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- 저자 : Du Ku Lee (검색결과 41 건)
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당뇨병 환자에서 Power Spectrum Analysis 를 이용한 자율신경계 이상의 검정
이두하(Du Ha Lee),황형기(Hyoung Ki Hwang),이형우(Hyoung Woo Lee),김영조(Young Jo Kim),심봉섭(Bong Sup Shim),이현우(Hyun Woo Lee),신동구(Dong Ku Shin),이상학(Sang Hak Lee),이준하(Jun Ha Lee) 대한내과학회 1991 대한내과학회지 Vol.41 No.5
N/A In order to assess the autonomic nervous system activity in normal subjects and in diabetic patients affected by different degrees of diabetic autonomic neuropathy, we applied autoregressive power spectral analysis to 35 diabetic patients and 15 normal controls. This analysis was then compared to conventional methods by CAN score tests. Each subject was placed on a bed and connected to electro-cardiographic electrodes. After 15-minute rest in a sitting position, the electrocardiogram (ECG) recorded 512 heartbeats in a supine position. Thereafter, the same measure was taken in a standing position. During the test, the subjects quietly breathed in synchronosity with a 15/min (0.25 Hz) metronome signal to obtain stationary respiratory activity without frequency change or phase drift. R-wave detection by fast peak detection algorithm and spectrum computation by Fast Fourier transform enabled the study of the power spectrum of heart rate fluctuations. The power of fluctuations at different frequencies was the result of sympathetic and vagal input into the sinoatrial node. The autoregressive power spectral density of RR interval variability contained 2 major components: a high frequency (0.25 Hz), which is a quantitative marker of cardiac vagal activity, and a low frequency (<0.15 Hz), which is a quantitative marker of sympathetic activity with vagal modulation. A marked reduction in HF spectral density was found in diabetic patients relative to the normal controls (p<0.001). When neural activity was provoked through standing, less decreased HF spectral density and less increased LF spectral density were noted in diabetic patients relative to the normal controls (p<0.01). When diabetic autonomic neuropathy was advanced, HF and LF spectral density changes were lost. This method is simple, repeatible, objective, and quantitative. It may facilitate the screening of diabetic patients for autonomic neuropathy and enable convenient quantitative fallow-up.
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Lee, Yong-Hoon,Lee, Wang-Hyu,Lee, Du-Ku,Shim, Hyeong-Kwon The Korean Society of Plant Pathology 2001 Plant Pathology Journal Vol.17 No.3
The plant growth-promoting Pseudomonas strains, WR8-3 (Pseudomonas fluorescens), WR9-11 (Pseudomonas sp.) and WR9-16 (P.putida), which induced resistance systematically in watermelon to gummy stem rot were investigated on their induced systemic resistance(ISR)-related characteristics. The pyoverdine production was repressed in the standard succinate medium by increasing the concentration of $\textrm{FeCL}_3$. But the iron-binding ability on chrome azurol S agar media (CAS) was observed only in the strains, WR8-3 and WR9-16. When the two strains were mutated, the resulting iron-binding siderophore-negative mutants, WR8-3m and WR 9-16m, failed to promote the growth of watermelon and to induce resistance. The strains, WR8-3 and WR 9-16, slightly inhibited the growth of Didymella bryoniae at a low concentration of $\textrm{FeCL}_3$ on Kong's medium B, but not to exert control dffect. The strain WR9-11 showed antagonism in the concentration of $\textrm{FeCL}_3$ from 0 to $1,000\mu\textrm{M}$. When the crude lipoplysaccharide of each strain was treated in the rhizosphere of watermelon, mean lesion area was similar to that of the untreated control. The strains, WR9-11 and WR9-16 produced some level of hydrogen cyanide (HCN). Salicylic acid production was not detected in all of the strains.
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Du-Ku Lee,Jai-Sung Shim,Hyeong-Kwon Shim,Yong-Hoon Lee,Wang-Hyu Lee 한국자원식물학회 1999 Plant Resources Vol.2 No.2
Sixteen isolates showing relatively strong antagonicity against the ginger rhizome rot pathogen, Pythium zingiberum, were selected among the 155 isolates from ginger rhizome surfaces and rhizospheres of ginger cultivation fields in Wanju, Chonbuk. The isolate, ‘HB 26-5 showing the strongest antagonicity was finally selected by testing duration of inhibition effect and pathogenicity to ginger. The isolated antagonistic microorganism, HB 26-5 , was rod shape, gram positive and formed endospore. The isolate produced acids utilizing glucose, arabinose, xylose and mannitol, and acetoin at VP test, and grew anaerobically. Temperature range for growth was from 10 to 400. Reaction to catalase and gelatin, hydrolysis were positive, and casein hydrolysis and indol production were negative. Based on the mycological characters and the fatty acid composition, it was identified as Bacillus polymyxa. The pathogenicity test of isolated Bacillus polymyxa HB 26-5 on 22 crop cultivars resulted that only the lettuce was influenced in germination, and the others were not affected.
