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      • SCOPUSKCI등재

        Bond Distortion and Electron States in Charged $C_{60}{^2-}$

        Fu, Rong-Tang,Fu, Rou-Li,Lee, Kee-Hag,Sun, Xin,Ye, Hong-Juan Korean Chemical Society 1993 Bulletin of the Korean Chemical Society Vol.14 No.6

        By considering both electron-electron and electron-lattice interactions, the effect of charge transfer on the bond structure and electronic states of $C_{60}$ is studied without configuration limitation. The results show that the electron-electron interaction does not eliminate the layer structure of the bond distortion and the self-trapping of transferred electrons. For charged ${C_{60}}^{2-}$, there exist two localized electronic states, which possess laminar wave functions, and four nonequivalent groups of carbon atoms, which induce a fine-structure in the NMR spectrum line.

      • KCI등재

        High‑Temperature Deformation Behavior of Duplex Mg–8.41Li–1.80Al–1.77Zn Alloy Processed by Friction Stir Processing

        Fu Rong Cao,Guo Qiang Xue,Bi Jin Zhou,Shun Cheng Wang 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.3

        To explore the ductility, a novel Mg–8.41Li–1.80Al–1.77Zn (designated as LAZ822) alloy was fabricated by casting,hot rolling and friction stir processing. The maximum elongation to failure of 489.5% was demonstrated in a fine-grainedLAZ822 alloy at a temperature of 573 K and an initial strain rate of 1.67 × 10−4 s−1. The true stress exponent of 2, the grainsize exponent of 2 and the activation energy of 89.44–121.14 kJ/mol confirm that grain boundary sliding controlled by latticediffusion governs the rate-controlling deformation process at the temperatures of 523 and 573 K. The viscous resistancemodels of dual phases were newly established. At 573 K, the lattice viscous resistance of the α-Mg phase is 2644 times aslarge as that of the β-Li phase, whereas the grain boundary viscous resistance of the α-Mg phase is 3.3 times as large as thatof the β-Li phase. Some α-Mg grains remain in an equiaxed state while the other α-Mg grains become connected at elevatedtemperatures. This experimental evidence corroborates the existence of dynamic grain connection growth. Cavity growthmechanism maps were constructed. The maps reveal that power-law cavity growth or strain controlled cavity growth is thepredominant cavity growth mechanism.

      • GRP78 Secreted by Colon Cancer Cells Facilitates Cell Proliferation via PI3K/Akt Signaling

        Fu, Rong,Yang, Peng,Wu, Hai-Li,Li, Zong-Wei,Li, Zhuo-Yu Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

        Glucose regulated protein 78 (GRP78) is usually recognized as a chaperone in the endoplasmic reticulum. However, increasing evidence indicates that GRP78 can be translocated to the cell surface, acting as a signaling receptor for a variety of ligands. Since little is known about the secretion of GRP78 and its role in the progression of colon cancer we here focused on GRP78 from colon cancer cells, and purified GRP78 protein mimicking the secreted GRP78 was able to utilize cell surface GRP78 as its receptor, activating downstream PI3K/Akt and Wnt/${\beta}$-catenin signaling and promote colon cancer cell proliferation. Our study revealed a new mode of action of autocrine GRP78 in cancer progression: secreted GRP78 binds to cell surface GRP78 as its receptor and activates intracellular proliferation signaling.

      • KCI등재

        Localization of QTLs for Husk Proportion and Lignin Content Using a High-Density Genetic Linkage Map of Brassica napus

        Fu You Fu,Lie Zhao Liu,You Rong Chai,Li Chen,Tao Yang,Ai Fen Ma,Cun Ming Qu,Lin Jiang,Zheng Sheng Zhang,Jia Na Li 한국유전학회 2007 Genes & Genomics Vol.29 No.3

