결핵성 복막염의 복강경검사 성적

윤덕구,박승국 大韓消化器病學會 1988 大韓消化器病學會誌 Vol.20 No.2

급성 유기인제 중독환자의 혈청 Cholinesterase 활성도와 임상적인 의의에 관하여

전동석,김재룡,박승국,김윤년,이경민,윤덕구 啓明大學校 醫科大學 1988 계명의대학술지 Vol.7 No.2

To study the pseudocholinesterase acticity and its clinical significance in patients with acute organophosphate poisoning, Authors checked the serum cholinesterase activity in 49 normal subjects and 31 acute organophosphate poisoned patients. The results were followings. 1. The mean pseudocholinesterase activity f normal subjects was 1271 IU/L in male and 1131 IU/L in female. The total mean cholinesterase activity was 1209/ IU/L. 2. The pseudocholinesterase activity of patients were significantly reduced compare to normal. 22 patients(73%) were below 10% of normal, 6 patients(20%) were between 10-20% of normal and only 2 patients (7%) were between 20-50% of normal. 3. As a whole there was more depressed cholinesterase activity in patients with comatous and drowsy mentality, but there was no statistically significant difference between three groups. 4. The pseudocholinesterase activity in patients with respiratory failure was more depressed than without respiratory failure, but there was no statistically significant difference between three groups. 4. The pseudocholinesterase activity in patients with respiratory failure was more depressed than without respiratory failure, but there was no statistically significant difference presented. 5. The mean arterial blood gas checked on arrival was pH 7.386, PaO?? 66mmHg, PaCO?? 38mmHg 02 Saturation 91%. There was noted no statistically significant correlation between pseudocholinesterase activity and these parameters. 6. The pseudocholinesterase activity on the 1st day of admission was 5.7% of normal and progressively increased during admission. On the 14th day of admission, the pseudocholinesterase activity was 35.5% of normal and it takes 20 days to reach 50% of normal. Authors concluded that serum cholinesterase activity of acute organonphosporus poisoned patients were markedly depressed and progressively increased during admission. As a whole the pseudocholine-sterase activity seemed to be related to the clinical findings but no statistically significant difference was found.

장티푸스 및 파라티푸스에 대한 Cefoperazone의 치료 효과

이경민,윤덕구 대한감염학회 1989 감염 Vol.21 No.1

Chloramphenicol was drug of choice in the treatment of typhoid fever but its side effects and emergence of resistant strain was considered as problem. Cefoperazone is semisynthetic 3rd generation cephalosporine and noted its activity against Gram negative bacilli including salmonella species. To evaluate the effect of cefoperazone in the treatment of typhoid and paratyphoid fever, authors treated 24 cases of typhoid fever and 8 cases of paratyphoid fever with cefoperazone and chloramphenicol and compaired its efficacy. Fever begin to lysed 4 days after cefoperazone therapy and 6.3 days after chloramphenicol therapy in the paratyphoid fever. In the typhoid fever, fever begin to lysed after 3.6 days both cefoperazone and chloramphenicol therapy. In the paratyphoid fever, Fever became completly lysed 6.0 days after cefoperazone therapy and 7.8 days after chloramphenicol therapy. In the typhoid fever, fever became completely lysed 5.7 days after cefoperazone therapy and 7.4 days after chloramphenicol therapy. In the cefoperazone treated group, 1 case of typhoid fever was relapsed after 2 weeks of treatment and 3 cases of typhoid fever were not responded to therapy. In chloramphenicol treated group, 1 case of typhoid fever was relapsed.

혈액배양에서 분리된 병원균과 항생제감수성에 관한 연구

박근용,윤덕구 대한감염학회 1988 감염 Vol.20 No.2

The results of blood cultures in febrile patients who visited or admitted to Keimyung University Hospital during 1981-1986 were analyzed and 349 cases of blood culture positive patients were studied in respect to clinical and antibiotic sensitivity. The results were as follows. The most frequently isolated microorganism was Salmonella and other were S. epidermidis and Pseudomonas in order of frequency. Twenty five percent of all microorganisms were isolated in 1986 and least microorganisms (10%) were isolated in 1982. The Salmonella was most frequently isolated in third decade and Staphylococcus as most frequently isolated below 10 years of age. Salmonella group A and D were isolated in all seasons but Salmonella group A were more freuqently isolated at November, December, May and July. Salmonella group D were more freqently isolated at May, June and December. The most common route of infection was gastrointestinal tract and other important routes of infection were skin, respiratory tract, but in 10% of cases, the routes were not able to identified. Salmonella group D showed 74% sensitivity to chloramphenicol and 68% sensitivity to ampicillin, but 19% resistance to ampicillin and 10% ti chloramphenicol. S. aureus showed 100% and 80% sensitivity to cephalothin and clinidamycin respectiviely but nearly all strains were resistant to ampicillin and pencillin. Gram-negative enteric bacteria showed 61% and 56% sensitivity to amikacin and gentamicin respectively but high resistance to penicillin, kanamycin and cephalothin. P. cepacia showed 83% sensitivity to chloramphenicol but very low sensitivity to other antibiotics.

