Gynecologic oncology group trials in uterine corpus malignancies: recent progress

David Scott Miller1,Louise P. King 대한부인종양학회 2008 Journal of Gynecologic Oncology Vol.19 No.4

The Gynecologic Oncology Group (GOG) has conducted multiple trials related to malignancies of the uterine corpus. Recently, several of these trials have been presented and/or published. Areas of focus included the feasibility of laparoscopic staging for endometrial cancer, the adjuvant management of locally advanced endometrial cancer, whole abdominal irradiation in maximally resected advanced endometrial carcinoma, and combination chemotherapy regimens for stage I and II carcinosarcoma after primary surgery and for advanced or recurrent carcinosarcoma. This article will discuss the background and details of each of these important advances. The Gynecologic Oncology Group (GOG) has conducted multiple trials related to malignancies of the uterine corpus. Recently, several of these trials have been presented and/or published. Areas of focus included the feasibility of laparoscopic staging for endometrial cancer, the adjuvant management of locally advanced endometrial cancer, whole abdominal irradiation in maximally resected advanced endometrial carcinoma, and combination chemotherapy regimens for stage I and II carcinosarcoma after primary surgery and for advanced or recurrent carcinosarcoma. This article will discuss the background and details of each of these important advances.

Ascophyllum nodosum and its symbionts: XI. The epiphyte Vertebrata lanosa performs better photosynthetically when attached to Ascophyllum than when alone

David J. Garbary,Anthony G. Miller,Ricardo A. Scrosati 한국조류학회I 2014 ALGAE Vol.29 No.4

Vertebrata lanosa is an abundant and obligate red algal epiphyte of Ascophyllum nodosum that forms part of a complex and highly integrated symbiotic system that includes the ascomycete, Mycophycias ascophylli. As part of ongoing studies to resolve interactions among species in the symbiosis, we used pulse amplitude modulation fluorimetry of chlorophyll a fluorescence, from photosystem II (PSII), to measure the maximum quantum yield (Fv / Fm) of PSII [QY(II)max] and relative photosynthetic electron transport rates (rETR), as a function of light intensity, in order to evaluate the photosynthetic capacity of the two algal symbionts in the field and in the laboratory under different treatments. Our primary question was ‘Is the ecological integration of these species reflected in a corresponding physiological integration involving photosynthetic process?’ In the laboratory we measured changes in QY(II)max in thalli of V. lanosa and A. nodosum over one week periods when maintained together in either attached or detached treatments or when maintained separated from each other. While the QY(II)max of PSII of A. nodosum remained high and showed no significant variation among treatments, V. lanosa showed decreasing performance in the following conditions: V. lanosa attached to A. nodosum, V. lanosa in the same culture, but not attached to A. nodosum, and V. lanosa alone. These results are consistent with observations in which rETR was reduced in V. lanosa maintained alone versus attached to A. nodosum. Values for QY(II)max in V. lanosa measured in the field in fully submerged thalli were similar to those measured in the laboratory when V. lanosa was attached to it obligate host A. nodosum. Our results provide evidence of a physiological association of the epiphyte and its host that reflects the known ecology.

Open Wide and We’ll See How You’ve Done: Proposing and Testing a Model of Injunctive Normative Influence in Dentist-Patient Interactions about Flossing

David Dryden Henningsen,Mary Lynn Miller Henningsen 한국언론학회 2024 Asian Communication Research Vol.21 No.1

Ascophyllum nodosum and its symbionts: XI. The epiphyte Vertebrata lanosa performs better photosynthetically when attached to Ascophyllum than when alone

Garbary, David J.,Miller, Anthony G.,Scrosati, Ricardo A. The Korean Society of Phycology 2014 ALGAE Vol.29 No.4

