Risk Factors, Patterns, and Outcomes of Late Recurrence after Liver Resection for Patients with Hepatocellular Carcinoma (Analysis of a Multicenter Cohort over 15 Years)

( Xin-fei Xu ),( Jiong-jie Yu ),( Ju-dong Li ),( Hao Xing ),( Jun Han ),( Zhen-li Li ),( Han Wu ),( Han Zhang ),( Jian-hong Zhong ),( Yi- Sheng Huang ),( Ya-hao Zhou ),( Ting-hao Chen ),( Hong Wang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Late recurrence (> 2 years) after liver resection of hepatocellular carcinoma (HCC) is usually considered as multi-centric tumors or de novo cancer formation. We aimed to investigate risk factors, patterns and outcomes of late recurrence after HCC resection. Methods: From a multicenter database from 2001 to 2015, 734 patients who were alive and recurrence-free at 2 years after curative resection of initial HCC were enrolled into this retrospective study. Univariate and multivariate Cox-regression analysis were used to identify independent risk factors of late recurrence. Patterns, treatments and outcomes of late recurrence were investigated and analyzed. Results: During a median follow-up of 78.0 months after surgery, 303 patients (41.3%) developed late recurrence. Multivariate analysis revealed that cirrhosis, macroscopic vascular invasion, satellites, and tumor size > 5cm were independent risk factors of late recurrence. Among them, 273 (90.1%) were sole intrahepatic recurrence, 30 (9.9%) were concurrent intrahepatic and extrahepatic recurrence, and none of them was sole extrahepatic recurrence; 165 (54.4%) patients received curative treatments for recurrent HCC, including re-resection, transplantation and local ablation. Multivariate analysis showed regular postoperative surveillance and receiving curative treatments were two independent protective factors of prolonging survival for those patients with late recurrence. Conclusions: Late recurrence is correlated with cirrhosis and certain tumor-related characteristics of initial HCC. The patterns of late recurrence suggest that postoperative surveillance after 2 years of surgery could be adjusted and more targeted. Regular postoperative surveillance improves the probability to receive curative treatments again, yielding to better outcomes for patients with late recurrence.

No Association Between the USP7 Gene Polymorphisms and Colorectal Cancer in the Chinese Han Population

Li, Xin,Wang, Yang,Li, Xing-Wang,Liu, Bao-Cheng,Zhao, Qing-Zhu,Li, Wei-Dong,Chen, Shi-Qing,Huang, Xiao-Ye,Yang, Feng-Ping,Wang, Quan,Wang, Jin-Fen,Xiao, Yan-Zeng,Xu, Yi-Feng,Feng, Guo-Yin,Peng, Zhi-Ha Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Colorectal cancer (CRC), now the third most common cancer across the world, is known to aggregate in families. USP7 is a very important protein with an important role in regulating the p53 pathway, which is critical for genomic stability and tumor suppression. We here genotyped eight SNPs within the USP7 gene and conducted a case-control study in 312 CRC patients and 270 healthy subjects in the Chinese Han population. No significant associations were found for any single SNP and CRC risk. Our data eliminate USP7 as a potential candidate gene towards for CRC in the Han Chinese population.

A Study on Chinese Corporate Social Responsibility Management Mode in Economic Transition Age - A Case Study of Beijing Retailing Industry

Li, Dong-xin,강태원,이용기 한국프랜차이즈경영학회 2011 프랜차이즈경영연구 Vol.2 No.2

For decades, corporate social responsibility (CSR) has been a subject of intense debate among scholars and practitioners. Discussions have generally focused on the role of business in society and the nature of an enterprise’s social responsibilities. The International Organization for Standardization (ISO) announced the implication of the ISO 26000 as the new guidance standard for social responsibility, which is built on the intellectual and practical infrastructure of ISO 9000 and ISO 14000. Although the enthusiasm for corporate social responsibility (CSR) has been echoed in the Chinese marketing literature, with the very low rate and level of CSR implementation in China’s enterprises based on 2011 report of Chinese Academy of Social Sciences, this paper will give a general statement on the current status and future management mode of CSR in China.

