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RISS 인기검색어
- 검색키워드
- 저자 : Luigi Menghini (검색결과 5 건)
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Luigi Menghini,Paola Massarelli,Giancarlo Bruni,Alessandro Menghini 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.2
We studied the anti-inflammatory and analgesic activity of extracts ofSideritis syriacaL. herba. Samples werecollected from the wild plant, dried, powdered, and extracted with hexane and methanol. The extracts were evaporated to dry-ness and then suspended in suitable solvent. They were then tested for anti-inflammatory activity in the carrageenin rat pawedema test and for analgesic activity in the Randall and Selitto test and in the tail-flick test. At 24 hours after the treatment,the gastric mucosa of each rat was observed macroscopically. Based on these results the hexane extract was fractionated bycolumn chromatography, and the fractions were obtained tested in the same way. Results showed interesting anti-inflamma-tory activity only for the hexane extract and all the fractions obtained from it. All the extracts and all the other fractionsshowed both peripheral and central analgesic activity. In rats treated with the tested compounds hyperemia and ulcers wereabsent. The data from this preliminary study reveal interesting pharmacological properties of S. syriacaL. herbaextracts re-lated to the marked analgesic activity and the absence of gastric ulcerogenic activity. The same is for anti-inflammatory ac-tivity, but in this case it seems to be related only to the apolar fraction.
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Antioxidant Effects of Garlic in Young and Aged Rat Brain In Vitro
Luigi Brunetti,Luigi Menghini,Giustino Orlando,Lucia Recinella,Sheila Leone,Francesco Epifano,Francesco Lazzarin,Annalisa Chiavaroli,Claudio Ferrante,Michele Vacca 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.5
Oxidative stress plays a key role in the pathogenesis of age-related neurodegeneration, and the nonenzymatic production of 8-iso-prostaglandin F2α (8-iso-PGF2α) may represent a reliable index of cellular oxidative damage. Garlic (Allium sativum) has been associated with peripheral antioxidant activities and therefore might prevent or reverse 8-iso-PGF2α production, but scant data are available on its possible neuroprotective effects. Therefore, we have studied the possible antioxidant effects of a garlic extract in rat brain synaptosomes obtained from young (3-month-old) and aged (14-month-old) male Wistar rats that were perfused, in vitro, with graded concentrations of a garlic extract (10–500μg/mL). Release in the effluent was evaluated, both in the basal state and after hydrogen peroxide-induced oxidative stress. In young rats, we observed a concentration-dependent inhibitory effect of the garlic extract on brain 8-iso-PGF2α production, both basally and after hydrogen peroxide-induced oxidative stimulus. In aged rats, 8-iso-PGF2α production was not affected by the garlic extract in the basal state, whereas, after hydrogen peroxide-induced oxidative stimulus, an antioxidant effect of the garlic extract appeared only at the higher concentration tested. In conclusion, garlic supplementation could be effective in preventing brain oxidative damage in young animals, whereas the aging brain seems to be resistant to the antioxidant effects of garlic, in vitro.
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Luigi Menghini,Lidia Leporini,Bruno Tirillini,Francesco Epifano,Salvatore Genovese 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
The chemical composition of the essential oil obtained from Apium nodiflorum (L.) Lag. (Family Apiaceae), a plant used in the ethnomedical traditions of the Abruzzo region (Central Italy) as a culinary herb, as a diuretic, and to cure stomachache, was analyzed by gas chromatography/mass spectrometry, and 14 components were identified. Limonene (27.72 %), p-cymene (23.06%), myristicine (18.51%), and β-pinene (6.62%) were the main components. The antimicrobial activity of the essential oil was assayed in vitro against Helicobacter pylori (strain DSMZ 4867), resulting in a minimum inhibitory concentration value of 12.5μg/mL.
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Anti-Inflammatory and Analgesic Effects of Spartium junceum L. Flower Extracts: A Preliminary Study
Luigi Menghini,Paola Massarelli,Giancarlo Bruni,Rita Pagiotti 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.3
Our objective was to study the anti-inflammatory and analgesic activity of extract of Spartium junceumL.flowers. Samples of flowers were collected from wild plants, dried, powdered, and extracted with hexane and methanol. Theextracts were evaporated to dryness and then suspended in suitable solvent. They were then tested for anti-inflammatory ac-tivity in the carrageenin rat paw edema test and for analgesic activity in the Randall and Selitto mechanical pressure test andin the tail-flick test. Twenty-four hours after treatment, the gastric mucosa of each rat was observed macroscopically. Basedon these results the hexane extract was fractioned by column chromatography, and the fractions obtained were tested in thesame way. The results showed good anti-inflammatory activity only for a single fraction of the hexane extract, while all theextracts and all the other hexane fractions showed both peripheral and central analgesic activity. In rats treated with the testedcompounds hyperemia and ulcers were absent. The data from this preliminary study reveal interesting pharmacological prop-erties of S. junceumL. flowers extract related to the marked analgesic activity and the absence of gastric ulcerogenic activ-ity.
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Phytochemical Investigation on Leaf Extract of Cordia salicifolia Cham.
Luigi Menghini,Francesco Epifano,Lidia Leporini,Rita Pagiotti,Bruno Tirillini 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1
The dichloromethane extract of leaves of Cordia salicifoliaCham. (Family Boraginaceae) was fractionated bySiO2 column chromatography and analyzed by gas chromatography, gas chromatography-mass spectrometry, and nuclear mag-netic resonance spectroscopy. The apolar extract is characterized by a very high content of (. )-spathulenol (0.53%). The ma-jor component of the extract exhibited a very weak activity as an inhibitor of growth of Helicobacter pylori in vitro(mini-mum inhibitory concentration. 200 .g/mL).
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