Persistent Left Superior Vena Cava Associated with an Anomalous Drainage of Right Superior Vena Cava into the Left Atrium

Davide Genovese,Roberto Zecchel,Alessandro Daniotti,Piergiuseppe Piovesana,Carlo Cernetti 대한심장학회 2021 Korean Circulation Journal Vol.51 No.8

Golimumab, a human antibody to tumour necrosis factor α given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD Study

Keystone, E C,Genovese, M C,Klareskog, L,Hsia, E C,Hall, S T,Miranda, P C,Pazdur, J,Bae, S-C,Palmer, W,Zrubek, J,Wiekowski, M,Visvanathan, S,Wu, Z,Rahman, M U BMJ Publishing Group 2009 Annals of the Rheumatic Diseases Vol.68 No.6

<P><B>Objective:</B></P><P>The phase III GO-FORWARD study examined the efficacy and safety of golimumab in patients with active rheumatoid arthritis (RA) despite methotrexate therapy.</P><P><B>Methods:</B></P><P>Patients were randomly assigned in a 3 : 3 : 2 : 2 ratio to receive placebo injections plus methotrexate capsules (group 1, n  =  133), golimumab 100 mg injections plus placebo capsules (group 2, n  =  133), golimumab 50 mg injections plus methotrexate capsules (group 3, n  =  89), or golimumab 100 mg injections plus methotrexate capsules (group 4, n  =  89). Injections were administered subcutaneously every 4 weeks. The co-primary endpoints were the proportion of patients with 20% or greater improvement in the American College of Rheumatology criteria (ACR20) at week 14 and the change from baseline in the health assessment questionnaire-disability index (HAQ-DI) score at week 24.</P><P><B>Results:</B></P><P>The proportion of patients who achieved an ACR20 response at week 14 was 33.1% in the placebo plus methotrexate group, 44.4% (p = 0.059) in the golimumab 100 mg plus placebo group, 55.1% (p = 0.001) in the golimumab 50 mg plus methotrexate group and 56.2% (p<0.001) in the golimumab 100 mg plus methotrexate group. At week 24, median improvements from baseline in HAQ-DI scores were 0.13, 0.13 (p = 0.240), 0.38 (p<0.001) and 0.50 (p<0.001), respectively. During the placebo-controlled portion of the study (to week 16), serious adverse events occurred in 2.3%, 3.8%, 5.6% and 9.0% of patients and serious infections occurred in 0.8%, 0.8%, 2.2% and 5.6%, respectively.</P><P><B>Conclusion:</B></P><P>The addition of golimumab to methotrexate in patients with active RA despite methotrexate therapy significantly reduced the signs and symptoms of RA and improved physical function.</P>

Evaluation of Indigenous Grains from the Peruvian Andean Region for Antidiabetes and Antihypertension Potential Using In Vitro Methods

Ranilla, Lena Galvez,Apostolidis, Emmanouil,Genovese, Maria Ines,Lajolo, Franco Maria,Shetty, Kalidas The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.4

The health-relevant functionality of 10 thermally processed Peruvian Andean grains (five cereals, three pseudocereals, and two legumes) was evaluated for potential type 2 diabetes-relevant antihyperglycemia and antihypertension activity using in vitro enzyme assays. Inhibition of enzymes relevant for managing early stages of type 2 diabetes such as hyperglycemia-relevant $\alpha$-glucosidase and a-amylase and hypertension-relevant angiotensin I-converting enzyme (ACE) were assayed along with the total phenolic content, phenolic profiles, and antioxidant activity based on the 1,1-diphenyl-2-picrylhydrazyl radical assay. Purple corn (Zea mays L.) (cereal) exhibited high free radical scavenging-linked antioxidant activity (77%) and had the highest total phenolic content ($8\;{\pm}\;1\;mg$ of gallic acid equivalents/g of sample weight) and a-glucosidase inhibitory activity (51% at 5mg of sample weight). The major phenolic compound in this cereal was protocatechuic acid ($287\;{\pm}\;15\;{\mu}g/g$ of sample weight). Pseudocereals such as Quinoa (Chenopodium quinoa Willd) and Kan.iwa (Chenopodium pallidicaule Aellen) were rich in quercetin derivatives ($1,131\;{\pm}\;56$ and $943\;{\pm}\;35\;{\mu}g$ [expressed as quercetin aglycone]/g of sample weight, respectively) and had the highest antioxidant activity (86% and 75%, respectively). Andean legumes (Lupinus mutabilis cultivars SLP-1 and H-6) inhibited significantly the hypertension-relevant ACE (52% at 5mg of sample weight). No a-amylase inhibitory activity was found in any of the evaluated Andean grains. This in vitro study indicates the potential of combination of Andean whole grain cereals, pseudocereals, and legumes to develop effective dietary strategies for managing type 2 diabetes and associated hypertension and provides the rationale for animal and clinical studies.

