웹 기반 중문검색시스템 SEARCH2000의 설계와 구현

Du Lin,Zhang Yibo,Sun Yufang 한국어정보학회 2002 한국어정보학 Vol.5ㆍ6 No.-

Study properties of soft subgrade soil stabilized by sewage sludge/lime and nano-SiO₂

Lin, Deng-Fong,Luo, Huan-Lin,Chen, Chien-Ta,Cai, Ming-Du Techno-Press 2016 Geomechanics & engineering Vol.10 No.6

The pozzolanic characteristics of a sludge incinerated into ash were determined in this study. Lime is commonly used as a stabilizer for the treatment of soils, whereas sewage sludge ash (SSA) is often applied with lime to improve soft subgrade soil. In this study, a cohesive soil categorized as A-4 (low-plasticity clay) by AASHTO classifications was mixed with SSA/lime with a 3:1 ratio. Nano-$SiO_2$ was also added to the soil. To identify changes in the workability, strength, permeability, and shear strength of the soft subgrade soil, basic soil tests were conducted, and the microstructure of the treated soil was analyzed. The results indicate that SSA/lime mixtures improve the properties of soft subgrade soil and transform the soil from "poor subgrade soil" to "good to excellent subgrade soil" with a CBR > 8. Additionally, the addition of 2% nano-$SiO_2$ increases the unconfined compressive strength of soft subgrade soil treated with SSA/lime mixture by approximately 17 kPa. However, the swelling of the treated soil increased by approximately 0.1% after the addition of nano-$SiO_2$ and lime. Thus, soil swelling should be considered before lime and nano-$SiO_2$ are applied to soft subgrade soil.

Numerical investigations of tip clearance flow characteristics of a pumpjet propulsor

Lin Lu,Yuefei Gao,Qiang Li,Lin Du 대한조선학회 2018 International Journal of Naval Architecture and Oc Vol.10 No.3

In this study, numerical investigations of the tip clearance flow characteristics of a pumpjet propulsor based on Computational Fluid Dynamics (CFD) method have been presented. The Zwart-Gerber-Belamri (Z-G-B) cavitation model based on Reynolds Averaged NaviereStokes (RANS) method is employed. The structured gird is applied. The formation and development of the tip clearance flows has been investigated and presented. The structure of the tip leakage vortex has been shown. The radial distributions of different velocity components with different Span along the axial direction have been carried out to present the influence of the tip clearance flow on the main flow. In addition, the influences of the tip clearance size on the pumpjet propulsor performance, including the impact on the velocity flow fields and the cavitation characteristic, have been presented.

Real-World Data of Pyrotinib-Based Therapy in Metastatic HER2-Positive Breast Cancer: Promising Efficacy in Lapatinib-Treated Patients and in Brain Metastasis

Ying Lin,Mingxi Lin,Jian Zhang,Biyun Wang,Zhonghua Tao,Yiqun Du,Sheng Zhang,Jun Cao,Leiping Wang,Xichun Hu 대한암학회 2020 Cancer Research and Treatment Vol.52 No.4

Purpose Pyrotinib is a newly-developed irreversible pan-ErbB receptor tyrosine kinase inhibitor. This study reported the first real-world data of pyrotinib-based therapy in metastatic human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC), focusing on efficacy in lapatinib-treated patients and in brain metastasis. Materials and Methods One hundred thirteen patients with metastatic HER2-positive BC treated with pyrotinib-based therapy in Fudan University Shanghai Cancer Center under non-clinical trial settings from September 1, 2018 to March 1, 2019 were included. Results Over half patients have received more than two lines of systematic therapy and exposed to two or more kinds of anti-HER2 agents. Most patients received a combined therapy, commonly of pyrotinib plus capecitabine, or vinorelbine or trastuzumab. Median progression-free survival (PFS) was 6.3 months (range, 5.54 to 7.06 months) and objective response rate (ORR) was 29.5%, with two patients (1.9%) achieving complete response. Lapatinib-naïve patients had significantly longer PFS than lapatinib-treated patients (9.0 months vs. 5.4 months, p=0.001). ORR for lapatinib-treated patients was 23.2%. Thirty-one of 113 patients have brain metastasis. Median PFS was 6.7 months and intracranial ORR was 28%. For patients without concurrent radiotherapy and/or brain surgery, the ORR was very low (6.3%). But for patients receiving concurrent radiotherapy and/or brain surgery, the ORR was 66.7%, and three patients achieved complete response. Most common adverse event was diarrhea. Conclusion Pyrotinib-based therapy demonstrated promising effects in metastatic HER2-positive BC and showed activity in lapatinib-treated patients. For patients with brain metastasis, pyrotinib-based regimen without radiotherapy showed limited efficacy, but when combined with radiotherapy it showed promising intracranial control.

