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Synthesis and Preliminary Antimicrobial Screening of New Benzimidazole Heterocycle
Fahmy, H.H.,El-masry, A.,Ali Abdelsahed, S.H. The Pharmaceutical Society of Korea 2001 Archives of Pharmacal Research Vol.24 No.1
A series of 2-methylbenzimidazole incorporated to different heterocycles through ethyl or carbamoylethyl groups at position 1 of benzimidazole were synthesized. Also 3-(2-methylbenzimidazol-1-yl)propanoic acid hydrazide incorporated with semicarbazides and thiosemicarbazides were prepared. Moreover, the triazole 5e underwent Michael addition and alkylation reaction. Some of the newly synthesized compounds showed considerable antimicrobial activity against gram positive, negative bacteria and yeast.