Antidiabetes and Antihypertension Potential of Commonly Consumed Carbohydrate Sweeteners Using In Vitro Models

Lena Galvez Ranilla,권영인,Maria Ines Genovese,Franco Maria Lajolo,Kalidas Shetty 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.2

Commonly consumed carbohydrate sweeteners derived from sugar cane, palm, and corn (syrups) were inves-tigated to determine their potential to inhibit key enzymes relevant to Type 2 diabetes and hypertension based on the totalphenolic content and antioxidant activity using in vitromodels. Among sugar cane derivatives, brown sugars showed higherantidiabetes potential than white sugars; nevertheless, no angiotensin I-converting enzyme (ACE) inhibition was detected inboth sugar classes. Brown sugar from Peru and Mauritius (dark muscovado) had the highest total phenolic content and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, which correlated with a moderate inhibition of yeast .-glucosidase with-out showing a significant effect on porcine pancreatic .-amylase activity. In addition, chlorogenic acid quantified by high-performance liquid chromatography was detected in these sugars (128. 6 and 144. 2 .g/g of sample weight, respectively).Date sugar exhibited high .-glucosidase, .-amylase, and ACE inhibitory activities that correlated with high total phenoliccontent and antioxidant activity. Neither phenolic compounds or antioxidant activity was detected in corn syrups, indicatingthat nonphenolic factors may be involved in their significant ability to inhibit .-glucosidase, .-amylase, and ACE. This studyprovides a strong biochemical rationale for further in vivo studies and useful information to make better dietary sweetenerchoices for Type 2 diabetes and hypertension management.

Chemical Composition and Inhibitory Activity Against Helicobacter pylori of the Essential Oil of Apium nodiflorum (Apiaceae)

Luigi Menghini,Lidia Leporini,Bruno Tirillini,Francesco Epifano,Salvatore Genovese 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1

The chemical composition of the essential oil obtained from Apium nodiflorum (L.) Lag. (Family Apiaceae), a plant used in the ethnomedical traditions of the Abruzzo region (Central Italy) as a culinary herb, as a diuretic, and to cure stomachache, was analyzed by gas chromatography/mass spectrometry, and 14 components were identified. Limonene (27.72 %), p-cymene (23.06%), myristicine (18.51%), and β-pinene (6.62%) were the main components. The antimicrobial activity of the essential oil was assayed in vitro against Helicobacter pylori (strain DSMZ 4867), resulting in a minimum inhibitory concentration value of 12.5μg/mL.

Evaluation of Indigenous Grains from the Peruvian Andean Region for Antidiabetes and Antihypertension Potential Using In Vitro Methods

Lena Galvez Ranilla,Emmanouil Apostolidis,Franco Maria Lajolo,Kalidas Shetty,Maria Ines Genovese 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.4

The health-relevant functionality of 10 thermally processed Peruvian Andean grains (five cereals, three pseudocereals, and two legumes) was evaluated for potential type 2 diabetes-relevant antihyperglycemia and antihypertension activity using in vitro enzyme assays. Inhibition of enzymes relevant for managing early stages of type 2 diabetes such as hyperglycemia-relevant α-glucosidase and α-amylase and hypertension-relevant angiotensin I-converting enzyme (ACE) were assayed along with the total phenolic content, phenolic profiles, and antioxidant activity based on the 1,1-diphenyl-2-picrylhydrazyl radical assay. Purple corn (Zea mays L.) (cereal) exhibited high free radical scavenging-linked antioxidant activity (77%) and had the highest total phenolic content (8±1mg of gallic acid equivalents/g of sample weight) and α-glucosidase inhibitory activity (51% at 5mg of sample weight). The major phenolic compound in this cereal was protocatechuic acid (287±15μg/g of sample weight). Pseudocereals such as Quinoa (Chenopodium quinoa Willd) and Kañiwa (Chenopodium pallidicaule Aellen) were rich in quercetin derivatives (1,131±56 and 943±35μg [expressed as quercetin aglycone]/g of sample weight, respectively) and had the highest antioxidant activity (86% and 75%, respectively). Andean legumes (Lupinus mutabilis cultivars SLP-1 and H-6) inhibited significantly the hypertension-relevant ACE (52% at 5mg of sample weight). No α-amylase inhibitory activity was found in any of the evaluated Andean grains. This in vitro study indicates the potential of combination of Andean whole grain cereals, pseudocereals, and legumes to develop effective dietary strategies for managing type 2 diabetes and associated hypertension and provides the rationale for animal and clinical studies.

Exploring New Applications for Rhodiola rosea: Can We Improve the Quality of Life of Patients with Short-Term Hypothyroidism Induced by Hormone Withdrawal?

