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      • Poster Session : PS 0349 ; Epidemiology and Public Health : Brucellosis Related Knowledge and Practices among Animal Breeding People in Turkey

        ( Dilek Kusaslan ), ( Huseyin Avni Sahin ), ( Gulnihal Guvendi ), ( Zuhal Cakmak ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: Infection with Brucella is a common problem in Eastern region of Turkey. For this reason the aim of study was to determine the Brucellosis related knowledge and practices among animal breeding people. Methods: Cross-sectional descriptive study was performed, between April and June 2014. The data were gathered by using a structured questionnaire that was filled during face to face interview to determine the knowledge and practices related to brucellosis. Data were evaluated by using SPSS computer software version 21. Results: All the people dealing with animals were included in this descriptive study. Of the 66 participants 53 (80. 3%) were women 13 (19. 7%) were men. 31 (%47) of the respondents were not able to read and write. Even though 65 (98. 5%) of the respondents had previous knowledge of brucellosis, 12 (18. 8%) of them knew the infection route properly and only 5 (7. 6%) of them were previously informed about brucellosis. 27 (40. 9%) of the respondents and 48 (72. 7%) of the respondent`s family members were infected with Brucella previously. 63 of the (95. 5%) respondents were making fresh cheese from raw milk and none of them were wearing gloves while milking, 16 of them were wearing gloves while handling animals. Information sources regarding the disease was; 28 health professionals, 27 neighbours, 23 relatives, 1 religious leader, none of them were teachers or veterinarians. The average time in the job was 21, 5 years among respondents. Conclusions: Brucellosis is a growing public health concern in developing countries like Turkey and is not a well-known disease among animal breeding people in Van region. So Brucella infection is still a public health problem in the region. In order to prevent and eradicate the disease, generalized education programs particularly aiming to prevent the disease spread are necessary.

      • KCI등재SCOPUS

        Is Human Kallikrein 11 in Non-small Cell Lung Cancer Treated Chemoradiotherapy Associated with Survival?

        Dilek,Unal,Celalettin,Eroglu,Arzu,Tasdemir,Hatice,Karaman,Neslihan,Kurtul,Arzu,Oguz,Sema,Sezgin,Goksu,Bunyamin,Kaplan 대한암학회 2016 Cancer Research and Treatment Vol.48 No.1

        Purpose Involvement of human kallikreins (hKs) in human cancers has been reported and several hKs are promising biomarkers of various cancers. The aim of this study was to evaluate the prognostic significance of hK11 expression in patients with non-metastatic non-small cell lung cancer (NSCLC). Materials and Methods The study included 44 patients with NSCLC. hK11 expression was determined by immuno- histochemical staining. Results The estimation of disease-free and overall survival by Kaplan-Meier was 11 months and 17 months, respectively. The estimation of overall survival by Kaplan-Meier was significantly higher in patients with hK11 strongly positive (2+) than in those with hK11 weakly positive (1+) (20 months vs. 11 months, p=0.032). Although not statistically different, the estimation of disease-free survival by Kaplan-Meier was higher in patients with hK11 strongly positive (2+) than in those with hK11 weakly positive (1+) (12 months vs. 9 months, p=0.113). Multivariate Cox regression analysis showed that the overall survival rates were significantly associated with response to chemoradiotherapy and the degree of staining with hK11. Conclusion The stronger hK11 expression in NSCLC appears to be associated with better survival rates. hK11 may be a prognostic biomarker of NSCLC.

