a subject is in a sleep state or not using a piezoelectric sensor-based BCG signal. This paper shows the AI method is more accurate than the method of classifying sleep states according to analyzing HRV and the ratio of LF/HF with ECG signal. In order to train the system, the subject's biosignals were acquired every 30 s, and 797 data were comparatively analyzed.
Park, Edmond Changkyun,Kim, Giwon,Jung, Jongsun,Wang, KyoungMin,Lee, Sunwoo,Jeon, Sin-Soo,Lee, Zee Won,Kim, Seung Il,Kim, Soohyun,Oh, Young-Taek,Shin, Ju-Hyun,Jang, Hong-Seok,Choi, Byung-Ock,Kim, Gun- Mary Ann Liebert 2013 OMICS Vol.17 No.5
<P>Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor, and notorious for resistance to chemoradiotherapy. MicroRNAs (miRNAs) are significantly involved in the initiation and progression of numerous cancers; however, the role of miRNAs in recurrence of tumors remains unknown. Here we tried to identify novel miRNAs that are differentially expressed in recurrent GBM. Tissue samples were obtained from patients with primary and recurrent GBM treated with chemoradiotherapy, and the expression changes of miRNAs were measured by microarray. A total of 318 miRNAs were expressed in the GBM patients. The expression of 43 miRNAs were significantly altered at least 2-fold in primary and recurrent GBMs. Bioinformatic analysis revealed that the differentially expressed miRNAs and their putative target genes were mainly involved in cell death, cellular development, and cellular growth and proliferation, which are the key regulators for stem cells. Pathway analysis supported that the miRNAs may regulate signaling associated with induction and maintenance of cancer and stem cell, such as p53, ErbB1, Notch, Wnt, and TGF-β signaling pathways. These data suggest that, in recurrent GBM, growth factor and anti-apoptotic signalings for cancer cell growth and proliferation are regulated by miRNAs. Our findings will aid future research in understanding the pathophysiology of recurrent GBM and identifying diagnostic markers and/or therapeutic targets for recurrence of GBM.</P>