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Eoh, Kyung Jin,Chung, Young Shin,Lee, So Hyun,Park, Sun-Ae,Kim, Hee Jung,Yang, Wookyeom,Lee, In Ok,Lee, Jung-Yun,Cho, Hanbyoul,Chay, Doo Byung,Kim, Sunghoon,Kim, Sang Wun,Kim, Jae-Hoon,Kim, Young Tae 대한암학회 2018 Cancer Research and Treatment Vol.50 No.3
<P><B>Purpose</B></P><P>Although the use of xenograft models is increasing, few studies have compared the clinical features or outcomes of epithelial ovarian cancer (EOC) patients according to the tumorigenicity of engrafted specimens. The purpose of this study was to evaluate whether tumorigenicity was associated with the clinical features and outcomes of EOC patients. </P><P><B>Materials and Methods</B></P><P>Eighty-eight EOC patients who underwent primary or interval debulking surgery from June 2014 to December 2015 were included. Fresh tumor specimens were implanted subcutaneously on each flank of immunodeficient mice. Patient characteristics, progression-free survival (PFS), and germline mutation spectra were compared according to tumorigenicity.</P><P><B>Results</B></P><P>Xenografts were established successfully from 49 of 88 specimens. Tumorigenicity was associated with lymphovascular invasion and there was a propensity to engraft successfully with high-grade tumors. Tumors from patientswho underwent non-optimal (residual disease ≥ 1 cm) primary orinterval debulking surgery had a significantly greater propensity to achieve tumorigenicity than those who received optimal surgery. In addition, patients whose tumors became engrafted seemed to have a shorter PFS and more frequent germline mutations than patients whose tumors failed to engraft. Tumorigenicity was a significant factor for predicting PFS with advanced International Federation of Gynecology and Obstetrics stage and high-grade cancers.</P><P><B>Conclusion</B></P><P>sTumorigenicity in a xenograft model was a strong prognostic factor and was associated with more aggressive tumors in EOC patients. Xenograft models can be useful as a preclinical tool to predict prognosis and could be applied to further pharmacologic and genomic studies on personalized treatments.</P>
Analysis of Radioactivity in Coal Fly Ash
Lee,Myung-Ho,Kim,Mi-Kyung,Shin,Hyun-Sang,Park,Doo-Wun,Lee,Chang-Woo,Rhee,Dong-Seok 대한방사선 방어학회 2000 방사선방어학회지 Vol.24 No.4
국내 석탄화력발전소에서 발생되는 비산석탄회의 방사능 농도 분석을 수행하였고 재활용을 위한 방사능 함량의 유해도를 평가하였다. TBP 용매추출법과 알파스펙트로메타를 사용하여 비산석탄회에 존재하는 우라늄 동위원소(U, U, U)의 방사능 농도를 측정하였으며, 감마스펙트로메타를 사용하여 Ra, Th, K 등의 방사능 농도를 결정하였다. 우라늄 동위원소의 농도측정결과 U, U, U의 방사능 농도은 평균적으로 각각 116.1, 5.01, 및 121.2 ㏃ ㎏으로 나타났으며, U/U의 방사능 농도비는 1.04 ± 0.03 로서 자연상태의 토양중 방사능 농도 비인 1.14 와 유사하였다. 동일시료에 대한 감마측정 결과 Ra, Th 및 K의 방사능 농도는 각각 101.7 ∼ 113.9, 39.5 ∼ 54.2 및 315.0 ∼ 990.6 ㏃ ㎏ 으로 나타났다. Ra, Th 및 K 동위원소의 농도를 사용하여 재활용 목적으로서의 비산석탄회의 방사능 함량 유해도를 평가하였고, 그 결과 본 연구의 대상물질인 비산석탄회의 방사능 함량은 허용기준치 이하로 나타났다. The specific radioactivity concentrations in the coal fly ash obtained from heat producing stations in Korea were analyzed and its radiological hazard for reuse in construction purpose was evaluated. The concentrations of uranium isotopes in the coal fly ash measured by TBP solvent extraction method and α-spectrometer were found to be about 116.1 ㏃ ㎏ for U, and 121.2 ㏃ ㎏ for U, respectively. The actibity ratio of U/U, in the coal fly ash was in 1.04 ± 0.03, which is similar to that of uncontaminated Korean soil in natural conditions (1.14). The specific radioactivities of Ra, Th and K in the coal fly ash were also determined using γ-spectrometer with a HPGe detector. The results showed that Ra, Th, and k in the coal fly ash were in concentrations of 101.7 ∼ 113.9, 39.5 ∼ 54.2 and 315.0 ∼ 990.6 ㏃ ㎏, respectively. With the specific radioactivities obtained from γ-spectrometric measurements of the coal fly ash, its radiological hazard for reuse was evaluated. The result showed that the radioactivity of the coal fly ash was in permissible level.