Vertebrata lanosa is an abundant and obligate red algal epiphyte of Ascophyllum nodosum that forms part of a complex and highly integrated symbiotic system that includes the ascomycete, Mycophycias ascophylli. As part of ongoing studies to resolve interactions among species in the symbiosis, we used pulse amplitude modulation fluorimetry of chlorophyll a fluorescence, from photosystem II (PSII), to measure the maximum quantum yield ($F_v/F_m$) of PSII [$QY(II)_{max}$] and relative photosynthetic electron transport rates (rETR), as a function of light intensity, in order to evaluate the photosynthetic capacity of the two algal symbionts in the field and in the laboratory under different treatments. Our primary question was 'Is the ecological integration of these species reflected in a corresponding physiological integration involving photosynthetic process?' In the laboratory we measured changes in $QY(II)_{max}$ in thalli of V. lanosa and A. nodosum over one week periods when maintained together in either attached or detached treatments or when maintained separated from each other. While the $QY(II)_{max}$ of PSII of A. nodosum remained high and showed no significant variation among treatments, V. lanosa showed decreasing performance in the following conditions: V. lanosa attached to A. nodosum, V. lanosa in the same culture, but not attached to A. nodosum, and V. lanosa alone. These results are consistent with observations in which rETR was reduced in V. lanosa maintained alone versus attached to A. nodosum. Values for $QY(II)_{max}$ in V. lanosa measured in the field in fully submerged thalli were similar to those measured in the laboratory when V. lanosa was attached to it obligate host A. nodosum. Our results provide evidence of a physiological association of the epiphyte and its host that reflects the known ecology.

임상검사실 측정방법의 일치화를 위한 추진방향

W. Greg Miller,Gary L. Myers,Mary Lou Gantzer,Stephen E. Kahn,E. Ralf Schönbrunner,Linda M. Thienpont,David M. Bunk,Robert H. Christenson,John H. Eckfeldt,Stanley F. Lo,C. Micha Nübling,Catharine M. S 대한진단검사의학회 2012 Laboratory Medicine Online Vol.2 No.1

Results between different clinical laboratory measurement procedures (CLMP) should be equivalent, within clinically meaningful limits, to enable optimal use of clinical guidelines for disease diagnosis and patient management. When laboratory test results are neither standardized nor harmonized, a different numeric result may be obtained for the same clinical sample. Unfortunately, some guidelines are based on test results from a specific laboratory measurement procedure without consideration of the possibility or likelihood of differences between various procedures. When this happens, aggregation of data from different clinical research investigations and development of appropriate clinical practice guidelines will be flawed. A lack of recognition that results are neither standardized nor harmonized may lead to erroneous clinical, financial, regulatory, or technical decisions. Standardization of CLMPs has been accomplished for several measurands for which primary (pure substance) reference materials exist and/or reference measurement procedures (RMPs) have been developed. However, the harmonization of clinical laboratory procedures for measurands that do not have RMPs has been problematic owing to inadequate definition of the measurand, inadequate analytical specificity for the measurand,inadequate attention to the commutability of reference materials, and lack of a systematic approach for harmonization. To address these problems,an infrastructure must be developed to enable a systematic approach for identification and prioritization of measurands to be harmonized on the basis of clinical importance and technical feasibility, and for management of the technical implementation of a harmonization process for a specific measurand.

The impact of incontinence etiology on artificial urinary sphincter outcomes

Adam R. Miller,Brian J. Linder,Laureano J. Rangel,David Y. Yang,Daniel S. Elliott 대한비뇨의학회 2017 Investigative and Clinical Urology Vol.58 No.4

Purpose: To evaluate the impact of incontinence etiology on artificial urinary sphincter (AUS) device outcomes. Materials and Methods: We identified 925 patients who underwent primary AUS placement from 1983 to 2011. The etiology of incontinence was categorized as radical prostatectomy alone, radical prostatectomy with radiation, benign prostate resection, and those with cryotherapy as a salvage prostate cancer treatment. Hazard regression and competing risk analyses were used to determine the association of the etiology of incontinence with device outcomes. Results: The distribution of the 4 etiologies of incontinence included: 598 patients (64.6%) treated with prostatectomy alone, 206 (22.2%) with prostatectomy and pelvic radiation therapy, 104 (11.2%) with benign prostate resection, and 17 (1.8%) with prior cryotherapy. With a median follow-up of 4.9 years (interquartile range, 1.2–8.8 years), there was significant difference in the cumulative incidence of device infection/urethral erosion events between the four etiologies (p=0.003). On multivariable analysis, prior cryotherapy (reference prostatectomy alone; hazard ratio [HR], 3.44; p=0.01), older age (HR, 1.07; p=0.0009) and history of a transient ischemic attack (HR, 2.57; p=0.04) were associated with an increased risk of device infection or erosion. Notably, pelvic radiation therapy with prostatectomy was not associated with an increased risk of device infection or erosion (reference prostatectomy alone, p=0.30). Conclusions: Compared to prostatectomy alone, prior treatment with salvage cryotherapy for recurrent prostate cancer was associated with an increased risk of AUS infection/erosion, whereas radiation (in addition to prostatectomy) was not.

