http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Fangyuan Li (검색결과 20 건)
- 무료
- 기관 내 무료
- 유료
-
Analysis and monitoring on jacking construction of continuous box girder bridge
Fangyuan Li,Peifeng Wu,Xinfei Yan 사단법인 한국계산역학회 2015 Computers and Concrete, An International Journal Vol.16 No.1
It is hard to guarantee the strict synchronization of all the jacking-up points in the integral jacking of a large-span continuous box girder bridge. This paper took the Hengliaojing Bridge as background, which need jacking up as an object with 295m length and more than 10,000tons weight, adopted 3D software to calculate the unsynchronized jacking-up working conditions, and studied the relationships between the unsynchronized vertical difference and the girder’s deformation behaviour. The aim is to verify the maximum value of the unsynchronized vertical difference, and guide the construction and ensure safety. The monitoring system with its contents is introduced corresponding to the analysis. The results of the deck relative elevations prove that it is difficult to avoid the deck torsional deformation for jacking different; especially the side span shows more deformations for its smaller stiffness. The maximum difference is smaller than the limited value with acceptable stresses in the sections. The jacking heights of the pier in each construction step are controlled regularly according to the design. The shifting of the whole bridge in longitudinal direction is smaller than in transverse direction. The several beginning steps are the key to adjust their support reactions. This study is one parts of the fundamental research for the code “Technical specification for bridge jacking-up and reposition of China”. The whole synchronous jacking project of the main bridge set a world record by the World Record Association for the whole bridge jacking project with the longest span of the world.
-
-
Self-Assembled Chlorin e6 Conjugated Chondroitin Sulfate Nanodrug for Photodynamic Therapy
Li, Fangyuan,Na, Kun American Chemical Society 2011 Biomacromolecules Vol.12 No.5
<P>Acetylated-chondroitin sulfate/chlorin e6 conjugates (Ac-CS/Ce6 1, 2, 3) were synthesized via the formation of an ester linkage between CS and Ce6 and evaluated as nanoscale drugs for photodynamic therapy. Ac-CS/Ce6 2 and 3 with higher Ce6 contents of 11.7 and 17.6%, respectively, had average diameters of <150 nm and were very stable in phosphate-buffered saline (PBS) for 1 month. The critical self-quenching concentration (CQC) of Ac-CS/Ce6 decreased as the conjugated-amount of Ce6 increased. All samples displayed autophotoquenching properties in aqueous solution, whereas their fluorescence intensity strongly correlated with the amount of Ce6 in the organic solvent dimethyl sulfoxide (DMSO). Compared with free Ce6, Ac-CS/Ce6 nanodrug photoactivity was maintained in terms of fluorescence properties and singlet oxygen (<SUP>1</SUP>O<SUB>2</SUB>) generation. In a HeLa cell culture system, we observed rapid cellular uptake of the Ac-CS/Ce6 nanodrug without any other ligands using confocal imaging and fluorescence-activated cell sorting (FACS) analysis. Upon light irradiation following cellular uptake, phototoxicity was detected via 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. The self-quenching effect and fluorescence recovery of Ac-CS/Ce6 were also determined both in vitro and in vivo. Taken together, our results indicate that Ac-CS/Ce6 has potential as an effective photodynamic therapy (PDT) prodrug for clinical application.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2011/bomaf6.2011.12.issue-5/bm200115v/production/images/medium/bm-2011-00115v_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm200115v'>ACS Electronic Supporting Info</A></P>
-
Fangyuan Li,Wenhao Li,Peifeng Wu 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.85 No.4
Girdling underpinning joints are key areas of concern for the pier-cutting bridge-lifting process. In this study, five specimens of an underpinning joint were prepared by varying the cross-sectional shape of the respective column, the process used to treat the beam-column interface (BCI), and the casting process. These specimens were subsequently analyzed through static failure tests. The BCI was found to be the weakest area of the joint, and the specimens containing a BCI underwent punching shear failure. The top of the girdling beam (GB) was subjected to a circumferential tensile force during slippage failure. Compared to the specimens with a smooth BCI, the specimens subjected to chiseling exhibited more pronounced circumferential compression at the BCI, which in turn considerably increased the shear capacity of the BCI and the ductility of the structure. The GB for the specimens containing a column with a circular cross-section exhibited better shear mechanical properties than the GB of other specimens. The BCI in specimens containing a column with a circular cross-section was more ductile during failure than that in specimens containing a column with a square cross-section.
