Improvement single-wall carbon nanotubes (SWCNTs) based on functionalizing with monomers 2-hydroxyethylmethacryate (HEMA) and N-vinylpyrrolidone (NVP) for pharmaceutical applications as cancer therapy

Fatemeh Abbaszadeh,Omid Moradi,Mehdi Norouzi,Omid Sabzevari 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.5

The functionalized carbon nanotubes play significant roles in the fields such as preparation of composite materials and biological technologies. This paper explains the covalent functionalization of single-wall carbon nanotubes (SWCNTs) with biomedical important monomers, 2-hydroxyethylmethacryate (HEMA) and N-vinylpyrrolidone (NVP) by chemical grafting of HEMA and PVP monomers via free radical polymerization. To get carboxylic acid functionalized SWCNTs, first the nanotubes were oxidized with a mixture of nitric acid and sulfuric acid (1:3). Then, the binding of HEMA and NVP onto the surface of SWCNTs was performed by chemical functionalization of HEMA, NVP with acid chloride-bound carbon nanotube by esterification reaction. These results were confirmed by FT-IR and SEM. The cell culture experiments conducted for pharmaceutical applications were used as cancer therapy.

RESOLUTION OF UNMIXED BIPARTITE GRAPHS

Fatemeh Mohammadi,Somayeh Moradi 대한수학회 2015 대한수학회보 Vol.52 No.3

Let G be a graph on the vertex set V (G) = {x1, . . . , xn} with the edge set E(G), and let R = K[x1, . . . , xn] be the polynomial ring over a field K. Two monomial ideals are associated to G, the edge ideal I(G) generated by all monomials xixj with {xi, xj} ∈ E(G), and the vertex cover ideal IG generated by monomials ∏xi∈C xi for all minimal vertex covers C of G. A minimal vertex cover of G is a subset C ⊂ V (G) such that each edge has at least one vertex in C and no proper subset of C has the same property. Indeed, the vertex cover ideal of G is the Alexander dual of the edge ideal of G. In this paper, for an unmixed bipartite graph G we consider the lattice of vertex covers LG and we explicitly describe the minimal free resolution of the ideal associated to LG which is exactly the vertex cover ideal of G. Then we compute depth, projective dimension, regularity and extremal Betti numbers of R/I(G) in terms of the associated lattice.

Prevalence of underweight and wasting in Iranian children aged below 5 years: a systematic review and meta-analysis

Moradi, Yousef,Shadmani, Fatemeh Khosravi,Mansori, Kamyar,Hanis, Shiva Mansouri,Khateri, Rozhin,Mirzaei, Hossein The Korean Pediatric Society 2018 Clinical and Experimental Pediatrics (CEP) Vol.61 No.8

Purpose: Wasting and underweight are the 2 main indicators of children's undernutrition. We aimed to estimate the prevalence of undernutrition at the national level in Iran. Methods: We performed a search for original articles published in international and Iranian databases including MEDLINE, Web of Science, Google Scholar, Scopus, CINHAL (Cumulative Index to Nursing and Allied Health Literature), Scientific Information Database, Irandoc, Iranmedex, and Magiran during January 1989-August 2017. Seven keywords, in English and Persian, including malnutrition, protein energy malnutrition, growth disorders, underweight wasting, weight loss, children below 5 years old, and children, were used to search the databases. Results: Finally, 17 articles were included in the meta-analysis, based on which the prevalence of underweight and wasting in Iranian children were estimated to be 11% and 5%, respectively. The prevalence rates of underweight among children in the central, western, southern, and northern parts of Iran and at the national level were 24%, 5%, 20%, 17%, and 6%, respectively. The prevalence rates of wasting in the central, western, southern, and northern parts of Iran and at the national level were 9%, 4%, 11%, 5%, and 4%, respectively. Conclusion: Although the prevalence of underweight and wasting in Iran was low, some parts of the country showed high prevalence. The main reason behind this difference in the prevalence of malnutrition may be due to the level of development in different regions.

RESOLUTION OF UNMIXED BIPARTITE GRAPHS

Mohammadi, Fatemeh,Moradi, Somayeh Korean Mathematical Society 2015 대한수학회보 Vol.52 No.3

Let G be a graph on the vertex set $V(G)=\{x_1,{\cdots},x_n\}$ with the edge set E(G), and let $R=K[x_1,{\cdots},x_n]$ be the polynomial ring over a field K. Two monomial ideals are associated to G, the edge ideal I(G) generated by all monomials $x_i,x_j$ with $\{x_i,x_j\}{\in}E(G)$, and the vertex cover ideal $I_G$ generated by monomials ${\prod}_{x_i{\in}C}{^{x_i}}$ for all minimal vertex covers C of G. A minimal vertex cover of G is a subset $C{\subset}V(G)$ such that each edge has at least one vertex in C and no proper subset of C has the same property. Indeed, the vertex cover ideal of G is the Alexander dual of the edge ideal of G. In this paper, for an unmixed bipartite graph G we consider the lattice of vertex covers $L_G$ and we explicitly describe the minimal free resolution of the ideal associated to $L_G$ which is exactly the vertex cover ideal of G. Then we compute depth, projective dimension, regularity and extremal Betti numbers of R/I(G) in terms of the associated lattice.

