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Fahed Zairi,Tarek Sunna,Moishe Liberman,Ghassan Boubez,Zhi Wang,Daniel Shedid 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.6
Study Design: Monocentric prospective study. Purpose: To assess the safety and effectiveness of the posterior approach for resection of advanced Pancoast tumors. Overview of Literature: In patients with advanced Pancoast tumors invading the spine, most surgical teams consider the combined approach to be necessary for “en-bloc ” resection to control visceral, vascular, and neurological structures. We report our preliminary experience with a single-stage posterior approach. Methods: We included all patients who underwent posterior en-bloc resection of advanced Pancoast tumors invading the spine in our institution between January 2014 and May 2015. All patients had locally advanced tumors without N2 nodes or distant metastases. All patients, except 1, benefited from induction treatment consisting of a combination of concomitant chemotherapy (cisplatin-VP16) and radiation. Results: Five patients were included in this study. There were 2 men and 3 women with a mean age of 55 years (range, 46–61 years). The tumor involved 2 adjacent levels in 1 patient, 3 levels in 1 patient, and 4 levels in 3 patients. There were no intraoperative complications. The mean operative time was 9 hours (range, 8–12 hours), and the mean estimated blood loss was 3.2 L (range, 1.5–7 L). No patient had a worsened neurological condition at discharge. Four complications occurred in 4 patients. Three complications required reoperation and none was lethal. The mean follow-up was 15.5 months (range, 9–24 months). Four patients harbored microscopically negative margins (R0 resection) and remained disease free. One patient harbored a microscopically positive margin (R1 resection) and exhibited local recurrence at 8 months following radiation treatment. Conclusions: The posterior approach was a valuable option that avoided the need for a second-stage operation. Induction chemoradiation is highly suitable for limiting the risk of local recurrence.
Psychoses of Epilepsy in Pregnancy: A Case Report
Mario Fahed,Seethalakshmi Ramanathan 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.2
To discuss the unique relationship between psychosis and seizures in a young individual, who is also pregnant. Psychosis of epilepsy can present in multitude of ways, including pre-ictal, ictal, post-ictal, chronic interictal, and forced normalization psychosis.
Apathy: Neurobiology, Assessment and Treatment
Mario Fahed,David C. Steffens 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.2
Apathy is a highly prevalent, disabling and treatment resistant syndrome. It is defined as a quantitative reduction of goal-directed activity in comparison to the patient’s previous level of in multiple dimensions including behavior/cognition, emotion and social interaction. It has been described in major depressive disorder, Alzheimer’s disease, frontotemporal dementia, Parkinson’s Disease, cerebrovascular disease, and vascular dementia, among others. This review will address the neuropsychology and associated neurobiological underpinnings of apathy in the above conditions, identify specific methods to assess apathy clinically, and review the literature on managing apathy across these various disorders.
Current developments in esterification reaction: A review on process and parameters
Zarmeena Khan,Fahed Javed,Zufishan Shamair,Ainy Hafeez,Tahir Fazal,Ambreen Aslam,William B. Zimmerman,Fahad Rehman 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.103 No.-
Esters are among the highest volume of industrial organic compounds produced. They are frequentlyemployed in various domestic and industrial processes. Fischer esterification regarded as the most commonand widely practiced process of ester synthesis, faces serious limitations of low conversion and highreaction time attributed largely to establishment of equilibrium. Ester hydrolysis, reverse reaction toesterification, starts by supply of a byproduct- water. Several approaches have been developed to avoidequilibrium establishment and to improve overall conversion and rate of reaction, a significant differenceexists between the current industrial practices and optimum esterification process/conditions. In the currentreview, a critical analysis of esterification techniques is conducted. Catalytic, non-catalytic thermalesterification, enzymatic esterification, along with factors affecting their productivity are discussed indetail. The current barriers, future challenges and potential of the esterification technologies are analyzed. Based on the comprehensive-data analysis, a novel technology-based solution is proposed.
Romain Bourcier,Mickael Mazighi,Julien Labreuche,Robert Fahed,Raphael Blanc,Benjamin Gory,Alain Duhamel,Gaultier Marnat,Suzana Saleme,Vincent Costalat,Serge Bracard,Hubert Desal,Arturo Consoli,Michel 대한뇌졸중학회 2018 Journal of stroke Vol.20 No.2
Background and Purpose In the Aspiration vs. Stent Retriever for Successful Revascularization (ASTER) trial, which evaluated contact aspiration (CA) versus stent retriever (SR) use as first-line technique, the impact of the susceptibility vessel sign (SVS) on magnetic resonance imaging (MRI) was studied to determine its influence on trial results. Methods We included patients having undergone CA or SR for M1 or M2 occlusions, who were screened by MRI with T2* gradient recalled echo. Occlusions were classified as SVS (+) or SVS (–) in each randomization arm. Modified thrombolysis in cerebral infarction (mTICI) 2b, 2c, or 3 revascularization rates were recorded and clinical outcomes assessed by the overall distribution of modified Rankin scale (mRS) at 90 days. Results Among the 202 patients included, 143 patients were SVS (+) (70.8%; 95% confidence interval [CI], 64.5% to 77.1%). Overall, there was no difference in angiographic and clinical outcomes according to SVS status. However, compared to SR, CA achieved a lower mTICI 2c/3 rate in SVS (+) patients (risk ratio [RR] for CA vs. SR, 0.60; 95% CI, 0.51 to 0.71) but not in SVS (–) (RR, 1.11; 95% CI, 0.69 to 1.77; P for interaction=0.018). A significant heterogeneity in favor of superiority of first-line SR strategy in SVS (+) patients was also found regarding the overall mRS distribution (common odds ratio for CA vs. SR, 0.40 vs. 1.32; 95% CI, 0.21 to 0.74 in SVS (+) vs. 95% CI, 0.51 to 3.35 in SVS (–); P for interaction=0.038). Conclusions As a first line strategy, SR achieved higher recanalization rates and a more favourable clinical outcome at 3 months compared to CA when MRI shows SVS within the thrombus.