-
Experimental study on the cable rigidness and static behaviors of AERORail structure
Fangyuan Li,Peifeng Wu,Dongjie Liu 국제구조공학회 2012 Steel and Composite Structures, An International J Vol.12 No.5
This paper presented a new aerial platform-AERORail for rail transport and its structure evolution based on the elastic stiffness of cable; through the analysis on the cable properties when the cable supported a small service load with high-tensile force, summarized the theoretical basis of the AERORail structure and the corresponding simplified analysis model. There were 60 groups of experiments for a single naked cable model under different tensile forces and different services loads, and 48 groups of experiments for the cable with rail combined structure model. The experimental results of deflection characteristics were compared with the theoretical values for these two types of structures under the same conditions. It proved that the results almost met the classical cable theory. The reason is that a small deflection was required when this structure was applied. After the tension increments tests with moving load, it is verified that the relationships between the structure stiffness and tension force and service load are simple. Before further research and applications are made, these results are necessary for the determination of the reasonable and economic tensile force, allowable service load for the special span length for this new platform.
-
Li Lun,Sun Liuqiao,Liang Xiaoping,Ou Qian,Tan Xuying,Li Fangyuan,Lai Zhiwei,Ding Chenghe,Chen Hangjun,Yu Xinxue,Wu Qiongmei,Wei Jun,Wu Feng,Wang Lijun 한국영양학회 2023 Nutrition Research and Practice Vol.17 No.6
BACKGROUND/OBJECTIVES: Previous research has shown maternal betaine supplementation alleviates fetal-derived hepatic steatosis. Therefore, this study examined the anti-inflammatory effect of maternal betaine intake in offspring mice and its mechanism. MATERIALS/METHODS: Female C57BL/6J mice and their offspring were randomly divided into 3 groups according to the treatment received during gestation and lactation: control diet (CD), fatty liver disease (FLD), and fatty liver disease + 1% betaine (FLD-BET). The FLD group was given a high-fat diet and streptozotocin (HFD + STZ), and the FLD-BET group was treated with HFD + STZ + 1% betaine. After weaning, the offspring mice were given a normal diet for 5 weeks and then dissected to measure the relevant indexes. RESULTS: Compared to the CD group, the offspring mice in the FLD group revealed obvious hepatic steatosis and increased serum levels of alanine aminotransferase, interleukin (IL)-6, and tumor necrosis factor (TNF)-α; maternal betaine supplementation reversed these changes. The hepatic mRNA expression levels of IL-6, IL-18, and Caspase-1 were significantly higher in the FLD group than in the CD group. Maternal betaine supplementation reduced the expression of IL-1β, IL-6, IL-18, and apoptosis-associated speck-like protein containing C-terminal caspase recruitment domain (ASC). Maternal betaine supplementation also reversed the increasing protein expressions of nitric oxide dioxygenase-like receptor family pyrin domain containing 3 (NLRP3), ASC, Caspase-1, IL-1β, and IL-18 in offspring mice exposed to HFD + STZ. Maternal betaine supplementation decreased the homocysteine (Hcy) and s-adenosine homocysteine (SAH) levels significantly in the livers. Furthermore, the hepatic Hcy concentrations showed significant inverse relationships with the mRNA expression of TNF-α, NLRP3, ASC, and IL-18. The hepatic SAH concentration was inversely associated with the IL-1β mRNA expression. CONCLUSIONS: The lipotropic and anti-inflammatory effect of maternal betaine supplementation may be associated with the inhibition of NLRP3 inflammasome in the livers of the offspring mice.
-
Bowen Li,Yidi Wang,Fangyuan Tian,Guanshu Li,Zhaohong Zhang,Jun Wang,Youtao Song 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.54 No.-
In order to expand the light response range of wide band-gap semiconductor photocatalyst (NaTaO3) for effective photocatalytic conversion of Cr(VI), an up-conversion luminescence agent (Er3+:YAlO3) is combined with NaTaO3 and a visible-light driven photocatalyst, NaTaO3/Er3+:YAlO3, is prepared. Moreover, several conduction band co-catalysts (Ag, Au and Pt) are deposited the surface of NaTaO3/Er3+: YAlO3, respectively, to facilitate the transfer rate of photo-generated electrons. X-ray diffractometer (XRD), energy dispersive X-ray spectroscopy (EDX) and scanning electron microscopy (SEM) analyses are employed to confirm the morphology, microstructure and composition of the prepared photocatalysts. In addition, UV–vis diffuse reflectance spectra are determined to explore the visible-light absorption properties of Er3+:YAlO3, NaTaO3, NaTaO3/Er3+:YAlO3 and X/NaTaO3/Er3+:YAlO3 (X = Ag, Au and Pt). Photoluminescence (PL) spectra are used to estimate the recombination rate of electron–hole pairs. The effects of irradiation time, photosource kind, solution acidity and used times on the photocatalytic capabilities of NaTaO3/Er3+:YAlO3 and X/NaTaO3/Er3+:YAlO3 (X = Ag, Au and Pt) are investigated in detail. The results show that the uses of up-conversion luminescence agent (Er3+:YAlO3) and co-catalysts (Ag, Au and Pt) can promote NaTaO3 to utilize visible-light to carry out the photocatalytic conversion of Cr(VI). Particularly, the prepared Au/NaTaO3/Er3+:YAlO3 nanocomposite with 1.0 wt% Au and 0.3:1.0 molar ratio of Er3+:YAlO3 and NaTaO3 shows the highest photocatalytic activity in conversion of Cr(VI).
