First measurement of the hubble constant from a dark standard siren using the dark energy survey galaxies and the LIGO/Virgo binary?black-hole merger GW170814

Soares-Santos, M.,Kim, W.S.,Oh, J.J.,Oh, S.H.,Son, E.J. University of Chicago Press for the American Astro 2019 ASTROPHYSICAL JOURNAL LETTERS - Vol.876 No.1

<P> We present a multi-messenger measurement of the Hubble constant H<SUB>0</SUB> using the binary-black-hole merger GW170814 as a standard siren, combined with a photometric redshift catalog from the Dark Energy Survey (DES). The luminosity distance is obtained from the gravitational wave signal detected by the Laser Interferometer Gravitational-Wave Observatory (LIGO)/Virgo Collaboration (LVC) on 2017 August 14, and the redshift information is provided by the DES Year 3 data. Black hole mergers such as GW170814 are expected to lack bright electromagnetic emission to uniquely identify their host galaxies and build an object-by-object Hubble diagram. However, they are suitable for a statistical measurement, provided that a galaxy catalog of adequate depth and redshift completion is available. Here we present the first Hubble parameter measurement using a black hole merger. Our analysis results in <I>H</><SUB>0</SUB>=75_{-32}^{+40}km s<SUP>-1</SUP>Mpc<SUP>-1</SUP>, which is consistent with both SN Ia and cosmic microwave background measurements of the Hubble constant. The quoted 68% credible region comprises 60% of the uniform prior range [20, 140] km s<SUP>-1</SUP> Mpc<SUP>-1</SUP>, and it depends on the assumed prior range. If we take a broader prior of [10, 220] km s<SUP>-1</SUP> Mpc<SUP>-1</SUP>, we find <I>H</I><SUB>0</SUB>=78_{-24}^{+96} km s<SUP>-1</SUP> Mpc<SUP>-1</SUP> (57% of the prior range). Although a weak constraint on the Hubble constant from a single event is expected using the dark siren method, a multifold increase in the LVC event rate is anticipated in the coming years and combinations of many sirens will lead to improved constraints on <I>H</I><SUB>0</SUB>. </P>

Body Composition as a Prognostic Factor of Neoadjuvant Chemotherapy Toxicity and Outcome in Patients with Locally Advanced Gastric Cancer

Carolina Palmela,Sónia Velho,Lisa Agostinho,Francisco Branco,Marta Santos,Maria Pia Costa Santos,Maria Helena Oliveira,João Strecht,Rui Maio,Marília Cravo,Vickie E. Baracos 대한위암학회 2017 Journal of gastric cancer Vol.17 No.1

Sarcopenia and sarcopenic obesity were associated with early termination of neoadjuvant chemotherapy in patients with gastric cancer; additionally, sarcopenic obesity was associated with poor survival.

Cytotoxic, Trypanocidal, and Antifungal Activities of Eugenia jambolana L.

Karla K.A. dos Santos,Edinardo F.F. Matias,Saulo R. Tintino,Celestina E.S. Souza,Maria F.B.M. Braga,Gla´ucia M.M. Guedes,Miriam Rolo´n,Celeste Vega,Antonieta Rojas de Arias,Jose´ G.M. Costa,Irwin A. M 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.1

Chagas’ disease, caused by Trypanosoma cruzi, is considered a public health problem. Nowadays, chemotherapy is the only available treatment for this disease, and the drugs currently used, nifurtimox and benzonidazole, present high toxicity levels. Alternatives for replacing these drugs are natural extracts from Eugenia jambolana, a plant used in traditional medicine because of its antimicrobial and biological activities. An ethanol extract from E. jambolana was prepared. To research in vitro anti-epimastigote activity, T. cruzi CL-B5 clone was used. Epimastigotes were inoculated at a concentration of 1 · 105/mL in 200 lL of tryptose-liver infusion. For the cytotoxicity assay J774 macrophages were used. To examine antifungal activity, Candida albicans, Candida tropicalis, and Candida krusei were used. This is the first record of trypanocide activity for E. jambolana. The effective concentration capable of killing 50% of the parasites was 56.42 lg/mL. The minimum inhibitory concentration was £ 1,024 lg/mL. Metronidazole showed a potentiation of its antifungal effect when combined with the ethanol extract of E. jambolana. Thus our results indicate that E. jambolana could be a source of plantderived natural products with anti-epimastigote and antifungal modifying activity with moderate toxicity.