Comparative Study on IMC LevelTV and Print Ads between Korea and China

Dong-Xin Li,강태원,이용기 한국프랜차이즈경영학회 2011 프랜차이즈경영연구 Vol.2 No.1

Supermarket Franchising, as a relatively new mode of retail business, is often regarded as one of the two hallmarks of the "Modern Logistics Revolution". After more than ten years of development, franchise supermarkets have been a rising force in retail business in China. As a product of a highly‐developed commercial economy, franchise supermarkets mainly deals in foodstuffs and other daily necessities, featuring low cost, high turnover rate, low prices and diversified inventory. Propelled by the conveniences that come with open shelves and self‐service shopping, franchise supermarkets have been growing very rapidly and the rise of many franchise supermarket brands bears testimony to its growth potential and profitability. Meanwhile, in the backdrop of this boom, some franchise supermarkets are going bankrupt. This paper analyzes the current status of franchise supermarkets and some factors bearing on their core competencies, so as to close the competitiveness gap with international retail giants.

Intermedins A and B; New Metabolites from Schisandra propinqua var. intermedia

Li, Hong-Mei,Lei, Chun,Luo, Yong-Ming,Li, Xiao-Nian,Li, Xiao-Lei,Pu, Jian-Xin,Zhou, San-Yun,Li, Rong-Tao,Sun, Han-Dong 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.6

A new dibenzocyclooctadiene lignan, intermedin A (1), and a new natural bisabolane sesquiterpenoid, intermedin B (2), were isolated from the aerial parts of Schisandra propinqua var. intermedia. Their structures were elucidated on the basis of extensive spectroscopical analysis.

A Study on Logistical System and Operational Models of Franchise Store Retailing in China

Li, Dong-xin,강태원 한국프랜차이즈경영학회 2012 프랜차이즈경영연구 Vol.3 No.1

Franchise store retailing is taking on ever greater roles in business and commerce in China. The diverse product range, small-batch order, high frequency and time-specific requirements inherent in retail logistics make it the most complicated of all categories of logistics. In franchise store retailing, expanding business scales make trans-regional development a trend. Without a well-functioning logistic system, the standardized delivery of products would be held back, impacting trans-regional development strategy and operational costs. Therefore, the efficiency of franchise store retailing largely depends on logistical efficiency. The integrated and streamlined management of franchise stores depends in large measure on their logistical centers. As such, logistical centers constitute the key link and bears on core competitiveness in franchise store retailing. This thesis begins with an analysis of the current developments and four basic logistical models of franchise store retailing in China, proceeds to summarize developmental trends as well as focal issues and proposes an efficiency enhancing plan.

Comparative Study on IMC Level TV and Print Ads between Korea and China

Dong Xin Li,Dong Il Lee 한국경영학회 2009 한국경영학회 통합학술발표논문집 Vol.2009 No.08

Feedforward coefficient identification and nonlinear composite feedback control with applications to 3-DOF planar motor

Li Xin,Yang Kai-ming,Zhu Yu,Yu Dong-dong 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.3

Due to modeling errors, accurate feedforward coefficient of the controller cannot be obtained with the standard method on the basis of the nominal model. Meanwhile, the system is uncertain in practice. Consequently, the MIMO (multi-input multi-output) system of the planar motor cannot be completely decoupled by feedback linearization, and the convergence of the tracking errors is no longer guaranteed. In order to improve the robustness and the tracking ability of the planar motor, a feedforward coefficient identification method and nonlinear composite feedback controller are proposed, thus guaranteeing stability by Lyapunov theory, wherein the feedforward coefficient can be obtained by the PD control experiment. The results of two different trajectory tracking experiments show that it is more accurate than the standard method. Moreover, this coefficient is suitable for different trajectories, so it avoids the drawback of ILC (iterative learning control) method, by which the feedforward term obtained cannot be reused if the length of the trajectory changes. The nonlinear composite feedback controller consists of u1 and u2 terms. u1 is designed to compensate for modeling errors, therefore the robustness is improved and the coupling effects among multi-DOF (degrees of freedom) are reduced. In balancing the trade-off between disturbance rejection and noise sensitivity, an amplitude-based variable-gain function is applied in u2. The trajectory tracking experimental results show that the overall controller is an attractive approach for the uncertain multi-DOF systems.