Jose´ M. Zubeldia,Hani A. Nabi,Miguel Jimenez del Rio,Jorge Genovese 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.6

Patients treated for differentiated thyroid cancer (DTC) are subjected to periodic surveillance that includes serum thyroglobulin measurements followed by radioiodine administrations for diagnostic and therapeutic purposes if necessary. Both procedures require adequately elevated blood levels of thyroid-stimulating hormone (TSH), which can be achieved by two approaches: parenteral administration of recombinant human TSH (rhTSH) or stopping thyroid hormone replacement until optimal levels of endogenous TSH are achieved. Although rhTSH administration does not require hormone withdrawal, it is not inexpensive and carries the risk of secondary effects. The latter option is simpler but induces a profound state of hypothyroidism, which results in physical and mental complaints that may interfere severely with the patient’s activities of daily living. Rhodiola rosea is a popular plant in traditional medical systems in Eastern Europe and Asia with a reputation for stimulating the nervous system, decreasing depression, enhancing work performance, and eliminating fatigue,all features of clinical hypothyroidism. Investigators have also suggested additional benefits such as cardioprotection or even tumor growth inhibition. Here, we propose R. rosea as a viable alternative treatment for the symptoms of short-term hypothyroidism in patients with DTC who require hormone withdrawal.

Anti-Inflammatory and Wound Healing Potential of Citrus Auraptene

Vu Dang La,Lei Zhao,Francesco Epifano,Salvatore Genovese,Daniel Grenier 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.10

Auraptene is the most abundant naturally occurring geranyloxycoumarin. It is primarily isolated from plants in the Rutaceae family, many of which, like citrus fruits, are used as food in many countries. Auraptene is a biologically active secondary metabolite with valuable properties. The aim of our study was to identify novel properties of auraptene with potential for managing periodontal diseases, an inflammatory disease of bacterial origin affecting the tissues surrounding and supporting the teeth. In vitro assays showed that auraptene decreased, in a dose-dependent manner, the secretion of matrix metalloproteinase 2 as well as key inflammatory mediators, including interleukin-6 (IL-6), IL-8, and chemokine (C-C motif) ligand-5 secreted by Aggregatibacter actinomycetemcomitans lipopolysaccharide-stimulated oral epithelial cells. Using gingival fibroblasts, auraptene showed a significant (P < .05) wound healing effect by its capacity to increase cell migration. In conclusion, auraptene shows promise for promoting wound healing and controlling periodontal diseases through its capacity to interfere with inflammatory mediator secretion.

Evaluation of Antihyperglycemia and Antihypertension Potential of Native Peruvian Fruits Using In Vitro Models

Pinto, Marcia Da Silva,Ranilla, Lena Galvez,Apostolidis, Emmanouil,Lajolo, Franco Maria,Genovese, Maria Ines,Shetty, Kalidas The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.2

Local food diversity and traditional crops are essential for cost-effective management of the global epidemic of type 2 diabetes and associated complications of hypertension. Water and 12% ethanol extracts of native Peruvian fruits such as Lucuma (Pouteria lucuma), Pacae (Inga feuille), Papayita arequipe$\tilde{n}$a (Carica pubescens), Capuli (Prunus capuli), Aguaymanto (Physalis peruviana), and Algarrobo (Prosopis pallida) were evaluated for total phenolics, antioxidant activity based on 2, 2-diphenyl-1-picrylhydrazyl radical scavenging assay, and functionality such as in vitro inhibition of $\alpha$-amylase, $\alpha$-glucosidase, and angiotensin I-converting enzyme (ACE) relevant for potential management of hyperglycemia and hypertension linked to type 2 diabetes. The total phenolic content ranged from 3.2 (Aguaymanto) to 11.4 (Lucuma fruit) mg/g of sample dry weight. A significant positive correlation was found between total phenolic content and antioxidant activity for the ethanolic extracts. No phenolic compound was detected in Lucuma (fruit and powder) and Pacae. Aqueous extracts from Lucuma and Algarrobo had the highest $\alpha$-glucosidase inhibitory activities. Papayita arequipe$\tilde{n}$a and Algarrobo had significant ACE inhibitory activities reflecting antihypertensive potential. These in vitro results point to the excellent potential of Peruvian fruits for food-based strategies for complementing effective antidiabetes and antihypertension solutions based on further animal and clinical studies.

Measurement facility for the evaluation of the backscattering in fiber: Realization of an OTDR operating at single photon level

Piacentini, Fabrizio,Meda, Alice,Traina, Paolo,Suk, Hong Kee,Degiovanni, Ivo Pietro,Brida, Giorgio,Gramegna, Marco,Berchera, Ivano Ruo,Genovese, Marco,Rastello, Maria Luisa World Scientific 2014 INTERNATIONAL JOURNAL OF QUANTUM INFORMATION Vol.12 No.2