Enhancement of the Antifungal Activity of Antimicrobial Drugs by Eugenia uniflora L.

Karla K.A. Santos,Edinardo F.F. Matias,Saulo R. Tintino,Celestina E.S. Souza,Maria F.B.M. Braga,Glaucia M.M. Guedes,Jose´ G.M. Costa,Irwin R.A. Menezes,Henrique Douglas Melo Coutinho 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.7

Candidiasis is the most frequent infection by opportunistic fungi such as Candida albicans, Candida tropicalis, and Candida krusei. Ethanol extract from Eugenia uniflora was assayed, for its antifungal activity, either alone or combined with four selected chemotherapeutic antimicrobial agents, including anphotericin B, mebendazole, nistatin, and metronidazole against these strains. The obtained results indicated that the association of the extract of E. uniflora to metronidazole showed a potential antifungal activity against C. tropicalis. However, no synergistic activity against the other strains was observed, as observed when the extract was associated with the other, not enhancing their antifungal activity.

Electronic Structure, Morphological Aspects, Optical and Electrochemical Properties of RuO2 Nanocrystals

R. C. Silva,A. F. Gouveia,J. C. Sczancoski,R. S. Santos,J. L. S. Sá,E. Longo,L. S. Cavalcante 대한금속·재료학회 2019 ELECTRONIC MATERIALS LETTERS Vol.15 No.5

This letter reports the synthesis of RuO2nanocrystals by the anionic surfactant-assisted hydrothermal method at 90 °C for24 h followed by heat treatment at 500 °C for 1 h. These crystals were structurally characterized by means of X-ray diffraction(XRD) and Rietveld refinement analysis. Field emission scanning electron microscopy (FE-SEM) was employed to observethe morphological features these crystals. The optical behavior was investigated by ultraviolet–visible (UV–Vis) spectroscopy. First-principles quantum mechanical calculations based on the density functional theory at the B3LYP level wereemployed to obtain the electronic band structure and density of states. For electrochemical behavior, the supercapacitorproperties of RuO2crystals were investigated by cyclic voltammetry. XRD patterns and Rietveld refinement data indicatethat RuO2crystals have a rutile-type tetragonal structure. FE-SEM images showed the presence of sphere-like RuO2crystalswith an average crystal sized at around 19.13 nm. The experimental band gap energy (Egap[exp]) was estimated at 2.60 eV byusing UV–Vis spectroscopy, while the theoretical calculations indicate an Egap[theo] at 1.92 eV. These calculations revealed aband structure predominantly composed of O 2p orbitals (valence band) and Ru 4d orbitals (conduction band). The specificcapacitance measured for RuO2film was 193 F g−1 at 5 mV s−1 in an electrode with 0.5 mg of electroactive material in 1 MNa2SO4solution.

One‑ and two‑dimensional carbon nanomaterials as adsorbents of cationic and anionic dyes from aqueous solutions

E. E. Pérez‑Ramírez,M. de la Luz‑Asunción,A. L. Martínez‑Hernández,G. de la Rosa‑Álvarez,S. Fernández‑Tavizón,P. Salas,C. Velasco‑Santos 한국탄소학회 2019 Carbon Letters Vol.29 No.2

One- and two-dimensional carbon nanomaterials were tested as adsorbents for the elimination of two anionic dyes, reactive red 2 and methyl orange, and the cationic dye methylene blue from aqueous solutions under the same conditions. Carbon nanomaterials performed well in the removal of dyes. Surface oxygenated groups in the nanomaterials improved the cationic dyes’ adsorption, but not the adsorption of the anionic dye. The interactions between nanomaterials and dyes were verified by infrared and Raman spectroscopy. The pseudo-second order kinetic model was better fitted to the kinetic experimental data than the Elovich and pseudo-first order models. The equilibrium adsorption data were best fitted by the Langmuir model. The dimensions and morphology of the carbon nanomaterials play an important role in the adsorption of the three dyes. The main mechanism of adsorption of anionic dyes is by the interactions of the aromatic rings of the dye structures and π delocalized electrons on carbon nanostructures; the adsorption of cationic dye is mainly due to electrostatic interactions.