-
Bo Li,Huimin Liang,Jiaxin You,Fangyuan Xiong,Jan K. Sykulski 한국자기학회 2019 Journal of Magnetics Vol.24 No.3
The paper addresses the issue of the working point migration in non-linear permanent magnets (PM). Starting from the considerations of energy, a novel working-point migration (WPM) model is proposed which can be incorporated into a magnetic equivalent circuit (MEC). The basic theory of working-point migration is discussed which focus on the second quadrant of the magnetic hysteresis loop. The calculation method of the WPM model is proposed based on the relationship between the recoil line model and the affine transformation hysteresis loop. The establishment method for the resultant working point is described by combining the demagnetization curve and the recoil line models in the minor hysteresis loop. The static characteristic of a bistable polarized magnetic system (BPMS), as used in actuators, is calculated using the magnetic circuit method based on the WPM, while a finite element model (FEM) is also derived. The calculation method for the WPM used in MEC is also discussed. The WPM based MEC model yields reasonable results, compared with FEM, of the latching force but with much faster calculation speeds. Furthermore, the working-point state of the PM is clearly illustrated. The test system of the BPMS prototype is established. The test data and WPM model calculation results are compared. It is shown that the WPM model provides accurate prediction of static characteristics of an electromagnetic system.
-
An Efficient Sparse Code Fusion Method for Image Enhancement
Jia Li,Yi Dong,Fangyuan Jiao 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.8
Image enhancement can improve the perception of information for human viewers, which is also a basic and pretty significant role in image processing. However, there also exist some limitations in most image enhancement algorithms. In this paper discuss the limitations of existing techniques of image enhancement. In order to solve the limitations well, a novel sparse code fusion (SCF) method is proposed, in which combine piecewise dictionaries strategy. The proposed method firstly is that color space conversion from RGB to Ycbcr color space, secondly enhanced Y component using piecewise sparse code fusion strategy, finally color image reconstruction. Experimental results show that our method can
-
Wang, Shuaifei,Li, Fangyuan,Qiao, Ruirui,Hu, Xi,Liao, Hongwei,Chen, Lumin,Wu, Jiahe,Wu, Haibin,Zhao, Meng,Liu, Jianan,Chen, Rui,Ma, Xibo,Kim, Dokyoon,Sun, Jihong,Davis, Thomas P.,Chen, Chunying,Tian, American Chemical Society 2018 ACS NANO Vol.12 No.12
<P>Ferroptosis, an iron-based cell-death pathway, has recently attracted great attention owing to its effectiveness in killing cancer cells. Previous investigations focused on the development of iron-based nanomaterials to induce ferroptosis in cancer cells by the up-regulation of reactive oxygen species (ROS) generated by the well-known Fenton reaction. Herein, we report a ferroptosis-inducing agent based on arginine-rich manganese silicate nanobubbles (AMSNs) that possess highly efficient glutathione (GSH) depletion ability and thereby induce ferroptosis by the inactivation of glutathione-dependent peroxidases 4 (GPX4). The AMSNs were synthesized <I>via</I> a one-pot reaction with arginine (Arg) as the surface ligand for tumor homing. Subsequently, a significant tumor suppression effect can be achieved by GSH depletion-induced ferroptosis. Moreover, the degradation of AMSNs during the GSH depletion contributed to <I>T</I><SUB>1</SUB>-weighted magnetic resonance imaging (MRI) enhancement as well as on-demand chemotherapeutic drug release for synergistic cancer therapy. We anticipate that the GSH-depletion-induced ferroptosis strategy by using manganese-based nanomaterials would provide insights in designing nanomedicines for tumor-targeted theranostics.</P> [FIG OMISSION]</BR>
DBpia연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