Comparative Study on the IMC Level of TV and Print Ads between Korea and China

Dong-xin Li,Dong Il Lee,Yong-Ki Lee,Mitch Griffin 한국마케팅과학회 2011 마케팅과학연구 Vol.21 No.1

?覆??大??播媒?的新?媒技?的?展??成??告?的?向?。??致以下情?的出?:多?化的媒?行止、用??料?的?展、多?用?需求?口味、客?希望?拓合算而且有效的??策?,以便迅速???化的市??境(金姆.翰.舒?茨,2003)。?肯?言整合???播?念已?深入??者的思想之中。在金姆.翰.舒?茨看?,如果市??境合适,整合???播是可接受?且可行的。?果,在???播?域,整合???播(IMC)是被?泛?用的??策略之一。?多?者用不同方法?定和??了影?整合???播?念的因素。 本次硏究??了中????告、?志?告整合???播的水平,主要包括以下???境因素:市?未成熟因素,?品投入因素。利用?2007年5月到2009年5月在中???共同收集的120?例子(60????告,60?平面?告),?行一??比硏究。 硏究?果表明,在集中程度和多?性方面:??的整合???播水平要?着高于中?,高投入?品的整合???播水平要高于低投入?品。在??,高投入?品的整合???播水平要比低投入?品的更??;在三??定的中?用例中,高投入?品的交王作用?低投入?品的?有??。部分?果表明,?家???境和?品投入有着相互的作用?影?。硏究?果充分?明,在??市????行整合???播???略方向有助于市?供?。 本次硏究?示整合???播操作和部署的方法以及?展方向,因各?的社?文化和???境而?。特?是由于市?成熟度、???展水平以及?本主?社?的??,在?前??具有更高的整合???播水平。相反,由于是一?更具社?主?性?的?家,中?的整合???播的?展水平上有所差?。而且,由于中?是一?在?土面?以及文化??都?超??的?家-中?有多?不同的?言、文化以及地理分布,整合???播也?不是那?太适合中?。?于?????有必要?各?社?在文化的社?制度上的差?、客?和代理的企?文化、目?消?者的文化?行硏究,使我?能??影?整合???播?展的因素?行准?分?。 本硏究的理?。首先,?果?示??已?成功度?整合???播?展的第二??段,?且?在?于通信技??用?第三?段。相比?而言,中???在市??通?略???第一??段,以及重新定????播范??第二?段。一?在中?最大的?告商(中????告公司)工作的管理人?,表示有?多因素影?整合???播在中?的?展。其中三?比?重要的因素是:中?的?告公司在?施整合???播??有考?到中?特殊的文化价?、特殊的中?媒? The development of new media technologies that have weakened the power of traditional mass media as an advertising channel. This has led to a diversified media sector and the development of consumer databases, widely varying consumers’ needs and tastes, and clients’ desires to develop cost-efficient and effective marketing strategies that quickly respond to the changing marketing environment (Kim, Han, and Schultz, 2003). Duncan (2005) declares that it’s hard to find an agency or client marketing executive who doesn’t believe in the IMC concept. In the view of Kim, Han, and Schultz (2003), IMC is acceptable and practicable if the market circumstances are suitable. As a result, Integrated Marketing Communications (IMC) is one of the most widely used concepts in the marketing communications field. Many scholars have identified and assessed the factors that influence the emergence of IMC in several ways. This study assesses the IMC level of television and magazine advertisements in Korea and China, compares and contrasts these two environments, and tests the market immaturity effect and product involvement effect on the level of IMC across these contexts. By utilizing 120 pairs of ad samples (60 television ads and 60 corresponding print advertisements) collected in both China and Korea between May 2007 and May 2009, a comparative study has been conducted. The findings suggest that the IMC level in Korea is significantly higher than that in China in terms of intensity and/or variety, the IMC level of ads for high-involvement products is higher than that for low-involvement products in terms of intensity and/or variety, the IMC level for high-involvement products is more positive than that for low-involvement in Korea, and the interaction for high-involvement shows no difference from that of for low-involvement in three of the given dimensions in China in terms of intensity and/or variety. Finally, the results partially show there is an interaction effect between country and product involvement. The results should prove helpful in providing marketers with strategic direction on implementing IMC in international markets as follows. This research shows the methods of IMC operation and deployment, as well as the developmental paths, differ based on socio-cultural and economic factors of certain societies. Specifically, due to differing levels of market maturity, economic development, and its capitalist society, Korea has a higher level of IMC currently deployed. Conversely, since China is a more socialist society, a different development level of IMC exists. Moreover, as China is a much larger and more diverse country - within its border are different languages, cultures, and geographic dispersions - than Korea, IMC may be less appropriate. To learn more about this issue, it will likely be necessary to conduct research including both cultural and institutional differences in each society, the corporate cultures of the client and the agency, as well as the target consumer cultures, to be able to accurately categorize those factors that affect the development level of IMC. The current study also has theoretical implications. First, the empirical results suggest that Korea has successfully passed the second stage of IMC development and is currently in the third stage for application of information technology. In contrast, China is still in stage 1 for tactical coordination of market communications and stage 2 for redefining the scope of marketing communications. A manager working in the largest advertising agency in China, China-Guangdong Advertising Agency, states several factors are influencing the development of IMC in China. The three more important factors are the implementation of IMC by Chinese advertising agencies without considering the special cultural values of China, the special characteristics of Chinese media, and the immature consumer market (Xin, 2004).