Citrus Pulp as a Dietary Source of Antioxidants for Lactating Holstein Cows Fed Highly Polyunsaturated Fatty Acid Diets

Santos, G.T.,Lima, L.S.,Schogor, A.L.B.,Romero, J.V.,De Marchi, F.E.,Grande, P.A.,Santos, N.W.,Kazama, R. Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.8

The effects of feeding pelleted citrus pulp (PCP) as a natural antioxidant source on the performance and milk quality of dairy cows fed highly polyunsaturated fatty acid (FA) diets were evaluated. Four lactating Holstein cows were assigned to a $4{\times}4$ Latinsquare. Treatments, on a dry matter (DM) basis, were i) control diet; ii) 3% soybean oil; iii) 3% soybean oil and 9% PCP and; iv) 3% soybean oil and 18% PCP. When cows fed on citrus pulp, the DM intake tended to decrease. The total tract apparent digestibility of DM and ether extract decreased when cows fed on the control diet compared to other diets. Cows fed PCP had higher polyphenols and flavonoids content and higher total ferric reducing antioxidant power (FRAP) in milk compared to those fed no pelleted citrus pulp. Cows fed 18% PCP showed higher monounsaturated FA and lower saturated FA in milk fat compared with cows fed the other diets. The lowest n-6 FA proportion was in milk fat from cows fed control. The present study suggests that pelleted citrus pulp added to 9% to 18% DM increases total polyphenols and flavonoids concentration, and the FRAP in milk.

Modelling of wine vinegar acetification bioreactor: Global sensitivity analysis and simplification of the model

Jorge E. Jiménez-Hornero,Inés Mª Santos Dueñas,Isidoro García-García 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-

First-principles models of any process usually describe its complex underlying mechanisms using differentialand algebraic equations including several unknown parameters, whose values must be normallyestimated from experimental data. In this context, assessment of the influence of each parameter onmodel outputs, also known as sensitivity analysis, is an invaluable tool to, for example, simplify the structureof such model. In this work, variance-based Global Sensitivity Analysis (GSA) using Sobol’ main andtotal effects was carried out on a previously proposed acetification process first-principles model. Threeparameters (KSE, KIA and KSO) showed less influence than the remaining nine considering their statedvalue ranges; KSE presented no influence in all the analysed experimental conditions, value variation ofKIA exhibited a slightly greater effect on experiments with higher mean acetic acid concentrations andKSO showed the strongest impact by varying its value in all the experiments. According to these results,the model was simplified and its simulation compared with the initially proposed model and the experimentaldata. The analysis performed, by way of example, can be of crucial importance for any otherprocess.

Tolerogenic Dendritic Cells Reduce Airway Inflammation in a Model of Dust Mite Triggered Allergic Inflammation

Luciana S. Aragão-França,Viviane C. J. Rocha,Andre Cronemberger-Andrade,F. H. B. Costa,José Fernandes Vasconcelos,Daniel Abensur Athanazio,Daniela Nascimento Silva,E. S. Santos,Cássio Santana Meira,C. 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.4

Purpose: The use of tolerogenic dendritic cells (TolDCs) to control exacerbated immune responses may be a prophylactic and therapeutic option for application in autoimmune and allergic conditions. The objective of this work was to evaluate the effects of TolDC administration in a mouse model of allergic airway inflammation caused by mite extract. Methods: Mouse bone marrow-derived TolDCs were induced by incubation with granulocyte- macrophage colony-stimulating factor (GM-CSF) and dexamethasone, and then characterized by flow cytometry and cytokine production by enzyme- linked immunosorbent assay (ELISA). For the in vivo model of Blomia tropicalis-induced allergy, mice transplanted with antigen-pulsed TolDCs were sensitized intraperitoneally with B. tropicalis mite extract (BtE) adsorbed to aluminium hydroxide. After challenge by nasal administration of BtE, bronchoalveolar lavage fluid (BALF), lungs, spleen and serum were collected for analysis. Results: Induction of TolDCs was efficiently achieved as shown by low expression of major histocompatibility complex (MHC) II, programmed death-ligand (PD-L) 2 and pro-inflammatory cytokine production, and up-regulation of interleukin (IL)-10, upon LPS stimulation in vitro. Transplantation of 1 or 2 doses of BtE-pulsed TolDCs reduced the number of inflammatory cells in BALF and lungs as well as mucus deposition. Moreover, compared to saline-injected controls, TolDC-treated mice showed lower serum levels of anti-BtE immunoglobulin E (IgE) antibodies as well as reduced Gata3 and IL-4 gene expression in the lungs and decreased IFN-γ levels in the supernatant of splenocyte cultures Transplantation of TolDCs increased the percentage of the regulatory T cells in the spleen and the lungs. Conclusions: Preventive treatment with TolDCs protects against dust mite-induced allergy in a mouse model, reinforcing the use of tolerogenic dendritic cells for the management of allergic conditions.