      • KCI등재SCOPUS

        Cytogenetic Finding of Breast Cancer Cases and in Their First-Degree Relatives

        Dilek,Aşcı,Çelik,Nurten,Özçelik,Erol,Eroğlu,Pınar,Aslan,Koşar 한국유방암학회 2013 Journal of breast cancer Vol.16 No.3

        Purpose: The aim of this study was to evaluate and compare the rate of sister chromatid exchange (SCE), the occurrence of micronuclei, and the lymphocyte proliferation rate index (PRI) in patients with breast cancer, their first-degree relatives, and healthy volunteers. Methods: We analyzed the frequency of SCE and micronuclei, and the PRI in the peripheral blood lymphocytes of 30 women with breast cancer, 22 of their female family members,and 20 age-matched healthy female volunteers. Results:SCE occurred significantly more often in the lymphocytes of breast cancer patients (10.84±0.4 per metaphase), compared with their first-degree relatives (7.45±0.54) and controls (5.94±0.2) (p<0.001 for both). The mean SCE frequency was not statistically different between first-degree relatives and controls (p=0.071). Similarly, micronuclei occurred at a significantly higher rate in breast cancer patients (9.6±0.72), and in their first-degree rela tives (7±0.64), compared to controls (3.85±0.4) (p<0.001 and p=0.001, respectively). There was also a significant difference between the occurrence of micronuclei in patients compared to their family members (p=0.021). The PRI was significantly lower in patients (1.61±0.1), compared with both their first-degree relatives (1.75±0.1), and controls (1.74±0.1) (p=0.001 and p=0.002,respectively). Conclusion: Increased SCE and the occurrence of micronuclei, as well as a reduced PRI are associated with breast cancer. Furthermore, increased SCE and the frequency of micronuclei in a first-degree relative suggest that they exhibit greater genetic instability than women of the same age.

      • KCI등재

        Highly uniform electrochromic tungsten oxide thin films deposited by ebeam evaporation for energy saving systems

        Dilek,Evecan,Esra,Zayim 한국물리학회 2019 Current Applied Physics Vol.19 No.2

        In the last few decades, there has been a surge of interest in using tungsten oxide thin films as an active layer of electrochromic device. These devices have several practical applications such as smart window of buildings and automobile glazing for energy saving. The main objective of this work was to construct highly homogeneous and uniform e-beam evaporated amorphous WO3-x based films into electrochromic devices, which were fully characterized for switching speed, coloration efficiencies and cycling voltammetry responses. Fabricated devices contain indium doped transparent oxide coated glass as the transparent conductive electrode, ∼200 nm thickness of WO3-x as the cathodically coloring material and a lithium perchlorate based conducting gel electrolyte. Xray diffraction patterns indicate that all as-deposited films are amorphous. Experimental results showed that both solid and liquid electrolyte electrochromic devices are initially very transparent that exhibit perfect optical modulation and coloration efficiency (up to 68.7 cm2 /C and 52.6 cm2 /C at 630 nm, respectively) due to easier intercalation of the Li+ within their structure. One of the more significant findings to emerge from this study is that e-beam coated electrochromic devices based on tungsten oxide thin films showed superior performance among to other coating methods. Therefore, excellent reversibility of color change behavior is attractive for pertinent use in electrochromic energy storage devices.

      • KCI등재SSCI

        How do Turkish nursing students plan their career after the graduation?: a questionnaire survey

        Dilek,Yildirim,Ayla,Kececi,Serap,Bulduk 서울대학교 교육연구소 2011 Asia Pacific Education Review Vol.12 No.3

        This research was planned as a cross-sectional and descriptive study for the purpose of determining nursing students' expectations from a workplace and what department, area, and positions they want to work in after graduation. The research population was comprised of the four university-based schools of nursing in Ankara province. The sample was comprised of 447 nursing students. A questionnaire developed by the researchers in light of information in the literature was used for data collection and had three sections including the participants' demographic characteristics, questions asking about where they wanted to work and expectations from the workplace where they want to work. The overwhelming majority of the students wanted to work as an academician at the university or in management at a hospital. The highest percentage of students wanted to work in pediatrics and the operating room, and the lowest percentage wanted to work in psychiatric nursing, geriatrics and care for the handicapped. The primary expectations students had from the workplaces where they wanted to work after graduation been an orientation to the workplace and educational opportunities, opportunities for promotion and job satisfaction. Explaining to students that the most significant need in the nursing profession is the shortage of nurses responsible for direct patient care may prevent them from developing wrong expectations and goals in their career planning.