심낭삼출을 동반한 CREST증후군 1례

윤덕구,박승국,박근용,전영준,이인규,박창호 啓明大學校 醫科大學 1986 계명의대학술지 Vol.5 No.2

CREST syndrome is variant of scleroderma characterized by calcinosis, Raynaud's phenomena, esophageal dysmotility, sclerodactyly & telangiectasia. In the past, it was believed that CREST patients live longer than scleroderma because rare involvement of internal organ, but recently noted that CREST patients may die early by involvement of internal organ. Recently, authors experience one case of CREST syndrome associated with pericardial effusion, herein presenting our experience and literature and reviewed.

폐결핵환자의 환기역학

윤덕구 ( Duk Koo Yun ),정태훈 ( Tae Hoon Jung ),박희명 ( Hi Myung Park ) 대한결핵 및 호흡기학회 1986 Tuberculosis and Respiratory Diseases Vol.33 No.4

월악산국립공원 자연관찰로 조성사례 및 이용객 행태

김종완,윤덕구,허영범,이배근,이현태 한국환경생태학회 2002 한국환경생태학회 학술대회지 Vol.2002 No.1

대구, 경북지역에서 발생한 쭈쭈가무시병의 임상적 고찰

양창현,윤덕구,박정모,손수호,이준호,김윤년 啓明大學校 醫科大學 1992 계명의대학술지 Vol.11 No.3

Tsutsugamushi disease is acute febrile illness primarily affecting farmer and prevalent in Autumn. The disease is characterized by fever, rash and eschar and sometimes it caused atypical pneumonitis and it should be differentiated by Leptospirosis and Korean hemorrhagic fever. We experienced 38 cases of Tsutsugamushi disease diagnosed by clinical and detection of tsutsugamushi antibody by indirect immunofluorescent technique. Studied subjects were 15 cases of male and 23 cases of female and the victim were primarily farmer(89%). Most cases were occurred in October and September and in 1990. Fever and chills(94%)were the most complaint symptoms and other complaint symptoms were myalgia cough and dyspnea in the order of frequency. Leuhocytosis or leukopenia was detected in 14% and 11% respectively and 83% were detected to have thrombocytopenia. Transaminase was elevated in 57% and BUN and creatinine was elevated in 3%. Physical examination showed eschar(84%), rash(82%) hypatosplenomegaly(24%),conjunctival injection and hyperemia of pharynx. chest X-ray showed interstitial pneumonitis (11%) pulmonary edema(11%) and cardiomegaly(8%). 57% were revealed positive reaction to indirect fluorescent antibody technique. Clinical response was very good in the treatment of tetracycline vibramycin, or chloramphenicol.

연제발표 : 만성 기관지염의 폐기능 -노력성 호기곡선, 최대 호기량 곡선 및 Closing Volumes을 중심으로-

정태훈,윤덕구,김중구,이병수,이장백,박희명 대한결핵 및 호흡기학회 1979 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.49 No.-

복부 방사성균증 1예

이상숙,윤덕구,박영관,김경목,박승국,이경민,권석룡,조원현 대한감염학회 1988 감염 Vol.20 No.3

Actinomycosis is chronic suppurative and granulomatous disease caused by Actinomyces specises and characterized by sulfur granule formation which frequently discharged via draining sinus. Actinomyces can affect cervicofacial, pulmonary, abdominal and pelvic area. Most of abdominal actinomycosis is developed after abdominal operation, trauma or inflammatory bowel disease and it must be differentiated from colon cancer, amaeboma, chronic appendicitis or intestinal tuberculosis. Recently we experienced one case of abdominal actinomycosis developed after peptic ulcer perforation. In this case we noted large secondary and tertiary abscess formation after surgical repairment of primary disese, afterward the abscess was proved as actinomycosis. Herein we presenting our experience and reviewed the literature.