ELECTROCHEMICAL Co 3 O 4 NANOPOROUS THIN FILMS SENSOR FOR HYDROGEN PEROXIDE DETECTION

GUANG SHENG CAO,RUILIN WANG,PEILONG WANG,XIN LI,YUE WANG,JUNPING LI,GUILONG WANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.4

The nanoporous Co 3 O 4 thin ¯lms were prepared on indium tin oxide (ITO) glasses by anelectrodeposition method. The surface morphology and composition of the nanoporous Co 3 O 4¯lms were characterized by scanning electron microscopy (SEM), energy-dispersive X-rayanalysis (EDS) and X-ray photoelectron spectroscopy (XPS). The results show that the as-deposited nanoporous Co 3 O 4 ¯lm is constructed by many interconnected nano°akes withthickness of about 40 nm. The cyclic voltammetry (CV) measurement indicates that thenanoporous Co 3 O 4 ¯lms exhibit remarkable electrocatalytic activities for the hydrogen peroxide(H 2 O 2 ) reduction which shows that it is a good candidate to be employed as electrode materialsfor electrochemical sensing of H 2 O 2 . Further analysis indicated that the detection sensitivityof the sensor was 1.357 mA mM? 1 cm? 2 and the detection limit was estimated to be about0.2 mM.

Efficacy of First-line Chemotherapy Affects the Second-Line Setting Response in Patients with Advanced Non-Small Cell Lung Cancer

Cao, Wa,Li, Ai-Wu,Ren, Sheng-Xiang,Chen, Xiao-Xia,Li, Wei,Gao, Guang-Hui,He, Ya-Yi,Zhou, Cai-Cun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

Background: Chemotherapy is the mainstay of treatment for the majority of patients with advanced non-small cell lung cancer (NSCLC) without driver mutations and many receive therapies beyond first-line. Second-line chemotherapy has been disappointing both in terms of response rate and survival and we know relatively little about the prognostic factors. Materials and Methods: One thousand and eight patients with advanced NSCLC who received second-line chemotherapy after progression were reviewed in Shanghai Pulmonary Hospital, China, from September 2005 to July 2010. We analyzed the effects of potential prognostic factors on the outcomes of second-line chemotherapy (overall response rate, ORR; progression free survival, PFS; overall survival, OS). Results: The response and progression free survival of first-line chemotherapy affects the ORR, PFS and OS of second-line chemotherapy (ORR: CR/PR 15.4%, SD 10.1%, PD2.3%, p<0.001; PFS: CR/PR 3.80 months, SD 2.77 months, PD 2.03 months, p<0.001; OS: CR/PR 11.60 months, SD 10.33 months, PD 6.57 months, p=0.578, p<0.001, p<0.001, respectively). On multivariate analysis, better response to first-line therapy (CR/PR: HR=0.751, p=0.002; SD: HR=0.781, p=0.021) and progression within 3-6 months (HR=0.626, p<0.001), together with adenocarcinoma (HR=0.815, p=0.017), without liver metastasis (HR=0.541, p=0.001), never-smoker (HR=0.772, p=0.001), and ECOG PS 0-1 (HR=0.745, p=0.021) were predictors for good OS following second-line chemotherapy. Conclusions: Patients who responded to first-line chemotherapy had a better outcome after second-line therapy for advanced NSCLC, and the efficacy of first-line chemotherapy, period of progression, histology, liver metastasis, smoking status and ECOG PS were independent prognostic factors for OS.

Expression and Prognostic Role of MEKK3 and pERK in Patients with Renal Clear Cell Carcinoma

Chen, Qi,Lu, Hong-sheng,Gan, Mei-fu,Chen, Lan-xi,He, Kai,Fan, Guang-min,Cao, Xue-quan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

Mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3 (MEKK3) is an important serine/threonine protein kinase and a member of the MAPK family. MEKK3 can effectively activate the MEK/ERK signaling pathway and promote an autocrine growth loop critical for tumor genesis, cell proliferation, terminal differentiation, apoptosis and survival. To explore the relationship between MEKK3 and cell apoptosis, clinicopathology and prognosis, we characterize the expression of MEKK3, pERK and FoxP3 in the renal clear cell carcinoma (RCCC). Protein expression was detected by tissue microarray and immunochemistry in 46 cases of RCCC and 28 control cases. Expression levels of CD3+,CD3+CD4+,CD3+CD8+,CD4+CD25+, CD4+CD25+ FoxP3+ were assessed by flow cytometry and analyzed for their association with pathological factors, correlation and prognosis in RCCC. Expression of MEKK3, pERK and FoxP3 was significantly up-regulated in RCCC as compared to control levels (p<0.01), associated with pathological grade (p<0.05)and clinical stage (p<0.05). CD4+CD25+ Foxp3+ Treg cells were also significantly increased in RCCC patients (p<0.05). Cox multivariate regression analysis showed that MEKK3, pERK expression and patholigical stage were independent prognostic factors in patients with RCCC (p<0.05). MEKK3 can be used as an important marker of early diagnosis and prognostic evaluation in RCCC. It may be associated with imbalance of anti-tumor immunity and overexpression of pERK. Expression of MEKK3 and pERK are significantly increased in RCCC, with protein expression and clinical stage acting as independent prognostic factors.