Numerical investigations of tip clearance flow characteristics of a pumpjet propulsor

Lu, Lin,Gao, Yuefei,Li, Qiang,Du, Lin The Society of Naval Architects of Korea 2018 International Journal of Naval Architecture and Oc Vol.10 No.3

In this study, numerical investigations of the tip clearance flow characteristics of a pumpjet propulsor based on Computational Fluid Dynamics (CFD) method have been presented. The Zwart-Gerber-Belamri (Z-G-B) cavitation model based on Reynolds Averaged Navier-Stokes (RANS) method is employed. The structured gird is applied. The formation and development of the tip clearance flows has been investigated and presented. The structure of the tip leakage vortex has been shown. The radial distributions of different velocity components with different Span along the axial direction have been carried out to present the influence of the tip clearance flow on the main flow. In addition, the influences of the tip clearance size on the pumpjet propulsor performance, including the impact on the velocity flow fields and the cavitation characteristic, have been presented.

사회적 협동조합의 특성과 지속가능성에 관한 연구

두성림 ( Cheng-lin Du ),장석인 ( Sug-in Chang ),배성필 ( Sung-pil Bae ),최호규 ( Ho-gyu Choi ) 산업진흥원 2020 산업진흥연구 Vol.5 No.1

한국의 사회적 협동조합은 2012년에 법으로 제정되었다. 하지만, 아직까지도 정착되는 과정에 있으며 제도적으로나 개념적으로 확립되지 못한 부분이 있어 사회적 협동조합이 실패하는 경우가 많다. 이러한 실패를 좀 더 줄이고자 본 연구는 협동 조합과 사회적 협동조합의 차이점과 특성, 개념을 파악하여 한국의 사회적 협동조합에 도움을 주는데 목적이 있다. 문헌연구를 바탕으로 나타난 결과는 다음과 같다. 첫째, 국내의 사회적 협동조합이 지속가능하기 위해서는 협동조합의 7원칙을 준수해야 한다. 특히, 제6원칙에서 사회적 협동조합의 연합회를 활성화하고 지역의 협동조합 간 소통을 통해서 경영지원 정보와 교육, 홍보, 전략 등을 공유함으로써 실패하는 확률을 낮춰야 할 필요성이 있다. 둘째, 사회적 협동조합의 판로지원을 위해 정부차원뿐만 아니라 일반기업에게도 적용될 수 있는 방안이 필요하다. 셋째, 사회적 협동조합의 활성화를 위해 정부와 민간의 관련정책이 통합적으로 설계되고 관리되어야 한다. 넷째, 사회적 인식개선을 위해 사회적 협동조합의 의미가 공익에 목적이 있음을 알리는 캠페인을 통해서 대중에게 홍보를 해야 하며, 정부는 사회적 협동조합을 육성할 수 있는 정책전문가 육성 시스템을 구축하는 것이 반드시 필요하다. 결론적으로 본 연구를 통해서 한국의 사회적 협동조합의 지속가능한 방법과 정부의 지원책 등을 제시함으로써 사회적 협동조합에게는 내부적인 방법을 제시하고 정부에게는 지원책에 관한 것을 제시하였다는데 큰 의미가 있다. Korea’s social cooperatives were enacted by law in December 2012. However, it is in the process of being settled and has not been established institutionally. So social cooperatives are failing. The purpose of this study is to reduce these failures. To this end, this study distinguished between co-operatives and social co-operatives. Also, the characteristics and concepts were identified. That is why we want to help our social cooperatives in Korea. The results based on the literature research are as follows. First, in order for domestic social co-operatives to be sustainable, the seven principles of co-operatives must be observed. In particular, the sixth principle is important. It is important to form a social cooperative association and to communicate with local cooperatives. Their communication is less likely to fail because they can share management support information, education, promotion, and strategies. Second, there is a need for a plan that can be applied not only to the government but also to general enterprises in order to support social co-operatives. Third, related policies of the government and the private sector should be designed and managed in an integrated manner to promote social cooperatives. Fourth, public relations should be promoted through campaigns to inform the public that the meaning of social cooperatives is for the public good. In addition, the government needs to build a program that fosters professionals who can foster social co-operatives. In conclusion, it is meaningful that this study suggests possible ways to develop social co-operatives in Korea, and provides support to the Korean government.