A New Seed Vigor Testing System for Ornamental Species Using Computerized Imaging Technology

Xiaolei Hu,David Tay,Miller B. McDonald 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

A divergent external loop confers antagonistic activity on floral regulators FT and TFL1

Ahn, Ji Hoon,Miller, David,Winter, Victoria J,Banfield, Mark J,Lee, Jeong Hwan,Yoo, So Yeon,Henz, Stefan R,Brady, Robert Leo,Weigel, Detlef Wiley (John WileySons) 2006 The EMBO journal Vol.25 No.3

<P>The Arabidopsis genes FT and TERMINAL FLOWER1 (TFL1) encode related proteins with similarity to human Raf kinase inhibitor protein. FT, and likely also TFL1, is recruited to the promoters of floral genes through interaction with FD, a bZIP transcription factor. FT, however, induces flowering, while TFL1 represses flowering. Residues responsible for the opposite activities of FT and TFL1 were mapped by examining plants that overexpress chimeric proteins. A region important in vivo localizes to a 14-amino-acid segment that evolves very rapidly in TFL1 orthologs, but is almost invariant in FT orthologs. Crystal structures show that this segment forms an external loop of variable conformation. The only residue unambiguously distinguishing the FT and TFL1 loops makes a hydrogen bond with a residue near the entrance of a potential ligand-binding pocket in TFL1, but not in FT. This pocket is contacted by a C-terminal peptide, which also contributes to the opposite FT and TFL1 activities. In combination, these results identify a molecular surface likely to be recognized by FT- and/or TFL1-specific interactors.</P>

Maturation and Desiccation Sensitivity in Developing Seeds of Lettuce (Lactuca sativa L.)

Roel C. Rabara,Miller B. McDonald,David Tay,Yael Vodovotz 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

따돌림 피해 경험이 청소년기 학교적응에 미치는 영향

이지언 ( Lee¸ Ji Yeon ),( Miller¸ David B. ),정익중 ( Chung¸ Ick-joong ) 이화여자대학교 사회복지연구소 2021 사회복지 실천과 연구 Vol.18 No.3

본 연구는 청소년기 따돌림 피해 경험이 학교적응에 미치는 경로에서 간접 효과의 영향력을 검증하고자 하였다. 이를 위해 2009년 한국아동청소년종합실태조사 자료를 활용하였다. 분석대상은 중학생(56.2%)과 고등학생(43.8%), 총 2,306명이다. 본 연구의 결과는 다음과 같다. 첫째, 따돌림 피해 경험이 학교적응에 미치는 경로에서 부정적 또래 관계의 매개 효과는 유의한 것으로 검증되었다. 둘째, 신체적 피해 경험이 학교적응에 미치는 간접 효과의 크기가 관계적 피해 경험이 학교적응에 미치는 영향력보다 더 큰 것으로 확인되었다. 셋째, 따돌림 피해 경험과 학교적응 간 경로에서 부정적인 또래 관계는 학교적응을 부정적(-)인 방향으로 더욱 심화시키는 것으로 검증되었다. 본 연구의 결과에 근거하여 따돌림 피해 경험을 가진 한국 청소년의 심리적 부적응을 완화하기 위한 효율적인 개입 방안을 제시하고자 한다. This study aimed to examine the associations between the two types of peer victimization (physical and relational) and South Korean adolescents’ school adjustment. The sample included 2,306 middle (56.2%) and high (43.8%) school students. This study explored the significant indirect effects and confirmed the most robust negative mediating factor that influences lower school adjustment in South Korean adolescents: negative peer relations. This study also found that the indirect effects of physical victimization on school adjustment are much larger than those of relational peer victimization on school adjustment. Additionally, our results also shed light on the negative peer relations variable, which can be considered a risk mediator for physically victimized adolescents in South Korea. The study concludes that existing prevention programs should be revised to ameliorate maladjustments at school.