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Fabio Garofalo,Dimitrios Christoforidis,Pietro G. di Summa,Béatrice Gay,Stéphane Cherix,Wassim Raffoul,Nicolas Demartines,Maurice Matter 대한대장항문학회 2014 Annals of Coloproctolgy Vol.30 No.3
Purpose: A sacral chordoma is a rare, slow-growing, primary bone tumor, arising from embryonic notochordal remnants. Radical surgery is the only hope for cure. The aim of our present study is to analyse our experience with the challenging treatment of this rare tumor, to review current treatment modalities and to assess the outcome based on R status. Methods: Eight patients were treated in our institution between 2001 and 2011. All patients were discussed by a multidisciplinary tumor board, and an en bloc surgical resection by posterior perineal access only or by combined anterior/posterior accesses was planned based on tumor extension. Results: Seven patients underwent radical surgery, and one was treated by using local cryotherapy alone due to low performance status. Three misdiagnosed patients had primary surgery at another hospital with R1 margins. Reresection margins in our institution were R1 in two and R0 in one, and all three recurred. Four patients were primarily operated on at our institution and had en bloc surgery with R0 resection margins. One had local recurrence after 18 months. The overall morbidity rate was 86% (6/7 patients) and was mostly related to the perineal wound. Overall, 3 out of 7 resected patients were disease-free at a median follow-up of 2.9 years (range, 1.6–8.0 years). Conclusion: Our experience confirms the importance of early correct diagnosis and of an R0 resection for a sacral chordoma invading pelvic structures. It is a rare disease that requires a challenging multidisciplinary treatment, which should ideally be performed in a tertiary referral center.
Mixed Adenoneuroendocrine Gastric Carcinoma: A Case Report and Review of the Literature
Giovanni Battista Levi Sandri,Fabio Carboni,Mario Valle,Alfredo Garofalo,Paolo Visca 대한위암학회 2014 Journal of gastric cancer Vol.14 No.1
We present a rare case of a gastric mixed adenoneuroendocrine tumor and review the related English literature. A 77-year-old Caucasian woman was admitted to our department with nausea, anorexia, weight loss, and anemia. Esophagogastroduodenoscopy showed a large (>7 cm) ulcerative mass in the greater curvature of the stomach. Biopsy showed the presence of an adenocarcinoma with moderate differentiation. The patient underwent D2 subtotal gastrectomy. Histopathological analysis revealed a diagnosis of mixed gastric adenoneuroendocrine carcinoma. The post-operative course was uneventful, and at the 6-month follow-up, the patient was alive without evidence of recurrence. Our review of the English literature suggested that such cases are most often reported from eastern countries. Multimodal treatment should be the aim for these patients because of the neuroendocrine component of the tumor.
Mixed Adenoneuroendocrine Gastric Carcinoma: A Case Report and Review of the Literature
Levi Sandri, Giovanni Battista,Carboni, Fabio,Valle, Mario,Visca, Paolo,Garofalo, Alfredo The Korean Gastric Cancer Association 2014 Journal of gastric cancer Vol.14 No.1
We present a rare case of a gastric mixed adenoneuroendocrine tumor and review the related English literature. A 77-year-old Caucasian woman was admitted to our department with nausea, anorexia, weight loss, and anemia. Esophagogastroduodenoscopy showed a large (>7 cm) ulcerative mass in the greater curvature of the stomach. Biopsy showed the presence of an adenocarcinoma with moderate differentiation. The patient underwent D2 subtotal gastrectomy. Histopathological analysis revealed a diagnosis of mixed gastric adenoneuroendocrine carcinoma. The post-operative course was uneventful, and at the 6-month follow-up, the patient was alive without evidence of recurrence. Our review of the English literature suggested that such cases are most often reported from eastern countries. Multimodal treatment should be the aim for these patients because of the neuroendocrine component of the tumor.
Beaton, Rachael L.,Freedman, Wendy L.,Madore, Barry F.,Bono, Giuseppe,Carlson, Erika K.,Clementini, Gisella,Durbin, Meredith J.,Garofalo, Alessia,Hatt, Dylan,Jang, In Sung,Kollmeier, Juna A.,Lee, Myun American Astronomical Society 2016 The Astrophysical journal Vol.832 No.2
<P>We present an overview of the Carnegie-Chicago Hubble Program, an ongoing program to obtain a 3% measurement of the Hubble constant (H-0) using alternative methods to the traditional Cepheid distance scale. We aim to establish a completely independent route to H-0 using RR Lyrae variables, the tip of the red giant branch (TRGB), and Type Ia supernovae (SNe Ia). This alternative distance ladder can be applied to galaxies of any Hubble type, of any inclination, and, using old stars in low-density environments, is robust to the degenerate effects of metallicity and interstellar extinction. Given the relatively small number of SNe. Ia host galaxies with independently measured distances, these properties provide a great systematic advantage in the measurement of H-0 via the distance ladder. Initially, the accuracy of our value of H-0 will be set by the five Galactic RR Lyrae calibrators with Hubble Space Telescope Fine-Guidance Sensor parallaxes. With Gaia, both the RR Lyrae zero-point and TRGB method will be independently calibrated, the former with at least an order of magnitude more calibrators and the latter directly through parallax measurement of tip red giants. As the first end-to-end 'distance ladder' completely independent of both Cepheid variables and the Large Magellanic Cloud, this path to H-0 will allow for the high-precision comparison at each rung of the traditional distance ladder that is necessary to understand tensions between this and other routes to H-0.</P>
Control of plasma profiles in DIII-D discharges
Gohil, P,Evans, T E,Ferron, J R,Moyer, R A,Petty, C C,Burrell, K H,Casper, T A,Garofalo, A M,Hyatt, A W,Jayakumar, R J,Kessel, C,Kim, J Y,La Haye, R J,Lohr, J,Luce, T C,Makowski, M A,Mazon, D,Menard, Published jointly by The Institute of Physics and 2006 Plasma physics and controlled fusion Vol.48 No.a5
<P>Active control of plasma profiles is an essential requirement for operating within plasma stability limits, for steady-state operation and for optimization of the plasma performance. In DIII-D, plasma profiles have been actively controlled using various actuators in the following manner: (a) real time closed loop control of the <I>q</I> profile evolution using electron cyclotron heating and neutral beam injection as actuators; (b) active control of the density and pressure profiles in quiescent H-mode and quiescent double barrier plasmas using electron cyclotron current drive (ECCD) and pellet injection; (c) active control of the edge profiles to suppress edge localized modes using resonant magnetic perturbation with toroidal mode number <I>n</I> = 3, (d) real time control of the current density profile to suppress neoclassical tearing modes using localized deposition of co-ECCD.</P>