신현상,이명호,김미경,박두원,이창우,이동석,Shin, Hyun-Sang,Lee, Myung-Ho,Kim, Mi-Kyung,Park, Doo-Wun,Lee, Chang-Woo,Rhee, Dong-Seok 대한방사선방어학회 1999 방사선방어학회지 Vol.24 No.4
국내 석탄화력발전소에서 발생되는 비산석탄회의 방사능 농도 분석을 수행하였고 재활용을 위한 방사능 함량의 유해도를 평가하였다. TBP 용매추출법과 알파스펙트로베타를 사용하여 비산석탄회에 존재하는 우라늄 동위원소($^{238}U,\;^{235}U,\;^{234}U$)의 방사능 농도를 측정하였으며, 감마스펙트로메타를 사용하여 $^{226}Ra,\;^{232}Th,\;^{40}K$ 등의 방사능 농도를 결정하였다. 우라늄 동위원소의 농도측정 결과 $^{238}U,\;^{235}U,\;^{234}U$의 방사능 농도는 평균적으로 각각 116.1, 5.01, 및 121.2 Bq $kg^{-1}$으로 나타났으며, $^{234}U/^{238}U$의 방사능 농도비는 $1.04\;{\pm}\;0.03$ 로서 자연상태의 토양중 방사능 농도 비인 1.14 와 유사하였다. 동일시료에 대한 감마측정 결과 $^{226}Ra,\;^{292}Th$ 및 $^{40}K$의 방사능 농도는 각각 $101.7\;{\sim}\;113.9,\;39.5\;{\sim}\;54.2$, 및 $315.0\;{\sim}\;990.6$ Bq $kg^{-1}$ 으로 나타났다. $^{226}Ra,\;^{292}Th$ 및 $^{40}K$ 동위원소의 농도를 사용하여 재활용 목적으로서의 비산석탄회의 방사능 함량 유해도를 평가하였고, 그 결과 본 연구의 대상물질인 비산석탄회의 방사능 함량은 허용기준치 이하로 나타났다. The specific radioactivity concentrations in the coal fly ash obtained from heat producing stations in Korea were analyzed and its radiological hazard for reuse in construction purpose was evaluated. The concentrations of uranium isotopes in the real fly ash measured by TBP solvent extraction method and $\alpha$-spectrometer were found to be about 116.1 Bq $kg^{-1}$ for $^{238}U$, 5.01 Bq $kg^{-1}$ for $^{235}U$, and 121.2 Bq $kg^{-1}$ for $^{234}U$, respectively. The activity ratio of $^{234}U/^{238}U$, in the coal fly ash was in $1.04\;{\pm}\;0.03$, which is similar to that of uncontaminated Korean soil in natural conditions (1.14). The specific radioactivities of $^{226}Ra,\;^{232}Th,\;and\;^{40}K$ in the coal fly ash were also determined using $\gamma$-spectrometer with a HPGe detector The results showed that $^{226}Ra,\;^{232}Th,\;and\;^{40}K$ in the coal fly ash were in concentrations of $101.7{\sim}113.9$, $39.5{\sim}54.2\;and\;315.0{\sim}990.6$ Bq $kg^{-1}$, respectively. With the specific radioactivities obtained from $\gamma$-spectrometric measurements of the coal fly ash, its radiological hazard for reuse was evaluated. The result showed that the radioactivity of the coal fly ash was in permissible level.