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Motion-based Optimum Design of a Slender Steel Footbridge and Assessment of Its Dynamic Behaviour
Javier Fernando Jiménez-Alonso,Andres Sáez 한국강구조학회 2017 International Journal of Steel Structures Vol.17 No.4
The improvement of construction materials together with the current aesthetic requirements has led the modern footbridges to a continuous increase in their slenderness. For this reason, the design of their structural systems is mainly conditioned by its dynamic response under pedestrian action. For long-span footbridges, control devices are needed to prevent unacceptable dynamic responses while providing economical designs. However, for medium-span footbridges, it is still possible to control their dynamic response via the modification of their natural frequencies. In this paper, an alternative motion-based design method is first proposed and further implemented for the design of a real footbridge. The main idea of this approach is to optimally determine the structural stiffness distribution to verify an adequate comfort class, while minimizing the self-weight. Furthermore, the uncertainties of its modal parameters are considered during its design. After the construction of the footbridge, its dynamic behaviour was experimentally assessed, with satisfactory results.
Jaqueline López-Ochoa,J. Fernando Montes-García,Candelario Vázquez,Patricia Sánchez-Alonso,Victor M. Pérez-Márquez,Patrick J. Blackall,Sergio Vaca,Erasmo Negrete-Abascal 한국미생물학회 2017 The journal of microbiology Vol.55 No.9
Gallibacterium, which is a bacterial pathogen in chickens, can form biofilms. Amyloid proteins present in biofilms bind Congo red dye. The aim of this study was to characterize the cell-surface amyloid-like protein expressed in biofilms formed by Gallibacterium strains and determine the relationship between this protein and curli, which is an amyloid protein that is commonly expressed by members of the Enterobacteriaceae family. The presence of amyloid-like proteins in outer membrane protein samples from three strains of G. anatis and one strain of Gallibacterium genomospecies 2 was evaluated. A protein identified as elongation factor-Tu (EF-Tu) by mass spectrometric analysis and in silico analysis was obtained from the G. anatis strain F149T. This protein bound Congo red dye, cross-reacted with anti-curli polyclonal serum, exhibited polymerizing properties and was present in biofilms. This protein also reacted with pooled serum from chickens that were experimentally infected with G. anatis, indicating the in vivo immunogenicity of this protein. The recombinant EF-Tu purified protein, which was prepared from G. anatis 12656-12, polymerizes under in vitro conditions, forms filaments and interacts with fibronectin and fibrinogen, all of which suggest that this protein functions as an adhesin. In summary, EF-Tu from G. anatis presents amyloid characteristics, is present in biofilms and could be relevant for the pathogenesis of G. anatis.
Unusual muscle of the anterior neck: cadaveric findings with surgical applications
Joe Iwanaga,Yoko Tabira,Christian Fisahn,Fernando Alonso,Koichi Watanabe,Jingo Kusukawa,Rod J. Oskouian,R. Shane Tubbs,Koh-ichi Yamaki 대한해부학회 2017 Anatomy & Cell Biology Vol.50 No.3
The omohyoid muscle typically has an inferior belly originating from the superior border of the scapula, and then passes deep to the sternocleidomastoid muscle where its superior belly passes almost vertically upward next to the lateral border of sternohyoid to attach to the inferior border of the body of the hyoid bone lateral to the insertion of sternohyoid. Herein, we report an unusual variant of the omohyoid and sternohyoid muscles. As the omohyoid muscle is commonly used as a surgical landmark during neck dissections, knowledge of its variations such as the one described in the current report is important to surgeons.
Role of Choline in the Modulation of Degenerative Processes: In Vivo and In Vitro Studies
Tania Merinas-Amo,Inmaculada Tasset-Cuevas,Antonio M. Dıaz-Carretero,Angeles Alonso-Moraga,Fernando Calahorro 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.3
The purpose of the present study was to examine the nutraceutical potential of choline as an added value to its well-known brain nutrient role. Several toxicity, antitoxicity, genotoxicity, antigenotoxicity, and longevity endpoints were checked in the somatic mutation and recombination test in in vivo Drosophila animal model. Cytotoxicity in human leukemia-60 cell line (HL-60) promyelocytic and NIH3T3 mouse fibroblast cells, proapoptotic DNA fragmentation, comet assay, methylation status, and macroautophagy (MA) activity were tested in in vitro assays. Choline is not only safe but it is also able to protect against the DNA damage caused by an oxidative genotoxin. Moreover, it improves the life extension in the animal model. The in vitro results show that it is able to exhibit genetic damage against leukemia HL-60 cells. Single-strand breaks in DNA are observed at the molecular level in treatments with choline, although only a significant hypermethylation on the long interspersed elements-1 and a hypomethylation on the satellite-alpha DNA repetitive DNA sequences of HL-60 cells at the lowest concentration (0.447 mM) were observed. Besides, choline decreased MA at the lower assayed concentration and the MA response to topoisomerase inhibitor (etoposide) is maintained in the presence of treatment with 0.22 mM choline. Taking into account the hopeful results obtained in the in vivo and in vitro assays, choline could be proposed as a substance with an important nutraceutical value for different purposes.