        Husk proportion (HP) and lignin content (LC) are two important traits of seed quality of B. napus. Efficient selection of these two traits is an important way to improve the seed quality in meal improvement. A set of recombinant inbred lines (RILs) of B. napus (GH06 × Zhongyou 821) was used for mapping QTLs of HP and LC in a two-year study in different environments. 509 markers (78 SSR markers, 66 RAPD markers and 365 SRAP markers) were mapped on 26 linkage groups with an average length of 73.96 cM. The map covered a total of 1923 cM, and the average distance between two adjacent markers was 3.78 cM. Analysis of variance of LC and HP indicated that. LC might not be significantly affected by environment (F = 2.96 < 3.02) and HP might be affected by genotype × environment interactions. A total of 15 significant QTLs were detected in eight linkage groups with a LOD threshold value of 2.5 (LR ≥ 11.5) by CIM, explaining 4.99-16.14% of phenotype variation. Some QTLs of LC and HP were detected in near regions of the same linkage groups, such as qLCBB05-6-1 and qLCWZ06-6-1, qLCBB05-10-2 and qLCBB06-10-1 and qLCWZ06-10-2, qHPBB05-9-3 and qHPBB06-9-1, qHPBB05-10-4 and qHPBB06-10-2 and qHPBB06-10-3 and qHPWZ06-10-1. This study indicates that the repeatedly detected QTLs of LC and HP might be major-effect QTLs of LC and HP.

      • KCI등재

        양귀자 장편소설의 남성 주체 재현 양상

        FU RONG 춘원연구학회 2022 춘원연구학보 Vol.- No.25

        이 글은 90년대 양귀자의 장편소설에 나타난 남성성의 재현 양상을 살펴봄으로써 양귀자가 헤게모니적 남성성에 부합하지 않는 중년 남성 인물을 창작함으로써 이분법적 젠더 규범의 틀을 무너뜨리고자 하는 것에 관심을 두었다는 점을 입증하고자 했다. 기존의 연구들은 양귀자의 첫 장편소설을 외면하거나 다른 장편소설의 대중성이나 페미니즘적인 양상만을 집중적으로 연구해 왔다. 본고는 양귀자가 90년대에 창작한 장편소설 세 편을 연구 대상으로 선정해 남성학적인 시각으로 남성과 남성 사이의 보이지 않는 위계질서를 깊이 들여다보고자 한 것이다. 남성 운동의 맥락에서 양귀자 장편소설에 등장한 중년 남성 인물들을 보면 이들은 각각 생계부양자 역할의 정당성에 대한 문제 제기, 남성의 내면적 감수성 인정, 능동적으로 부성의 회복 등 중요한 의제들을 다루고 있었다. 2장은 자본주의 억압 구조가 남녀 성별 분업 역할을 강화하고 남성에게 가족생계부양자의 역할을 강요했다는 점을 살펴보았다. 『희망』에서 금전적인 수입이 없는 우연 아버지의 아메리칸 드림은 가정 내부 구성원들에 의해서 단지 조롱과 비난만 받는 실정이고 찌르레기 아저씨의 중동 취업은 가난으로부터의 탈출 전략으로 여겨졌지만 끝내 성공적으로 작동하지 못한다.『모순』의 주인공 안진진의 아버지는 실직과 사업 실패로 인해 산업화 시기의 헤게모니적 남성성과 거리가 먼 존재로 주변화되었던 멜랑콜리 주체이다. 작가는 세 중년 남성의 삶을 재현함으로써 자본을 가지지 못한 남성에게는 인간으로서의 자리조차 보장되지 않는다는 점을 보여준다. 청년 세대들이 중년 세대에게 보내는 동정과 연민, 신뢰와 인정은 비규범적인 남성들의 입장을 깊이 이해한 양귀자의 작가 의식을 반영한다. 3장에서는 『나는 소망한다 내게 금지된 것을』을 연구 대상으로 삼아 강민주의 마음을 바꾸게 한 것은 백승하에 대한 사랑이라기보다 그의 부성애 때문이라는 독해 방식을 새로 제기하였다. 이 소설에는 강민주가 백승하라는 중개자를 경유해서 욕망의 대상인 부성애에 가까이 다가갈 수 있었음을 보여주는 동시에 가정 안에서 아버지의 역할을 되찾고자 한 남성들의 시대적 욕구도 어느 정도 반영되어 있다. 이는 90년대 ‘좋은 아버지 되기’ 운동과 연관 지어서 검토할 때 90년대 한국 남성학 운동의 한 단면을 보여준 것이라고 할 수 있다.