A Study on Corporate Social Responsibility(CSR) in China

두성림 ( Cheng-lin Du ),장석인 ( Sug-in Chang ),이상은 ( Sang-eun Lee ) 사회혁신기업연구원 2021 혁신기업연구 Vol.6 No.2

2001년 중국은 세계무역기구(WTO) 가입 후, 세계 경제 활동에 적극적으로 참여하면서 중국 기업의 해외시장 진출은 더욱 가속화되고 있다. 따라서 오늘날 중국에서 기업의 사회적 책임(CSR)은 현지 기업뿐만 아니라 글로벌 기업에서도 중요한 이슈로 인식되고 있다. 중국 국유기업은 대부분 정부 주도의 CSR 원칙에 따라 사회적 책임(Social Responsibility)을 수행하였다. 세계적 글로벌기업은 국제적인 비정부 기구(NGO)가 제시한 포괄적 CSR 가이드라인을 따르고 있지만, 중국의 국유기업은 대부분 중국 정부가 제정한 CSR 원칙에 따르고 있다. 본 연구의 목적은 첫째, 기업의 사회적 책임(CSR)에 대한 전반적인 개념을 분석하고자 한다. 둘째, 중국 기업의 사회적 책임(CSR)에 대한 발전과정을 검토보고자 한다. 셋째, 중국기업의 사회적 책임(CSR)의 규범동향과 구성 내용을 분석하고, 나아가서 중국 CSR과 글로벌 CSR에 대한 비교 분석하고자 한다. 넷째, 본 연구의 결과와 시사점을 제시하고자 한다. Since China joined the World Trade Organization(WTO) in 2001, China has been actively participating in global economic activities, accelerating Chinese companies' entry into overseas markets. Therefore, in China today, corporate social responsibility(CSR) is recognized as an important issue not only for local companies but also for global companies. Most of the state-owned enterprises in China have implemented Social Responsibility in accordance with the government-led CSR principles. While global global enterprises follow comprehensive CSR guidelines presented by international non-governmental organizations(NGOs), most state-owned enterprises in China follow the CSR principles established by the Chinese government. The purpose of this study is to first analyze the overall concept of corporate social responsibility(CSR). Second, I would like to review the development process of Chinese corporate social responsibility(CSR). Third, we will analyze the normative trends and composition of Chinese corporate social responsibility(CSR), and furthermore, compare and analyze Chinese CSR and global CSR. Fourth, we would like to present the results and implications of this study.

해외 사회적 협동조합 사례연구 -이탈리아, 캐나다 및 프랑스-

두성림 ( Cheng-lin Du ),장석인 ( Sug-in Chang ),진재근 ( Jae-keun Jin ),이남겸 ( Nam-gyum Lee ) 산업진흥원 2020 산업진흥연구 Vol.5 No.1