Prevalence of underweight and wasting in Iranian children aged below 5 years: a systematic review and meta-analysis

Yousef Moradi,Fatemeh Khosravi Shadmani,Kamyar Mansori,Shiva Mansouri Hanis,Rozhin Khateri,Hossein Mirzaei 대한소아청소년과학회 2018 Clinical and Experimental Pediatrics (CEP) Vol.61 No.8

Purpose: Wasting and underweight are the 2 main indicators of children’s undernutrition. We aimed to estimate the prevalence of undernutrition at the national level in Iran. Methods: We performed a search for original articles published in international and Iranian databases including MEDLINE, Web of Science, Google Scholar, Scopus, CINHAL (Cumulative Index to Nursing and Allied Health Literature), Scientific Information Database, Irandoc, Iranmedex, and Magiran during January 1989–August 2017. Seven keywords, in English and Persian, including malnutrition, protein energy malnutrition, growth disorders, underweight wasting, weight loss, children below 5 years old, and children, were used to search the databases. Results: Finally, 17 articles were included in the meta-analysis, based on which the prevalence of underweight and wasting in Iranian children were estimated to be 11% and 5%, respectively. The prevalence rates of underweight among children in the central, western, southern, and northern parts of Iran and at the national level were 24%, 5%, 20%, 17%, and 6%, respectively. The prevalence rates of wasting in the central, western, southern, and northern parts of Iran and at the national level were 9%, 4%, 11%, 5%, and 4%, respectively. Conclusion: Although the prevalence of underweight and wasting in Iran was low, some parts of the country showed high prevalence. The main reason behind this difference in the prevalence of malnutrition may be due to the level of development in different regions.

Assessing the spatial distribution of sports spaces within walking distance in Tehran

Salarvandian Fatemeh,Hosseini Seyed Ali,Moradi Aram,Karoubi Mehdi 서울시립대학교 도시과학연구원 2020 도시과학국제저널 Vol.24 No.4

Spatial equity in urban sports services has received a lot of attention due to the importance of physical activities in public health-related issues. Using GIS network and spatial statistical analysis, a total number of 22 regions in Tehran were studied to investigate the possible differences in terms of physical activity spaces per capita and pedestrian accessibility to sports facilities services. The findings revealed that some regions have an undersupply of sports spaces, while others have insufficient access to these services. Considering the population density, the results showed that the regions with the highest population and residential density have fewest facilities. Unexpectedly, regions with more sports spaces per capita appeared to have the lowest accessibility to the sports facilities. It was also found that having more sports spaces available per capita does not necessarily imply greater accessibility within walking distances. This means major sports facilities are located in areas with relatively minimal opportunities to use them.

In search of subcortical and cortical morphologic alterations of a normal brain through aging: an investigation by computed tomography scan

Mehrdad Ghorbanlou,Fatemeh Moradi,Mohammad Hassan Kazemi-Galougahi,Maasoume Abdollahi 대한해부학회 2024 Anatomy & Cell Biology Vol.57 No.1

Morphologic changes in the brain through aging, as a physiologic process, may involve a wide range of variables including ventricular dilation, and sulcus widening. This study reports normal ranges of these changes as standard criteria. Normal brain computed tomography scans of 400 patients (200 males, 200 females) in every decade of life (20 groups each containing 20 participants) were investigated for subcortical/cortical atrophy (bicaudate width [BCW], third ventricle width [ThVW], maximum length of lateral ventricle at cella media [MLCM], bicaudate index [BCI], third ventricle index [ThVI], and cella media index 3 [CMI3], interhemispheric sulcus width [IHSW], right hemisphere sulci diameter [RHSD], and left hemisphere sulci diameter [LHSD]), ventricular symmetry. Distribution and correlation of all the variables were demonstrated with age and a multiple linear regression model was reported for age prediction. Among the various parameters of subcortical atrophy, BCW, ThVW, MLCM, and the corresponding indices of BCI, ThVI, and CMI3 demonstrated a significant correlation with age (R2≥0.62). All the cortical atrophy parameters including IHSW, RHSD, and LHSD demonstrated a significant correlation with age (R2≥0.63). This study is a thorough investigation of variables in a normal brain which can be affected by aging disclosing normal ranges of variables including major ventricular variables, derived ventricular indices, lateral ventricles asymmetry, cortical atrophy, in every decade of life introducing BW, ThVW, MLCM, BCI, ThVI, CMI3 as most significant ventricular parameters, and IHSW, RHSD, LHSD as significant cortical parameters associated with age.

