C-Flavonoidal Glycosides from Erythrina caffra Flowers

Sawsan El Masry,Hala M. Hammoda,Mohamed M. Radwan,Samir A. Ross,Hala H. Zaatout 한국생약학회 2010 Natural Product Sciences Vol.16 No.4

A phytochemical investigation of the ethanolic extract of Erythrina caffra flowers from an Egyptian origin yielded three C-flavonoidal glycosides; 5,7,4`-trihydroxyflavone-8-C-β-D-glucopyranoside (vitexin) (1), 5,7,4`-trihydroxyflavone-6-C-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (isovitexin-2``-β-D-glucopyranoside) (2), 5, 7, 4`-trihydroxyflavone-6, 8-di-C-β-D-glucopyranoside (vicenin-2) (3) and one O-flavonoidal glycoside; kaempferol-3-O-β-D-glucopyranosyl) (1→2)-β-D-glucopyranoside (4). The structures of the isolated compounds (1 - 4) were elucidated using different spectral techniques (UV, 1D and 2D NMR and HRESIMS). This is the first report for the isolation of flavonoidal glycosides from Erythrina caffra. The antibacterial, antifungal, antimalarial, and antileishmanial activities of the isolates were evaluated. In addition, the cytotoxic activity of the ethanolic extract and the main fractions were tested using brine shrimp bioassay.

Hydrogels as Template Nanoreactors for Silver Nanoparticles Formation and Their Antimicrobial Activities

Hazem El-Sherif,Mansour El-Masry,Amany Kansoh 한국고분자학회 2011 Macromolecular Research Vol.19 No.11

Silver nanoparticles were synthesized and stabilized using the hydrogel template method. The synthesized hydrogels were composed of acrylamide and styrene sulfonic acid sodium salt monomers with different molar ratios. The copolymer with the highest ionic monomer content was interpenetrated with different chitosan concentrations. The main goal of this study was to evaluate the antimicrobial activity of the prepared hydrogels. The formation of silver nanoparticles within the swollen hydrogel was mainly due to an ion exchange process via the sulfonate and amino groups of the hydrogels. The surface morphology showed a uniform distribution of silver nanoparticles throughout the hydrogel structure. These nanoparticles had face-centered-cubic unit cell structure and dimensions less than 70 nm, as determined by X-ray and UV-visible spectroscopy, respectively. To investigate the antimicrobial activities of the prepared composites, their inhibitory effect was evaluated against bacteria, fungi, and yeasts. Increasing the ionic monomer and chitosan content enhanced both the swelling properties and the antimicrobial activities of these composites. The results clarified that the most sensitive strain was Bacillus subtilis.

Constituents of Erythrina caffra Stem Bark Grown in Egypt

Sawsan El-Masry,Hala M. Hammoda,Hala H. Zaatout,Saleh I. Alqasoumi,Maged S. Abdel-Kader 한국생약학회 2010 Natural Product Sciences Vol.16 No.4

A new 3-indolyl propionate alkaloid; (-) abrine (1), was isolated from the alcohol extract of Erythrina caffra stem bark together with the alkaloid (-) hypaphorine (2). Phytochemical investigation of the chloroform extract led to the isolation of one fatty alcohol; 1-octacosanol, isolated for the first time from genus Erythrina, two dienoid alkaloids; erythraline and erysodine, and three isoflavonoids; 3S (+) 2'-O-methylphaseollidinisoflavan (3), (6aR, 11aR)- 3-hydroxy-10-dimethylallyl-9-methoxypterocarpan, known as sandwicensin (4) and 3R (-) erythbidin A (5). It is worth mentioning that this is the first report for the isolation of these isoflavonoids from E. caffra. The absolute configuration of 3S (+) 2'-O-methylphaseollidinisoflavan (3) was not previously reported. The isolated isoflavonoids showed promising antibacterial activity against Staphylococcus aureus. Keywords - Erythrina caffra, alkaloids, isoflavanoids, Staphylococcus aureus

Using Denosumab as a Nonsurgical Management of Aneurysmal Bone Cysts in the Pelvis

Ayman Mohammad El Masry,Sherif Ishak Azmy,Mohamed Abdel Rahman Mustafa,Mohammad Abdelmoemen Abuelhadid 대한정형외과학회 2024 Clinics in Orthopedic Surgery Vol.16 No.1

