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        Real Time Related Key Attack on Hummingbird-2

        ( Kai Zhang ),( Lin Ding ),( Junzhi Li ),( Jie Guan ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.8

        Hummingbird is a lightweight encryption and message authentication primitive published in RISC`09 and WLC`10. In FSE`11, Markku-Juhani O.Saarinen presented a differential divide-and-conquer method which has complexity upper bounded by 2<sup>64</sup> operations and requires processing of few megabytes of chosen messages under two related nonces (IVs). The improved version, Hummingbird-2, was presented in RFIDSec 2011. Based on the idea of differential collision, this paper discovers some weaknesses of the round function WD16. Combining with the simple key loading algorithm, a related-key chosen-IV attack which can recover the full secret key is proposed. Under 15 pairs of related keys, the 128 bit initial key can be recovered, requiring 2<sup>27</sup> chosen IV and the computational complexity is O(2<sup>27</sup>). In average, the attack needs several minutes to recover the full 128-bit secret key on a PC. The experimental result corroborates our attack. The result shows that the Hummingbird-2 cipher can`t resist related key attack.

      • KCI등재

        CK2 phosphorylates AP-2α and increases its transcriptional activity

        ( Kai Qun Ren ),( Shuang Lin Xiang ),( Fang Li He ),( Wen Feng Zhang ),( Xiao Feng Ding ),( Yan Yang Wu ),( Li Ping Yang ),( Jian Lin Zhou ),( Xiang Gao ),( Jian Zhang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.7

        Transcription factor AP-2α involves in the process of mammalian embryonic development and tumorigenesis. Many studies have shown that AP-2α functions in association with other interacting proteins. In a two-hybrid screening, the regulatory subunit β of protein casein kinase 2 (CK2β) was identified as an interacting protein of AP-2α; we confirmed this interaction using in-vitro GST pull-down and in-vivo co-immunoprecipitation assays; in an endogenous co-immunoprecipitation experiment, we further found the catalytic subunit α of protein casein kinase 2 (CK2α) also exists in the complex. Phosphorylation analysis revealed that AP-2α was phosphorylated by CK2 kinase majorly at the site of Ser429, and such phosphorylation could be blocked by CK2 specific inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) in a dose-dependent manner. Luciferase assays demonstrated that both CK2α and CK2β enhanced the transcription activity of AP-2α; moreover, CK2β increased the stability of AP-2α. Our data suggest a novel cellular function of CK-2 as a transcriptional co-activator of AP-2α.

      • KCI등재

        CT-Based Radiomics Signature for Preoperative Prediction of Coagulative Necrosis in Clear Cell Renal Cell Carcinoma

        Xu Kai,Liu Lin,Li Wenhui,Sun Xiaoqing,Shen Tongxu,Pan Feng,Jiang Yuqing,Guo Yan,Ding Lei,Zhang Mengchao 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.6

        Objective: The presence of coagulative necrosis (CN) in clear cell renal cell carcinoma (ccRCC) indicates a poor prognosis, while the absence of CN indicates a good prognosis. The purpose of this study was to build and validate a radiomics signature based on preoperative CT imaging data to estimate CN status in ccRCC. Materials and Methods: Altogether, 105 patients with pathologically confirmed ccRCC were retrospectively enrolled in this study and then divided into training (n = 72) and validation (n = 33) sets. Thereafter, 385 radiomics features were extracted from the three-dimensional volumes of interest of each tumor, and 10 traditional features were assessed by two experienced radiologists using triple-phase CT-enhanced images. A multivariate logistic regression algorithm was used to build the radiomics score and traditional predictors in the training set, and their performance was assessed and then tested in the validation set. The radiomics signature to distinguish CN status was then developed by incorporating the radiomics score and the selected traditional predictors. The receiver operating characteristic (ROC) curve was plotted to evaluate the predictive performance. Results: The area under the ROC curve (AUC) of the radiomics score, which consisted of 7 radiomics features, was 0.855 in the training set and 0.885 in the validation set. The AUC of the traditional predictor, which consisted of 2 traditional features, was 0.843 in the training set and 0.858 in the validation set. The radiomics signature showed the best performance with an AUC of 0.942 in the training set, which was then confirmed with an AUC of 0.969 in the validation set. Conclusion: The CT-based radiomics signature that incorporated radiomics and traditional features has the potential to be used as a non-invasive tool for preoperative prediction of CN in ccRCC.

      • Parallel-Plate Capacitor Structures with Enhanced Linearity

        Ching-Lieh Li,Chih-Wei Hsueh,Ding-Kai Lin 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7

        In this paper, the FDTD method is employed to calculate the static capacitance of several parallel-plate capacitors. The study of the capacitor characteristics is made to emphasis on the linearity analysis for the possible sensor application. The linearity of several parallel-plate structures is examined, which include a simple parallelplate capacitor, a parallel-plate structure with guard ring only, etc. Although the guard ring is usually utilized to increase the linearity of a simple parallel-plate capacitor, it is found that the linearity of a parallel-plate capacitor with guard ring is actually the same as a simple parallel-plate capacitor with the same plate area. Afterwards, a new parallel-plate structure with pins inserted in between the parallel plates is proposed to reduce the linearity deviation as the separation of the parallel plates changes.

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