      • KCI등재SSCI

        The effects of the cooperative learning method supported by multiple intelligence theory on Turkish elementary students' mathematics achievement

        Dilek,Is¸ık 서울대학교 교육연구소 2009 Asia Pacific Education Review Vol.10 No.4

        In the present experimental study, the effects of the cooperative learning method supported by multiple intelligence theory (CLMI) on elementary school fourth grade students' academic achievement and retention towards the mathematics course were investigated. The participants of the study were 150 students who were divided into two experimental (used CLMI) and two control groups (used traditional method). "Mathematics Achievement Test," "Teele Inventory for Multiple Intelligences" and "Personal Information Form" were used as the measurement instruments of the study. The findings of this research have indicated that CLMI has a more significant effect on academic achievement than the traditional method. Yet, regarding the retention scores, CLMI has not significant effect on retention.

      • KCI등재SCIESCOPUS

        External Jugular Vein Catheterization Using ‘Intra-Atrial Electrocardiogram'

        Dilek,Karaaslan,Ugur,Altinisik,Tulay,Tuncer,Peker,Esra,Nayir,Sadik,Ozmen 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.2

        Purpose: To investigate the reliability of intra-atrial electrocardiogram (ECG) use for external jugular vein (EJV) catheterization. Materials and Methods: Patients undergoing open heart surgery in Suleyman Demirel University Hospital between February and June 2006 were included in the study. Using a sterile Seldinger technique, a triple lumen polyurethane central venous catheter was introduced (Certofix® Trio V 720, length 20 cm, 7 French) under intra-atrial ECG guidance. The presence of an increase in P-wave size was recorded. Just after the surgery, a portable chest X-ray was taken. The method was considered to be successful when a change in P-wave could be seen and the catheter was in the superior vena cava, as well as when there was no change in P-wave and the catheter was not in the superior vena cava. Results: In six patients (12%), we were not able to advance the guidewire. In the remaining 44 patients, the catheter was inserted without problem. Eight of these 44 catheters were positioned in the innominate vein, with a malposition ratio of 18%. The success rate of external jugular vein cannulation with intra-atrial ECG was 95%. No complications occured related to the EJV cannulation. Conclusion: Considering that it is easily accessed without complication, and the malposition is successfully detected by intra-atrial ECG, EJV is a suitable access for central venous cannulation when internal jugular vein (IJV) is not usable. Purpose: To investigate the reliability of intra-atrial electrocardiogram (ECG) use for external jugular vein (EJV) catheterization. Materials and Methods: Patients undergoing open heart surgery in Suleyman Demirel University Hospital between February and June 2006 were included in the study. Using a sterile Seldinger technique, a triple lumen polyurethane central venous catheter was introduced (Certofix® Trio V 720, length 20 cm, 7 French) under intra-atrial ECG guidance. The presence of an increase in P-wave size was recorded. Just after the surgery, a portable chest X-ray was taken. The method was considered to be successful when a change in P-wave could be seen and the catheter was in the superior vena cava, as well as when there was no change in P-wave and the catheter was not in the superior vena cava. Results: In six patients (12%), we were not able to advance the guidewire. In the remaining 44 patients, the catheter was inserted without problem. Eight of these 44 catheters were positioned in the innominate vein, with a malposition ratio of 18%. The success rate of external jugular vein cannulation with intra-atrial ECG was 95%. No complications occured related to the EJV cannulation. Conclusion: Considering that it is easily accessed without complication, and the malposition is successfully detected by intra-atrial ECG, EJV is a suitable access for central venous cannulation when internal jugular vein (IJV) is not usable.