Background: Aneurysmal bone cysts (ABCs) are infrequent, benign, and locally destructive lesions that most commonly occur during the first two decades of life. They usually affect the metaphysis of the long bones, but the pelvis is involved in 8%–12% of the cases. The management of pelvic ABCs is a challenging issue due to difficulties in choosing the appropriate approach, adjacent neurovascular bundles, the risk of intraoperative bleeding with difficulty achieving good hemostasis, and the risk of injury to the hip or sacroiliac joints. Limited data exist concerning the use of denosumab as a non-surgical treatment for pelvic ABCs. Our hypothesis was that denosumab might be an effective and safe solo treatment of cases with ABCs in the pelvis. Methods: We retrospectively assessed 20 patients with ABCs in the pelvis, who were treated by denosumab as a solo agent without surgery. Patients were assessed regarding disease control, the incidence of recurrence and non-oncological complications, and functional outcome. Results: The mean follow-up period was 38.5 months. Disease control was achieved in 16 patients (80%), with no local recurrence. Tolerable drug-related complications occurred in 15% of cases. The mean Musculoskeletal Tumor Society score was 92.3%. Conclusions: Denosumab may provide a reliable option in the nonsurgical treatment of ABCs of pelvic origin with expected lower morbidity than the surgical solution and tolerable complications. Further studies on the safety profile and long-term effects of denosumab especially in skeletally immature patients are required.

Cross-Section Properties and Elastic Lateral-Torsional Buckling Capacity of Steel Delta Girders

Omar Y. El Masri,Eric M. Lui 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.3

In this paper, the behavior of slender steel delta girders (SDG) is investigated both analytically and numerically. In the analytical analysis, closed-form equations for cross-section properties of SDG are derived. They are then compared with solutions obtained numerically. Using these cross-section properties, the theoretical elastic lateral-torsional buckling (LTB) strength of these girders are determined and compared with results obtained from a fi nite element analysis. The results show that the theoretical LTB equation derived for general open monosymmetric I-sections can be applied to these delta girders. Additionally, it is shown that a simplifi ed expression for the coeffi cient of monosymmetry x derived for I-sections can be used in the computation of LTB strength for SDG. A parametric study is then performed to demonstrate the eff ectiveness of SDG in achieving a favorable strength-to-weight ratio when compared to standard I-section members. Based on the results of this parametric study, it is recommended that the height and width of the delta region of the cross-section be equal to two-fi fth the height of the web and three-quarter the width of the compression fl ange, respectively.

Acceptance Sampling Plans in the Rayleigh Model

Baklizi Ayman,El-Masri Abedel-Qader,AL-Nasser Amjad The Korean Statistical Society 2005 Communications for statistical applications and me Vol.12 No.1

Assume that the life times of the units under test follow the Rayleigh distribution and the test is terminated at a pre assigned time. Acceptance sampling plans are developed for this situation. The minimum sample size necessary to ensure the specified average life are obtained and the operating characteristic values of the sampling plans and producer's risk are given. An example is given to illustrate the methodology.

Synthesis and Preliminary Antimicrobial Screening of New Benzimidazole Heterocycle

Fahmy, H.H.,El-masry, A.,Ali Abdelsahed, S.H. The Pharmaceutical Society of Korea 2001 Archives of Pharmacal Research Vol.24 No.1

A series of 2-methylbenzimidazole incorporated to different heterocycles through ethyl or carbamoylethyl groups at position 1 of benzimidazole were synthesized. Also 3-(2-methylbenzimidazol-1-yl)propanoic acid hydrazide incorporated with semicarbazides and thiosemicarbazides were prepared. Moreover, the triazole 5e underwent Michael addition and alkylation reaction. Some of the newly synthesized compounds showed considerable antimicrobial activity against gram positive, negative bacteria and yeast.

The status of clinical trials regarding root canal sealers

Malak Ahmad AL,Masri Yasmina EL,Al Ziab Mira,Zrara Nancy,Baroud Tarek,Salameh Pascale 대한치과보존학회 2024 Restorative Dentistry & Endodontics Vol.49 No.1

Objectives This study aimed to present the results and analyses of clinical trials, including updates on the different functions of root canal sealers. Materials and Methods In June 2023, we performed a comprehensive search of ClinicalTrials.gov to identify interventional clinical trials pertaining to root canal sealers. In total, 23 clinical trials conducted up to June 2023 were included in this study. Results Approximately half of the trials (11 out of 23) were completed, while none were terminated or withdrawn. Each included trial had a minimum of 10 participants, with 11 trials having more than 100 participants. None of the assessed trials provided outcomes, and the majority (17 out of 23) lacked associated publications. In terms of geographic distribution, the USA and Canada did not contribute to any root canal sealer trials. Conclusions This study highlights the lack of diversity in trial locations, the absence of reported results, and a scarcity of clinical trials examining the physicochemical properties of different sealers. Most published trials primarily focused on assessing the post-operative pain effect of these sealers, but no significant difference was found regarding post-operative pain control. Objectives This study aimed to present the results and analyses of clinical trials, including updates on the different functions of root canal sealers. Materials and Methods In June 2023, we performed a comprehensive search of ClinicalTrials.gov to identify interventional clinical trials pertaining to root canal sealers. In total, 23 clinical trials conducted up to June 2023 were included in this study. Results Approximately half of the trials (11 out of 23) were completed, while none were terminated or withdrawn. Each included trial had a minimum of 10 participants, with 11 trials having more than 100 participants. None of the assessed trials provided outcomes, and the majority (17 out of 23) lacked associated publications. In terms of geographic distribution, the USA and Canada did not contribute to any root canal sealer trials. Conclusions This study highlights the lack of diversity in trial locations, the absence of reported results, and a scarcity of clinical trials examining the physicochemical properties of different sealers. Most published trials primarily focused on assessing the post-operative pain effect of these sealers, but no significant difference was found regarding post-operative pain control.

Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of small interfering RNA

Yousef, Amany I,El-Masry, Omar S,Abdel Mohsen, Mohamed A Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.2

Background: $K^-Ras$ activation is an early event in colorectal carcinogenesis and associated mutations have been reported in about 40% of colorectal cancer patients. These mutations have always been responsible for enhancing malignancy and silencing them is associated with attenuation of tumorigenicity. Among downstream effectors are the RAF/MEK/ERK and the PI3K/Akt signaling pathways. PI3K/Akt signaling leads to reduction of apoptosis, stimulated cell growth and enhanced proliferation. Ellagic acid (EA), a naturally occurring antioxidant, has recently emerged as a promising anti-cancer agent. Purpose: To evaluate the impact of cellular genetic makeup of two colon cancer cell lines with different genetic backgrounds, HCT-116 ($K^-Ras^-/p53^+$) and Caco-2 ($K^-Ras^+/p53^-$), on response to potential anti-tumour effects of EA. In addition, the influence of $K^-Ras$ silencing in HCT-116 cells was investigated. Materials and Methods: Cellular proliferation, morphology and cell cycle analysis were carried out in addition to Western blotting for detecting total Akt and p-Akt (at Thr308 and Ser473) in the presence and absence of different concentrations of EA. Cell proliferation was also assessed in cells transfected with different concentrations of $K^-Ras$ siRNA or incubated with ellagic acid following transfection. Results: The results of the present study revealed that EA exerts anti-proliferative and dose-dependent pro-apoptotic effects. Cytostatic and cytotoxic effects were also observed. p-Akt (at Thr308 and Ser473) was downregulated. Moreover, EA treatment was found to (i) reduce $K^-Ras$ protein expression; (ii) in cells transfected with siRNA and co-treated with EA, pronounced anti-proliferative effects as well as depletion of p-Akt (at Thr308) were detected. Conclusions: Cellular genetic makeup ($K^-Ras^-/p53^-$) was not likely to impose limitations on targeting EA in treatment of colon cancer. EA had a multi-disciplinary pro-apoptotic anti-proliferative approach, having inhibited Akt phosphorylation, induced cell cycle arrest and showed an anti-proliferative potential in HCT-116 cells (expressing mutant $K^-Ras$).

Use and Evaluation of Lignin as Ion Exchangers

Ads, Essam.N.,Nada, A.M.A.,El-Masry, A.M. Korean Chemical Society 2011 대한화학회지 Vol.55 No.1

수산화나트륨과 과산화 무기산을 사용하여 흑색 액체로부터 수산화 리그닌과 과산화 리그닌을 얻었다. 과산화 리그닌을 10% HCl을 사용하여 가수분해하여 가수분해 리그닌을 얻었다. 카르복실화와 인산화과정을 거쳐 카르복시 리그닌과 인산화 리그닌을 얻었다. 에피클로르히드린을 사용하여 가교 리그닌도 얻었다. 이들 얻어진 리그닌들을 적외선분광법, 열김량분석, 시차열분석법으로 분석 하였다. 이들 얻어진 리그닌의 금속이온 흡착효과를 조사하였다. 과산화 리그닌이 수산화된 리그닌 보다 흡착 능력이 우수하였다. Modified lignins were prepared. Soda and peroxy lignins were precipitated from black liquor produced from bagasse pulping with soda and peroxyacid pulping process. The precipitated lignins were hydrolyzed using 10% HCl. Different functional groups were also incorporated into lignin by carboxylation and phosphorylation reactions. Moreover crosslinking of these lignins were carried out using epichlorohydrin. Characterization of the modified lignins and lignins derivative were carried out using Infrared spectroscopy. Thermal analysis of these compounds were also carried out using TGA and DTA techniques. Efficiency of sorption of metal ions by the modified lignin was also investigated. It was found that, the peroxylignin and its derivatives show higher efficiency toward metal ions uptake than the soda lignin.