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( Eun Hui Joo ),( Sung Woon Chang ),( Hyun Mee Ryu ),( Eun Hee Ahn ),( Min Jung Baek ),( Ji Yeon Lee ),( Hyun Jung Lee ),( Young Ran Kim ),( Hee Young Cho ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: To demonstrate the prediction potential value of first-trimester placental volume and maternal clinical characteristics, and serum screening biomarker for fetal growth restriction (FGR) in singleton pregnancy. Methods: Between November 2016 and May 2018, this was a prospective case-control study of pregnancies which enrolled at Bundang CHA medical center. There were 268 pregnancies without FGR and 83 pregnancies with FGR. Maternal serum pregnancy-associated plasma protein A (PAPP-A) and estimated placental volume were determined at 10+0 to 13+0 weeks and we reviewed ultrasound findings which were enrolled. We measured the width, height, and thickness of the placenta and calculated the placental volume using the established mathematical calculation method. We evaluated the associations with FGR in the first trimester based on estimated placental volume (EPV), maternal clinical characteristics and serum biomarkers by using multiple logistic regression analysis. Results: We found that the mean placental volume was not significantly different (295.25g without FGR and 328.05g with FGR, p-value: 0.9531) between two groups. However, the PAPP-A MoM showed lower level in the women with FGR than women without FGR (0.81[0.18-2.18], 1.03 [0.17-3.01] p-value: 0.0062, respectively). The prediction model of FGR using combined EPV, maternal age, history of smoking and PAPP-A was achieving an area under the curve of 0.67 overall. Conclusion: A risk prediction of FGR model with maternal clinical characteristics, PAPP-A and EPVcan be adopted for the first-trimester screening of FGR in singleton pregnancy.
Strain-induced delamination of edge-grafted graphite
Choi, Eun-Kyung,Jeon, In-Yup,Shin, Yeon-Ran,Baek, Jong-Beom The Royal Society of Chemistry 2012 Chemical communications Vol.48 No.90
<P>Edge-selectively grafted graphite (EGG) with poly(ether-ketone) was prepared by the Friedel–Crafts acylation in a mild polyphosphoric acid (PPA)–phosphorous pentoxide (P<SUB>2</SUB>O<SUB>5</SUB>) mixture. The homogeneous reaction dope was coagulated in air moisture at different temperatures. The morphology of expanded EGG was changed from balls, balls/rods and rods with respect to coagulation temperatures of 80, 60, 40 and 25 °C, respectively.</P> <P>Graphic Abstract</P><P>The formation of graphene rose and accordion morphologies could be controlled by the coagulation rate of edge-selectively grafted graphite (EGG) with poly(ether-ketone) in air moisture, resulting in delamination of EGG to a few layers of graphene nanoplatelets by strain-induced expansion. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cc36031d'> </P>
Initial Stemness Maintenance of Pig Epiblast Stem Cells (pEpiSCs)
Sang-Ki Baek,Sang-Hoon Park,Mi-Ran Lee,Hye-Ju Eun,Song-Yi Moon,Joon-Hee Lee 한국동물번식학회 2012 Reproductive & Developmental Biology(Supplement) Vol.36 No.2s
Since embryonic stem cells (ESCs) were first established from explant cultures of in vivo day 3.5 mouse embryos, the establishment of ESCs from species such as primates and rat has been developed. However, this success relies on the development of culture medium suitable for human and rat cells, which has different requirements from the murine ESC. In general, the establishment of ESC from pig and cow is of great interest both the agricultural perspective and for biomedical application. Large animal models, particularly pig, are likely to provide models of human genetic diseases and transplantation research where rodent models are inappropriate. However, establishment of ESCs establishment from pigs has remained an elusive goal. In the present study, we focused on signaling transduction regulation in pig epiblast stem cells (pEpiSCs). Pig epiblasts were isolated from early tubular stage embryos collected in vivo day 10.5~12 after insemination. Epiblasts were separated from trophoblast and underlying primitive endoderm using 21G needles and fine forceps. Epiblasts were cultured on mitomycin C (10 μl/ml) treated mouse embryonic feeder cells in Dulbecco’s modified Eagle’s medium (DMEM) containing 1% minimal essential medium (MEM) nonessential amino acids, 1% penicillin/ streptomycin, 1% glutamine, 0.007% β-mercaptoethanol, 5 ng/ml bFGF and 1 ng/ml LIF. After plating rapid differentiation of isolated epiblasts to extraembryonic cell types was visualized in most cultures but stem cells were enclosed by these differentiated cells. We have established seven pig epiblast stem cells lines (pEpiSC1-7) from Days 10.5-12 pig embryos. pEpiSC expressed the pluripotent markers including OCT4, NANOG, SOX2 and NODAL at 3-5 passage. In addition, the modification of culture condition by the inclusion of particular protein kinase inhibitor such as Akt inhibitor, PD0325091(PD), delyed rapid differentiation of pEpiSCs. These results showed that stemness of pEpiSCs can be maintained by regulation of signaling pathway. * This work was partly supported by a grant from the NPR (2011-0013703) and the Next-Generation BioGreen 21 Program (No. PJ008209), Rural Development Administration, Republic of Korea.
박은지,Seon-Eun Baek,김미경,Ae-Ran Kim,Hyo-ju Park,Ojin Kwon,이준환,유정은 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.3
Background: Danggwijagyaksan (DJS) has been one of the most widely used herbal medicines for gynecological disorders in traditional East Asian medicine. Several clinical studies about DJS have shown improvement in menopausal symptoms. This pilot study aimed to evaluate the efficacy, safety and feasibility of DJS for treating climacteric syndrome with a blood-deficiency-dominant pattern. Methods: This was a randomized, double-blind, placebo-controlled pilot trial. A group of 45-to 60-year-old women with climacteric syndrome were registered for the trial. The participants received treatment over a 4-week period and were then followed for 4 weeks. The primary outcome measure was the mean change in the Menopause Rating Scale (MRS). Secondary outcome measures included the World Health Organization Quality of Life-BREF (WHOQOL-BREF), the Blood-Deficiency Scoring System (BDSS), lean body mass, and serum hormone levels, including follicle-stimulating hormone (FSH) and estradiol (E2) levels. Results: The MRS and BDSS scores decreased significantly in both groups, but the differences between two groups were not significant. The WHOQOL-BREF scores increased in the control group. No statistically meaningful differences in serum hormone levels or lean body mass were observed in both groups. There were no serious adverse events, and the laboratory tests were within the normal range. The recruitment rate, completion rate and medication adherence rate were over 90% in both groups, indicating high feasibility. Conclusions: DJS showed clinical effectiveness in the treatment of climacteric syndrome with a blood-deficiency-dominant pattern. Additionally, DJS was shown to be safe and feasible for a large-scale study to confirm the efficacy of the treatment. Trial registration: Clinical Research Information Service (CRIS, https://cris.nih.go.kr): KCT0002387.