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Lee, Yong-Hoon,Lee, Wang-Hyu,Shim, Hyeong-Kwon,Lee, Du-Ku The Korean Society of Plant Pathology 2000 Plant Pathology Journal Vol.16 No.6
The selected five plant growth-promoting rhizobacteria (PGPR) strains, WR8-3 (Pseudomonas fluorescens), WR8-6 (P. putida), WR9-9 (P. fluorescens), WR9-11 (Pseudomonas sp.), and WR9-16 (P. putida) isolated in the rhizosphere of watermelon plants were tested on their growth promotion and control effect against gummy stem rot of watermelon. Strains, WR8-3 and WR9-16 significantly increased stem length of watermelon, and there was a little increase in leaf area, fresh weight and root length when strains, WR8-3, WR9-9 and WR9-16 were treated. Generally, seed treatment was better for plant growth promotion than the soil drench, but there was no significant difference. Seed treatment and soil drench of each bacterial strain also significantly reduced the mean lesion area (MLA) by gummy stem rot, but there was no significant difference between the two treatments. At initial inoculum densities of each strain ranging from 10$^6\;to\;10^{15}$ cfu/g seed, approximately the same level of disease resistance was induced. But resistance induction was not induced at the initial inoculum density of 10$^3$ cfu/g seed. Resistance was induced by treating the strains, WR9-9, WR9-11 and WR9-16, on all of four watermelon varieties tested, and there was no significant difference in the decrease of gummy stem rot among varieties. Populations of the strains treated initially at log 9-10 cfu/g seed, followed with a rapid decrease from planting day to 1 week after planting, but the population density was maintained above log 5.0 cfu/g soil until 4 weeks after planting. Generally no or very weak in vitro antagonism was observed at the strains treated excepting WR9-11. Rifampicin-resistant bacteria which had been inoculated were not detected in the stems or leaves, which suggesting that the bacterium and the pathogens remained spatially separated during the experiment. This is the first report of rsistance induction in watermelon to gummy stem rot by PGPR strains.
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Lee, Sol,Lee, Hae-Jeung,Chun, Yoon-Seok,Seol, Du-jin,Kim, Jong-Kyu,Ku, Sae-Kwang,Lee, Young-Joon Society of Preventive Korean Medicine 2018 대한예방한의학회지 Vol.22 No.1
Objectives : The present study investigated the anti-obese and blood flow improvement activities of aqueous extracts of ginseng berry (GBe) on the mild diabetic obese mice as compared with metformin. Methods : After end of 56 days of continuous oral administrations of GBe 150, 100 and 50 mg/kg, or metformin 250 mg/kg, anti-obese and blood flow improvement effects - the changes of body weights, body and abdominal fat density by in live dual-energy x-ray absorptionmetry (DEXA), tail bleeding time, prothrombin time (PT), activated partial thromboplastin time (aPTT), serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) levels, aorta and serum cyclic guanosine monophosphate (cGMP), nitric oxide (NO) and endothelin (ET)-1 levels, aorta phosphorylated PI3K (pPI3K), phosphorylated Akt (pAkt) and phosphorylated p38 MAPK (pp38 MAPK) levels were systemically analyzed. In addition, aorta vascular dilation and constriction related gene mRNA expressions - PI3K, Akt, eNOS, p38 MAPK and ET-1 were also analyzed by realtime RT-PCR. Results : The obesity and related blood flow impairment, induced by 84 days of continuous HFD supply, were significantly inhibited by 56 days of continuous oral treatment of GBe 150, 100 and 50mg/kg, dose-dependently, and they also dramatically normalized the changes of the aorta vascular dilation and constriction related gene mRNA expressions, also dose-dependently. Especially, GBe 150 mg/kg constantly showed favorable inhibitory activities against type II diabetes related obesity and vascular disorders through PI3K/Akt pathway and p38 MAPK mediated cGMP, NO and ET-1 expression modulatory activities, as comparable to those of metformin 250 mg/kg in HFD mice. Conclusion : By assessing the key parameters for anti-obese and blood flow improvement activities on the HFD-induced mild diabetic obese mice, the present work demonstrated that GBe 150, 100 and 50 mg/kg showed favorable anti-obese and blood flow improvement effects in HFD-induced type II diabetic mice, through PI3K/Akt pathway and p38 MAPK mediated cGMP, NO and ET-1 expression modulatory activities.
