유방암에서 PCNA, c-erbB-2 그리고 p53의 표출양상에 관한 연구

김득수,김의한,양승하 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Breast carcinoma is a common malignant tumor in korea. Various oncogenes have been found in malignant tumor cells. There were many reports for correlation betwee PCNA, c-erbB-2, and p53, and prognosis of breast carcinoma, but is controversial. We performed immunohistochemical stain for PCNA, c-erbB-2, and p53 for 27 cases of benign tumor and 49 cases of carcinoma of the breast and evaluated expression rate of each antigens, and we compared their correlation with prognosis of patients in breast carcinoma. The results were as follow; 1) PCNA LI of benign tumor and carcinoma of breast were 74.04±17.85 and 71.86±21.57. c-erbB-2 expression rates were 85.19% and 79.59%, and p53 were 0% and 51.02%. 2) PCNA LI showed no difference according to types of benign tumor and to types, histologic grade, and lymph node metastatic status of carcinoma. 3) c-erbB-2 showed higher expression rate in grade Ⅱ(87.5%) and grade Ⅲ(88.89%) than grade Ⅰ(62.50%) in breast carcinoma but it was not significant difference. 4) p53 showed significantly higher expression rate in left side and non-metastatic cases compared to right side and metastatic cases(each p<0.05), and it showed increasing expression rate according to highening of grade without significant differnece(p=0.069). 5) The expression of p53 in breast carcinoma showed significant correlation with proliferative activity of tumor cells(P<0.05). Above results showed that there was correlation the expression of p53 and poor prognosis of patients and proliferative activity of tumor cells in breast carcinoma. c-erbB-2 showed indistinctive correlation with prognosis and no correlation with proliferative activity of tumor cells. PCNA showed no relation to prognosis

家宅信仰을 통한 韓國傳統住居空間의 意味 解釋

천득염,나경수,손희하,나하영 전남대학교호남문화연구소 2001 호남학 Vol.28 No.-

The Korean Traditional Dwelling House is product of a social environment which reflects the thought, religion. Therefore, to understand the meaning of the Korean Traditional Dwelling House, it is necessary to study the dweller' thought about men-world. The purpose of this study is to understand the meaning of the Korean Traditional Dwelling House by analyzing the Residential Religion. In conclusion, the Residential Religion is related closely to the Korean Traditional Dwelling House. On such a context, the Korean Traditional Dwelling House is regarded as a sacred house where gods dwell. Accordingly the Korean Traditional House has the dualism as the space of men and gods, and the hierarchic structure by hierarchy of gods.

韓拏山과 百頭山의 蘭草科 植物 比較

임영득,김수남 仁川敎育大學校 科學敎育硏究所 1997 과학교육논총 Vol.9 No.-

63 kinds of orchids grow in Mt. Halla and 43 in Mt. Paekdu. Mt. Paekdu has many kinds of orchids comparing with central district of Korean Penninsula. Common Species in both mountains are Gymnadenia conopsea, Galeochis cyclochila. Coeloglossum viride var bracteatum, Platanthera hologotis, pogonia japonica Goodyera maximowicziana and Malaxis monophyllos, and they belong to alpine orchids,

광주광역시 근대건축물의 건축적 특성에 관한 조사연구 : 현존 근대건축물을 중심으로 Focused on the remained modern architecture

김진안,탁형수,천득염 대한건축학회 2003 대한건축학회논문집 Vol.19 No.11

The existing studies about buildings during modern period, from the Japanese annexation of Korea to the Liberation, are limited around Seoul and major port cities like In-chon and Pu-san. It has to be made sure that architectural development of circumstance at a small or middle-scale city should be simultaneously examined. The purpose of this study is that the materials, which could historically prosepect architectural activities of the times, should be sorted out by examining and discovering modern buildings before they are destroyed, and the opportunity to newie regards modern buildings as a cultural heritage should be constituted.

치면세마처치 인식도와 구강위생지수 변화에 대한 연구

이은숙 ; 한만덕 ; 나수정 ; 장종화 김천대학교 2016 김천대학교 논문집 Vol.19 No.-

This study was performed to analyze

기질적 뇌증후군환자에 대한 Nimodipine의 효과

황인담,안득수,황익근 최신의학사 1989 最新醫學 Vol.32 No.9

살균방법을 달리한 시유의 저장성

정인철,권수득,문윤희 慶星大學校 1994 論文集 Vol.15 No.2

Experiments were carried out to investigate market milk treated by LTLT, HTST, UHT methods and analysed storage stability of these products at 5℃ and 30℃ by 24 hour interval. In case of LTLT, storage periods were possible to 6 days in 5℃, thermophile bacteria was more than HTST and UHT. Storage stability during stored in 30℃ was impossible only one day, psychrophile bacteria was more than HTST and UHT. In case of HTST, storage periods were possible to 6 days in 5℃, psychrophile bacteria was more than LTLT and UHT. Storage stability during stored in 30℃ was impossible only one day. In case of UHT, storage periods were possible to 7 days in 5℃, storage stability except boiling test was safe to 1st and thermophile bacteria was more than LTLT, HTST during stored in 30℃.

Shearography를 이용한 타이어 내부결함의 정량평가 및 진전 모니터링

김경석,정승택,김종수,유득남 한국비파괴검사학회 2003 학술대회 논문집 Vol.- No.1

In recent years, shearogrpahy has significantly improved capabilities in the areas of unbond and separation detection in tires. Although shearography has many advantages for qualitative evaluation, the technique remains the problem of quantitative analysis of inside defects, because shearography needs several effective factors including the amount of shearing, shearing direction and induced load, which exist as barrier for the quantitative analysis of inside defects. In this study, the factors were optimized and the size of cracks inside of tire has been quantitatively determined. Since the factors are highly dependent on inspectors skill and also affect the in-situ workability.

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

Relationship between mandibular condyle and angle fractures and the presence of mandibular third molars

Deuk-Hyun Mah,Su-Gwan Kim,Seong-Yong Moon,Ji-Su Oh,Jae-Seek You 대한구강악안면외과학회 2015 대한구강악안면외과학회지 Vol.41 No.1

Objectives: We retrospectively evaluated the impact of mandibular third molars on the occurrence of angle and condyle fractures. Materials and Methods: This was a retrospective investigation using patient records and radiographs. The sample set consisted of 440 patients with mandibular fractures. Eruption space, depth and angulation of the third molar were measured. Results: Of the 144 angle fracture patients, 130 patients had third molars and 14 patients did not. The ratio of angle fractures when a third molar was present (1.26 : 1) was greater than when no third molar was present (0.19 : 1; odds ratio, 6.58; P〈0.001). Of the 141 condyle fractures patients, the third molar was present in 84 patients and absent in 57 patients. The ratio of condyle fractures when a third molar was present (0.56 : 1) was lower than when no third molar was present (1.90 : 1; odds ratio, 0.30; P〈0.001). Conclusion: The increased ratio of angle fractures with third molars and the ratio of condyle fractures without a third molar were statistically signifi- cant. The occurrence of angle and condyle fractures was more affected by the continuity of the cortical bone at the angle than by the depth of a third molar. These results demonstrate that a third molar can be a determining factor in angle and condyle fractures.