자궁경부 상피종양에서 human papillomavirus 감염과 survivin 발현

윤재호,정동준,이정은,박동명,배동한,선우재근,백무준,김창진 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Human papillomavirus (HPV) has been considered a causative agent of uterine cervical carcinoma. HPV is a DNA oncogenic virus, which is well known as a causative virus in uterine cervical carcinoma. The virus is classified into two groups genotypically, low risk and high risk, according to the carcinogenic potentiality, and the determination of the viral genotype is important in clinical practice. Recently, numerous genotypes can be determined by high throughput method using DNA chip. Survivin is a recently characterized inhibitor of anti-apoptosis (IAP) protein, which is abundantly expressed in most solid and hematological malignancies, but undetectable in normal adult tissues. In this study, HPV genotypes are determined by DNA chip and the expression of survivin was examined by immunohistochemistry in 80 cases of uterine cervical intraepithelial neoplasia (CIN) and invasive carcinoma to see the roles of HPV and survivin in the carciogenesis of uterine cervical epithelial neoplasia. The results were as follows: 1. HPV positive rate was 72.5%, while negative rate was 27.5% in 80 cases of CIN and invasive carcinoma. The CIN and invasive carcinoma showed higher HPV positive rate (p <0.05). 2. HPV positive rate according to the histologic grade were 60%, 65%, 77% and 90% in CINI, CINII, CINII and invasive carcinoma, respectively. HPV positive rate showed increasing tendency according to the histologic grade, though there was no statistical significance. 3. The most frequent genotype was type 16 and the next were 58, 52, 18 and 33 in order of frequency. 4. Survivin was expressed in 96.3% of CIN and invasive carcinoma. The expression rate of survivin showed no significant difference between the histologic grade of CIN and invasive carcinoma, but showed tendency of increased expression rate in invasive carcinoma. 5. Survivin was expressed in HPV positive and in HPV negative each as in 95.5% and 96.6% respectively. There was no significant difference of survivin expression between HPV positive and negative cases. The above results suggest that HPV has no effect on the regulation of survivin expresson level in the uterine cervical intraepithelial neoplasia and invasive carcinomas.

지방화시대의 지역사회운동의 역할과 과제

윤준상,김동섭 公州大學校 産業開發硏究所 1999 産業開發硏究 Vol.7 No.-

After 1960's, the urbanization and industriaization have been nation=leading in Korea. Also, the policy process oriented only the public good as a result nuder the authoritarian government, ommiting democratic proccess without taking public opinion into consideration. As result of these, each community's specific circumstance was not reflected in regional development and brought forward various social problems such as income and development disparity etc. However, operation of local autonomy, gradual realization of democracy and enlargement of demand on bottom-up made a community movements quantitatively and qualitatively. Community movements have played a very essential role as the major means of protest in such problems of community people concerned. Especially, in the cases of underprivileged social strata and area, community movement is an important means in the formation of political opinion and policy making processes to the their local government. Community movement should be based on the community people's needs. Community movement organizations should be made programs solving people's needs is to be established in local government level. So, the desirable directions for the development of community movement in community level are as follows: ① the settlement of Local Agenda, ② the development of community common sense, ③ the activation and solidarity of community movement organizations, ④ the development of community leadership, ⑤ the activation of local press and regional informatization, ⑥ the support of local government to the community movement organizations.

다공성세라믹에 의한 에멀전상 유분흡착에 관한 연구

윤동준,권이열,김주영 漢陽大學校 環境科學硏究所 1988 環境科學論文集 Vol.9 No.-

본 연구는 다공성세라믹에 소수성처리를 하여 Emulsified oil의 흡착에 관하여 고찰하였다. 실험에 사용한 다공성세라믹에 Corn-oil, Kerosene 및 Bunker-A의 Emulsified oil을 회분식으로 실험하였다. 다공성세라믹의 particle size, 온도, pH 및 흡착제의 양을 변화시키며서 각 인자에 대하여 특성을 관찰한 결과, 제거율은 Bunker-A, Kerosen, Corn oil의 순서을 나타났으며, Activated Carbon과 비교실험하여 Activated Carbon보다 30%이상 좋은 유분제거율을 보였다. This investigation was carried out to study on the absorption properties of emulsified oils by porous ceramics. In this experiment, emulsified oils of corn oil, kerosene and bunker-A were used by porous ceramics in batch type experiment. The specific characterics were observated by factors particle size of porous ceramics, temperature, pH and amounts of absorbents. The efficiency of removal showed the sequence of bunker-A, kerosene, and corn oil. In the comparative experiment of activated carbon. the efficiency of removal of porous ceramics showed more high(over 30%) than it of activated carbon.