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재배양식에 따른 벼 줄무늬잎마름병 전염원인 애멸구의 밀도
이두구(Lee, Du-Ku),심형권(Shim, Hyeong-Kwon),박종철(Park, Jong-Chul),최만영(Choi, Man-Young),강미형(Kang, Mi-Hyung),김재덕(Kim, Jae-Duk),박진우(Park, Jin-Woo),노태환(Noh, Tae-Hwan) 한국자원식물학회 2006 한국자원식물학회지 Vol.19 No.4
In double cropping fields, there has been a risk of increase rice stripe viral disease outbreaking as the vector, small brown planthopper that overwinter in barley fields increases. Especially rice cultivation in Honam region has two types of cropping system such as rice only cropping in a season and double cropping both of rice and barley. In double cropping system, harvesting of barley could induce migration of the vector from barley to rice field. We found that the vector s density was different in rice fields by distance from barley field. The vector s density in rice field was highest 63 numbers within one meter from the neighbor barley field, and the numbers reduced greatly as the distance from barley field increases. The disease incidence according to rice cultivation methods was different, Donjin 1 was appeared to be a susceptible variety showing 2.4% and 2.5% of disease incidence in direct and transplanting cultivation, respectively. The small brown planthopper in a nearby rice field reach peak 3 days after the barley field was harvested. 보리 재배면적 증가로 인하여 월동한 애멸구 밀도증가가 벼 줄무늬잎마름병의 대면적 발생 위험이 상존하고 있다. 특히 호남지역은 보리재배 논과 1모작 이앙 또는 직파재배 논이 혼재하고 있어 보리 수확과 동시에 보독충인 애멸구는 벼가 자라고 있는 논으로 대규모 이동하여 병 발생을 조장하고 있다. 재배양식에 따른 줄무늬잎마름병 발생양상은 1모작 이앙과 담수직파 재배에서 병발생이 각각 2.5, 2.4%로 이모작 이앙 1.3%보다 높았다. 보리재배 논과의 2m 이내의 거리에서 보리 수확 3일전 애멸구 밀도는 5마리에서 수확 3일후 63마리로 급격하게 증가하였다. 또한 보리재배 논과 거리가 멀어짐에 따라서 애멸구 밀도는 크게 감소하였다.
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PCR을 이용한 국내 및 수입 축산물 유래 Listeria monocytogenes의 유전학적 분석연구
우용구,이수화,이철현,최정수,류재두,김영일,이오수,김봉환 한국수의공중보건학회 2003 예방수의학회지 Vol.27 No.2
One hundred-fifty two of Listeria strains were isolated from domestic chicken carcasses, a slaughter-houses from nationwide from 1996 to 1997 and imported livestock products from a ten foreign countries including the USA, China, France and Thailand. To substitute the laborious and time consuming procedures of clinical laboratory standard diagnostic methods, the rapid and specific multiplex PCR(M-PCR), which was designed to amplify a three kinds of genes simultaneously f3r specific detection and differentiation of L. monocytogenes(LM) by one step procedure, was established. The LM strains confirmed with M-PCR were analysed to their genetic diversities by RAPD using the two primers(D87 & MMTl), and also evaluated on their discriminatory abilities(na) between two primers. our study also conducted the REP-PCR and ERIC-PCR for evaluation of the possibility of REP and ERIC elements for genetic subtyping of LM strains. According to the REP-PCR and ERIC-PCR fingerprinting patterns, LM strains were divided into 7(ERIC-type) and 4(REP-type) major clusters at the relative clone cut off value of 80%. According to the computer analysis of PCR results using the GelCompar Ⅱ software, ERIC-PCR(DI=0.955) had expressed the most high discriminatory ability and followed by REP-PCR(DI=0.952), RAPD(D87; 0.954, MMT1; 0.937), in order. The combined analysis of the present PCR results was also expressed the reliable and useful discriminatory ability(DI=0.916). This study suggested that PCR based methods could be used as an reliable, reproducible, rapid, and highly discriminatory method for the genetic differentiation of genus Listeria.
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