Lack of any Prognostic Value of Body Mass Index for Patients Undergoing Chemoradiotherapy for Esophageal Squamous Cell Carcinoma

Zhang, Fang,Wang, Chuan-Sheng,Sun, Bo,Tian, Guang-Bo,Cao, Fang-Li,Cheng, Yu-Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Background: The relationship between body mass index(BMI) and outcomes after chemoradiotherapy(CRT) has not been systematically addressed. The purpose of this study was to evaluate the effect of BMI on survival in patients with esophageal squamous cell carcinoma (ESCC). Materials and Methods: Sixty ESCC cases were retrospectively reviewed in this study. Patient overall survival(OS) and disease-free survival (DFS) were compared between two groups (BMI< $24.00kg/m^2$ and $BMI{\geq}24.00kg/m^2$). Results: There were 41 patients in the low/normal BMI group (BMI< $24.00kg/m^2$) and 19 in the high BMI group ($BMI{\geq}24.00kg/m^2$). No significant differences were observed in patient characteristics between these. We found no difference in 2-year OS and DFS associated with BMI (p=0.763 for OS; p=0.818 for DFS) using the Kaplan-Meier method. Univariate analysis revealed that higher clinical stage was prognostic for worse 2-year OS and DFS, metastasis for 2-year OS, lymph node status for 2-year DFS, while age, gender, smoking, drinking, tumor location and BMI were not prognostic. There were no differences in the 2-year OS (hazard ratio=1.117; p=0.789) and DFS(hazard ratio=1.161; p=0.708) between BMI groups in multivariate analysis, whereas we found statistical differences in the 2-year OS and DFS associated with clinical stage, gender and tumor infiltration (p<0.04), independent of age, smoking, drinking, tumor location, the status of lymph node metastases and BMI. Conclusions: BMI was not associated with survival in patients with ESCC treated with CRT as primary therapy. BMI should not be considered a prognostic factor for patients undergoing CRT for ESCC.

Influence of Chongcao Yigan Capsule on Function of Intestinal Flora and Chemoprevention for Patients with Chronic Hepatitis B-Induced Liver Fibrosis

Zhao, Xiao-Hu,Cao, Zheng-Yu,Shen, Yang,Lv, Yu-Feng,Tao, Guang-Rong,Chen, Sheng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Objective: Hapatitis B visus (CHB)-induced fibrosis is a precancerous condition of liver. To explore the influence of Chongcao Preparation (Chongcao Yigan Capsule) on the function of intestinal flora and chemoprevention for patients with CHB-induced liver fibrosis. Methods: A total of 136 patients with CHB-induced liver fibrosis were randomly divided into control group treated with lamivudine (LAM) and research group added with Chongcao Yigan Capsule for totally 48 weeks. The changes of intestinal flora, secretory immunoglobin A (SIgA), serum albumin (ALB), prealbumin (PALB), IgA and IgG at different time points in both groups were observed. Results: Before treatment, there was no significant difference between two groups in each index (P>0.05). After treatment, the intestinal flora were evidently optimized in research group than treatment before (P<0.05 or P<0.01), and were apparently better than those in control group (P<0.05 or P<0.01); SIgA was obviously increased and ALB, PALB, IgA and IgG were markedly improved in research group than treatment before (P<0.05 or P<0.01), and were significantly better than those in control group (P<0.05 or P<0.01). Conclusions: Chongcao Yigan Capsule could regulate the intestinal flora, increase SIgA, serum ALB and PALB concentrations and significantly improve serum IgA and IgG as well as strengthen the immunological function and autologous repair capacity of patients with CHB-induced liver fibrosis.

Study on Enhancing Lightning Protection Scheme of Catenary in Subway Viaduct Section

Li, Rui-Fang,Chen, Kui,Chen, Li-Sheng,Cao, Xiao-Bin,Wu, Guang-Ning,Zhang, Xue-Qin The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.2

Viaduct increases the height of subway catenary, namely magnifies lightning attraction scope that lead to higher possibility of suffering lightning stroke. Therefore, it is necessary to analyze performance of lightning striking to catenary of subway in viaduct section and propose an improving lightning protection scheme. In this paper, using ATP-EMTP simulation software to establish an associated model to evaluate lightning withstand level of catenary with existing lightning protection schemes including arrester and grounding point, an improving lightning protection scheme is proposed - every pillar ground earth and arresters are installed with some installing spacing between 200m to 400m based on lightning damage degree and reliability requirements - according to analyzing results: while lightning withstand level is lowest for lightning striking to the neutral pillar, lightning withstand level is greatest for lightning striking to the both-ends pillar that arrester and grounding point are both installed; grounding point could obviously improve lightning withstand level for lightning striking to ground wire while arrester could obviously improve the lightning withstand level for lightning striking to catenary; every pillar ground earth could enhance the lowest lightning withstanding level up to 2.5 times than of that pillar ground earth across every 200m.

Study on Enhancing Lightning Protection Scheme of Catenary in Subway Viaduct Section

Rui-Fang Li,Kui Chen,Li-Sheng Chen,Xiao-Bin Cao,Guang-Ning Wu,Xue-Qin Zhang 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.2

Viaduct increases the height of subway catenary, namely magnifies lightning attraction scope that lead to higher possibility of suffering lightning stroke. Therefore, it is necessary to analyze performance of lightning striking to catenary of subway in viaduct section and propose an improving lightning protection scheme. In this paper, using ATP-EMTP simulation software to establish an associated model to evaluate lightning withstand level of catenary with existing lightning protection schemes including arrester and grounding point, an improving lightning protection scheme is proposed — every pillar ground earth and arresters are installed with some installing spacing between 200m to 400m based on lightning damage degree and reliability requirements — according to analyzing results: while lightning withstand level is lowest for lightning striking to the neutral pillar, lightning withstand level is greatest for lightning striking to the both-ends pillar that arrester and grounding point are both installed; grounding point could obviously improve lightning withstand level for lightning striking to ground wire while arrester could obviously improve the lightning withstand level for lightning striking to catenary; every pillar ground earth could enhance the lowest lightning withstanding level up to 2.5 times than of that pillar ground earth across every 200m.