Impact Studies of Cultural Value and Environmental Value Factors on the Development of Environmental Marketing in China

Dong-Xin Li 중앙대학교 한국전자무역연구소 2010 전자무역연구 Vol.8 No.4

현대의 환경과 자원 문제는 좀 더 중요해졌기 때문에 전통적 마케팅 모델은 근본적인 전략적 그리고 지속가능한 인류 발전에 거스른다는 것이 점차적으로 실현되어 왔다. 그러므로 환경 마케팅이라고 불리는 인간과 자연 사이에서 조정된 개발을 달성할 수 있도록 하기 위해 생태, 경제와 사회를 포함한 마케팅 모델을 달성하기 위한 긴급한 필요성이 충족되어야 한다. 환경 마케팅 기업들은 녹색소비의 수요를 충족시키기 위해 지속 가능한 성장의 국제 동향에 맞추어야 한다. 그러나 뒤늦게 시작된 중국의 녹색 마케팅 때문에 동시에 도입에서의 확실한 성과는 아직 많은 문제에 부딪히고 있다. 그러므로 본 논문은 중국 기업의 지속가능한 성장의 환경 문제의 영향을 언급하는 것을 목적으로 한다. Tao Te Ching에 따라서 문화적 가치와 환경 가치의 영향과 인간행동에 대한 자연법의 중대한 영향은 Lao Tzu의 사고의 관점에서 연구되었다. 또한 본 논문은 분석된 사례인 중국 환경 마케팅의 현재 도입 상황을 논의하고 사례를 분석하며 제안된 아이디어에 대하여 논의한다. As modern environmental and resource problems become more prominent, the traditional marketing model has gradually been realized to run counter to the fundamental strategic and sustainable human development. Hence the urgent need should be satisfied to achieve marketing model incorporating ecology, economy and society to achieve coordinated development between man and nature, which is called environmental marketing. Environmental marketing enterprises need to comply with the global trend of sustainable growth to meet the demand of green consumption. However, due to the late start of Green Marketing in China, certain achievements in the same time in implementation is still confronted with many problems. Therefore, this paper aims to state the impacts of environmental problems on sustainable growth of Chinese enterprises. The impacts of cultural and environmental values, according to Tao Te Ching, and the important impacts of natural laws on human’s behavior have been studied from the perspective of Lao Tzu’s thought. In addition, this paper discusses the current implementation status of China’s environmental marketing, analyze the case, and rationalize the proposed ideas.