CCM key comparison CCM.D-K4 'Hydrometer'

Lorefice, S,Becerra, L O,Lenard, E,Lee, Y J,Lee, W G,Madec, T,Meury, P A,Caceres, J,Santos, C,Vamossy, C,Man, J,Fen, K,Toda, K,Wright, J,Bettin, H,Toth, H BUREAU INTERNATIONAL DES POIDS ET MESURES 2016 METROLOGIA -BERLIN- Vol.53 No.-

<P></P> <P>This report presents the comparison philosophy, methodology, analysis and the results of the designed CCM.D-K4 key comparison that covered the calibration of high resolution hydrometers for liquid and alcoholometers in the density range 600 kg/m<SUP>3</SUP> to 2000 kg/m<SUP>3</SUP> at the temperature of 20°C. The main purpose of this comparison was not only to evaluate the degree of equivalence in the calibration of high accuracy hydrometers between NMI participants, but also to link, were it is possible, the results of previous comparisons to Key Comparison Reference Values (KCRVs) of CCM.D-K4. Eleven NMI laboratories took part in the CCM.D-K4 divided in two groups (petals).</P> <P>With the CCM.D-K4 purpose, two similar sets consisting of three hydrometers for liquid density determinations and an alcoholometer were circulated to the NMI participants as a travelling standard in the time interval from January 2011 to April 2012.</P> <P>Twelve Key Comparison Reference Values (KCRVs) for each petal have been obtained at the density values related to the tested density marks of the transfer standards by the results of participants. The KCRVs and corresponding uncertainties were calculated by the weighted mean in the case of consistent results, otherwise the median was used.</P> <P>The degree of equivalence (DoE) with respect to the corresponding KCRV was determined for each participant and, in this particular comparison, the Weighted Least Squares (WLS) method was used to link the individual DoE of each participant by a continuous function.</P> <P>Significant drift of the transfer standards was not detected.</P> <P>This report also gives instructions on calculating pair-wise degrees of equivalence, with the addition of any information on correlations that may be necessary to estimate more accurately as well as the procedure for linking international comparisons to the CCM.D-K4. Finally an example of linkage to the CCM.D-K4 is given by dealing with the results of the bilateral comparison between INRiM and NMIA, which was added to this comparison so that all participants were engaged after the breakage of the 9340171 artefact.</P> <P>A particularly good agreement was found among the results provided by most of the participants, even if some systematic differences and either underestimated or overestimated uncertainties of the submitted results can be identified with respect to the KCRVs. In general the deviations of the laboratory results to the KCRVs are within of 1/3rd to 1/4th of a scale division and the uncertainty at 95% is usually within half a division. During the analysis of the submitted results, a systematic difference between the first and last immersed mark was also noted, possibly due to a temperature gradient along the stem and/or wetting of the stem around the tested mark, and therefore a corrected claimed uncertainty from each laboratory is expected. However this comparison may help the laboratories to solve some residual or marginal problems as well as to better understand the uncertainty components.</P> <P>The comparison fully supports the calibration measurement capabilities table in the BIPM key comparison database (KCDB). The results can be used to link regional comparisons to this CCM key comparison</P> <H2>Main text</H2> <P> To reach the main text of this paper, click on <A HREF='http://www.bipm.org/utils/common/pdf/final_reports/M/D-K4/CCM.D-K4_Final_Report.pdf'>Final Report</A>. Note that this text is that which appears in Appendix B of the BIPM key comparison database <A HREF='http://kcdb.bipm.org/'>kcdb.bipm.org/</A>.</P> <P>The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).</P>