Elevated temperature resistance of concrete columns with axial loading
Alaskar, Abdulaziz,Alyousef, Rayed,Alabduljabbar, Hisham,Alrshoudi, Fahed,Mohamed, Abdeliazim Mustafa,Jermsittiparsert, Kittisak,Ho, Lanh Si Techno-Press 2020 Advances in concrete construction Vol.9 No.4
The influence of temperature on the material of concrete filled columns (CFCs) under axial loading has been quantitatively studied in this research. CFCs have many various advantages and disadvantages. One of the important inefficiency of classic CFCs design is the practical lack of hooped compression under the operational loads because of the fewer variables of Poisson's rate of concrete compared to steel. This is the reason why the holder tends to break away from the concrete core in elastic stage. It is also suggested to produce concrete filled steel tube columns with an initial compressed concrete core to surpass their design. Elevated temperatures have essentially reduced the strengths of steel tubes and the final capacity of CFCs exposed to fire. Thus, the computation of bearing capacity of concrete filled steel tube columns is studied here. Sometimes, the structures of concrete could be exposed to the high temperatures during altered times, accordingly, outcomes have shown a decrement in compressive-strength, then an increase with the reduction of this content. In addition, the moisture content at the minimal strength is declined with temperature rising. According to Finite Element (FE), the column performance assessment is carried out according to the axial load carrying capacities and the improvement of ductility and strength because of limitations. Self-stress could significantly develop the ultimate stiffness and capacity of concrete columns. In addition, the design equations for the ultimate capacity of concrete columns have been offered and the predictions satisfactorily agree with the numerical results. The proposed based model (FE model of PEC column) 65% aligns with the concrete exposed to high temperature. Therefore, computed solutions have represented a better perception of structural and thermal responses of CFC in fire.
Effect of molar ratios on strength, microstructure & embodied energy of metakaolin geopolymer
Abadel, Aref A.,Albidah, Abdulrahman S.,Altheeb, Ali H.,Alrshoudi, Fahed A.,Abbas, Husain,Al-Salloum, Yousef A. Techno-Press 2021 Advances in concrete construction Vol.11 No.2
In this study, twenty-five geopolymer (GP) mixes were prepared by varying the alkaline solids to Metakaolin (MK) and sodium silicate to NaOH ratios from 0.1 to 0.5 and 0.2 to 1.0, respectively, thus giving a wide range of molar ratios of silica to alumina, sodium oxide to alumina and water to sodium oxide. The compressive strength of these GP mixes was determined for four curing schemes involving oven curing at 100℃ for 24 h and three ambient curing with the curing ages of 3, 14, and 28 days. The test results revealed that for the manufacture of GP binder for structural applications of strength up to 90 MPa, the molar ratio of silica to alumina should be greater than 2.3, sodium oxide to alumina should be between 0.6 to 1.2, and water to sodium oxide should not exceed 12. The compressive strength of ambient cured GP mortar gets stabilized at 28 days of ambient curing. Experimental findings were also corroborated by GP microstructure analysis. The embodied energy of MK-based GP mortars, especially of high strength, is significantly less than the cement mortar of equivalent strength.
False-Positive Gallium-68 DOTATATE PET/CT in Vertebral Hemangioma
Ahmed Abdulrahman Alruwaili,Alaa Khalid Alduraibi,Alzayed Mohammed Fahed 대한핵의학회 2021 핵의학 분자영상 Vol.55 No.2
A healthy 52-year-old man started to have few minutes spells of palpitation, tachycardia, hot flashes, and chest tightness. He had a lab work-up for carcinoid, including 5-hydroxyindoleacetic acid (5-HIAA), which was negative. Months later, his symptoms became worse which warranted further investigation to exclude carcinoid disease. Gallium-68 DOTATATE positron emission tomography combined with computed tomography (PET/CT) scanning was performed to assess the patient for carcinoid tumor. It showed foci of radiotracer avidity in the thoracic and lumber spine. Magnetic resonance imaging (MRI) for the vertebral lesions showed atypical hemangioma. Subsequently, follow-up serum chromogranin A testing was negative.