      • KCI등재

        Microstructural Evolution and Dynamic Recrystallization Behavior of the Homogenized 2195 Al–Li Alloy During Hot Deformation

        Rong Fu,Yuanchun Huang,Yu Liu,Hui Li 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.9

        The thermal deformation behavior in homogenized 2195 Al–Li alloy was studied at different deformation temperatures(370–520 °C and strain rates (0.001–1 s−1). The flow stress decreases with decreasing strain rate or increasing temperature. The significant decrease in flow stress from 370 to 420 °C is related to the fact that movements of dislocations and (sub)grain boundaries at low temperatures are hindered by the dynamic precipitation of numerous fine secondary phases (mainlyAl2CuLi(T1) phases). Meanwhile, it was found that flow localization regions appear in the microstructure at 370 °C/1 s−1. Besides, DRX and DRV increase with decreasing lnZ (Zener–Hollomon parameter) values, particularly for lnZ values lessthan 26.32 (520 °C/0.1 s−1). The DRX mechanism was discussed for different lnZ based on the variation of misorientationangle and the characteristics of different DRXs. The DDRX is dominant when lnZ ≥ 30.70; CDRX and DDRX dominate at30.70 > lnZ > 26.32; CDRX mainly occurs at lnZ ≤ 26.32; when lnZ value decreases to 21.72, DRX grains with the characteristicsof CDRX and GDRX appear.

      • SCIESCOPUSKCI등재
      • Paris polyphylla Smith Extract Induces Apoptosis and Activates Cancer Suppressor Gene Connexin26 Expression

        Li, Fu-Rong,Jiao, Peng,Yao, Shu-Tong,Sang, Hui,Qin, Shu-Cun,Zhang, Wei,Zhang, Ya-Bin,Gao, Lin-Lin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

        Background: The inhibition of tumor cell growth without toxicity to normal cells is an important target in cancer therapy. One possible way to increase the efficacy of anticancer drugs and to decrease toxicity or side effects is to develop traditional natural products, especially from medicinal plants. Paris polyphylla Smith has shown anti-tumour effects by inhibition of tumor promotion and inducement of tumor cell apoptosis, but mechanisms are still not well understood. The present study was to explore the effect of Paris polyphylla Smith extract (PPSE) on connexin26 and growth control in human esophageal cancer ECA109 cells. Methods: The effects of PPSE on Connexin26 were examined by RT-PCR, western blot and immunofluorescence; cell growth and proliferation were examined by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay. Results: PPSE inhibited the growth and proliferation on esophageal cancer ECA109 cells, while increasing the expression of connexin26 mRNA and protein; conversely, PPSE decreased Bcl-2 and increased Bad. Conclusion: This study firstly shows that PPSE can increase connexin26 expression at mRNA and protein level, exerting anti-tumour effects on esophageal cacner ECA109 cells via inhibiting cell proliferation and inducing cell apoptosis.

      • Some Motifs Were Important for Myostatin Transcriptional Regulation in Sheep (Ovis aries)

        Du, Rong,An, Xiao-Rong,Chen, Yong-Fu,Qin, Jian Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.4

        Many motifs along the 1.2 kb myostatin promoter (MSTNpro) in sheep have been found by the MatInspecter program in our recent study. To further verify the role of the motifs and better understand the transcriptional regulation mechanism of the myostatin gene in sheep, the reporter gene EGFP (enhanced green fluorescent protein) was selected and the wild-type (W) vector MSTNPro$^W$-EGFP or motif-mutational (M) vector MSTNPro$^M$-EGFP were constructed. The transcriptional regulation activities were analyzed by detecting the fluorescence strength of EGFP in C2C12 myoblasts transfected with the vectors. The results showed that E-box (E) 3, E4, E5 and E7, particularly E3, E5 and E7, had important effects on the activity of the 1.2 kb sheep myostatin promoter. In addition, we also detected several other important motifs such as MTBF (muscle-specific Mt binding factor), MEF2 (myocyte enhancer factor 2), GRE (glucocorticoid response elements) and PRE (progesterone response elements) along the sheep myostatin promoter by the mutational analysis.

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