      • KCI등재SSCISCOPUS

        Genetic Variations in Attention Deficit Hyperactivity Disorder Subtypes and Treatment Resistant Cases

        Dilek,Unal,Mehmet,Fatih,Unal,Mehmet,Alikasifoglu,Arda,Cetinkaya 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.4

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        ObjectiveaaWe evaluated the distribution of alpha-2A adrenergic receptor (ADRA2A) and catechol-o-methyltransferase (COMT) single nucleotide polymorphisms (SNPs) among ADHD subtypes and other homogeneous patient populations including treatment-resistant cases and patients with high symptom severity. Methodsaa121 ADHD patients aged 6–18 years were included in the study. Diagnosis and subtypes designation were confirmed using the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS) and symptoms were evaluated using the Conners' Parent (CPRS) and Teacher Rating Scales (CTRS). The response to methylphenidate was assessed objectively using the Clinical Global Impression-Severity Scale (CGI-S) and Global Assessment of Functioning Scale (GAS) as well as the Continuous Performance (CPT) and Trail Making tests (TMT-A, B). Patients were genotyped for ADRA2A (rs1800544) and COMT (rs4680) SNPs by PCR/RFLP and compared to a gender-matched control group. ResultsaaAlthough there was no association of COMT (rs4680) SNP with symptoms or diagnosis, the ADRA2A polymorphism, low socioeconomic status (SES), and comorbid psychiatric diagnosis were all associated with poor response to methylphenidate in logistic regression analysis. ConclusionaaClinicians may consider adjuvant strategies when these negative factors are present to increase the success of tailored ADHD treatments in the future.

      • KCI등재SCIESCOPUS

        Effectiveness of Different Cleaning Agents against the Colonization of Candida spp and the in Vitro Detection of the Adherence of These Yeast Cells to Denture Acrylic Surfaces

        A.,Dilek,Nalbant,Ayse,Kalkanci,Bano,Filiz,Semra,Kustimur 연세대학교의과대학 2008 Yonsei medical journal Vol.49 No.4

        Purpose: The aim of this study is to examine the effect Klorhex and Fittydent, which are used as  cleaning agents on the adhesion of Candida on the surfaces of acrylic denture and palatal mucosa. In addition, ability of yeasts to adhere to acrylic strips was evaluated after applying these agents in vitro. Materials and Methods: Each group of 15 patients  cleaned their dentures with either Klorhex or with Fittydent. The control group cleaned their dentures  with water. Results: It was found that  62.2% of  the patients had colonies of Candida species on their palatal mucosa which was reduced to 51.1%  after using these cleaning agents. The colonization rate with Candida spp on their dentures  was reduces from  82.2% to  68.8%  using these cleaning agents.  The mean adhesion value of the Candida strains isolated from the acrylic strips were found to be 75cell/strip prior to applying the Klorhex and Fittydent  and 37.5cell/strip and 15cell/strip after  applying these agents, respectively. Conclusion: These results showed that Klorhex and Fittydent have a certain preventive effect on the colonization rate of Candida spp on the surface of these dentures, the palatal mucosa, as well as on the acrylic strips in vitro.

      • Mothers' Knowledge and Attitudes about HPV Vaccination to Prevent Cervical Cancers

        Kose,,Dilek,Erkorkmaz,,Unal,Cinar,,Nursan,Altinkaynak,,Sevin Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

        Background: Cervical cancer which is one of the most preventable cancers is an important public health problem worldwide, and especially in developing countries. The aim of this study was to determine knowledge and attitudes about the HPV vaccination of mothers with 0- to 18-year old children. Materials and Methods: Written approval was taken from the local authorities. The study subjects consisted of 799 mothers who agreed to participate. The data were collected via a "Personal Information Form" which included 30 questions that were prepared by the researchers themselves in line with the literature. The data were collected by face to face interviews with the mothers. Analyses were performed using commercial software. Results: The mean age of the mothers who participated in the study was $32.0{\pm}6.52$, and 88.1% reported no information about HPV, and 83.5% no information about HPV vaccination. Only 0.7% of the mothers had daughters who had HPV vaccination, and 44.3% of the mothers who had sons were found out to be indecisive about having HPV vaccination. There was a significant corelation between the educational status of the mothers and their knowledge about HPV vaccination (p<0.05). However, there was no significant correlation in terms of economic conditions (p>0.05). Conclusions: This study suggested that mothers had very little information on HPV and HPV vaccination. Knowledge of the disease and its vaccination is an essential factor for the success of the vaccination program. It is of great importance that mothers are trained in this subject by health professionals.

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