Health concerns regarding the effect of the COVID-19 pandemic on male fertility

Hamidreza Mosleh,Fatemeh Moradi,Mehdi Mehdizadeh,Marziyeh Ajdary,Alaa Moeinzadeh,Ronak Shabani 대한생식의학회 2021 Clinical and Experimental Reproductive Medicine Vol.48 No.3

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus found in China in 2019. The disease caused by SARS-CoV-2, coronavirus disease 2019 (COVID-19), has been found to be closely related to the cells that secrete angiotensin-converting enzyme 2 (ACE2). ACE2 is involved in the renin-angiotensin system and is widely secreted in several tissues, including the testis, which has raised concerns because organs with high expression of the ACE2 receptor are susceptible to infection. Analyses have shown that in testicular cells, such as spermatogonia, seminiferous duct cells, Sertoli cells, and Leydig cells, there is a high expression level of ACE2. Therefore, SARS-CoV-2 may damage male reproductive tissues and cause infertility. Since male infertility is an important problem, scientists are evaluating whether COVID-19 may influence male infertility through the ACE2 receptor.

Frequency, shape, and estimated volume of intracranial physiologic calcification in different age groups investigated by brain computed tomography scan: a retrospective study

Mehrdad Ghorbanlou,Fatemeh Moradi,Mehdi Mehdizadeh 대한해부학회 2022 Anatomy & Cell Biology Vol.55 No.1

Intracranial calcification is referred to calcification of parenchyma and vascular structures in brain which can be physiologic or pathologic. This study was conducted with the purpose of investigating the frequency, location, pattern, dimensions and estimated volume of intracranial physiologic calcification (IPC) by computer tomography in different age groups. In this cross-sectional retrospective study, brain computed tomography scans of 216 patients were analyzed in 9 age groups each containing 24 patients from 2 to 89 years old. Data were analyzed by SPSS software using one way analysis of variance (ANOVA, post hoc Tukey), chi square, and linear regression tests (P≤0.05 was considered significant). Rate of calcification in different areas were as follows: pineal gland (75.0%), habenula (36.4%), pineohabenula (15.0%), right lateral ventricle choroid plexus (RCP) (67.7%), left lateral ventricle choroid plexus (LCP) (62.7%), falx cerebri (26.8%), petroclinoid ligament (13.2%), tentorium cerebelli (6.8%), third ventricle choroid plexus (0.9%), fourth ventricle choroid plexus (2.7%), basal ganglia (0.9%). A significant correlation exists between the presence of calcification in pineal, habenula, RCP, and LCP (P≤0.001). Nodular shape of calcification was dominant (47.9%). Estimated volume of pineal calcification showed increased levels in group 8 (70-79 years old) compared to group 2 (10-19 years old) (P≤0.05). Since the accurate description of radiologic appearance of IPCs (location, shape, and size) accompanied with age and clinical manifestation is of great importance in diagnosis and distinguishing from pathologic calcification—for example in patients with melatonin dysregulation or schizophrenic patients—this study was required.

Promoter Methylation Status of Two Novel Human Genes, UBE2Q1 and UBE2Q2, in Colorectal Cancer: a New Finding in Iranian Patients

Mokarram, Pooneh,Shakiba-Jam, Fatemeh,Kavousipour, Soudabeh,Sarabi, Mostafa Moradi,Seghatoleslam, Atefeh Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18

Background: The ubiquitin-proteasome system (UPS) degrades a variety of proteins which attach to specific signals. The ubiquitination pathway facilitates degradation of damaged proteins and regulates growth and stress responses. This pathway is altered in various cancers, including acute lymphoblastic leukemia, head and neck squamous cell carcinoma and breast cancer. Recently it has been reported that expression of newly characterized human genes, UBE2Q1 and UBE2Q2, putative members of ubiquitin-conjugating enzyme family (E2), has been also changed in colorectal cancer. Epigenetics is one of the fastest-growing areas of science and nowadays has become a central issue in biological studies of diseases. According to the lack of information about the role of epigenetic changes on gene expression profiling of UBE2Q1 and UBE2Q2, and the presence of CpG islands in the promoter of these two human genes, we decided to evaluate the promoter methylation status of these genes as a first step. Materials and Methods: The promoter methylation status of UBE2Q1 and UBE2Q2 was studied by methylation-specific PCR (MSP) in tumor samples of 60 colorectal cancer patients compared to adjacent normal tissues and 20 non-malignant controls. The frequency of the methylation for each gene was analyzed by chi-square method. Results: MSP results revealed that UBE2Q2 gene promoter were more unmethylated, while a higher level of methylated allele was observed for UBE2Q1 in tumor tissues compared to the adjacent normal tissues and the non malignant controls. Conclusions: UBE2Q1 and UBE2Q2 genes show different methylation profiles in CRC cases.