지방자치단체의 국제교류 활성화방안에 관한 연구 : 천안시를 중심으로

윤준상,최동만,길중섭 공주대학교산업개발연구소 2000 産業開發硏究 Vol.8 No.-

The 21st century is the era of localization or local autonomy. It means that civil organizations or local autonomous bodies do not depend on the central government or are not controlled by it and that they are gradually expanding their scope to play independent role in the international society. In this era of globalization, local governments should build power and ability to meet the environment change actively, and should raise the services of talent who can establish proper polices suitable for the vitalization of local autonomy. Under such circumstances, this study of the Cheonan-city was aimed at arranging the problems related to the international exchanges between local autonomous governments and thereby, suggesting the reform measures to promote them. In order to analyze the condition of international exchanges, they were categorized in large into those through sisterhood relationship, human exchanges, organization status and budget scale of the international exchanges.

열대 지역에서 통일형 초다수성 벼 품종의 생육 및 수량성 비교

이지윤,준현,성환,손영보,송유천,한상익,박동수,권영업,이철원,이종희 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

급성 유기인제 중독환자의 혈청 Cholinesterase 활성도와 임상적인 의의에 관하여

전동석,김재룡,박승국,김윤년,이경민,윤덕구 啓明大學校 醫科大學 1988 계명의대학술지 Vol.7 No.2

To study the pseudocholinesterase acticity and its clinical significance in patients with acute organophosphate poisoning, Authors checked the serum cholinesterase activity in 49 normal subjects and 31 acute organophosphate poisoned patients. The results were followings. 1. The mean pseudocholinesterase activity f normal subjects was 1271 IU/L in male and 1131 IU/L in female. The total mean cholinesterase activity was 1209/ IU/L. 2. The pseudocholinesterase activity of patients were significantly reduced compare to normal. 22 patients(73%) were below 10% of normal, 6 patients(20%) were between 10-20% of normal and only 2 patients (7%) were between 20-50% of normal. 3. As a whole there was more depressed cholinesterase activity in patients with comatous and drowsy mentality, but there was no statistically significant difference between three groups. 4. The pseudocholinesterase activity in patients with respiratory failure was more depressed than without respiratory failure, but there was no statistically significant difference between three groups. 4. The pseudocholinesterase activity in patients with respiratory failure was more depressed than without respiratory failure, but there was no statistically significant difference presented. 5. The mean arterial blood gas checked on arrival was pH 7.386, PaO?? 66mmHg, PaCO?? 38mmHg 02 Saturation 91%. There was noted no statistically significant correlation between pseudocholinesterase activity and these parameters. 6. The pseudocholinesterase activity on the 1st day of admission was 5.7% of normal and progressively increased during admission. On the 14th day of admission, the pseudocholinesterase activity was 35.5% of normal and it takes 20 days to reach 50% of normal. Authors concluded that serum cholinesterase activity of acute organonphosporus poisoned patients were markedly depressed and progressively increased during admission. As a whole the pseudocholine-sterase activity seemed to be related to the clinical findings but no statistically significant difference was found.