사회적 협동조합의 공공 이익 사명으로 공공의 이익을 생산하는 제품과 서비스를 통해 직접 수행된다는 경제적·사회적 목적 실현을 위해서 긍정적으로 노력하고 있는 사회적 협동조합이 꾸준히 확대되고 있다. 본 연구는 사회적 협동조합의 국제 현황, 국제 사례를 살펴보고, 선진국 사례를 중심으로 문제점과 대안을 제시한다. 지속가능한 경제 성장을 위하여 필요한 문제를 해결해야하면서도 사회에서 요구하는 점에 대한 해결책을 모색하고자 하였다. 이러한 본 연구의 목적을 달성하기 위하여 이탈리아, 캐나다, 프랑스 등의 선진국 사회적 협동조합 현황을 정리하고 비교·분석하였다. 연구 결과 이탈리아, 프랑스, 캐나다의 협동조합이 주는 시사점으로는 첫째, 사회적 문제와 지역사회의 고용과 일자리 같은 현안에 협동조합의 원칙을 지켜야 하며 둘째, 협동조합의 초기 안정과 지속적인 성장을 위한 자금조달 제도를 검토하고 지원금융체제를 확립하여야 하고 셋째, 협동조합과 관련한 법제도와 협동조합을 지원하고 육성할 수 있는 네트워크 조직의 육성 등 협동조합의 생태계가 조성되어야 하는 것이다. Social co-operatives, which are working positively to realize the economic and social purpose of being carried out directly through products and services producing the public interest, are steadily expanding under the public interest mission of social co-operatives. It has important theoretical and practical significance to study the model of social co-operatives tailored to the local situation in Korea based on international experience. This study looks at the international status of social co-operatives, international cases, and puts forward problems and suggestions centering on cases of advanced countries. It sought to find a solution to what society required only by solving the problems necessary for sustainable economic growth. In order to achieve the objectives of this study, the social cooperatives of advanced countries, such as Italy, Canada, and France, were organized, compared and analyzed. The study found that the implications of co-operatives in Italy, France and Canada are as follows. First, it is needed to adhere to the principles of co-operatives in pending issues such as social problems and employment and jobs in the community. Second, it is necessary to establish a supportive financial system for the cooperative’s initial stability and sustainability. Third, the ecosystem of co-operatives should be formed to support and foster legal systems and network organizations.

Tumor-derived CD4+CD25+ Tregs Inhibit the Maturation and Antigen-Presenting Function of Dendritic Cells

Du, Yong,Chen, Xin,Lin, Xiu-Qing,Wu, Wei,Huang, Zhi-Ming Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7

CD4+CD25+regulatory T cells (Tregs) play a key role in regulation of immnue response and maintenance of self-tolerance. Studies have found Tregs could suppress tumor-specific T cell-mediated immune response and promote cancer progression. Depletion of Tregs can enhance antitumor immunity. Dendritic cells (DCs) are professional antigen-presenting cells and capable of activating antigen-specific immune responses, which make them ideal candidate for cancer immunotherapy. Now various DC vaccines are considered as effective treatment for cancers. The aim of this study was to evaluate variation of Tregs in BALB/C mice with hepatocellular carcinoma and investigate the interaction between tumor-derived Tregs, effector T cells (Teff) and splenic DCs. We found the percentages of Tregs/CD4+ in the peripheral blood of tumor-bearing mice were higher than in normal mice. Tumor-derived Tregs diminished the up-regulation of costimulatory molecule expression on splenic DCs, even in the presence of Teff cells and simultaneously inhibited IL-12 and $TNF-{\alpha}$ secretion by DCs.

Network Analyses of Gene Expression following Fascin Knockdown in Esophageal Squamous Cell Carcinoma Cells

Du, Ze-Peng,Wu, Bing-Li,Xie, Jian-Jun,Lin, Xuan-Hao,Qiu, Xiao-Yang,Zhan, Xiao-Fen,Wang, Shao-Hong,Shen, Jin-Hui,Li, En-Min,Xu, Li-Yan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13

Fascin-1 (FSCN1) is an actin-bundling protein that induces cell membrane protrusions, increases cell motility, and is overexpressed in various human epithelial cancers, including esophageal squamous cell carcinoma (ESCC). We analyzed various protein-protein interactions (PPI) of differentially-expressed genes (DEGs), in fascin knockdown ESCC cells, to explore the role of fascin overexpression. The node-degree distributions indicated these PPI sub-networks to be characterized as scale-free. Subcellular localization analysis revealed DEGs to interact with other proteins directly or indirectly, distributed in multiple layers of extracellular membrane-cytoskeleton/ cytoplasm-nucleus. The functional annotation map revealed hundreds of significant gene ontology (GO) terms, especially those associated with cytoskeleton organization of FSCN1. The Random Walk with Restart algorithm was applied to identify the prioritizations of these DEGs when considering their relationship with FSCN1. These analyses based on PPI network have greatly expanded our comprehension of the mRNA expression profile following fascin knockdown to future examine the roles and mechanisms of fascin action.