다공성 세라믹에 의한 중금속 이온의 흡착거동에 관한연구

윤동준,권이열,홍성자 漢陽大學校 環境科學硏究所 1989 環境科學論文集 Vol.10 No.-

본 연구는 다공성 세라믹을 이용하여 수용액중의 중금속 이온(Cu(Ⅱ),Pb(Ⅱ)의 흡착특성을 회분석(Batch Test) 실험으로 고찰하였다. 다공성 세라믹(porous ceramics)의 흡착능을 비교하기 위하여 Sand와 활성탄(Activated Carbon)을 비교흡착제로 사용하였으며, 실온에서 중금속 이온농도가 20mg/ι인 용액 50ml에 대하여 pH(2.0±0.5, 3.0±0.5, 6.0±0.5), 접촉시간(0.5hr, 1hr, 2hr,3hr) 및 흡착제양을 변화시키면서 각 인자에 대한 특성을 관찰하였다. 흡착제양이 4.0g이고 접촉시간이 3hr, pH6.0±0.5일 때 Sand는 Cu(Ⅱ), Pb(Ⅱ) 및 Zn(Ⅱ)의 제거율이 7.8%, 18.6% 및 7.1%로 나타났다. 활성탄 (0.3g)은 Cu(Ⅱ), Pb(Ⅱ) 및 Zn(Ⅱ)의 제거율이 99.5% , 99.5% 및 73.8%로 나타났다. 이에 대하여 다공성 세라믹은 Cu(Ⅱ)가 97.8%, Pb(Ⅱ)가 99.0% over 및 Zn(Ⅱ)가 38.3%로서 Cu(Ⅱ)와 Pb(Ⅱ)에 대하여 좋은 제거율을 보였다. This investigation was carried out to study on the sorption characteristics of heavy metallic ions (Cu(Ⅱ), Pb(Ⅱ), Zn(Ⅱ)) by porous ceramics in batch type experiment. To compare the sorption ability of porous ceramics, sand and activated carbon were used as comparative adsorbents. At room temperature the sorption characteristics were observed by factors-pH(2.0±0.5, 3.0±0.5, 6.0±0.5), contact time(0.5hr, 1hr, 2hr, 3hr), amounts of adsorbents for 50ml solution of 20mg/ιof each heavy metallic ions.

한국의 대선진국 직접투자에 대한 소고: 구조적 시장방어론 : 가전산업을 대상으로

윤동진,전용욱 韓國國際經營學會 1991 國際經營硏究 Vol.2 No.1

개도국의 대선진국 직접투자는 흐름방향면에서 역투자로서의 의미를 지니며 전통적인 해외직접투자와는 그 특징이 상이하기 때문에 기존의 해외직접투자이론으로서는 그 설명이 어렵다고 할 수 있다. 본고에서는 한국제조업 중 대선진국 직접투자가 가장 활발한 가전산업의 해외투자를 분석한 결과 가전산업의 대선진국투자는 i) 독점적 우위의 부재, ⅱ) 방어적이고 생존적인 차원에서의 진출 ⅲ) 미성숙한 유형의 투자라는 특징을 가짐을 알아내고 이를 바탕으로 기존이론의 설명력 한계를 살펴본 다음, 대선진국 역투자를 설명할 수 있는 새로운 이론을 제시하고자 한다. 즉 한국가전산업의 역투자는 우리 경제의 성장구조적인 특징으로 인해 선택된 대량생산- 저가수출전략이라는 기존의 의사결정을 단기간내에 바꿀 수 없는 경직성으로인해 독점적 우위없이 불가피하게 이루어진, 수출시장보호라는 생산차원에서 내려진 구조적 시장방어행위임을 알 수 있었다. 이러한 특성으로 인해 가전 산업의 대선진국투자는 그 생명이 길지 못할 것으로 예상되므로 독점적우위확보, 글로벌 네투워크화, 전략적제휴 등을 통하여 이에 대한 대책을 마련해야 할 것이다.

한국인 소녀의 신체발육에 관한 체질인류학적 연구

윤경준,김동창 중앙대학교 의과대학 의과학연구소 1985 中央醫大誌 Vol.10 No.4

Anthropometry on three items(stature, head length, head breadth) was carried out to 3,074 Korean girls of an age group of 12 to 15 years. In addition to them, the head length breadth index was calculated according to each age group. The results obtained are as follows: 1. The average stature showed 148.94㎝ in 12 years age group, 152.21㎝ in 13 years age group, 153.57㎝ in 14 years age group and 157.45㎝ in 15 years age group respectively. The growth pattern of stature showed remarkably high values ranging from 14 to 15 years age group. 2. The average head length showed 16.83㎝ in 12 years age group, 16.89㎝ in 13 years age group, 16.99㎝ in 14 years age group and 17.05㎝ in 15 years age group respectively. 3. The average head breadth showed 14.83㎝ in 12 years age group, 14.90㎝ in 13 years age group, 14.93㎝ in 14 years age group and 15.06㎝ in 15 years age group respectively. 4. The average head length breadth index showed 88.24 in 12 years age group, 88.31 in 13 years age group, 87.98 in 14 years age group and 88.51 in 15 years age group respectively. Therefore, it was found that all of the indices obtained in this belonged to hyperbrachycephaly.

개에서 발생한 이버멕틴 중독증 1례

여동원,윤기영,박정호,이왕희,송근호,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1

A 1-year old, intact male Jin-do dog with ataxia, hypersalivation and anorexia was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. Ivermectin toxicosis was diagnosed by the history taking, clinical signs, physical examination and neurological examination. After therapy with intravenous fluid and lipid emulsion administration, the clinical signs were found to have significantly improved.